W Schumann

Summary

Affiliation: University of Bayreuth
Country: Germany

Publications

  1. ncbi request reprint FtsH--a single-chain charonin?
    W Schumann
    Institute of Genetics, University of Bayreuth, Germany
    FEMS Microbiol Rev 23:1-11. 1999
  2. pmc The FtsH protein accumulates at the septum of Bacillus subtilis during cell division and sporulation
    W Wehrl
    Institute of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    J Bacteriol 182:3870-3. 2000
  3. ncbi request reprint Function and regulation of temperature-inducible bacterial proteins on the cellular metabolism
    W Schumann
    Institute of Genetics, University of Bayreuth, Germany
    Adv Biochem Eng Biotechnol 67:1-33. 2000
  4. ncbi request reprint Post-transcriptional regulation of the Bacillus subtilis dnaK operon
    G Homuth
    Institute of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    Mol Microbiol 32:1183-97. 1999
  5. pmc The GroE chaperonin machine is a major modulator of the CIRCE heat shock regulon of Bacillus subtilis
    A Mogk
    Institute of Genetics, University of Bayreuth, Germany
    EMBO J 16:4579-90. 1997
  6. ncbi request reprint Cloning and sequencing of the hrcA gene of Bacillus stearothermophilus
    A Mogk
    Institute of Genetics, University of Bayreuth, Germany
    Gene 194:133-6. 1997
  7. pmc The dnaK operon of Bacillus subtilis is heptacistronic
    G Homuth
    Institute of Genetics, University of Bayreuth, Germany
    J Bacteriol 179:1153-64. 1997
  8. ncbi request reprint Alkaline shock induces the Bacillus subtilis sigma(W) regulon
    T Wiegert
    Institute of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    Mol Microbiol 41:59-71. 2001
  9. ncbi request reprint Transcriptional analysis of three Bacillus subtilis genes coding for proteins with the alpha-crystallin domain characteristic of small heat shock proteins
    S Reischl
    Institute of Genetics, University of Bayreuth, D 95440, Germany
    FEMS Microbiol Lett 194:99-103. 2001
  10. pmc Development of a new integration site within the Bacillus subtilis chromosome and construction of compatible expression cassettes
    B Hartl
    Institute of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    J Bacteriol 183:2696-9. 2001

Collaborators

Detail Information

Publications24

  1. ncbi request reprint FtsH--a single-chain charonin?
    W Schumann
    Institute of Genetics, University of Bayreuth, Germany
    FEMS Microbiol Rev 23:1-11. 1999
    ..Therefore, FtsH may serve to maintain quality control of some cytoplasmic and membrane proteins. Such ATP-dependent proteases with intrinsic chaperone activity have been designated charonins...
  2. pmc The FtsH protein accumulates at the septum of Bacillus subtilis during cell division and sporulation
    W Wehrl
    Institute of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    J Bacteriol 182:3870-3. 2000
    ..These observations revealed a new function of FtsH...
  3. ncbi request reprint Function and regulation of temperature-inducible bacterial proteins on the cellular metabolism
    W Schumann
    Institute of Genetics, University of Bayreuth, Germany
    Adv Biochem Eng Biotechnol 67:1-33. 2000
    ..Neither an alternative sigma factor nor a repressor seems to be involved in the regulation of the cold shock genes in E. coli, the only species studied so far in this respect...
  4. ncbi request reprint Post-transcriptional regulation of the Bacillus subtilis dnaK operon
    G Homuth
    Institute of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    Mol Microbiol 32:1183-97. 1999
    ..These results show that B. subtilis is using various, especially post-transcriptional, regulatory mechanisms to fine tune the expression of the individual genes of the heptacistronic dnaK operon...
  5. pmc The GroE chaperonin machine is a major modulator of the CIRCE heat shock regulon of Bacillus subtilis
    A Mogk
    Institute of Genetics, University of Bayreuth, Germany
    EMBO J 16:4579-90. 1997
    ..These results suggest that the GroE chaperonin machine modulates the activity of the HrcA repressor and therefore point to a novel function of GroE as a modulator of the heat shock response...
  6. ncbi request reprint Cloning and sequencing of the hrcA gene of Bacillus stearothermophilus
    A Mogk
    Institute of Genetics, University of Bayreuth, Germany
    Gene 194:133-6. 1997
    ..Furthermore, we could show that the HrcA protein derived from the thermophilic microorganism responds to HS in a similar way as reported for the Bs HrcA protein...
  7. pmc The dnaK operon of Bacillus subtilis is heptacistronic
    G Homuth
    Institute of Genetics, University of Bayreuth, Germany
    J Bacteriol 179:1153-64. 1997
    ..Blocking transcription of the suboperon from the upstream heat-inducible promoter did not impair growth and viability at high temperatures...
  8. ncbi request reprint Alkaline shock induces the Bacillus subtilis sigma(W) regulon
    T Wiegert
    Institute of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    Mol Microbiol 41:59-71. 2001
    ..In addition, we found several genes clearly not belonging to that regulon. This analysis represents the first report of an extracellular stimulus inducing the sigmaW regulon...
  9. ncbi request reprint Transcriptional analysis of three Bacillus subtilis genes coding for proteins with the alpha-crystallin domain characteristic of small heat shock proteins
    S Reischl
    Institute of Genetics, University of Bayreuth, D 95440, Germany
    FEMS Microbiol Lett 194:99-103. 2001
    ..No expression of the yocM gene was found under all standard laboratory conditions tested. Both a cotP knockout mutant as well as a cotM cotP double knockout turned out to be viable and form spores and exhibited no germination defect...
  10. pmc Development of a new integration site within the Bacillus subtilis chromosome and construction of compatible expression cassettes
    B Hartl
    Institute of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    J Bacteriol 183:2696-9. 2001
    ..These experiments demonstrate that both integration sites can be used simultaneously to obtain regulated expression of desired genes...
  11. ncbi request reprint The genes of lepA and hemN form a bicistronic operon in Bacillus subtilis
    G Homuth
    Institute of Genetics, University of Bayreuth, Germany
    Microbiology 142:1641-9. 1996
    ..The data suggest that most of the transcripts originating at the potential vegetative promoter are terminated at the intergenic terminator. Readthrough transcription into the downstream dnaK operon was not found...
  12. pmc SsrA-mediated tagging in Bacillus subtilis
    T Wiegert
    Institute of Genetics, University of Bayreuth, D 95440 Bayreuth, Germany
    J Bacteriol 183:3885-9. 2001
    ..HrcA remained stable only in clpX or clpP knockouts, which suggests that this ATP-dependent protease is primarily responsible for the degradation of SsrA-tagged proteins in B. subtilis...
  13. pmc hrcA, the first gene of the Bacillus subtilis dnaK operon encodes a negative regulator of class I heat shock genes
    A Schulz
    Institute of Genetics, University of Bayreuth, Germany
    J Bacteriol 178:1088-93. 1996
    ..Overproduction of HrcA protein prior to a heat shock almost completely prevented growth at a high temperature. These data clearly demonstrate that the hrcA product serves as a negative regulator of class I heat shock genes...
  14. ncbi request reprint Cloning and sequencing of the dnaK operon of Bacillus stearothermophilus
    M Herbort
    Institute of Genetics, University of Bayreuth, Germany
    Gene 170:81-4. 1996
    ..The dnaJ gene could complement an Escherichia coli dnaJts mutant for growth at high temperature. Sequencing and hybridization data strongly suggest that the Bt chromosome contains an analog of dnaJ...
  15. pmc Functional analysis of the secretory precursor processing machinery of Bacillus subtilis: identification of a eubacterial homolog of archaeal and eukaryotic signal peptidases
    H Tjalsma
    Department of Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751 NN Haren, The Netherlands
    Genes Dev 12:2318-31. 1998
    ..Notably, the newly identified SPase SipW is highly similar to SPases from archaea and the ER membrane of eukaryotes, suggesting that these enzymes form a subfamily of the type I SPases, which is conserved in the three domains of life...
  16. pmc Transcriptional control of Bacillus subtilis hemN and hemZ
    G Homuth
    Institut fur Genetik, Universitat Bayreuth, 95440 Bayreuth, Germany
    J Bacteriol 181:5922-9. 1999
    ..Finally, only hemZ was found to be fivefold induced by the presence of H(2)O(2), indicating further coregulation of heme biosynthesis with the formation of the tetrapyrrole enzyme catalase...
  17. pmc Cloning, sequencing, and molecular analysis of the dnaK locus from Bacillus subtilis
    M Wetzstein
    Lehrstuhl fur Genetik, Universitat Bayreuth, Germany
    J Bacteriol 174:3300-10. 1992
    ..The biological property of this inverted repeat as a putative key element in the induction of heat shock genes is discussed. The dnaK locus was mapped at about 223 degrees on the B. subtilis genetic map...
  18. ncbi request reprint Cloning and mapping of the Bacillus subtilis locus homologous to Escherichia coli ent genes
    R Adams
    Lehrstuhl fur Genetik, Universitat Bayreuth, Germany
    Gene 133:119-21. 1993
    ..This B. subtilis ent locus was mapped at about 41 degrees. Its inactivation did not cause any detectable phenotype...
  19. pmc Molecular cloning, sequencing, and transcriptional analysis of the groESL operon from Bacillus stearothermophilus
    U Schön
    Lehrstuhl fur Genetik, Universitat Bayreuth, Germany
    J Bacteriol 175:2465-9. 1993
    ..The groESL operon of B. stearothermophilus could complement E. coli groES(Ts) and groEL(Ts) mutants for growth at high temperature and for propagation of phage lambda...
  20. ncbi request reprint Promoters of major Escherichia coli heat shock genes seem non-functional in Bacillus subtilis
    M Wetzstein
    Lehrstuhl fur Genetik, Universitat Bayreuth, F R G
    FEMS Microbiol Lett 60:55-8. 1990
    ..subtilis. This indicates that E. coli heat shock promoters are nonfunctional in B. subtilis...
  21. pmc Complete nucleotide sequence of the Bacillus subtilis dnaK gene
    M Wetzstein
    Lehrstuhl fur Genetik, Universitat Bayreuth, FRG
    Nucleic Acids Res 18:2172. 1990
  22. pmc Nucleotide sequence of a Bacillus subtilis gene homologous to the grpE gene of E. coli located immediately upstream of the dnaK gene
    M Wetzstein
    Lehrstuhl fur Genetik, Universitat Bayreuth, FRG
    Nucleic Acids Res 18:1289. 1990
  23. pmc Cloning, sequencing, mapping, and transcriptional analysis of the groESL operon from Bacillus subtilis
    A Schmidt
    Lehrstuhl fur Genetik, Universitat Bayreuth, Germany
    J Bacteriol 174:3993-9. 1992
    ..A 9-bp inverted repeat within the 5' leader region of the mRNA might be involved in regulation of the heat shock response. By using PBS1 transduction, the groESL operon was mapped at about 342 degrees...
  24. pmc Essential Bacillus subtilis genes
    K Kobayashi
    Graduate School of Information Science, Nara Institute of Science and Technology, Nara 630 0101, Japan
    Proc Natl Acad Sci U S A 100:4678-83. 2003
    ..Unexpectedly, most genes involved in the Embden-Meyerhof-Parnas pathway are essential. Identification of unknown and unexpected essential genes opens research avenues to better understanding of processes that sustain bacterial life...