Johannes Schumacher

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi request reprint Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample
    Kerstin U Ludwig
    Department of Genomics, Life and Brain Center, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    J Neural Transm 115:1587-9. 2008
  2. pmc Serotonin transporter polymorphisms and panic disorder
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Sigmund Freud Str, 25, 53127 Bonn, Germany
    Genome Med 2:40. 2010
  3. pmc Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling
    J Becker
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Transl Psychiatry 2:e136. 2012
  4. pmc Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    Erik G Jonsson
    Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institutet, Stockholm, Sweden
    BMC Psychiatry 4:4. 2004
  5. ncbi request reprint [Genetics of bipolar affective disorders. Current status of research for identification of susceptibility genes]
    J Schumacher
    Institut fur Humangenetik, Universitatsklinikum Bonn
    Nervenarzt 73:581-92; quiz 593-4. 2002
  6. pmc Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 78:52-62. 2006
  7. ncbi request reprint Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder
    J Schumacher
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 9:203-7. 2004
  8. ncbi request reprint No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Hum Genet 114:115-7. 2003
  9. ncbi request reprint Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 141:663-5. 2006
  10. doi request reprint Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample
    Kerstin U Ludwig
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 18:310-2. 2008

Detail Information

Publications37

  1. doi request reprint Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample
    Kerstin U Ludwig
    Department of Genomics, Life and Brain Center, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    J Neural Transm 115:1587-9. 2008
    ..We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence...
  2. pmc Serotonin transporter polymorphisms and panic disorder
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Sigmund Freud Str, 25, 53127 Bonn, Germany
    Genome Med 2:40. 2010
    ....
  3. pmc Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling
    J Becker
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Transl Psychiatry 2:e136. 2012
    ..In conclusion, the present study provides evidence that ZNF804A might have a role in cognitive traits of relevance to reading and spelling, and underlines the phenotypic complexity that might be associated with ZNF804A...
  4. pmc Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    Erik G Jonsson
    Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institutet, Stockholm, Sweden
    BMC Psychiatry 4:4. 2004
    ..CSF monoamine metabolite concentrations are partly determined by genetic influences...
  5. ncbi request reprint [Genetics of bipolar affective disorders. Current status of research for identification of susceptibility genes]
    J Schumacher
    Institut fur Humangenetik, Universitatsklinikum Bonn
    Nervenarzt 73:581-92; quiz 593-4. 2002
    ..New methods are being developed for linkage disequilibrium mapping and candidate gene approaches. One can be optimistic that over the next few years bipolar susceptibility genes will be identified...
  6. pmc Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 78:52-62. 2006
    ....
  7. ncbi request reprint Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder
    J Schumacher
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 9:203-7. 2004
    ..The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background...
  8. ncbi request reprint No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Hum Genet 114:115-7. 2003
    ..0). Thus, our study does not support the hypothesis of an involvement of DUP25 in panic disorder...
  9. ncbi request reprint Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 141:663-5. 2006
    ..Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population...
  10. doi request reprint Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample
    Kerstin U Ludwig
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 18:310-2. 2008
    ..We thus conclude that the causative variant/s in DCDC2 conferring susceptibility to dyslexia in our sample remain/s to be identified...
  11. ncbi request reprint No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophrenia
    Rami Abou Jamra
    Institute of Human Genetics, Department of Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 17:43-5. 2007
    ....
  12. doi request reprint Further evidence for DYX1C1 as a susceptibility factor for dyslexia
    Faten Dahdouh
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 19:59-63. 2009
    ..As the dyslexia community still considers the role of DYX1C1 unsettled, we explored the contribution of this gene in a sample of 366 trios of German descent...
  13. doi request reprint Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 18:199-203. 2008
    ..Based on the functional evidence and on the hypothesis that further genes, which are involved in the regulation of D-serine, could be involved in the disease aetiology, we considered VAMP2 and VAMP3 as candidate genes for BPAD...
  14. doi request reprint Variation in GRIN2B contributes to weak performance in verbal short-term memory in children with dyslexia
    Kerstin U Ludwig
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:503-11. 2010
    ..These results suggest that variation within GRIN2B may contribute to the genetic background of specific cognitive processes which are correlates of the dyslexia phenotype...
  15. pmc The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D 53111 Bonn, Germany
    Schizophr Bull 32:599-608. 2006
    ....
  16. doi request reprint Further evidence for a susceptibility locus contributing to reading disability on chromosome 15q15-q21
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 18:137-42. 2008
    ..Linkage and association studies in dyslexia suggest that a susceptibility locus exists on chromosome 15q15-q21...
  17. ncbi request reprint No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
    Psychiatr Genet 15:195-8. 2005
    ..Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder...
  18. ncbi request reprint Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn
    Biol Psychiatry 58:307-14. 2005
    ....
  19. ncbi request reprint Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Hum Mol Genet 17:87-97. 2008
    ..Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD...
  20. ncbi request reprint A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:878-84. 2010
    ..25 and 1.46. Our findings may indicate that MCHR2 is a putative risk factor for BPAD. These findings should be interpreted with caution and replicated in independent BPAD samples...
  21. pmc The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 81:974-86. 2007
    ..Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies...
  22. ncbi request reprint No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophrenia
    Rami Abou Jamra
    Institute of Human Genetics bInstitute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
    Psychiatr Genet 16:91. 2006
  23. pmc A systematic eQTL study of cis-trans epistasis in 210 HapMap individuals
    Jessica Becker
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Eur J Hum Genet 20:97-101. 2012
    ..In summary, our results provide novel insights into the complex genome-transcriptome regulation...
  24. doi request reprint The genetics of panic disorder
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Germany
    J Med Genet 48:361-8. 2011
    ..Here, the authors summarise the latest genetics findings about PD, and give an overview of anticipated future developments...
  25. pmc Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24
    Johannes Schumacher
    Institute of Human Genetics, Life and Brain Center, University of Bonn, D 53105 Bonn, Germany
    Am J Hum Genet 77:1102-11. 2005
    ....
  26. pmc Genetics of dyslexia: the evolving landscape
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    J Med Genet 44:289-97. 2007
    ..This review presents a summary of the latest insights into the genetics of dyslexia and an overview of anticipated future developments...
  27. ncbi request reprint Haplotype interaction analysis of unlinked regions
    Tim Becker
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Genet Epidemiol 29:313-22. 2005
    ..The method described here has been implemented in FAMHAP...
  28. pmc Homozygosity mapping in 64 Syrian consanguineous families with non-specific intellectual disability reveals 11 novel loci and high heterogeneity
    R Abou Jamra
    Institute of Human Genetics, University of Erlangen Nuremberg, Schwabachanlage 10, Erlangen, Germany
    Eur J Hum Genet 19:1161-6. 2011
    ..Systematic analysis of large numbers of affected families, as presented here, will help discovering the genetic causes of ID...
  29. ncbi request reprint Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 126:79-81. 2004
    ..Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes...
  30. ncbi request reprint No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis
    Roland Ivo
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 16:197-203. 2006
    ..In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin...
  31. pmc Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
    Sven Cichon
    Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
    Am J Hum Genet 88:372-81. 2011
    ..These areas are involved in cognition and emotion regulation and have previously been implicated in BD by neuropsychological, neuroimaging, and postmortem studies...
  32. pmc Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Hum Genet 77:140-8. 2005
    ..The X-chromosomal location of AR stresses the importance of the maternal line in the inheritance of AGA...
  33. doi request reprint Behavioral changes in G72/G30 transgenic mice
    David M Otte
    Institute of Molecular Psychiatry, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Eur Neuropsychopharmacol 19:339-48. 2009
    ..These results demonstrate that expression of the human G72/G30 gene locus in mice produces behavioral phenotypes that are relevant to psychiatric disorders...
  34. pmc Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
    Jessica Becker
    1 Institute of Human Genetics, University of Bonn, Bonn, Germany 2 Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Eur J Hum Genet 22:675-80. 2014
    ..Like in other neurocognitive disorders, our findings underline the need for larger sample sizes to validate possibly weak genetic effects. ..
  35. doi request reprint Genome-wide association study reveals two new risk loci for bipolar disorder
    Thomas W Mühleisen
    1 Institute of Human Genetics, University of Bonn, D 53127 Bonn, Germany 2 Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany 3 Institute of Neuroscience and Medicine INM 1, Research Centre Julich, D 52425 Julich, Germany 4
    Nat Commun 5:3339. 2014
    ..31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD. ..
  36. doi request reprint Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumors
    Nils Rahner
    Institute of Human Genetics, BMZ, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Fam Cancer 11:19-26. 2012
    ..The present results suggest that neither rare nor common genetic variants in ESR1, ESR2, MAX, PCNA, or KAT2A contribute to the development of Lynch syndrome...
  37. doi request reprint Nine new twin pairs with esophageal atresia: a review of the literature and performance of a twin study of the disorder
    Anna Carina Schulz
    Department of Neonatology, Children s Hospital, University of Bonn, Bonn, Germany
    Birth Defects Res A Clin Mol Teratol 94:182-6. 2012
    ..Nine twin pairs with EA were identified from our clinical service, prompting the performance of a systematic review of the literature and the first reported twin study of isolated EA...