Gerhard Schuler

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi request reprint Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility
    Volker Adams
    University Leipzig Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
    Cardiovasc Res 73:120-9. 2007
  2. ncbi request reprint Expression of cyclooxygenase-II (COX-II) and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD)/prostaglandin F-synthase (PGFS) in bovine placentomes: implications for the initiation of parturition in cattle
    G Schuler
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Faculty of Veterinary Medicine, Justus Liebig University, D 35392 Giessen, Germany
    Placenta 27:1022-9. 2006
  3. ncbi request reprint Reciprocal expression of 17alpha-hydroxylase-C17,20-lyase and aromatase cytochrome P450 during bovine trophoblast differentiation: a two-cell system drives placental oestrogen synthesis
    G Schuler
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus Liebig University, Frankfurter Strasse 106, D 35392 Giessen, Germany
    Reproduction 131:669-79. 2006
  4. ncbi request reprint Immunolocalization of progesterone receptors in bovine placentomes throughout mid and late gestation and at parturition
    G Schuler
    Klinik für Geburtshilfe, Gynäkologie und Andrologie der Grobeta und Kleintiere mit Tierärztlicher Ambulanz, Justus Liebig Universitat, D 35392 Giessen, Germany
    Biol Reprod 61:797-801. 1999
  5. ncbi request reprint Estrogen receptor beta (ERbeta) is expressed differently from ERalpha in bovine placentomes
    G Schuler
    Klinik für Geburtshilfe, Gynäkologie und Andrologie der Gross und Kleintiere mit Tierärztlicher Ambulanz, Justus Liebig Universitat, Giessen, Germany
    Exp Clin Endocrinol Diabetes 113:107-14. 2005
  6. ncbi request reprint Occurrence of estrogen receptor alpha in bovine placentomes throughout mid and late gestation and at parturition
    Gerhard Schuler
    Klinik für Geburtshilfe, Gynäkologie und Andrologie der Gross und Kleintiere mit Tierärztlicher Ambulanz, Justus Liebig Universitat, Frankfurter Strasse 106, D 35392 Giessen, Germany
    Biol Reprod 66:976-82. 2002
  7. doi request reprint Investigations into the mechanisms controlling parturition in cattle
    Sima Shenavai
    Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus Liebig University Giessen, Frankfurter Strasse 106, D 35392 Giessen, Germany
    Reproduction 144:279-92. 2012
  8. ncbi request reprint Expression of oestrogen receptors alpha and beta and of aromatase in the testis of immature and mature boars
    H M Mutembei
    Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, Germany
    Reprod Domest Anim 40:228-36. 2005
  9. doi request reprint Use of the progesterone (P4) receptor antagonist aglepristone to characterize the role of P4 withdrawal for parturition and placental release in cows
    Sima Shenavai
    Faculty of Veterinary Medicine, Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, Germany
    Reproduction 140:623-32. 2010
  10. ncbi request reprint Determination of free and conjugated oestrogens in peripheral blood plasma, feces and urine of cattle throughout pregnancy
    B Hoffmann
    Ambulatorische und Geburtshilfliche Veterinärklinik, Justus Liebig Universitat Giessen, Germany
    Exp Clin Endocrinol Diabetes 105:296-303. 1997

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility
    Volker Adams
    University Leipzig Heart Center Leipzig, Department of Cardiology, Leipzig, Germany
    Cardiovasc Res 73:120-9. 2007
    ..However, it is unknown whether the E3-ubiquitin ligases MAFbx and Murf-1 are involved in this remodeling process and whether their expression is regulated by TNF-alpha...
  2. ncbi request reprint Expression of cyclooxygenase-II (COX-II) and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD)/prostaglandin F-synthase (PGFS) in bovine placentomes: implications for the initiation of parturition in cattle
    G Schuler
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Faculty of Veterinary Medicine, Justus Liebig University, D 35392 Giessen, Germany
    Placenta 27:1022-9. 2006
    ....
  3. ncbi request reprint Reciprocal expression of 17alpha-hydroxylase-C17,20-lyase and aromatase cytochrome P450 during bovine trophoblast differentiation: a two-cell system drives placental oestrogen synthesis
    G Schuler
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus Liebig University, Frankfurter Strasse 106, D 35392 Giessen, Germany
    Reproduction 131:669-79. 2006
    ..P450c17 expression appears to be quickly down-regulated and P450arom is up-regulated when UTCs enter the TGC differentiation pathway...
  4. ncbi request reprint Immunolocalization of progesterone receptors in bovine placentomes throughout mid and late gestation and at parturition
    G Schuler
    Klinik für Geburtshilfe, Gynäkologie und Andrologie der Grobeta und Kleintiere mit Tierärztlicher Ambulanz, Justus Liebig Universitat, D 35392 Giessen, Germany
    Biol Reprod 61:797-801. 1999
    ....
  5. ncbi request reprint Estrogen receptor beta (ERbeta) is expressed differently from ERalpha in bovine placentomes
    G Schuler
    Klinik für Geburtshilfe, Gynäkologie und Andrologie der Gross und Kleintiere mit Tierärztlicher Ambulanz, Justus Liebig Universitat, Giessen, Germany
    Exp Clin Endocrinol Diabetes 113:107-14. 2005
    ....
  6. ncbi request reprint Occurrence of estrogen receptor alpha in bovine placentomes throughout mid and late gestation and at parturition
    Gerhard Schuler
    Klinik für Geburtshilfe, Gynäkologie und Andrologie der Gross und Kleintiere mit Tierärztlicher Ambulanz, Justus Liebig Universitat, Frankfurter Strasse 106, D 35392 Giessen, Germany
    Biol Reprod 66:976-82. 2002
    ..The results suggest a role for placental estrogens as paracrine factors involved in the regulation of placental growth and differentiation...
  7. doi request reprint Investigations into the mechanisms controlling parturition in cattle
    Sima Shenavai
    Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus Liebig University Giessen, Frankfurter Strasse 106, D 35392 Giessen, Germany
    Reproduction 144:279-92. 2012
    ..The results provide new information on the initiation of parturition in cattle but raise many new questions...
  8. ncbi request reprint Expression of oestrogen receptors alpha and beta and of aromatase in the testis of immature and mature boars
    H M Mutembei
    Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, Germany
    Reprod Domest Anim 40:228-36. 2005
    ..P450 aromatase immunoreaction was restricted to the cytoplasm of Leydig cells. These findings suggest that testicular ER may be important factors contributing to onset and maintenance of spermatogenesis in the boar...
  9. doi request reprint Use of the progesterone (P4) receptor antagonist aglepristone to characterize the role of P4 withdrawal for parturition and placental release in cows
    Sima Shenavai
    Faculty of Veterinary Medicine, Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, Germany
    Reproduction 140:623-32. 2010
    ....
  10. ncbi request reprint Determination of free and conjugated oestrogens in peripheral blood plasma, feces and urine of cattle throughout pregnancy
    B Hoffmann
    Ambulatorische und Geburtshilfliche Veterinärklinik, Justus Liebig Universitat Giessen, Germany
    Exp Clin Endocrinol Diabetes 105:296-303. 1997
    ..Main product of placental oestrogen synthesis is scE1, the concentrations of f and c E2 beta and E2 alpha in plasma largely result from oestrogen metabolism and enterohepatic circulation...
  11. ncbi request reprint Characterization of the canine 3beta-hydroxysteroid dehydrogenase and its expression in the corpus luteum during diestrus
    M P Kowalewski
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, D 35392 Giessen, Germany
    J Steroid Biochem Mol Biol 101:254-62. 2006
    ..01) and immunhistochemistry may indicate that the provision of progesterone is controlled by availability of the enzyme rather than the substrate...
  12. ncbi request reprint Tripolar acytokinetic mitosis and formation of feto-maternal syncytia in the bovine placentome: different modes of the generation of multinuclear cells
    K Klisch
    Institute of Veterinary Anatomy, Histology, and Embryology, Justus Leibig University Giessen, Germany
    Anat Embryol (Berl) 200:229-37. 1999
    ..Although trinuclear feto-maternal hybrid cells are the standard outcome of the fusion of binuclear trophoblast giant cells with uterine epithelial cells, some syncytia with at least five nuclei were observed in the uterine epithelium...
  13. ncbi request reprint Receptor blockers - general aspects with respect to their use in domestic animal reproduction
    B Hoffmann
    Klinik für Geburtshilfe, Gynäkologie und Andrologie der Gross und Kleintiere mit Tierärztlicher Ambulanz der Justus Liebig Universität Giessen, Frankfurter Strasse 106, D 35392, Giessen, Germany
    Anim Reprod Sci 60:295-312. 2000
    ..Also, the release of GnRH can be inhibited by respective antagonists; however, their use in reproduction is still hampered by the high dose requirement and the side effects observed...
  14. ncbi request reprint Fibroblast growth factor (FGF)-1, FGF2, FGF7 and FGF receptors are uniformly expressed in trophoblast giant cells during restricted trophoblast invasion in cows
    C Pfarrer
    Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University, D 35392 Giessen, Germany
    Placenta 27:758-70. 2006
    ....
  15. ncbi request reprint Investigations on the activity of bovine placental oestrogen sulfotransferase and -sulfatase from midgestation to parturition
    B Hoffmann
    , , , Giessen, Germany
    Exp Clin Endocrinol Diabetes 109:294-301. 2001
    ..e. activation of conjugated oestrogens) are expressed in close proximity to each other. In this respect the finding of oestrogen receptors in caruncular stromal cells is of particular interest...
  16. ncbi request reprint The bovine placenta; a source and target of steroid hormones: observations during the second half of gestation
    B Hoffmann
    Klinik für Geburtshilfe, Gynäkologie und Andrologie der Gross und Kleintiere mit Tierärztlicher Ambulanz, Justus Liebig Universitat, D 35392 Giessen, Germany
    Domest Anim Endocrinol 23:309-20. 2002
    ..05) paralleled local estrogen tissue concentrations. The results suggest that placental estrogens and P4 are important factors controlling caruncular growth, differentiation and function...
  17. doi request reprint Placental steroids in cattle: hormones, placental growth factors or by-products of trophoblast giant cell differentiation?
    G Schuler
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, Germany
    Exp Clin Endocrinol Diabetes 116:429-36. 2008
    ..Collectively, despite some evidence from recent studies for putative roles of placental steroids in cattle their exact functions in the bovine species remain still undefined...
  18. doi request reprint Expression and activity of steroid sulphatase in the boar testis
    H M Mutembei
    Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus Liebig University Giessen, Giessen, Germany
    Reprod Domest Anim 44:17-23. 2009
    ....
  19. ncbi request reprint Expression of cyclooxygenase 1 and 2 in the canine corpus luteum during diestrus
    Mariusz Pawel Kowalewski
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus Liebig University Giessen, Frankfurter Strasse 106, D 35392 Giessen, Germany
    Theriogenology 66:1423-30. 2006
    ..These data suggested that increased expression of Cox2 is associated with luteal growth and development and not luteal regression. Furthermore, the expression of Cox1 more likely reflected activity of a housekeeping gene...
  20. pmc Uropathogenic E. coli induce different immune response in testicular and peritoneal macrophages: implications for testicular immune privilege
    Sudhanshu Bhushan
    Department of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus Liebig University Giessen, Giessen, Germany
    PLoS ONE 6:e28452. 2011
    ....
  21. doi request reprint Intracoronary compared with intravenous bolus abciximab application in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the randomized Leipzig immediate percutaneous coronary intervention abciximab IV
    Holger Thiele
    Department of Internal Medicine Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Circulation 118:49-57. 2008
    ..Intracoronary abciximab bolus application results in high local drug concentrations and may be more effective than a standard intravenous bolus...
  22. ncbi request reprint A tetraantennary glycan with bisecting N-acetylglucosamine and the Sd(a) antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins
    Karl Klisch
    Abteilung Neuroanatomie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Glycobiology 18:42-52. 2008
    ..The study defines the substantial changes of PAG N-glycosylation in the course of pregnancy. This promotes the hypothesis that PAGs may have different carbohydrate-mediated functions at different stages of pregnancy...
  23. ncbi request reprint Transapical minimally invasive aortic valve implantation: multicenter experience
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 116:I240-5. 2007
    ..To evaluate initial multicenter results with minimally invasive transapical aortic valve implantation (TAP-AVI) for high risk patients with aortic stenosis...
  24. ncbi request reprint ST-segment recovery and prognosis in patients with ST-elevation myocardial infarction reperfused by prehospital combination fibrinolysis, prehospital initiated facilitated percutaneous coronary intervention, or primary percutaneous coronary intervention
    Holger Thiele
    Department of Internal Medicine Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Am J Cardiol 98:1132-9. 2006
    ..In addition, STR has been confirmed to predict prognosis in timely optimized reperfusion strategies...
  25. ncbi request reprint Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial
    Henning Morawietz
    Department of Vascular Endothelium and Microcirculation, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Circulation 114:I296-301. 2006
    ....
  26. ncbi request reprint Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies
    Marcus Sandri
    Heart Center, Department of Internal Medicine Cardiology, University of Leipzig, Leipzig, Germany
    Circulation 111:3391-9. 2005
    ..The aim of the present study was to determine whether ischemic stimuli during ET are required to promote CPC mobilization in patients with cardiovascular diseases...
  27. ncbi request reprint Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia
    Volker Adams
    University Leipzig, Heart Center Leipzig, Germany
    Arterioscler Thromb Vasc Biol 24:684-90. 2004
    ..The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs...
  28. ncbi request reprint Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study
    Volker Adams
    University Leipzig Heart Center Leipzig, Clinic of Cardiology, Germany
    Cardiovasc Res 54:95-104. 2002
    ..In vitro studies, using different cell types, suggest that inflammatory cytokines are potential triggers to induce iNOS expression...
  29. ncbi request reprint Neointima formation after stent implantation in an experimental model of restenosis: polytetrafluoroethylene-covered versus uncovered stainless steel stents
    Peter B Sick
    Heart Center, Department for Internal Medicine Cardiology, University of Leipzig, Germany
    Heart Dis 4:18-25. 2002
    ..In this stent-restenosis model, regional and individual proliferation processes and not the membrane-covering strut-to-strut distances determine lumen restenosis...