Affiliation: University of Giessen
Schuler G, Wirth C, Teichmann U, Failing K, Leiser R, Thole H, et al
. Occurrence of estrogen receptor alpha in bovine placentomes throughout mid and late gestation and at parturition. Biol Reprod. 2002;66:976-82 pubmed
..The results suggest a role for placental estrogens as paracrine factors involved in the regulation of placental growth and differentiation. ..
Schuler G, Ozalp G, Hoffmann B, Harada N, Browne P, Conley A. Reciprocal expression of 17alpha-hydroxylase-C17,20-lyase and aromatase cytochrome P450 during bovine trophoblast differentiation: a two-cell system drives placental oestrogen synthesis. Reproduction. 2006;131:669-79 pubmed
..P450c17 expression appears to be quickly down-regulated and P450arom is up-regulated when UTCs enter the TGC differentiation pathway. ..
Schuler G, Dezhkam Y, Tenbusch L, Klymiuk M, Zimmer B, Hoffmann B. SULFATION PATHWAYS: Formation and hydrolysis of sulfonated estrogens in the porcine testis and epididymis. J Mol Endocrinol. 2018;61:M13-M25 pubmed publisher
..The results suggest that in porcine Leydig cells, SE may be produced as a reservoir to support the levels of bioactive UE via the sulfatase pathway during periods of low activity of the pulsatile testicular steroidogenesis. ..
Zimmer B, Tenbusch L, Klymiuk M, Dezhkam Y, Schuler G. SULFATION PATHWAYS: Expression of SULT2A1, SULT2B1 and HSD3B1 in the porcine testis and epididymis. J Mol Endocrinol. 2018;61:M41-M55 pubmed publisher
..Surprisingly, in addition to a high expression of SRD5A2 in the epididymal head, a substantial expression of HSD3B1 was detected, which increased along the organ. ..
Schuler G, Teichmann U, Taubert A, Failing K, Hoffmann B. Estrogen receptor beta (ERbeta) is expressed differently from ERalpha in bovine placentomes. Exp Clin Endocrinol Diabetes. 2005;113:107-14 pubmed
Schuler G, Teichmann U, Kowalewski M, Hoffmann B, Madore E, Fortier M, et al
. Expression of cyclooxygenase-II (COX-II) and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD)/prostaglandin F-synthase (PGFS) in bovine placentomes: implications for the initiation of parturition in cattle. Placenta. 2006;27:1022-9 pubmed
von Hof J, Sprekeler N, Schuler G, Boos A, Kowalewski M. Uterine and placental expression of HPGD in cows during pregnancy and release of fetal membranes. Prostaglandins Other Lipid Mediat. 2017;128-129:17-26 pubmed publisher
..Placentomes stained primarily in fetal compartments; interplacentomal signals were observed in endometrial glandular and luminal epithelium. Results indicate that HPGD may play a role during establishment and termination of gestation. ..
Schuler G, SÃ¡nchez Guijo A, Hartmann M, Wudy S. Simultaneous profiles of sulfonated androgens, sulfonated estrogens and sulfonated progestogens in postpubertal boars (sus scrofa domestica) measured by LC-MS/MS. J Steroid Biochem Mol Biol. 2018;179:55-63 pubmed publisher
..In postpartal females (n=5) concentrations of all analytes assessed were undetectable, suggesting that in pigs the adrenals are not a quantitatively significant source of s-St. ..
Klymiuk M, Neunzig J, Bernhardt R, SÃ¡nchez Guijo A, Hartmann M, Wudy S, et al
. Efficiency of the sulfate pathway in comparison to the Î”4- and Î”5-pathway of steroidogenesis in the porcine testis. J Steroid Biochem Mol Biol. 2018;179:64-72 pubmed publisher
..In conclusion, a physiologically relevant sulfate pathway for the production of C19-steroids from P5S via CYP17A1 is very unlikely in the porcine testis. ..