Andreas Schulze

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Spectrophotometric microassay for delta-aminolevulinate dehydratase in dried-blood spots as confirmation for hereditary tyrosinemia type I
    A Schulze
    Division of Metabolic and Endocrine Diseases, University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Clin Chem 47:1424-9. 2001
  2. ncbi Expanded newborn screening for inborn errors of metabolism by electrospray ionization-tandem mass spectrometry: results, outcome, and implications
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, Department of General Pediatrics, University Children s Hospital, Heidelberg, Germany
    Pediatrics 111:1399-406. 2003
  3. ncbi Creatine deficiency syndromes
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, University Children s Hospital, Heidelberg, Germany
    Mol Cell Biochem 244:143-50. 2003
  4. ncbi Lack of creatine in muscle and brain in an adult with GAMT deficiency
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, Department of General Pediatrics, University Children s Hospital, Heidelberg, Germany
    Ann Neurol 53:248-51. 2003
  5. ncbi Accurate measurement of free carnitine in dried blood spots by isotope-dilution electrospray tandem mass spectrometry without butylation
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, Department of General Pediatrics, University Children s Hospital, Im Neuenheimer Feld 153, D 69120 Heidelberg, Germany
    Clin Chim Acta 335:137-45. 2003
  6. ncbi Evaluation of 6-year application of the enzymatic colorimetric phenylalanine assay in the setting of neonatal screening for phenylketonuria
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, University Children s Hospital, Im Neuenheimer Feld 150, 69120, Heidelberg, Germany
    Clin Chim Acta 317:27-37. 2002
  7. ncbi Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation
    A Schulze
    Department of General Pediatrics, Division of Metabolic and Endocrine Diseases, University Children s Hospital, Im Neuenheimer Feld 150, Heidelberg, 69120, Germany
    Mol Genet Metab 74:413-9. 2001
  8. doi Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts
    Alexa Schieck
    Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Hepatology 58:43-53. 2013
  9. ncbi A method for quantitative acylcarnitine profiling in human skin fibroblasts using unlabelled palmitic acid: diagnosis of fatty acid oxidation disorders and differentiation between biochemical phenotypes of MCAD deficiency
    Jürgen G Okun
    Division of Metabolic and Endocrine Diseases, Department of General Pediatrics, University Children s Hospital, Im Neuenheimer Feld 150, D 69120 Heidelberg, Germany
    Biochim Biophys Acta 1584:91-8. 2002
  10. ncbi Acylcarnitine profiles of preterm infants over the first four weeks of life
    Jochen Meyburg
    Department of Neonatology, Division of Metabolic and Endocrine Diseases, University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Pediatr Res 52:720-3. 2002

Collaborators

Detail Information

Publications39

  1. ncbi Spectrophotometric microassay for delta-aminolevulinate dehydratase in dried-blood spots as confirmation for hereditary tyrosinemia type I
    A Schulze
    Division of Metabolic and Endocrine Diseases, University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Clin Chem 47:1424-9. 2001
    ..We developed a semiquantitative assay based on inhibition of delta-aminolevulinate dehydratase (ALA-D) by succinylacetone...
  2. ncbi Expanded newborn screening for inborn errors of metabolism by electrospray ionization-tandem mass spectrometry: results, outcome, and implications
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, Department of General Pediatrics, University Children s Hospital, Heidelberg, Germany
    Pediatrics 111:1399-406. 2003
    ....
  3. ncbi Creatine deficiency syndromes
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, University Children s Hospital, Heidelberg, Germany
    Mol Cell Biochem 244:143-50. 2003
    ..The study of creatine deficiency syndromes and their comparative consideration contributes to the better understanding of the pathophysiological role of creatine and other guanidino compounds in man...
  4. ncbi Lack of creatine in muscle and brain in an adult with GAMT deficiency
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, Department of General Pediatrics, University Children s Hospital, Heidelberg, Germany
    Ann Neurol 53:248-51. 2003
    ....
  5. ncbi Accurate measurement of free carnitine in dried blood spots by isotope-dilution electrospray tandem mass spectrometry without butylation
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, Department of General Pediatrics, University Children s Hospital, Im Neuenheimer Feld 153, D 69120 Heidelberg, Germany
    Clin Chim Acta 335:137-45. 2003
    ..To test the feasibility of free carnitine (FC) determination in dried blood spot specimens (DBS) by stable isotope-dilution electrospray-ionisation tandem mass spectrometry (MS/MS)...
  6. ncbi Evaluation of 6-year application of the enzymatic colorimetric phenylalanine assay in the setting of neonatal screening for phenylketonuria
    Andreas Schulze
    Division of Metabolic and Endocrine Diseases, University Children s Hospital, Im Neuenheimer Feld 150, 69120, Heidelberg, Germany
    Clin Chim Acta 317:27-37. 2002
    ..The aim of this study was to evaluate an enzymatic phenylalanine (Phe) determination in the whole context spanning from the initial investigation over the recall period, up to the confirmation or exclusion of the disease...
  7. ncbi Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation
    A Schulze
    Department of General Pediatrics, Division of Metabolic and Endocrine Diseases, University Children s Hospital, Im Neuenheimer Feld 150, Heidelberg, 69120, Germany
    Mol Genet Metab 74:413-9. 2001
    ..This indicates for the first time that GAA may exert an important epileptogenic potential in man. Arginine restriction in combination with ornithine supplementation represents a new and rationale therapeutic approach in GAMT deficiency...
  8. doi Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts
    Alexa Schieck
    Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Hepatology 58:43-53. 2013
    ..In addition, this provides the basis for the application of the peptides as vehicles for hepatocyte-specific drug targeting...
  9. ncbi A method for quantitative acylcarnitine profiling in human skin fibroblasts using unlabelled palmitic acid: diagnosis of fatty acid oxidation disorders and differentiation between biochemical phenotypes of MCAD deficiency
    Jürgen G Okun
    Division of Metabolic and Endocrine Diseases, Department of General Pediatrics, University Children s Hospital, Im Neuenheimer Feld 150, D 69120 Heidelberg, Germany
    Biochim Biophys Acta 1584:91-8. 2002
    ..In conclusion, this novel technique is a powerful tool for the investigation of fatty acid oxidation disorders under standardized conditions in fibroblasts...
  10. ncbi Acylcarnitine profiles of preterm infants over the first four weeks of life
    Jochen Meyburg
    Department of Neonatology, Division of Metabolic and Endocrine Diseases, University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Pediatr Res 52:720-3. 2002
    ..However, the commonly used metabolite ratios should still allow the detection of inborn errors of metabolism...
  11. doi Solid-phase synthesis of the lipopeptide Myr-HBVpreS/2-78, a hepatitis B virus entry inhibitor
    Alexa Schieck
    Department of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Molecules 15:4773-83. 2010
    ..It was possible to minimize the occurrence of side products due to the positive effects related to higher reaction temperature. In conclusion, the peptide is accessible by stepwise SPPS without the necessity of segment coupling...
  12. doi Hepatocyte polarization is essential for the productive entry of the hepatitis B virus
    Andreas Schulze
    Department of Infectious Diseases, Molecular Virology, Otto Meyerhof Zentrum, University Hospital Heidelberg, Heidelberg, Germany
    Hepatology 55:373-83. 2012
    ..However, disruption of cell-cell junctions allowed the additional infection of cells that do not display a PHH-like polarization...
  13. doi Comparison of lung accumulation of cationic liposomes in normal rats and LPS-treated rats
    Susanne Herber-Jonat
    Division of Neonatology, University Children s Hospital, Perinatal Center, Ludwig Maximilian University Munich, Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Inflamm Res 60:245-53. 2011
    ..Thereafter, a bronchoalveolar lavage (BAL) was done and the lungs were perfused with saline and formalin. Accumulation of liposomes was assessed by quantitative confocal microscopy and determination of rhodamine-content in lung tissue...
  14. pmc Proteoglycans act as cellular hepatitis delta virus attachment receptors
    Oscar Lamas Longarela
    Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Baden Wurttemberg, Germany
    PLoS ONE 8:e58340. 2013
    ..In summary, HDV infection, comparable to HBV infection, requires binding to the carbohydrate side chains of hepatocyte-associated heparan sulfate proteoglycans as attachment receptors, while P2XR are not actively involved...
  15. doi Very low birth weight preterm infants are at risk for hypoglycemia once on total enteral nutrition
    Alex Staffler
    Division of Neonatology, University Children s Hospital, Perinatal Center Grosshadern, Ludwig Maximilian University, Munich, Germany
    J Matern Fetal Neonatal Med 26:1337-41. 2013
    ..Further studies evaluating a possible impact of these common although asymptomatic episodes on later development could help to better define thresholds that should be considered as "hypoglycemia" in this population. ..
  16. pmc Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction
    Andreas Schulze
    Department of Infectious Diseases, Molecular Virology, Otto Meyerhof Zentrum, University of Heidelberg, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany
    J Virol 84:1989-2000. 2010
    ..It requires an N-terminal acyl moiety and a highly conserved sequence that is present in primate but not rodent or avian hepadnaviruses, indicating different entry pathways for the different family members...
  17. ncbi Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS
    Tamara Werner
    Department of Pediatrics, University Children s Hospital, Mannheim, Germany
    Epilepsia 48:72-6. 2007
    ..To determine the influence of valproate (VPA) treatment on acylcarnitines in children with epilepsy...
  18. ncbi Hypoxia decreases cellular ATP demand and inhibits mitochondrial respiration of a549 cells
    Kristin Heerlein
    Medical Clinic VII, Sports Medicine, University of Heidelberg, Heidelberg, Germany
    Am J Respir Cell Mol Biol 32:44-51. 2005
    ..Our findings indicate that inhibition of the Na/K-ATPase by hypoxia contributes little to energy preservation in hypoxia. It remains unclear to what extent hypoxic inhibition of mitochondrial metabolism affects ATP-consuming processes...
  19. ncbi Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus
    Christian Opherk
    Molecular Biology of the Cell I, Deutsches Krebsforschungszentrum, University Children s Hospital, Heidelberg, Germany
    Mol Endocrinol 18:1346-53. 2004
    ..These findings show the essential role of GR function in liver glucose metabolism during fasting and in diabetic mice and indicate that liver-specific GC antagonists could be beneficial in control of diabetic hyperglycemia...
  20. doi Electrical impedance tomography is able to track changes in respiratory function in endotoxin-challenged rodents
    Susanne Herber-Jonat
    Division of Neonatology, University Children s Hospital, Perinatal Center, Ludwig Maximilian University Munich, Grosshadern, Munich, Marchioninistr 15, Munich D 81377, Germany
    Respirology 14:680-8. 2009
    ..Electrical impedance tomography (EIT) has been suggested as a technique for quantifying lung inflammation in ALI. However, EIT has not been evaluated in a rodent model of ALI...
  21. ncbi Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans
    Andreas Schulze
    Department of Molecular Virology, Otto Meyerhof Zentrum OMZ, University of Heidelberg, Heidelberg, Germany
    Hepatology 46:1759-68. 2007
    ..This interaction initializes the multistep entry process of HBV and cannot be bypassed by alternative routes...
  22. ncbi Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease?
    Markus Wyss
    Roche Vitamins AG, Biotechnology Department VFB, Building 203 113A, CH 4070 Basel, Switzerland
    Neuroscience 112:243-60. 2002
    ..g., coronary heart disease or cerebrovascular disease. Although compelling, these results require further confirmation in clinical studies in humans, together with a thorough evaluation of the safety of oral creatine supplementation...
  23. ncbi Frequencies of inherited organic acidurias and disorders of mitochondrial fatty acid transport and oxidation in Germany
    Georg F Hoffmann
    Department of Paediatrics, University of Heidelberg, Germany
    Eur J Pediatr 163:76-80. 2004
    ..These conditions were related to considerable morbidity and mortality. Considerations for their inclusion in expanded newborn screening programmes might be warranted...
  24. ncbi Survival and major neonatal complications in infants born between 22 0/7 and 24 6/7 weeks of gestation (1999-2003)
    Susanne Herber-Jonat
    Department of Obstetrics and Gynecology, Divisison of Neonatology, Klinikum Grosshadern, University of Munich, Munich, Germany
    Am J Obstet Gynecol 195:16-22. 2006
    ..This study was undertaken to compare survival and morbidity until discharge in infants born after 22-23 versus 24 weeks' gestational age (GA)...
  25. ncbi Maternal and neonatal morbidity of emergency caesarean sections with a decision-to-delivery interval under 30 minutes: evidence from 10 years
    Peter Hillemanns
    Department of Obstetrics and Gynaecology, Ludwig Maximilian University of Munich, Klinikum Grosshadern, 81377 Munich, Germany
    Arch Gynecol Obstet 268:136-41. 2003
    ..The purpose was to investigate the decision-to-delivery interval for emergency caesarean section and to compare the perioperative maternal and neonatal morbidity to that of intrapartum non-emergent caesarean section...
  26. ncbi Denaturing gradient gel electrophoresis for the molecular characterization of six patients with guanidinoacetate methyltransferase deficiency
    Chike B Item
    Department of Pediatrics, University Hospital and General Hospital AKH, Währingerstrasse 18 20, A 1090 Vienna, Austria
    Clin Chem 48:767-9. 2002
  27. ncbi Steroid profiling by tandem mass spectrometry improves the positive predictive value of newborn screening for congenital adrenal hyperplasia
    Carla Z Minutti
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:3687-93. 2004
    ..This would prevent unnecessary blood draws, medical evaluations, and stress to families...
  28. ncbi Staphylococcal scalded skin syndrome related to an exfoliative toxin A- and B-producing strain in preterm infants
    Esther Rieger-Fackeldey
    Department of Obstetrics and Gynaecology, Division of Neonatology, Klinikum Grosshadern, Ludwig Maximilian University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Eur J Pediatr 161:649-52. 2002
    ..Purified toxins were injected into newborn mice to confirm toxin activity. Besides the strain isolated from the first patient, only one isolate from the medical staff was positive for the genes encoding ETA and ETB...
  29. ncbi Respiratory gas conditioning in infants with an artificial airway
    Andreas Schulze
    Department of Obstetrics and Gynecology, Division of Neonatology, Ludwig Maximilian University, Marchioninistrasse 15, D 81377 Munich, Germany
    Semin Neonatol 7:369-77. 2002
    ..There is no evidence that conditioning of inspired gas to core body temperature and full water vapour saturation may promote nosocomial respiratory infections...
  30. ncbi Effect of body temperature on the pattern of spontaneous breathing in extremely low birth weight infants supported by proportional assist ventilation
    Esther Rieger-Fackeldey
    Department of Obstetrics and Gynecology Grosshadern, Division of Neonatology, Ludwig Maximilian University of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
    Pediatr Res 54:332-6. 2003
    ..This response pattern occurred consistently and is currently of uncertain clinical significance...
  31. ncbi [Child endangerment by maternal alcohol, nicotine and drug abuse]
    Andreas Schulze
    Neonatologie an der Kinik für Geburtshilfe und Frauenheilkunde der Universität München
    Kinderkrankenschwester 23:263-7. 2004
  32. ncbi Heparin-mediated extracorporeal low density lipoprotein precipitation as a possible therapeutic approach in preeclampsia
    Ying Wang
    Institute of Clinical Chemistry, University Hospital Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    Transfus Apher Sci 35:103-10. 2006
    ..We conclude that H.E.L.P. apheresis reduced maternal circulating levels of proinflammatory and coagulatory markers and plasma viscosity without overt maternal or neonatal clinical side effects...
  33. ncbi Creatine and creatine kinase in health and disease--a bright future ahead?
    Markus Wyss
    DSM Nutritional Products Ltd, Biotechnology R and D, Bldg 203 17B, P O Box 3255, CH 4002 Basel, Switzerland
    Subcell Biochem 46:309-34. 2007
    ....
  34. ncbi Pre-symptomatic treatment of creatine biosynthesis defects
    Andreas Schulze
    University of Toronto, Department of Paediatrics, Division of Clinical and Metabolic Genetics, and Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Subcell Biochem 46:167-81. 2007
    ..Although long-term data are lacking, the results suggest that complete prevention of neurological sequelae in early treated patients could be feasible (Battini et al., 2006; Schulze et al., 2006)...
  35. ncbi Premature infants are less capable of maintaining thermal balance of head and body with increases of thermal environment than with decreases
    Georg Simbruner
    Department of Neonatology, Leopold Franzens University, Innsbruck, Tyrol, Austria
    Am J Perinatol 22:25-33. 2005
    ..Premature infants are less able to cope with increases in incubator temperature given that rectal and nasopharyngeal temperature change more when environmental temperature is increased...
  36. ncbi Adaptive mechanical backup ventilation for preterm infants on respiratory assist modes - a pilot study
    Susanne Herber-Jonat
    Department of Obstetrics and Gynecology, Division of Neonatology, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377, Munich, Germany
    Intensive Care Med 32:302-8. 2006
    ..The common approach to this problem is a regular conventional mechanical ventilation, which is initiated and withdrawn in an "on/off" function...
  37. ncbi Successful treatment of a guanidinoacetate methyltransferase deficient patient: findings with relevance to treatment strategy and pathophysiology
    Krijn T Verbruggen
    Beatrix Children s Hospital, University Medical Centre Groningen, University of Groningen, The Netherlands
    Mol Genet Metab 91:294-6. 2007
    ..Addition of high dose ornithine to the treatment led to further normalization of plasma GAA, while cerebral Cr and GAA did not improve further...
  38. ncbi Antecedents of respiratory pauses in extremely low birth weight infants supported by proportional assist ventilation
    Esther Rieger-Fackeldey
    Department of Gynecology and Obstetrics, Division of Neonatology, Klinikum Grosshadern, Ludwig Maximilian University of Munich, Munich, Germany
    J Matern Fetal Neonatal Med 19:49-55. 2006
    ..To determine characteristics of breathing patterns prior to respiratory pauses in extremely low birth weight (ELBW) infants breathing spontaneously under proportional assist ventilation (PAV)...
  39. ncbi Randomized crossover comparison of proportional assist ventilation and patient-triggered ventilation in extremely low birth weight infants with evolving chronic lung disease
    Andreas Schulze
    Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, FL, USA
    Neonatology 92:1-7. 2007
    ..Refinement of ventilatory techniques remains a challenge given the persistence of chronic lung disease of preterm infants...