Jorg B Schulz

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc Chemoresistance of glioblastoma cancer stem cells--much more complex than expected
    Dagmar Beier
    Department of Neurology, RWTH Aachen, Medical School, Pauwelsstrasse 30, 52074 Aachen, Germany
    Mol Cancer 10:128. 2011
  2. doi request reprint Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6
    Jorg B Schulz
    Department of Neurodegeneration and Restorative Research, Center for Neurological Medicine, University of Gottingen, Gottingen, Germany
    Neuroimage 49:158-68. 2010
  3. doi request reprint Diagnosis and treatment of Friedreich ataxia: a European perspective
    Jorg B Schulz
    Department of Neurology, University Hospital, RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany
    Nat Rev Neurol 5:222-34. 2009
  4. doi request reprint Sustained effects of once-daily memantine treatment on cognition and functional communication skills in patients with moderate to severe Alzheimer's disease: results of a 16-week open-label trial
    Jorg B Schulz
    Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany
    J Alzheimers Dis 25:463-75. 2011
  5. doi request reprint Basic science in Parkinson's disease: its impact on clinical practice
    Jorg B Schulz
    Department of Neurology, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Neurol 258:S299-306. 2011
  6. ncbi request reprint Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease
    Katrin Meuer
    Department of Neurology, University of Gottingen, Waldweg 33, 37073 Gottingen, Germany
    J Neurochem 97:675-86. 2006
  7. doi request reprint Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data
    Heike Jacobi
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Lancet Neurol 12:650-8. 2013
  8. ncbi request reprint Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis
    Guido Straten
    Neuroregeneration Laboratory, Department of Neurology, University of Tubingen, D 72076 Tubingen, Germany
    Neurobiol Dis 11:123-33. 2002
  9. doi request reprint Spinocerebellar ataxia types 1, 2, 3 and 6: the clinical spectrum of ataxia and morphometric brainstem and cerebellar findings
    Heike Jacobi
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Strase 25, 53105 Bonn, Germany
    Cerebellum 11:155-66. 2012
  10. pmc Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery
    Anja Drinkut
    DFG Research Center Molecular Physiology of the Brain CMPB at University Medicine Göttingen, Gottingen, Germany
    Mol Ther 20:534-43. 2012

Detail Information

Publications59

  1. pmc Chemoresistance of glioblastoma cancer stem cells--much more complex than expected
    Dagmar Beier
    Department of Neurology, RWTH Aachen, Medical School, Pauwelsstrasse 30, 52074 Aachen, Germany
    Mol Cancer 10:128. 2011
    ..Thus, the interaction of CSC and chemotherapy is more complex than may be expected and it is necessary to consider these factors in order to overcome chemoresistance in the patient...
  2. doi request reprint Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6
    Jorg B Schulz
    Department of Neurodegeneration and Restorative Research, Center for Neurological Medicine, University of Gottingen, Gottingen, Germany
    Neuroimage 49:158-68. 2010
    ..We therefore aimed to visualize, quantify and correlate localized brain atrophy with clinical symptoms in SCA1, SCA3, and SCA6...
  3. doi request reprint Diagnosis and treatment of Friedreich ataxia: a European perspective
    Jorg B Schulz
    Department of Neurology, University Hospital, RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany
    Nat Rev Neurol 5:222-34. 2009
    ..This Review provides guidelines, from a European perspective, for the diagnosis of Friedreich ataxia, differential diagnosis of ataxias and genetic counseling, and treatment of neurological and non-neurological symptoms...
  4. doi request reprint Sustained effects of once-daily memantine treatment on cognition and functional communication skills in patients with moderate to severe Alzheimer's disease: results of a 16-week open-label trial
    Jorg B Schulz
    Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany
    J Alzheimers Dis 25:463-75. 2011
    ..2%) patients. In patients with moderate to severe AD, once-daily memantine (20 mg) treatment significantly improved cognition and functional communication and was found to have a favorable safety and tolerability profile...
  5. doi request reprint Basic science in Parkinson's disease: its impact on clinical practice
    Jorg B Schulz
    Department of Neurology, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Neurol 258:S299-306. 2011
    ..Early, even pre-symptomatic diagnosis might be key to successfully establish disease-modifying treatments...
  6. ncbi request reprint Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease
    Katrin Meuer
    Department of Neurology, University of Gottingen, Waldweg 33, 37073 Gottingen, Germany
    J Neurochem 97:675-86. 2006
    ..Thus our data suggest that G-CSF is a novel therapeutic opportunity for the treatment of Parkinson's disease, because it is well-tolerated and already approved for the treatment of neutropenic conditions in humans...
  7. doi request reprint Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data
    Heike Jacobi
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Lancet Neurol 12:650-8. 2013
    ..Spinocerebellar ataxias (SCAs) are autosomal, dominantly inherited, fully penetrant neurodegenerative diseases. Our aim was to study the preclinical stage of the most common SCAs: SCA1, SCA2, SCA3, and SCA6...
  8. ncbi request reprint Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis
    Guido Straten
    Neuroregeneration Laboratory, Department of Neurology, University of Tubingen, D 72076 Tubingen, Germany
    Neurobiol Dis 11:123-33. 2002
    ..4% of the total RGC population. These findings underline the neuroprotective potential of synergistic effects of a combination of different treatment strategies...
  9. doi request reprint Spinocerebellar ataxia types 1, 2, 3 and 6: the clinical spectrum of ataxia and morphometric brainstem and cerebellar findings
    Heike Jacobi
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Strase 25, 53105 Bonn, Germany
    Cerebellum 11:155-66. 2012
    ..The seemingly low prevalence of cerebellar oculomotor deficits in SCA1 and SCA2 is most probably related to the defective saccadic system in these disorders...
  10. pmc Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery
    Anja Drinkut
    DFG Research Center Molecular Physiology of the Brain CMPB at University Medicine Göttingen, Gottingen, Germany
    Mol Ther 20:534-43. 2012
    ..Astrocytic neurotrophic factor expression may open new venues for neurotrophic factor-based gene therapy targeting severe diseases of the brain...
  11. doi request reprint Consistent neurodegeneration and its association with clinical progression in Huntington's disease: a coordinate-based meta-analysis
    Imis Dogan
    Department of Neurology, RWTH Aachen University, Aachen, Germany
    Neurodegener Dis 12:23-35. 2013
    ..In the past decade, whole-brain magnetic resonance imaging (MRI) studies have provided accumulating evidence for widely distributed cortical and subcortical atrophy in the early course of the disease...
  12. pmc Diminished activation of motor working-memory networks in Parkinson's disease
    Claudia Rottschy
    Department of Neurology, RWTH Aachen University, Aachen, Germany
    PLoS ONE 8:e61786. 2013
    ....
  13. doi request reprint Genotype-specific patterns of atrophy progression are more sensitive than clinical decline in SCA1, SCA3 and SCA6
    Kathrin Reetz
    Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Brain 136:905-17. 2013
    ....
  14. pmc The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity
    Erin K Butler
    Department of Neurology, University Medical Center, RWTH Aachen, Germany
    PLoS Genet 8:e1002488. 2012
    ..Interestingly, TRAP1 has previously been shown to be phosphorylated by the serine/threonine kinase PINK1, thus providing a potential link of PINK1 via TRAP1 to α-Synuclein...
  15. doi request reprint Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors
    Antje Krenz
    Department of Neurodegeneration and Restorative Research, DFG Research Center for Molecular Physiology of Brain and Center for Neurological Medicine, University of Gottingen, Gottingen, Germany
    J Neurochem 108:139-46. 2009
    ....
  16. ncbi request reprint Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial
    Mikael Simons
    Department of Neurology, University of Tubingen, Germany
    Ann Neurol 52:346-50. 2002
    ..The reduction of Abeta40 correlated with the reduction of 24S-hydroxycholesterol. These changes were not observed in more severely affected patients...
  17. doi request reprint Depression comorbidity in spinocerebellar ataxia
    Tanja Schmitz-Hübsch
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Mov Disord 26:870-6. 2011
    ..Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown...
  18. pmc Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila
    Hannes VoSSfeldt
    Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany
    PLoS ONE 7:e47452. 2012
    ..We identified various unknown modifiers of polyQ toxicity. Large-scale analysis indicated a dissociation of polyQ aggregation and toxicity...
  19. pmc TDP-43-mediated neuron loss in vivo requires RNA-binding activity
    Aaron Voigt
    Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany
    PLoS ONE 5:e12247. 2010
    ..Using this bi-systemic approach we uncovered a requirement of inherent TDP-43 RNA-binding function--but not ALS/FTLD-linked mutation, mislocalization, or truncation--for TDP-43-mediated neurotoxicity in vivo...
  20. doi request reprint Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease
    Florian Nagel
    Neurologische Universitatsklinik, Gottingen, Germany
    J Neurochem 105:853-64. 2008
    ..The use of Tat-fusion proteins might therefore be a valuable tool to deliver molecular chaperones like Hsp70 into the brain and may be the starting point for new protective strategies in neurodegenerative diseases...
  21. doi request reprint Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia
    Arno Reich
    Department of Neurology, University Hospital and Medical School, RWTH Aachen University, D 52074 Aachen, Germany
    J Neurosci 31:225-33. 2011
    ..These processes were rescued by lentiviral Faim2 gene transfer. In summary, we provide evidence that Faim2 is a novel neuroprotective molecule in the context of cerebral ischemia...
  22. doi request reprint BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution
    Kamila Sroka
    Department of Neurology, University Hospital Gottingen, Waldweg, Gottingen, Germany
    J Neurochem 111:801-7. 2009
    ..In summary, we present BAG1 as a therapeutic tool modulating key steps in htt toxicity in vitro and ameliorating htt toxicity in vivo...
  23. doi request reprint Drosophila as a screening tool to study human neurodegenerative diseases
    Sarah Lenz
    Department of Neurology, University Medical Center, RWTH Aachen, Aachen, Germany
    J Neurochem 127:453-60. 2013
    ..Here, we provide a brief overview of how flies can be used to analyze molecular mechanisms underlying human neurodegenerative diseases...
  24. ncbi request reprint Palmitoylation is a sorting determinant for transport to the myelin membrane
    Anja Schneider
    Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strausse 3, 72076 Tubingen, Germany
    J Cell Sci 118:2415-23. 2005
    ..Thus, we conclude that palmitoylation is a sorting determinant for transport to the myelin membrane...
  25. doi request reprint Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice
    Eva M Szego
    Department of Neurodegeneration and Restorative Research, Georg August University, DFG Research Center, Molecular Physiology of Brain, Gottingen, Germany
    Neurobiol Aging 34:589-601. 2013
    ....
  26. doi request reprint Comparison of three clinical rating scales in Friedreich ataxia (FRDA)
    Katrin Burk
    Department of Neurodegeneration and Restorative Research, Centers of Molecular Physiology of the Brain and Neurological Medicine, University of Gottingen, Gottingen, Germany
    Mov Disord 24:1779-84. 2009
    ..Because SARA is characterized by high interrater reliability and practicability, SARA is applicable and well suited forclinical trials of FRDA...
  27. pmc Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models
    Damla Pinar Karpinar
    Department for NMR based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    EMBO J 28:3256-68. 2009
    ....
  28. doi request reprint PKC links Gq-coupled receptors to DAT-mediated dopamine release
    Felipe Opazo
    Department of Neurodegeneration and Restorative Research, Center for Neurological Medicine, Gottingen, Germany
    J Neurochem 114:587-96. 2010
    ..Activation of muscarinic receptors and PKC also induced release from a cell line expressing the norepinephrine transporter, suggesting that transport-mediated release might be relevant in further brain areas...
  29. doi request reprint Accumulation and clearance of alpha-synuclein aggregates demonstrated by time-lapse imaging
    Felipe Opazo
    Center for Neurological Medicine, Department for Neurodegeneration and Restorative Research, University of Gottingen, Gottingen, Germany
    J Neurochem 106:529-40. 2008
    ..In contrast to earlier assumptions build-up, reduction and clearance of alpha-synuclein aggregation thus appear a highly dynamic process...
  30. doi request reprint Monitoring progression in Friedreich ataxia (FRDA): the use of clinical scales
    Katrin Burk
    Department of Neurology, University of Marburg, Marburg, Germany
    J Neurochem 126:118-24. 2013
    ..All scales have been validated and compared with regard to their testing properties. ..
  31. doi request reprint Parkinson's disease and dementia: a longitudinal study (DEMPARK)
    Monika Balzer-Geldsetzer
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    Neuroepidemiology 37:168-76. 2011
    ..Parkinson's disease (PD) is a progressive neurodegenerative motor disorder. However, non-motor complications frequently alter the course of the disease. A particularly disabling non-motor symptom is dementia...
  32. pmc Targeted ablation of oligodendrocytes triggers axonal damage
    Aniket Ghosh
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 6:e22735. 2011
    ..The models used in this study provide valuable systems for the investigation of therapeutic strategies to prevent axonal or neuronal damage...
  33. doi request reprint Self-rated health status in spinocerebellar ataxia--results from a European multicenter study
    Tanja Schmitz-Hübsch
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Mov Disord 25:587-95. 2010
    ..This model explained 30.5% of EQ-VAS variance in the whole sample and might be extrapolated to other SCA genotypes...
  34. doi request reprint Magnetic resonance imaging in spinocerebellar ataxias
    Susanne Döhlinger
    Department of Neurodegeneration and Restorative Research, Centers of Molecular Physiology of the Brain and Neurological Medicine, University of Gottingen, Waldweg 33, D 37073 Gottingen, Germany
    Cerebellum 7:204-14. 2008
    ....
  35. doi request reprint Modulation of Hippocampal Neuroplasticity by Fas/CD95 Regulatory Protein 2 (Faim2) in the Course of Bacterial Meningitis
    Simone C Tauber
    From the Department of Neurology SCT, BF, JBS, AR, University Hospital and Institute of Neuropathology JW, BS, Medical Faculty, RWTH Aachen University, Aachen Department of Neurodegeneration and Restorative Research KH, Georg August University, Göttingen DFG Research Center, Molecular Physiology of the Brain CMPB, Göttingen Department of Geriatrics RN, Evangelisches Krankenhaus Göttingen Weende, Gottingen, Germany
    J Neuropathol Exp Neurol 73:2-13. 2014
    ..Hence, time-dependent modulation of neuroplasticity by Faim2 may offer a new therapeutic approach for reducing hippocampal neuronal cell death and improving cognitive deficits after bacterial meningitis. ..
  36. doi request reprint Cognitive effects of deep brain stimulation for essential tremor: evaluation at 1 and 6 years
    Ines A Heber
    Division of Neuropsychology, Department of Neurology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52064, Aachen, Germany
    J Neural Transm 120:1569-77. 2013
    ..Neither stereotactic surgery nor electrical stimulation affected higher cognitive processes. This study proposes that cerebello-thalamo-cortical pathways in humans are involved in tasks of simple reaction time...
  37. ncbi request reprint Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson's disease
    Olaf Eberhardt
    Department of Neurology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Toxicol Lett 139:135-51. 2003
    ..g. by inhibition of caspases, blocks or delays cell death but may not recover neuronal function. At this stage, the combination of an anti-apoptotic together with a neurorestorative therapy may be promising...
  38. ncbi request reprint Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons
    Anja Schneider
    Center for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Neurobiol Dis 23:573-7. 2006
    ..These results suggest a key role for cholesterol in aggregation of Abeta...
  39. doi request reprint Alternate-form reliability of the Montreal cognitive assessment screening test in a clinical setting
    Ana S Costa
    Department of Neurology, RWTH Aachen University Hospital, Germany
    Dement Geriatr Cogn Disord 33:379-84. 2012
    ..For serial assessments, alternate forms are needed to overcome possible practice effects. Our objective was to investigate the reliability of two German MoCA alternate forms for longitudinal assessment applications...
  40. pmc TRAP1 rescues PINK1 loss-of-function phenotypes
    Li Zhang
    Department of Neurology, University Medical Center, RWTH Aachen, Aachen D 52074, Germany
    Hum Mol Genet 22:2829-41. 2013
    ..Thus, our data suggest a functional role of TRAP1 in maintaining mitochondrial integrity downstream of PINK1 and complex I deficits but parallel to or upstream of Parkin. ..
  41. doi request reprint Investigating function and connectivity of morphometric findings--exemplified on cerebellar atrophy in spinocerebellar ataxia 17 (SCA17)
    Kathrin Reetz
    Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Neuroimage 62:1354-66. 2012
    ....
  42. pmc Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity
    Peter Teismann
    Department of Neurodegeneration and Restorative Research, Center of Molecular Physiology of the Brain, University of Gottingen, Gottingen, Germany
    Neurobiol Aging 33:2478-90. 2012
    ..Our results suggest that activation of RAGE contributes to MPTP/MPP(+)-induced death of dopaminergic neurons that may be mediated by NF-κB activation...
  43. doi request reprint A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice
    Eva M Szego
    Department of Neurodegeneration and Restorative Research, Georg August University, DFG Research Center Molecular Physiology of the Brain CMPB, Gottingen, 37073, Germany
    Neurobiol Dis 45:591-600. 2012
    ..Our findings reveal that the presence of A30P αsyn inhibits the regeneration of nigrostriatal dopaminergic fibers, and that L-DOPA treatment might interact with the pathogenesis in PD...
  44. doi request reprint Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes
    Sigurd D Sussmuth
    Department of Neurology, University of Ulm, Ulm, Germany
    Mov Disord 25:1284-8. 2010
    ..In conclusion, this preliminary data show that changes in CSF tau and Abeta1-42 may indicate different protein processing in PSP patients and might, therefore, be relevant in the differentiation of PSP subtypes...
  45. pmc A Global In Vivo Drosophila RNAi Screen Identifies a Key Role of Ceramide Phosphoethanolamine for Glial Ensheathment of Axons
    Aniket Ghosh
    Max Planck Institute for Experimental Medicine, Gottingen, Germany Department of Neurology, University of Gottingen, Gottingen, Germany
    PLoS Genet 9:e1003980. 2013
    ..Supplementing sphingosine into the diet rescued the neuropathy in flies. Thus, our RNAi study in Drosophila identifies a key role of ceramide phosphoethanolamine in wrapping of axons by glia. ..
  46. ncbi request reprint Relation between regional functional MRI activation and vascular reactivity to carbon dioxide during normal aging
    Axel Riecker
    Department of Neurology, University of Tubingen, Tubingen, Germany
    J Cereb Blood Flow Metab 23:565-73. 2003
    ..In older subjects, cerebral vessels may not react as effectively in response to a vasodilating stimulus, which will lead to differences in the number of voxels that pass a criterion threshold despite similar neuronal activation...
  47. ncbi request reprint New developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applications
    Alexander Storch
    Technical University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
    J Neurol 251:VI/33-8. 2004
    ..Furthermore, we discuss the major problems in the translation of results from preclinical research into successful clinical trials...
  48. pmc RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals
    Sebastian Kowsky
    Department of Neurodegeneration and Restorative Research, Centers of Molecular Physiology of the Brain and Neurological Medicine, University of Goettingen, Waldweg 33, D 37073 Goettingen, Germany
    Proc Natl Acad Sci U S A 104:20049-54. 2007
    ..We therefore conclude that RET signaling has no influence on the survival of dopaminergic neurons in the MPTP model of Parkinson's disease but rather facilitates the regeneration of dopaminergic axon terminals...
  49. doi request reprint Clinical experience with high-dose idebenone in Friedreich ataxia
    Jorg B Schulz
    Department of Neurology, University Medical Centre, RWTH Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    J Neurol 256:42-5. 2009
    ..On the basis of these results, two phase 3 trials have been initiated, one in the United States with young ambulatory patients and one in Europe without limits on age and disease severity...
  50. doi request reprint Clinical significance of post-interventional cerebral hyperdensities after endovascular mechanical thrombectomy in acute ischaemic stroke
    Omid Nikoubashman
    Klinik für Diagnostische und Interventionelle Neuroradiologie, Uniklinik Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Neuroradiology 56:41-50. 2014
    ..This study aims to investigate the clinical significance of post-interventional cerebral hyperdensities (PCHD) after endovascular mechanical thrombectomy in acute ischaemic stroke...
  51. doi request reprint Drosophila melanogaster as a model organism for Alzheimer's disease
    Katja Prüßing
    Department of Neurology, University Medical Center, RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Mol Neurodegener 8:35. 2013
    ..Here, we provide a brief overview of how fly models of AD have contributed to our knowledge of the pathomechanisms of disease. ..
  52. doi request reprint Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: a meta-analysis
    Thomas Nickl-Jockschat
    Department of Psychiatry, Psychotherapy and Psychosomatic, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Brain Struct Funct 217:115-25. 2012
    ..Although different pathologies are underlying MCI, the observed neuroanatomical pattern of structural changes may reflect the common clinical denominator of cognitive impairment...
  53. ncbi request reprint Penguins and hummingbirds: midbrain atrophy in progressive supranuclear palsy
    Klaus Gröschel
    Department of Neurology, University of Jena, Gottingen, Germany
    Neurology 66:949-50. 2006
  54. pmc Feasibility of prehospital teleconsultation in acute stroke--a pilot study in clinical routine
    Sebastian Bergrath
    Department of Anesthesiology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
    PLoS ONE 7:e36796. 2012
    ..Inter-hospital teleconsultation improves stroke care. To transfer this concept into the emergency medical service (EMS), the feasibility and effects of prehospital teleconsultation were investigated...
  55. doi request reprint Mechanisms of neurodegeneration in idiopathic Parkinson's disease
    Jorg B Schulz
    Department of Neurodegeneration and Restorative Research, Center for Neurological Medicine, University Medical Center Gottingen, Germany
    Parkinsonism Relat Disord 13:S306-8. 2007
    ..Cell death mechanisms include excitotoxicity, calcium overload, apoptosis and autophagia. Here, I will briefly review the molecular mechanisms of neurodegeneration in Parkinson's disease and point out potential treatment options...
  56. ncbi request reprint Membrane-permeable Bcl-xL prevents MPTP-induced dopaminergic neuronal loss in the substantia nigra
    Gunnar P H Dietz
    Neurologische Universitatsklinik, Gottingen, Germany
    J Neurochem 104:757-65. 2008
    ....
  57. doi request reprint Update on the pathogenesis of Parkinson's disease
    Jorg B Schulz
    Dept of Neurodegeneration and Restorative Research, Center for Neurological Medicine, University of Gottingen, Gottingen, Germany
    J Neurol 255:3-7. 2008
    ..Finally cell death is executed by excitotoxicity, apoptosis and autophagy and appears to be facilitated by neuroinflammatory processes...
  58. ncbi request reprint Gene dosage-dependent effects of bcl-2 expression on cellular survival and redox status
    Jan Seyfried
    Department of Neurology, University of Bonn, Bonn, Germany
    Free Radic Biol Med 34:1517-30. 2003
    ..Our data suggest that bcl-2 expression is beneficial only in a limited gene dosage range and that high-level expression of bcl-2 exerts potential deleterious effects...
  59. ncbi request reprint FasL (CD95L/APO-1L) resistance of neurons mediated by phosphatidylinositol 3-kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane protein 35
    Christoph P Beier
    Department of Neurology, Medical School, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 25:6765-74. 2005
    ..These results demonstrate that LFG mediated the FasL resistance of CGNs and that, under certain circumstances, e.g., inhibition of the PI 3-kinase-Akt/PKB pathway, CGNs were sensitized to FasL...