Research Topics
Genomes and Genes | Hendrik Schulze-KoopsSummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
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Detail Information
Publications
The role of the T cell in autoimmune inflammationAlla Skapenko
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Arthritis Res Ther 7:S4-14. 2005..Here, we review the functional abnormalities and the contribution of different T cell subsets to rheumatoid inflammation...
Generation and regulation of human Th1-biased immune responses in vivo: a critical role for IL-4 and IL-10Alla Skapenko
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
J Immunol 172:6427-34. 2004..The results suggest that both IL-4 and IL-10 contribute to controlling the development of a human Th1-biased immune reaction...- The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cellsFrancis Dodeller
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen-Nuremberg, Erlangen, Germany
Eur J Immunol 35:3631-42. 2005..Together, the data suggest that p38 plays a key role in human Th2 cell immune responses... - GATA-3 in human T cell helper type 2 developmentAlla Skapenko
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, 91054, Germany
J Exp Med 199:423-8. 2004..Taken together, the data strongly suggest that GATA-3 is an important transcription factor in regulating human Th2 cell differentiation in vivo... - The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursorsAlla Skapenko
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Erlangen, Germany
J Immunol 175:6107-16. 2005..Moreover, our findings might provide the basis for the design of novel therapeutic approaches for targeted immunotherapy with Tregs to known Ags in autoimmune diseases or graft-vs-host reactions... - Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritisIryna Prots
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Germany
Arthritis Rheum 54:1491-500. 2006..To examine whether single-nucleotide polymorphisms (SNPs) of the interleukin-4 receptor gene IL4R influence susceptibility to, or radiographic progression in, rheumatoid arthritis (RA)... - Regulation of myeloid cell function and major histocompatibility complex class II expression by tumor necrosis factorRuediger B Mueller
Nikolaus Fiebiger Center for Molecular Medicine and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Arthritis Rheum 52:451-60. 2005..Thus, anti-TNF treatment might lead to augmented T cell activation by myeloid cells, thereby promoting immune responses to (auto)antigens and the development of antinuclear antibodies that are frequently associated with anti-TNF therapy... - Analysis of Th1/Th2 T-cell subsetsAlla Skapenko
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Erlangen, Germany
Methods Mol Med 136:87-96. 2007..Here, we briefly discuss the advantages and disadvantages of these methods and describe in detail a standard protocol for the analysis of human Th subsets by means of detection of cytoplasmic cytokines by flow cytometry... - Regulatory T cells in rheumatoid arthritisJan Leipe
Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen-Nuremberg, Erlangen, Germany
Arthritis Res Ther 7:93. 2005..Here we review existing knowledge of CD4+CD25+ T cells and discuss their role in the pathogenesis of rheumatic diseases... - IFNGR1 single nucleotide polymorphisms in rheumatoid arthritisStefan Mattyasovszky
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen, Germany
Arthritis Res Ther 8:R63. 2006..Surprisingly, however, neither position was polymorphic in the 364 individuals examined, indicating that IFNGR1 does not contribute to susceptibility to rheumatoid arthritis, at least in Caucasians... - Treg cells suppress osteoclast formation: a new link between the immune system and boneMario M Zaiss
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
Arthritis Rheum 56:4104-12. 2007..To investigate whether Treg cells can suppress osteoclast differentiation, and to define a new potential link between the immune system and the skeleton... 
Remission of demyelinating polyneuropathy with immunoadsorption, low dose corticosteroids and anti-CD20 monoclonal antibodyJürgen Rech
Medical Department III, University of Erlangen Nuremberg, Erlangen, Germany
Ther Apher Dial 12:205-8. 2008..Immunoadsorption in combination with a monoclonal anti-CD20 antibody in patients with demyelinating polyneuropathy with anti-MAG is effective and can be used an alternative treatment option in patients with progressive disease...- The p38 mitogen-activated protein kinase signaling cascade in CD4 T cellsFrancis Dodeller
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, and Department of Internal Medicine III, University of Erlangen-Nuremberg, Glueckstrasse 6, 91054 Erlangen, Germany
Arthritis Res Ther 8:205. 2006..These new data suggest that p38 MAPK inhibitors may elicit several unwanted effects in human autoimmune diseases but may be useful for the treatment of allergic disorders... - Lack of genetic association of the interleukin-4 receptor single-nucleotide polymorphisms I50V and Q551R with erosive disease in psoriatic arthritisJesus Lascorz
University of Erlangen Nuremberg, Erlangen, Germany
Arthritis Rheum 54:4023-4. 2006 - Induction of cyclooxygenase-2 and enhanced release of prostaglandin E(2) and I(2) in human endothelial cells by engagement of CD40Christoph D Garlichs
Medical Clinic II, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
Atherosclerosis 163:9-16. 2002..The hypothesis was tested that CD40-CD154 interaction is involved in the induction of cyclooxygenase-2 and the release of prostanoids in human endothelial cells... - Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiationPetya Dimitrova
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen-Nuremberg, Erlangen, Germany
J Immunol 169:3392-9. 2002..Moreover, the results further suggest that differentiation of CD4 T cells can be regulated at the level of nucleotide biosynthesis... - Immature and maturation-resistant human dendritic cells generated from bone marrow require two stimulations to induce T cell anergy in vitroThomas G Berger
Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
PLoS ONE 4:e6645. 2009..Together, we show the generation of immature, maturation-resistant lowGM-DC for potential clinical use in transplant rejection and propose a two-step-model of T cell anergy induction by immature DC... - Lymphopenia and autoimmune diseasesHendrik Schulze-Koops
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Germany
Arthritis Res Ther 6:178-80. 2004