Research Topics
Genomes and Genes
Species | Johannes SchumacherSummaryAffiliation: University of Bonn Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sampleKerstin U Ludwig
Department of Genomics, Life and Brain Center, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
J Neural Transm 115:1587-9. 2008..We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence...
Serotonin transporter polymorphisms and panic disorderJohannes Schumacher
Institute of Human Genetics, University of Bonn, Sigmund Freud Str, 25, 53127 Bonn, Germany
Genome Med 2:40. 2010....- Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteersErik G Jonsson
Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institutet, Stockholm, Sweden
BMC Psychiatry 4:4. 2004..CSF monoamine metabolite concentrations are partly determined by genetic influences... 
[Genetics of bipolar affective disorders. Current status of research for identification of susceptibility genes]J Schumacher
Institut fur Humangenetik, Universitatsklinikum Bonn
Nervenarzt 73:581-92; quiz 593-4. 2002..New methods are being developed for linkage disequilibrium mapping and candidate gene approaches. One can be optimistic that over the next few years bipolar susceptibility genes will be identified...- No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approachJohannes Schumacher
Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
Hum Genet 114:115-7. 2003..0). Thus, our study does not support the hypothesis of an involvement of DUP25 in panic disorder... - Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorderJ Schumacher
Institute of Human Genetics, University of Bonn, Germany
Mol Psychiatry 9:203-7. 2004..The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background... - Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexiaJohannes Schumacher
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Hum Genet 78:52-62. 2006.... - Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sampleKerstin U Ludwig
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Psychiatr Genet 18:310-2. 2008..We thus conclude that the causative variant/s in DCDC2 conferring susceptibility to dyslexia in our sample remain/s to be identified... - No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophreniaRami Abou Jamra
Institute of Human Genetics, Department of Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
Psychiatr Genet 17:43-5. 2007.... - Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Psychiatr Genet 18:199-203. 2008..Based on the functional evidence and on the hypothesis that further genes, which are involved in the regulation of D-serine, could be involved in the disease aetiology, we considered VAMP2 and VAMP3 as candidate genes for BPAD... - Further evidence for a susceptibility locus contributing to reading disability on chromosome 15q15-q21Johannes Schumacher
Institute of Human Genetics, University of Bonn, Bonn, Germany
Psychiatr Genet 18:137-42. 2008..Linkage and association studies in dyslexia suggest that a susceptibility locus exists on chromosome 15q15-q21... - The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?Rami Abou Jamra
Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D 53111 Bonn, Germany
Schizophr Bull 32:599-608. 2006.... - Variation in GRIN2B contributes to weak performance in verbal short-term memory in children with dyslexiaKerstin U Ludwig
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 153:503-11. 2010..These results suggest that variation within GRIN2B may contribute to the genetic background of specific cognitive processes which are correlates of the dyslexia phenotype... - Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 141:663-5. 2006..Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population... - A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 153:878-84. 2010..25 and 1.46. Our findings may indicate that MCHR2 is a putative risk factor for BPAD. These findings should be interpreted with caution and replicated in independent BPAD samples... - Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorderSven Cichon
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Hum Mol Genet 17:87-97. 2008..Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD... - Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depressionJohannes Schumacher
Institute of Human Genetics, University of Bonn, Bonn
Biol Psychiatry 58:307-14. 2005.... - No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophreniaRami Abou Jamra
Institute of Human Genetics bInstitute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
Psychiatr Genet 16:91. 2006 - No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
Psychiatr Genet 15:195-8. 2005..Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder... - Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24Johannes Schumacher
Institute of Human Genetics, Life and Brain Center, University of Bonn, D-53105 Bonn, Germany
Am J Hum Genet 77:1102-11. 2005.... - Further evidence for DYX1C1 as a susceptibility factor for dyslexiaFaten Dahdouh
Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
Psychiatr Genet 19:59-63. 2009..As the dyslexia community still considers the role of DYX1C1 unsettled, we explored the contribution of this gene in a sample of 366 trios of German descent... - A systematic eQTL study of cis-trans epistasis in 210 HapMap individualsJessica Becker
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Eur J Hum Genet 20:97-101. 2012..In summary, our results provide novel insights into the complex genome-transcriptome regulation... - The genetics of panic disorderJohannes Schumacher
Institute of Human Genetics, University of Bonn, Germany
J Med Genet 48:361-8. 2011..Here, the authors summarise the latest genetics findings about PD, and give an overview of anticipated future developments... - Genetics of dyslexia: the evolving landscapeJohannes Schumacher
Institute of Human Genetics, University of Bonn, Bonn, Germany
J Med Genet 44:289-97. 2007..This review presents a summary of the latest insights into the genetics of dyslexia and an overview of anticipated future developments... - The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6qRami Abou Jamra
Institute of Human Genetics, University of Bonn, Bonn, Germany
Am J Hum Genet 81:974-86. 2007..Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies... - Haplotype interaction analysis of unlinked regionsTim Becker
Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Genet Epidemiol 29:313-22. 2005..The method described here has been implemented in FAMHAP... - Homozygosity mapping in 64 Syrian consanguineous families with non-specific intellectual disability reveals 11 novel loci and high heterogeneityR Abou Jamra
Institute of Human Genetics, University of Erlangen Nuremberg, Schwabachanlage 10, Erlangen, Germany
Eur J Hum Genet 19:1161-6. 2011..Systematic analysis of large numbers of affected families, as presented here, will help discovering the genetic causes of ID... - No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysisRoland Ivo
Institute of Human Genetics, University of Bonn, Bonn, Germany
Psychiatr Genet 16:197-203. 2006..In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin... - Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorderRami Abou Jamra
Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 126:79-81. 2004..Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes... - Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorderSven Cichon
Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
Am J Hum Genet 88:372-81. 2011..These areas are involved in cognition and emotion regulation and have previously been implicated in BD by neuropsychological, neuroimaging, and postmortem studies... - Behavioral changes in G72/G30 transgenic miceDavid M Otte
Institute of Molecular Psychiatry, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
Eur Neuropsychopharmacol 19:339-48. 2009..These results demonstrate that expression of the human G72/G30 gene locus in mice produces behavioral phenotypes that are relevant to psychiatric disorders... - Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopeciaAxel M Hillmer
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Am J Hum Genet 77:140-8. 2005..The X-chromosomal location of AR stresses the importance of the maternal line in the inheritance of AGA... - Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumorsNils Rahner
Institute of Human Genetics, BMZ, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
Fam Cancer 11:19-26. 2012..The present results suggest that neither rare nor common genetic variants in ESR1, ESR2, MAX, PCNA, or KAT2A contribute to the development of Lynch syndrome... - Nine new twin pairs with esophageal atresia: a review of the literature and performance of a twin study of the disorderAnna Carina Schulz
Department of Neonatology, Children s Hospital, University of Bonn, Bonn, Germany
Birth Defects Res A Clin Mol Teratol 94:182-6. 2012..Nine twin pairs with EA were identified from our clinical service, prompting the performance of a systematic review of the literature and the first reported twin study of isolated EA...