Research Topics
| Daniela Schulz-ErtnerSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Detail Information
Publications
Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniquesDaniela Schulz-Ertner
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Cancer 104:338-44. 2005....
Carbon ion radiotherapy of skull base chondrosarcomasDaniela Schulz-Ertner
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 67:171-7. 2007..To evaluate the effectiveness and toxicity of carbon ion radiotherapy in chondrosarcomas of the skull base...
Particle radiation therapy using proton and heavier ion beamsDaniela Schulz-Ertner
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
J Clin Oncol 25:953-64. 2007..Clinical trials investigating proton and carbon ion RT will be summarized and discussed in the context of their relevance to recent concepts of treatment with RT...
Carbon ion radiotherapy for chordomas and low-grade chondrosarcomas of the skull base. Results in 67 patientsDaniela Schulz-Ertner
Department of Clinical Radiology, University of Heidelberg, Germany
Strahlenther Onkol 179:598-605. 2003..To prospectively evaluate outcome and toxicity after carbon ion radiotherapy (RT) in chordomas and low-grade chondrosarcomas...
Temporal lobe reactions after radiotherapy with carbon ions: incidence and estimation of the relative biological effectiveness by the local effect modelIngmar Schlampp
Department of Radiation Oncology, University of Heidelberg, Germany
Int J Radiat Oncol Biol Phys 80:815-23. 2011....
Influence of radiotherapy treatment concept on the outcome of patients with localized ependymomasStephanie E Combs
Neuro Radiation Oncology Research Group, Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 71:972-8. 2008..To assess the outcome of 57 patients with localized ependymomas treated with radiotherapy (RT)...
Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon intensity-modulated radiation therapy (IMRT) and a carbon ion boostDaniela Schulz-Ertner
Department of Radiation Oncology, University of Heidelberg, Germany
Strahlenther Onkol 179:345-51. 2003..This treatment planning study investigates the physical advantage of combined photon intensity-modulated radiation therapy (IMRT) plus carbon ion boost compared to photon IMRT alone...
Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomasDaniela Schulz-Ertner
Department of Radiation Oncology, University of Heidelberg, Heidelberg
Int J Radiat Oncol Biol Phys 68:449-57. 2007..The aim of this study was to evaluate the effectiveness and toxicity of carbon ion radiotherapy in chordomas of the skull base...
Results of carbon ion radiotherapy in 152 patientsDaniela Schulz-Ertner
Department of Clinical Radiology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
Int J Radiat Oncol Biol Phys 58:631-40. 2004..This study summarizes the experience with raster scanned carbon ion radiation therapy (RT) at the Gesellschaft für Schwerionenforschung (GSI), Darmstadt, Germany since 1997...
Feasibility and toxicity of combined photon and carbon ion radiotherapy for locally advanced adenoid cystic carcinomasDaniela Schulz-Ertner
Department of Clinical Radiology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 56:391-8. 2003..To investigate clinical feasibility and toxicity of combined photon and carbon ion radiotherapy in locally advanced adenoid cystic carcinomas (ACC) within a prospective Phase I/II trial...
Radiochemotherapy in patients with primary glioblastoma comparing two temozolomide dose regimensStephanie E Combs
Neuro Radiation Oncology Research Group, Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 71:999-1005. 2008..To evaluate toxicity and outcomes in patients with primary glioblastoma (GB) treated with postoperative radiochemotherapy (RCHT) with temozolomide (TMZ) comparing two dose regimens...
Radiochemotherapy with temozolomide as re-irradiation using high precision fractionated stereotactic radiotherapy (FSRT) in patients with recurrent gliomasStephanie E Combs
Neuro Radiation Oncology Research Group, Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
J Neurooncol 89:205-10. 2008..To evaluate outcome after fractionated stereotactic radiotherapy (FSRT) and concomitant daily temozolomide (TMZ) in patients with recurrent gliomas...
Reirradiation of recurrent WHO grade III astrocytomas using fractionated stereotactic radiotherapy (FSRT)Stephanie E Combs
Department of Radiation Oncology German Cancer Research Center DKFZ, INF 280, Heidelberg, Germany
Strahlenther Onkol 181:768-73. 2005..To assess the effect of reirradiation in recurrent WHO grade III astrocytomas...
Acute toxicity of combined photon IMRT and carbon ion boost for intermediate-risk prostate cancer - acute toxicity of 12C for PCAnna V Nikoghosyan
Department of Radiation Oncology, University of Heidelberg, Germany
Acta Oncol 50:784-90. 2011....
Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull baseStephanie E Combs
Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
Cancer 115:1348-55. 2009..The current study was conducted to evaluate the outcome of carbon ion radiotherapy (RT) in children and young adults with skull base chordomas and chondrosarcomas...
Temozolomide combined with irradiation as postoperative treatment of primary glioblastoma multiforme. Phase I/II studyStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Strahlenther Onkol 181:372-7. 2005..To evaluate the feasibility and toxicity of irradiation and concomitant administration of 50 mg/m(2) temozolomide in patients with primary malignant glioma, this phase I/II study was conducted...
Comparative evaluation of radiochemotherapy with temozolomide versus standard-of-care postoperative radiation alone in patients with WHO grade III astrocytic tumorsStephanie E Combs
University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany
Radiother Oncol 88:177-82. 2008..No significant difference in overall survival or progression-free survival between both groups was calculated. RCHT seems not to result in an improved outcome. Further randomized studies are needed to support these results...
Fractionated stereotactic radiotherapy in patients with benign or atypical intracranial meningioma: long-term experience and prognostic factorsStefanie Milker-Zabel
Department of Clinical Radiology, Radiation Therapy, University of Heidelberg, INF 400, D 69120 Heidelberg, Germany
Int J Radiat Oncol Biol Phys 61:809-16. 2005..To analyze our long-term experience and prognostic factors after fractionated stereotactic radiotherapy (FSRT) in patients with benign or atypical intracranial meningioma...
Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patientsStephanie E Combs
Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 70:987-92. 2008..To evaluate efficacy and toxicity in elderly patients with glioblastoma multiforme (GBM) treated with postoperative radiochemotherapy with temozolomide (TMZ)...
Carbon ion radiation therapy for high-risk meningiomasStephanie E Combs
Department of Radiation Oncology, University Hospital of Heidelberg, 69120 Heidelberg, Germany
Radiother Oncol 95:54-9. 2010..We analyzed outcome after a carbon ion boost in combination with precision photon radiation therapy in patients with meningiomas...
Evaluation of therapeutic potential of heavy ion therapy for patients with locally advanced prostate cancerAnna Nikoghosyan
Division of Radiation Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 58:89-97. 2004..To investigate the feasibility of raster scanned heavy charged particle therapy in the treatment of prostate cancer (PCa,) with special regard to the influence of internal organ motion on the dose distribution...
Fractionated stereotactic radiotherapy in low-grade astrocytomas: long-term outcome and prognostic factorsChristian Plathow
Division of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 57:996-1003. 2003..To evaluate outcome after fractionated stereotactic radiotherapy (RT) of patients with World Health Organization Grade 2 astrocytoma in terms of progression-free survival, overall survival, toxicity, quality of life, and prognostic factors...
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocolStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
BMC Cancer 6:133. 2006..Therefore, addition of EGFR-inhibition with cetuximab to the current standard treatment approach with radiotherapy and TMZ seems promising...
Intensity modulated radiotherapy (IMRT) in patients with carcinomas of the paranasal sinuses: clinical benefit for complex shaped target volumesStephanie E Combs
University of Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
Radiat Oncol 1:23. 2006..The aim of the study was to evaluate the clinical outcome of intensity modulated radiotherapy (IMRT) in 46 patients with paranasal sinus tumors with special respect to treatment-related toxicity...
Efficacy of fractionated stereotactic reirradiation in recurrent gliomas: long-term results in 172 patients treated in a single institutionStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
J Clin Oncol 23:8863-9. 2005..To evaluate the efficacy of fractionated stereotactic radiotherapy (FSRT) performed as reirradiation in 172 patients with recurrent low- and high-grade gliomas...
Radiotherapy for chordomas and low-grade chondrosarcomas of the skull base with carbon ionsDaniela Schulz-Ertner
Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg 69120, Germany
Int J Radiat Oncol Biol Phys 53:36-42. 2002..Compared to photon irradiation, carbon ions provide physical and biologic advantages that may be exploited in chordomas and chondrosarcomas...
Improved correlation of the neuropathologic classification according to adapted world health organization classification and outcome after radiotherapy in patients with atypical and anaplastic meningiomasStephanie E Combs
Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 81:1415-21. 2011..To evaluate the correlation between the 1993 and 2000/2007 World Health Organization (WHO) classification with the outcome in patients with high-grade meningiomas...
Fractionated stereotactic conformal radiotherapy in the management of large chemodectomas of the skull baseAngelika Zabel
Department of Radiotherapy, German Cancer Research Center, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 58:1445-50. 2004..To evaluate the role of fractionated stereotactic conformal radiotherapy (FSRT) as a noninvasive method in the management of large chemodectomas of the skull base...
Fractionated stereotactic radiation therapy in the management of primary oligodendroglioma and oligoastrocytomaStephanie E Combs
Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 62:797-802. 2005....
On the cost-effectiveness of Carbon ion radiation therapy for skull base chordomaOliver Jäkel
Department of Medical Physics in Radiation Oncology, Heidelberg, Germany
Radiother Oncol 83:133-8. 2007..The cost-effectiveness of Carbon ion radiotherapy (RT) for patients with skull base chordoma is analyzed...
Stereotactic radiosurgery (SRS): treatment option for recurrent glioblastoma multiforme (GBM)Stephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Cancer 104:2168-73. 2005..This article describes the results of a study of stereotactic radiosurgery (SRS) in the treatment of patients with recurrent malignant glioma...
Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcomaClaudia Blattmann
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 154, 69120 Heidelberg, Germany
BMC Cancer 10:96. 2010..They achieve a higher relative biological effectiveness. Phase I/II dose escalation studies of HIT in adults with non-resectable bone and soft tissue sarcomas have already shown favorable results...
Treatment of cerebral metastases from breast cancer with stereotactic radiosurgeryStephanie E Combs
Department of Radiation Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
Strahlenther Onkol 180:590-6. 2004..To elucidate the role of SRS in this context, a retrospective study evaluating the benefit of SRS and prognostic factors for survival was performed...
Local high-dose radiotherapy and sparing of normal tissue using intensity-modulated radiotherapy (IMRT) for mucosal melanoma of the nasal cavity and paranasal sinusesStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Strahlenther Onkol 183:63-8. 2007..To evaluate the clinical outcome of intensity-modulated radiotherapy (IMRT) in patients with mucosal melanoma (MM) of the nasal cavity and paranasal sinuses...
Precision radiotherapy for hemangiopericytomas of the central nervous systemStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Cancer 104:2457-65. 2005..The present analysis evaluates the role of precision RT in the management of HAP of the central nervous system (CNS) and represents one of the largest series of HAP treated with RT that can be found in the literature...
Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomasStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
Int J Radiat Oncol Biol Phys 76:193-200. 2010..To evaluate the outcomes of patients with vestibular schwannoma (VS) treated with fractionated stereotactic radiotherapy (FSRT) vs. those treated with stereotactic radiosurgery (SRS)...
Local radiotherapeutic management of ependymomas with fractionated stereotactic radiotherapy (FSRT)Stephanie E Combs
Department of Radiation Oncology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
BMC Cancer 6:222. 2006..To assess the role of Fractionated Stereotactic Radiotherapy (FSRT) in the management of ependymomas...
Carbon ion radiation therapy for chordomas and low grade chondrosarcomas--current status of the clinical trials at GSIDaniela Schulz-Ertner
Dept of Clinical Radiology, University of Heidelberg, Heidelberg, Germany
Radiother Oncol 73:S53-6. 2004....
Management of acoustic neuromas with fractionated stereotactic radiotherapy (FSRT): long-term results in 106 patients treated in a single institutionStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 63:75-81. 2005..To assess the long-term outcome and toxicity of fractionated stereotactic radiotherapy for acoustic neuromas in 106 patients treated in a single institution...
Intensity Modulated Radiotherapy (IMRT) and Fractionated Stereotactic Radiotherapy (FSRT) for children with head-and-neck-rhabdomyosarcomaStephanie E Combs
University of Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
BMC Cancer 7:177. 2007....
In vitro responsiveness of glioma cell lines to multimodality treatment with radiotherapy, temozolomide, and epidermal growth factor receptor inhibition with cetuximabStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 68:873-82. 2007..The majority of glioblastoma multiforme (GBM) cells express the epidermal growth factor receptor (EGFR). The present study evaluates the combination of temozolomide (TMZ), EGFR inhibition, and radiotherapy (RT) in GBM cell lines...
Fractionated stereotactic radiotherapy of optic pathway gliomas: tolerance and long-term outcomeStephanie E Combs
Department of Radiation Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 62:814-9. 2005..To evaluate the effectiveness and toxicity of fractionated stereotactically guided radiotherapy (FSRT) in the management of optic glioma...
Long-term outcome of high-precision radiotherapy in patients with brain stem gliomas: results from a difficult-to-treat patient population using fractionated stereotactic radiotherapyStephanie E Combs
Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
Radiother Oncol 91:60-6. 2009..To assess long-term outcome in 85 patients with brain stem gliomas treated with fractionated stereotactic radiation therapy (FSRT)...
Fractionated stereotactic radiotherapy for craniopharyngiomasDaniela Schulz-Ertner
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 54:1114-20. 2002..To investigate outcome and toxicity after fractionated stereotactic radiation therapy (FSRT) in patients with craniopharyngiomas...
Treatment outcome after linac-based radiosurgery in cerebral arteriovenous malformations: retrospective analysis of factors affecting obliterationAngelika Zabel
Department of Radiotherapy, German Cancer Research Center, Heidelberg, Germany
Radiother Oncol 77:105-10. 2005..We investigated patient outcome and factors affecting obliteration rate after radiosurgery in cerebral arteriovenous malformations (AVM)...
Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003--a single institution's experienceEva Maria Stoiber
Department of Radiation Oncology, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany
Radiat Oncol 5:122. 2010..To evaluate the effectivity of fractionated radiotherapy in adolescent and adult patients with pineal parenchymal tumors (PPT)...
The role of radiation therapy in the management of desmoid tumorsDaniela Schulz-Ertner
Department of Radiation Oncology, University of Heidelberg, Germany
Strahlenther Onkol 178:78-83. 2002..To investigate the role of radiation therapy (RT) in the management of desmoid tumors...
Achievement of long-term local control in patients with craniopharyngiomas using high precision stereotactic radiotherapyStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Cancer 109:2308-14. 2007..The long-term outcome in patients with craniopharyngiomas treated with fractionated stereotactic radiotherapy (FSRT) was evaluated...
Long-term outcome of stereotactic radiosurgery (SRS) in patients with acoustic neuromasStephanie E Combs
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 64:1341-7. 2006..To evaluate the effectiveness and long-term outcome of stereotactic radiosurgery (SRS) for acoustic neuromas (AN)...
A clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcomaFalk Roeder
Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
BMC Cancer 12:287. 2012....
Improved target volume definition for fractionated stereotactic radiotherapy in patients with intracranial meningiomas by correlation of CT, MRI, and [68Ga]-DOTATOC-PETStefanie Milker-Zabel
Department of Radiation Oncology, Radiation Therapy, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 65:222-7. 2006..Because meningiomas show a high expression of somatostatin receptor subtype 2, somatostatin analogs such as DOTATOC offer the possibility of receptor-targeted imaging...
Long-term outcome of postoperative irradiation in patients with newly diagnosed WHO grade III anaplastic gliomasMonika Nagy
Department of Radiation Oncology University Hospital of Heidelberg, Heidelberg, Germany
Tumori 95:317-24. 2009..In most analyses, WHO grade III and 1V tumors are not analyzed separately. The present analysis reports outcome after postoperative radiotherapy in patients with WHO grade III gliomas...
Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell linesStephanie E Combs
Department of Radiation Oncology, University of Heidelberg
Int J Radiat Biol 85:126-37. 2009..To investigate the cytotoxic effect of high linear-energy transfer (LET) carbon irradiation on glioblastoma cells lines in combination with temozolomide (TMZ)...
Radiotherapeutic alternatives for previously irradiated recurrent gliomasStephanie E Combs
University Hospital of Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, German
BMC Cancer 7:167. 2007....
Radiotherapy in the treatment of primary osteosarcoma--a single center experienceSusanne Oertel
Department of Radiooncology, University Clinic Heidelberg, Germany
Tumori 96:582-8. 2010..To analyze our experiences concerning radiation treatment in patients with osteosarcoma...
Radiation therapy with charged particlesDaniela Schulz-Ertner
Department of Radiation Oncology, University of Heidelberg, Germany
Semin Radiat Oncol 16:249-59. 2006....
Acute radiation-induced toxicity of heavy ion radiotherapy delivered with intensity modulated pencil beam scanning in patients with base of skull tumorsDaniela Schulz-Ertner
Department of Clinical Radiology, University of Heidelberg, Heidelberg, Germany
Radiother Oncol 64:189-95. 2002..No unexpected acute dose limiting toxicity was observed. With regard to toxicity, a substantial improvement compared to passive beam shaping technology is achieved...
Follow-up gliomas after radiotherapy: 1H MR spectroscopic imaging for increasing diagnostic accuracyMatthias Philipp Lichy
Department of Radiology, German Cancer Research Center, Heidelberg, Germany
Neuroradiology 47:826-34. 2005..We conclude that 1H SI is helpful in characterising new suspicious lesions in irradiated gliomas, particularly if pre-MRI is not available for evaluating follow-up...
Intensity-modulated radiotherapy of sacral chordoma--a case report and a comparison with stereotactic conformal radiotherapyChristoph Thilmann
Department of Radiotherapy, German Cancer Research Center, Heidelberg
Acta Oncol 41:395-9. 2002..The volume of bowel receiving a dose higher than 40 Gy was reduced from 400 cc with CRT to 220 cc with IMRT. If particle therapy is not available, IMRT seems to be a promising alternative in the treatment of sacral chordomas...
Influence of setup errors on spinal cord dose and treatment plan quality for cervical spine tumours: a phantom study for photon IMRT and heavy charged particle radiotherapyChristian P Karger
Deutsches Krebsforschungszentrum, Abteilung Medizinische Physik Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Phys Med Biol 48:3171-89. 2003..Dose distributions produced with carbon ions, however, are more sensitive to setup errors, which have to be considered during treatment...
Comments to the forum of M. GoiteinChristian P Karger
Z Med Phys 14:200; author reply 201. 2004
