Richard Schulz

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. pmc Obstructive sleep apnea, oxidative stress and cardiovascular disease: lessons from animal studies
    Rio Dumitrascu
    Department of Sleep Medicine, University of Giessen Lung Center, Klinikstrasse 33, 35392 Giessen, Germany
    Oxid Med Cell Longev 2013:234631. 2013
  2. pmc Early neurovascular uncoupling in the brain during community acquired pneumonia
    Bernhard Rosengarten
    Department of Neurology, Justus Liebig University of Giessen, Klinikstrasse 33, 35392 Giessen, Germany
    Crit Care 16:R64. 2012
  3. pmc Nocturnal atrial fibrillation in a patient with obstructive sleep apnoea
    R Schulz
    Department of Pulmonary and Critical Care Medicine, Justus Liebig University, 35392 Giessen, Germany
    Thorax 60:174. 2005
  4. ncbi request reprint Reversal of nocturnal periodic breathing in primary pulmonary hypertension after lung transplantation
    Richard Schulz
    Division of Pulmonary and Critical Care Medicine, Justus Liebig University, Giessen
    Chest 125:344-7. 2004
  5. ncbi request reprint [Pulmonary hypertension and sleep-related breathing disorders]
    R Schulz
    Medizinische Klinik II, Justus Liebig Universitat, Giessen
    Pneumologie 59:270-4. 2005
  6. ncbi request reprint Circulating adrenomedullin in obstructive sleep apnoea
    Richard Schulz
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    J Sleep Res 15:89-95. 2006
  7. ncbi request reprint Changes in extracranial arteries in obstructive sleep apnoea
    R Schulz
    Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Justus Liebig University, Klinikstr 36, 35392 Giessen, Germany
    Eur Respir J 25:69-74. 2005
  8. doi request reprint [Obstruction of the upper airways in humans and animal models]
    R Schulz
    Universitätsklinik Giessen und Marburg, Medizinische Klinik II, Schlafmedizinisches Labor, Giessen
    Pneumologie 64:447-9. 2010
  9. ncbi request reprint Sleep apnoea in heart failure
    R Schulz
    University of Giessen Lung Center, Klinikstr 36, 35392 Giessen, and Charité University Hospital Berlin, Sleep Disorders Centre, Department of Cardiology Pulmonary Medicine, Germany
    Eur Respir J 29:1201-5. 2007
  10. ncbi request reprint Nocturnal periodic breathing in primary pulmonary hypertension
    R Schulz
    Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Justus Liebig University, Giessen, Germany
    Eur Respir J 19:658-63. 2002

Detail Information

Publications71

  1. pmc Obstructive sleep apnea, oxidative stress and cardiovascular disease: lessons from animal studies
    Rio Dumitrascu
    Department of Sleep Medicine, University of Giessen Lung Center, Klinikstrasse 33, 35392 Giessen, Germany
    Oxid Med Cell Longev 2013:234631. 2013
    ....
  2. pmc Early neurovascular uncoupling in the brain during community acquired pneumonia
    Bernhard Rosengarten
    Department of Neurology, Justus Liebig University of Giessen, Klinikstrasse 33, 35392 Giessen, Germany
    Crit Care 16:R64. 2012
    ..To investigate if the dysfunction is also present in less severe inflammatory diseases we studied the neurovascular coupling in patients suffering from community acquired pneumonia...
  3. pmc Nocturnal atrial fibrillation in a patient with obstructive sleep apnoea
    R Schulz
    Department of Pulmonary and Critical Care Medicine, Justus Liebig University, 35392 Giessen, Germany
    Thorax 60:174. 2005
  4. ncbi request reprint Reversal of nocturnal periodic breathing in primary pulmonary hypertension after lung transplantation
    Richard Schulz
    Division of Pulmonary and Critical Care Medicine, Justus Liebig University, Giessen
    Chest 125:344-7. 2004
    ..This case illustrates the crucial roles of blood gas alterations and hemodynamic impairment in the emergence of PB in PPH, and is in favor of a genuine association between advanced right heart failure and the development of SDB...
  5. ncbi request reprint [Pulmonary hypertension and sleep-related breathing disorders]
    R Schulz
    Medizinische Klinik II, Justus Liebig Universitat, Giessen
    Pneumologie 59:270-4. 2005
    ..In conclusion, SDB might cause PH (OSA-associated PH). On the other hand, PH might lead to the development of SDB (CSR in congestive heart failure, periodic breathing in IPAH)...
  6. ncbi request reprint Circulating adrenomedullin in obstructive sleep apnoea
    Richard Schulz
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    J Sleep Res 15:89-95. 2006
    ..AM upregulation might be considered as an adaptive mechanism to counteract the emergence of OSA-related cardiovascular disease...
  7. ncbi request reprint Changes in extracranial arteries in obstructive sleep apnoea
    R Schulz
    Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Justus Liebig University, Klinikstr 36, 35392 Giessen, Germany
    Eur Respir J 25:69-74. 2005
    ....
  8. doi request reprint [Obstruction of the upper airways in humans and animal models]
    R Schulz
    Universitätsklinik Giessen und Marburg, Medizinische Klinik II, Schlafmedizinisches Labor, Giessen
    Pneumologie 64:447-9. 2010
    ..It is hoped that findings from animal studies will in the future impact on the management of patients with OSA, in particular if they are non-compliant with CPAP therapy...
  9. ncbi request reprint Sleep apnoea in heart failure
    R Schulz
    University of Giessen Lung Center, Klinikstr 36, 35392 Giessen, and Charité University Hospital Berlin, Sleep Disorders Centre, Department of Cardiology Pulmonary Medicine, Germany
    Eur Respir J 29:1201-5. 2007
    ..This diagnostic approach should probably be adopted for all of these patients irrespective of the presence of sleep-related symptoms...
  10. ncbi request reprint Nocturnal periodic breathing in primary pulmonary hypertension
    R Schulz
    Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Justus Liebig University, Giessen, Germany
    Eur Respir J 19:658-63. 2002
    ..The clinical and prognostic significance of periodic breathing in primary pulmonary hypertension needs to be determined by further studies...
  11. ncbi request reprint Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia
    Richard Schulz
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 165:67-70. 2002
    ..This might constitute an adaptive mechanism to counterbalance the emergence of OSA-related cardiovascular disease...
  12. doi request reprint [Obstructive sleep apnoea and metabolic syndrome]
    R Schulz
    Medizinische Klinik II Schlaflabor, Universitätsklinikum Giessen und Marburg, Standort Giessen, Giessen
    Pneumologie 62:88-91. 2008
    ..It is known that CPAP therapy can ameliorate OSA-associated hypertension. In contrast, the effects of CPAP treatment on insulin resistance and dyslipidaemia have to be further elucidated by large, randomised interventional trials...
  13. ncbi request reprint [Sleep apnea and cardiovascular disease--results from animal studies]
    R Schulz
    Medizinische Klinik II, Universitätsklinikum Giessen und Marburg, Standort Giessen
    Pneumologie 62:18-22. 2008
    ..It is anticipated that animal studies will continue to enhance our understanding of the pathogenesis of these disorders...
  14. ncbi request reprint [Obstructive sleep apnea-related cardiovascular disease]
    Richard Schulz
    Medizinische Klinik II Schlaflabor, Universitätsklinikum Giessen und Marburg, Standort Giessen, 35392 Giessen
    Med Klin (Munich) 101:321-7. 2006
    ..Furthermore, long-term CPAP therapy leads to a reduction in important clinical endpoints such as the rates of myocardial infarction and stroke...
  15. doi request reprint Sleep apnea in precapillary pulmonary hypertension
    Rio Dumitrascu
    University of Giessen Lung Center, Germany
    Sleep Med 14:247-51. 2013
    ..Pilot studies have described the occurrence of sleep apnea in patients with precapillary pulmonary hypertension (PH). However, there are no data on the prevalence of sleep-related breathing disorders in larger patient cohorts with PH...
  16. doi request reprint Quality of life in clinically stable adult cystic fibrosis out-patients: associations with daytime sleepiness and sleep quality
    Anna Bouka
    Department of Sleep Medicine and Adult CF Service, University of Giessen Lung Center, Klinik Str 33, 35392 Giessen, Germany
    Respir Med 106:1244-9. 2012
    ..Patients with cystic fibrosis (CF) may suffer from sleep disturbances and reduced health-related quality of life (HRQoL). However, the relationships of daytime sleepiness and sleep quality to HRQoL in CF have not yet been investigated...
  17. doi request reprint HbA1c in pulmonary arterial hypertension: a marker of prognostic relevance?
    Michael J Belly
    Department of Internal Medicine, University of Giessen Lung Center, Giessen, Germany
    J Heart Lung Transplant 31:1109-14. 2012
    ..Patients with pulmonary arterial hypertension (PAH) exhibit impaired glucose metabolism and increased insulin resistance. The clinical consequences of these metabolic changes are not known...
  18. pmc Serum proteome profiling identifies novel and powerful markers of cystic fibrosis liver disease
    Timo Rath
    Justus Liebig University Giessen, Department of Internal Medicine, Division of Gastroenterology, Giessen, Germany
    PLoS ONE 8:e58955. 2013
    ..However, routine sensitive diagnostic tools for CFLD are lacking. Within this study, we aimed to identify new experimental biomarkers for the detection of CFLD...
  19. doi request reprint Obstructive sleep apnea in a patient with the Melkersson-Rosenthal syndrome
    Hans Joachim Eisele
    University of Giessen Lung Center, Giessen, Germany
    Sleep Breath 14:245-7. 2010
    ..Melkersson-Rosenthal syndrome (MRS) is a rare disorder of unknown etiology. It is characterized by the triad of macrocheilitis, peripheral facial palsy, and lingua plicata...
  20. doi request reprint TIMP-1/-2 and transient elastography allow non invasive diagnosis of cystic fibrosis associated liver disease
    Timo Rath
    Justus Liebig University Giessen, Department of Internal Medicine, Division of Gastroenterology, 35385 Giessen, Germany
    Dig Liver Dis 44:780-7. 2012
    ..Cystic fibrosis (CF) associated liver disease develops in approximately 30% of CF patients. However, routine sensitive diagnostic tools are lacking...
  21. ncbi request reprint Antioxidant vitamin C improves endothelial function in obstructive sleep apnea
    Mathias Grebe
    Division of Cardiology and Angiology, Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 173:897-901. 2006
    ..Obstructive sleep apnea (OSA) is associated with oxidative stress, endothelial dysfunction, and increased cardiovascular morbidity and mortality...
  22. doi request reprint Dynamic hyperinflation during exercise in patients with precapillary pulmonary hypertension
    Manuel J Richter
    Department of Internal Medicine, University of Giessen Lung Center, Giessen, Germany
    Respir Med 106:308-13. 2012
    ..Patients with pulmonary arterial hypertension often present with a mild obstructive lung pattern, however, the functional consequences are not known...
  23. ncbi request reprint [Prevalence of stroke and transitory ischemic attacks in obstructive sleep apnea: a retrospective analyis so f 187 consecutive patients]
    R Schulz
    Medizinische Klinik II, , Giessen
    Pneumologie 54:575-9. 2000
    ..Further prospective studies controlling for confounding factors such as age, body weight and arterial hypertension are needed to clarify the risk potential of OSA for the development of cerebrovascular disorders...
  24. doi request reprint [Pulmonary hypertension in hereditary haemorrhagic teleangiectasia]
    F Reichenberger
    Lungenzentrum, Medizinische Klinik II, Universitätsklinikum Giessen und Marburg, Standort Giessen
    Pneumologie 63:669-74. 2009
    ..In hereditary haemorrhagic teleangiectasia (HHT) can be accompanied by pulmonary arteriovenous vascular malformations (PAVM). Pulmonary hypertension (PH) is regarded as a rare pulmonary manifestation...
  25. doi request reprint Noninvasive detection of early pulmonary vascular dysfunction in scleroderma
    F Reichenberger
    University Giessen Lung Centre, University Hospital Giessen, Germany
    Respir Med 103:1713-8. 2009
    ..Pulmonary arterial hypertension is a serious complication in scleroderma and early diagnosis is warranted...
  26. ncbi request reprint [Inhalation combination therapy in chronic obstructive lung disease. TRISTAN-study]
    W Seeger
    Medizinische Klink II, Universitätsklinikum Giessen
    Internist (Berl) 45:727-8. 2004
  27. doi request reprint Executive functions and cognitive subprocesses in patients with obstructive sleep apnoea
    Stefanie Lis
    Department of Psychiatry, Justus Liebig University Giessen, Giessen, Germany
    J Sleep Res 17:271-80. 2008
    ..In contrast, reduced accuracy during the WM task in the OSAS group could not be explained by deficits in more elementary cognitive processes...
  28. doi request reprint Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation
    Martin Roderfeld
    Justus Liebig University Giessen, Department of Internal Medicine, Germany
    J Cyst Fibros 8:338-47. 2009
    ..We investigated whether a panel of serum MMPs is associated with both, impairment of pulmonary function and occurrence of pulmonary exacerbations (PEx) in adult patients with CF...
  29. pmc Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids
    Konstantin Mayer
    University of Giessen Lung Center UGLC, Medical Clinic II, Justus Liebig University Giessen, Klinikstr 36, D 35392 Giessen, Germany
    Am J Respir Crit Care Med 179:474-83. 2009
    ..The n-3 FA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and mediators derived from EPA and DHA possess reduced inflammatory potency...
  30. doi request reprint Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury
    M B Schaefer
    University of Giessen Lung Center, Medical Clinic II, Justus Liebig University Giessen, Klinikstr 36, D 35392 Giessen, Germany
    Eur Respir J 32:1344-53. 2008
    ..Activation of peroxisome proliferator-activated receptor-alpha by WY 14,643 reduced acute lung injury and vascular leakage. Fibrates may possess beneficial effects in acute pulmonary diseases beyond their lipid-lowering capability...
  31. doi request reprint Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms
    N Sommer
    University of Giessen Lung Center, Medical Clinic II V, Justus Liebig University Giessen, Giessen, Germany
    Eur Respir J 32:1639-51. 2008
    ....
  32. ncbi request reprint Cellular pathophysiology and therapy of pulmonary hypertension
    H Olschewski
    Medical Clinic II, Justus-Liebig-University, Giessen, Germany
    J Lab Clin Med 138:367-77. 2001
    ..Therapeutic approaches in the future may aim at the transforming growth factor beta pathway and at the identification of early stages of the disease to prevent further disease progression...
  33. ncbi request reprint Prevalence and outcomes of caregiving after prolonged (> or =48 hours) mechanical ventilation in the ICU
    KyungAh Im
    Epidemiology Data Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 127 Parran Hall, Pittsburgh, PA 15261, USA
    Chest 125:597-606. 2004
    ....
  34. ncbi request reprint Generalized anxiety disorder in late life: lifetime course and comorbidity with major depressive disorder
    Eric J Lenze
    Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:77-80. 2005
    ..The authors assessed the course and comorbidity of late-life GAD and MDD...
  35. pmc Socioeconomic position and incident mobility impairment in the Cardiovascular Health Study
    Cheryl K Nordstrom
    Wayne State University, Center for Health Research, Detroit, MI, USA
    BMC Geriatr 7:11. 2007
    ..We investigated if personal socioeconomic position (SEP) factors and neighborhood characteristics were associated with incident mobility impairment in the elderly...
  36. ncbi request reprint Matrix metalloproteinase-2, caveolins, focal adhesion kinase and c-Kit in cells of the mouse myocardium
    Woo Jung Cho
    Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    J Cell Mol Med 11:1069-86. 2007
    ..Also, MMP-2 is closely associated with FAK at FB and c-Kit at ICLC. Thus, Cav-1 expression is not necessary for Cav-2 expression. Cav-3 or Cav-3 with Cav-2 has the capability to make Cav...
  37. doi request reprint Endothelial dependence of matrix metalloproteinase-mediated vascular hyporeactivity caused by lipopolysaccharide
    Jonathan Cena
    Department of Pharmacology, Cardiovascular Research Group, University of Alberta, Edmonton, Alberta, Canada
    Eur J Pharmacol 582:116-22. 2008
    ..The vascular endothelium contributes to MMP-mediated vascular dysfunction induced by LPS. The protective effect of MMP inhibition is endothelium-dependent and is a novel mechanism by which MMPs contribute to vascular dysfunction...
  38. doi request reprint Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4
    Sandra Donnini
    Departments of Molecular Biology, University of Siena, Via A Moro, 2, Siena 53100, Italy
    FEBS Lett 582:1135-40. 2008
    ..HPLC/ESI-MS/MS analysis of peroxynitrite-treated TIMP-4 showed modifications at Y114, Y195, Y188 and Y190. In conclusion, TIMP-4 nitration might be a potential mechanism contributing to cardiovascular disease and cancer...
  39. doi request reprint Inhibiting matrix metalloproteinase-2 reduces protein release into coronary effluent from isolated rat hearts during ischemia-reperfusion
    Justyna Fert-Bober
    Dept of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada
    Basic Res Cardiol 103:431-43. 2008
    ..Therefore, we hypothesize that inhibiting MMPs reduces the MMP-2 dependent disruption of the coronary endothelium and subsequent protein release during I/R...
  40. pmc Dementia patient suffering and caregiver depression
    Richard Schulz
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Alzheimer Dis Assoc Disord 22:170-6. 2008
    ..Medical treatment of patients that maintain or improve memory but do not address suffering may have little impact on the caregiver. Alzheimer disease patient suffering should be systematically assessed and treated by clinicians...
  41. doi request reprint Calcium extrusion by plasma membrane calcium pump is impaired in caveolin-1 knockout mouse small intestine
    Ahmed F El-Yazbi
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Eur J Pharmacol 591:80-7. 2008
    ..We suggest that this is due to the close spatial arrangement that allows calcium extrusion from a privileged cytosolic space between caveolae and sarcoplasmic reticulum...
  42. ncbi request reprint Hospital costs in patients receiving prolonged mechanical ventilation: does age have an impact?
    Lakshmipathi Chelluri
    Department of Critical Care Medicine, Room 637, 6th Floor Scaife, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Crit Care Med 31:1746-51. 2003
    ..The aging of the population is one of the causes of the increase in healthcare costs in the past few decades. It is controversial whether chronological age alone should be used in making healthcare decisions...
  43. pmc Frequency and correlates of advance planning among cognitively impaired older adults
    Jennifer Hagerty Lingler
    Department of Health and Community Systems, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:643-9. 2008
    ..To examine the prevalence and sociodemographic correlates of written advance planning among patients with or at risk for dementia-imposed decisional incapacity...
  44. ncbi request reprint Depression and distress predict time to cardiovascular disease in dementia caregivers
    Brent T Mausbach
    Department of Psychiatry, University of California, San Diego, CA 92093 0680, USA
    Health Psychol 26:539-44. 2007
    ..This study assessed the impact of depressive symptoms and distress from patient problem behaviors on time to developing a diagnosis of cardiovascular disease (CVD) in a sample of 643 dementia family caregivers...
  45. ncbi request reprint Hydrogen peroxide causes cardiac dysfunction independent from its effects on matrix metalloproteinase-2 activation
    Hernando Leon
    Department of Pediatrics, Cardiovascular Research Group, 4 62 Heritage Medical Research Centre, University of Alberta, Edmonton, AB T6G 2S2, Canada
    Can J Physiol Pharmacol 85:341-8. 2007
    ..The deleterious effect of H2O2 on cardiac function was abolished by pyruvate but not by the MMPs inhibitors. This study suggests that in intact hearts, H2O2 induces contractile dysfunction independent of MMPs activation...
  46. ncbi request reprint Use of cognitive enhancement medication in persons with Alzheimer disease who have a family caregiver: results from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) project
    Steven H Belle
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Geriatr Psychiatry 12:250-7. 2004
    ..The authors examined the frequency and appropriateness of use, the importance of a family caregiver in medication decisions for dementia patients, and differences in access to medical care...
  47. ncbi request reprint Adaptive self-regulation of unattainable goals: goal disengagement, goal reengagement, and subjective well-being
    Carsten Wrosch
    Department of Psychology, Concordia University, Montreal, QC, Canada
    Pers Soc Psychol Bull 29:1494-508. 2003
    ..In addition, the results showed that goal disengagement and goal reengagement can have interactive effects on subjective well-being. The importance of the findings for effective self-regulation and successful development are discussed...
  48. ncbi request reprint MMP-2 and MMP-9 and their tissue inhibitors in the plasma of preterm and term neonates
    Christina G Schulz
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Pediatr Res 55:794-801. 2004
    ..MMP and TIMP may be involved in the feto-neonatal development and may contribute to the pathogenesis of BPD and/or IVH in critically ill preterm neonates...
  49. ncbi request reprint Long-term mortality and quality of life after prolonged mechanical ventilation
    Lakshmipathi Chelluri
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA
    Crit Care Med 32:61-9. 2004
    ..To describe and identify factors associated with mortality rate and quality of life 1 yr after prolonged mechanical ventilation...
  50. ncbi request reprint Obstructive sleep apnea due to HIV-associated lipodystrophy
    Richard Schulz
    Clin Infect Dis 37:1398-9. 2003
  51. ncbi request reprint A methodology for describing and decomposing complex psychosocial and behavioral interventions
    Sara J Czaja
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Florida 33136, USA
    Psychol Aging 18:385-95. 2003
    ....
  52. pmc The Resources for Enhancing Alzheimer's Caregiver Health (REACH): project design and baseline characteristics
    Stephen R Wisniewski
    Department of Epidemiology, University of Pittsburgh, Pennsylvania 15261, USA
    Psychol Aging 18:375-84. 2003
    ..Caregivers reported high levels of depressive symptoms and moderate burden. Care recipients were older, with a mean age of 79, and were moderately to severely impaired with mean Mini-Mental State Exam scores of 13/30...
  53. ncbi request reprint Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  54. ncbi request reprint Prevalence and correlates of anxiety symptoms in well-functioning older adults: findings from the health aging and body composition study
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, San Francisco, California 94121
    J Am Geriatr Soc 51:499-504. 2003
    ..To determine the prevalence and correlates of anxiety symptoms in the absence of depression, in older black and white people...
  55. ncbi request reprint The association of race and socioeconomic status with cardiovascular disease indicators among older adults in the health, aging, and body composition study
    Ronica N Rooks
    Laboratory of Epidemiology, National Institute on Aging, Bethesda, Maryland, USA
    J Gerontol B Psychol Sci Soc Sci 57:S247-56. 2002
    ..But, accounting for a broad interpretation of socioeconomic status (SES) (i.e., education, family income, home ownership, and other assets) would reduce these differences...
  56. ncbi request reprint Nitrate tolerance does not increase production of peroxynitrite in the heart
    Tamas Csont
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, H 6720, Hungary
    Am J Physiol Heart Circ Physiol 283:H69-76. 2002
    ..This is the first demonstration that, although the systemic effects of nitroglycerin may be deleterious due to enhancement of extracardiac peroxynitrite formation, nitroglycerin does not result in oxidative damage in the heart...
  57. ncbi request reprint Investigating moderator hypotheses in aging research: statistical, methodological, and conceptual difficulties with comparing separate regressions
    Jason T Newsom
    Institute on Aging, Portland State University, OR 97207 0751, USA
    Int J Aging Hum Dev 57:119-50. 2003
    ..These results clearly illustrate that the analysis strategy researchers choose may have important bearing on theory in aging research such as conclusions regarding the role of social support across the life span...
  58. ncbi request reprint Inhibition of inducible nitric oxide synthase and superoxide production reduces matrix metalloproteinase-9 activity and restores coronary vasomotor function in rat cardiac allografts
    Koso Egi
    Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
    Eur J Cardiothorac Surg 26:262-9. 2004
    ..We investigated the contribution of inducible nitric oxide synthase (iNOS) derived NO and superoxide on (MMP)-9 activity and to changes in coronary vasomotor function in rat cardiac allografts...
  59. ncbi request reprint Physiological levels of amyloid peptides stimulate the angiogenic response through FGF-2
    Silvia Cantara
    Pharmacology Section, Department of Molecular Biology, University of Siena, Siena, Italy
    FASEB J 18:1943-5. 2004
    ..The angiogenesis promoted by Abeta peptides via FGF-2 might have implications for understanding the initial stages of Alzheimer's disease and for the design of therapies targeting beta amyloid...
  60. pmc Depressive symptoms in older African-American and white adults with functional difficulties: the role of control strategies
    Laura N Gitlin
    Center for Applied Research on Aging and Health, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Am Geriatr Soc 55:1023-30. 2007
    ..To examine whether control-oriented strategies buffer effects of functional difficulties on depressive symptoms over time in older African-American and white adults with disability...
  61. ncbi request reprint E-care: a telecommunications technology intervention for family caregivers of dementia patients
    Sanford Finkel
    Council for Jewish Elderly, Chicago, IL, USA
    Am J Geriatr Psychiatry 15:443-8. 2007
    ..An additional objective was to determine if the intervention could be implemented by a community-based social service agency...
  62. ncbi request reprint PPARalpha: essential component to prevent myocardial oxidative stress?
    Richard Schulz
    Am J Physiol Heart Circ Physiol 293:H11-2. 2007
  63. ncbi request reprint Making sense of mild cognitive impairment: a qualitative exploration of the patient's experience
    Jennifer Hagerty Lingler
    Department of Psychiatry, Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, 121 University Place, Pittsburgh, PA 15260, USA
    Gerontologist 46:791-800. 2006
    ..Yet, little is known about the subjective experience of living with a diagnosis of mild cognitive impairment. This study examines, from the patient's perspective, the experience of living with and making sense of the diagnosis...
  64. ncbi request reprint Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approaches
    Richard Schulz
    Cardiovascular Research Group, Departments of Pediatrics and Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Annu Rev Pharmacol Toxicol 47:211-42. 2007
    ..MMP-2 proteolyzes specific targets within the cell to cause acute, reversible contractile dysfunction. Inhibitors of MMPs are discussed and their possible use for the therapy of acute heart injury caused by oxidative stress is examined...
  65. ncbi request reprint Does who you marry matter for your health? Influence of patients' and spouses' personality on their partners' psychological well-being following coronary artery bypass surgery
    John M Ruiz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Pers Soc Psychol 91:255-67. 2006
    ..Relationship satisfaction moderated these effects. These results suggest that partners' personality traits are important determinants of both patients' and their caregiving spouses' well-being...
  66. ncbi request reprint Predictors of complicated grief among dementia caregivers: a prospective study of bereavement
    Richard Schulz
    University Center for Social and Urban Research, University of Pittsburgh, 121 University Place, Pittsburgh, PA 15260, USA
    Am J Geriatr Psychiatry 14:650-8. 2006
    ..This is the first study to prospectively assess predictors of complicated grief among family caregivers of patients with dementia who experience the death of their care recipient...
  67. ncbi request reprint Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease
    Serena Viappiani
    Am J Physiol Heart Circ Physiol 290:H2167-8. 2006
  68. ncbi request reprint The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines
    Tamas Csont
    Cardiovascular Research Group, Department of Pharmacology and Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 4 62 HMRC, Edmonton, AB, Canada T6G 2S2
    J Mol Cell Cardiol 39:833-40. 2005
    ....
  69. pmc Nitrosative stress and pharmacological modulation of heart failure
    Pal Pacher
    Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9413, Room 2S24, Bethesda, MD 20892 9413, USA
    Trends Pharmacol Sci 26:302-10. 2005
    ....
  70. ncbi request reprint The course of functional decline in older people with persistently elevated depressive symptoms: longitudinal findings from the Cardiovascular Health Study
    Eric J Lenze
    Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Am Geriatr Soc 53:569-75. 2005
    ..To examine the relationship between persistently high depressive symptoms and long-term changes in functional disability in elderly persons...
  71. ncbi request reprint Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2
    Wenjie Wang
    Department of Pharmacology, Cardiovascular Research Group, University of Alberta, 4 62 Heritage Medical Research Centre, Edmonton, Alberta, T6G 2S2 Canada
    Cardiovasc Res 53:165-74. 2002
    ..As oxidants like ONOO(-) are known to activate matrix metalloproteinases (MMPs), we examined whether they play a role in the detrimental action of ONOO(-) in isolated perfused rat hearts...