C Schule

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. doi request reprint The role of allopregnanolone in depression and anxiety
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany Electronic address
    Prog Neurobiol 113:79-87. 2014
  2. doi request reprint Lithium but not carbamazepine augments antidepressant efficacy of mirtazapine in unipolar depression: an open-label study
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 10:390-9. 2009
  3. ncbi request reprint Mirtazapine inhibits salivary cortisol concentrations in anorexia nervosa
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 30:1015-9. 2006
  4. ncbi request reprint [New insights into the pathogenesis and pathophysiology of depression]
    C Schule
    Klinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat, Nussbaumstrasse 7, 80336, Munchen
    Nervenarzt 78:531-47; quiz 548-9. 2007
  5. ncbi request reprint Effects of combination treatment with mood stabilizers and mirtazapine on plasma concentrations of neuroactive steroids in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 32:669-80. 2007
  6. ncbi request reprint Mirtazapine monotherapy versus combination therapy with mirtazapine and aripiprazole in depressed patients without psychotic features: a 4-week open-label parallel-group study
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 8:112-22. 2007
  7. ncbi request reprint Neuroendocrinological mechanisms of actions of antidepressant drugs
    C Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    J Neuroendocrinol 19:213-26. 2007
  8. ncbi request reprint Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 31:1019-25. 2006
  9. ncbi request reprint The combined T3/TRH test in depressed patients and healthy controls
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Psychoneuroendocrinology 30:341-56. 2005
  10. ncbi request reprint The influence of 4-week treatment with sertraline on the combined T3/TRH test in depressed patients
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:334-40. 2005

Detail Information

Publications66

  1. doi request reprint The role of allopregnanolone in depression and anxiety
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany Electronic address
    Prog Neurobiol 113:79-87. 2014
    ..TSPO ligands such as XBD 173 increase neurosteroidogenesis and have anxiolytic effects with a favorable side effect profile. ..
  2. doi request reprint Lithium but not carbamazepine augments antidepressant efficacy of mirtazapine in unipolar depression: an open-label study
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 10:390-9. 2009
    ..The purpose of the present open-label study was to investigate the antidepressant efficacy of lithium and carbamazepine as augmentation strategies in unipolar depressed inpatients...
  3. ncbi request reprint Mirtazapine inhibits salivary cortisol concentrations in anorexia nervosa
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 30:1015-9. 2006
    ....
  4. ncbi request reprint [New insights into the pathogenesis and pathophysiology of depression]
    C Schule
    Klinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat, Nussbaumstrasse 7, 80336, Munchen
    Nervenarzt 78:531-47; quiz 548-9. 2007
    ..These upcoming pathophysiological concepts have also initiated novel treatment approaches whose clinical utility still has to be demonstrated...
  5. ncbi request reprint Effects of combination treatment with mood stabilizers and mirtazapine on plasma concentrations of neuroactive steroids in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 32:669-80. 2007
    ....
  6. ncbi request reprint Mirtazapine monotherapy versus combination therapy with mirtazapine and aripiprazole in depressed patients without psychotic features: a 4-week open-label parallel-group study
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 8:112-22. 2007
    ....
  7. ncbi request reprint Neuroendocrinological mechanisms of actions of antidepressant drugs
    C Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    J Neuroendocrinol 19:213-26. 2007
    ....
  8. ncbi request reprint Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 31:1019-25. 2006
    ....
  9. ncbi request reprint The combined T3/TRH test in depressed patients and healthy controls
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Psychoneuroendocrinology 30:341-56. 2005
    ....
  10. ncbi request reprint The influence of 4-week treatment with sertraline on the combined T3/TRH test in depressed patients
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:334-40. 2005
    ..07%) and after the 4-week treatment with sertraline (-58.92%). Apparently, the therapeutic efficacy of antidepressants such as sertraline is not related to the regulation of HPT axis activity in depressed patients...
  11. ncbi request reprint Time course of hypothalamic-pituitary-adrenocortical axis activity during treatment with reboxetine and mirtazapine in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, Munich, 80336, Germany
    Psychopharmacology (Berl) 186:601-11. 2006
    ....
  12. doi request reprint Effects of mirtazapine on dehydroepiandrosterone-sulfate and cortisol plasma concentrations in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 43:538-45. 2009
    ..In the present study, the impact of mirtazapine on DHEA-S and cortisol (COR) levels was investigated in relation to clinical response in depressed patients...
  13. doi request reprint Mirtazapine does not influence tetrahydrodeoxycorticosterone levels in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 11:308-13. 2010
    ..In the present study, the impact of mirtazapine on 3alpha,5alpha-THDOC levels was investigated in relation to clinical response in depressed patients...
  14. doi request reprint Hypothalamic-pituitary-adrenocortical system dysregulation and new treatment strategies in depression
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Expert Rev Neurother 9:1005-19. 2009
    ..Thus, it is unclear at present to what extent new, clinically effective antidepressant therapies can be developed based on the corticoid receptor hypothesis of depression...
  15. pmc The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    PLoS ONE 4:e4324. 2009
    ..In this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated...
  16. ncbi request reprint Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006
    ..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
  17. ncbi request reprint Effects of alprazolam on cholecystokinin-tetrapeptide-induced panic and hypothalamic-pituitary-adrenal-axis activity: a placebo-controlled study
    P Zwanzger
    Department of Psychiatry, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Neuropsychopharmacology 28:979-84. 2003
    ..In conclusion, our data show that alprazolam reduces CCK-4-induced panic, which supports the hypothesis of a possible interaction between the GABA and the CCK system...
  18. ncbi request reprint Neuroactive steroids as modulators of depression and anxiety
    D Eser
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuroscience 138:1041-8. 2006
    ..The modulation of GABA type A-receptors by neuroactive steroids might contribute to the pathophysiology of depression and anxiety disorders and might offer new targets for the development of novel anxiolytic compounds...
  19. ncbi request reprint Sleep deprivation and hypothalamic-pituitary-adrenal (HPA) axis activity in depressed patients
    C Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Psychiatr Res 35:239-47. 2001
    ....
  20. doi request reprint Impact of gene-gender effects of adrenergic polymorphisms on hypothalamic-pituitary-adrenal axis activity in depressed patients
    S Haefner
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Neuropsychobiology 58:154-62. 2008
    ..We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression...
  21. ncbi request reprint The combined dexamethasone-CRH test before and after repetitive transcranial magnetic stimulation (rTMS) in major depression
    P Zwanzger
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, Germany
    Psychoneuroendocrinology 28:376-85. 2003
    ..Here, we investigated whether repetitive transcranial magnetic stimulation (rTMS) also leads to a normalization of HPA system activity in depressed patients...
  22. doi request reprint Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany
    Mol Psychiatry 13:1093-101. 2008
    ..Patients with depression show reduced GM volumes, particularly when they are homozygous for the L(A)-allele, suggesting that these patients are more vulnerable for morphological changes during depressive episodes...
  23. ncbi request reprint Attenuation of HPA axis hyperactivity and simultaneous clinical deterioration in a depressed patient treated with mirtazapine
    C Schule
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 2:103-5. 2001
    ..However, this amelioration of HPA system dysregulation is not necessarily accompanied by clinical improvement...
  24. ncbi request reprint Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression
    C Minov
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 303:119-22. 2001
    ..However, subtypes might be identified at least on a basis of differential treatment response...
  25. ncbi request reprint Neuroactive steroids and affective disorders
    D Eser
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Pharmacol Biochem Behav 84:656-66. 2006
    ..In conclusion, neuroactive steroids are important endogenous modulators of depression and anxiety and may provide a basis for development of novel therapeutic agents in the treatment of affective disorders...
  26. ncbi request reprint Endocrinological effects of high-dose Hypericum perforatum extract WS 5570 in healthy subjects
    C Schule
    Department of Psychiatry, University of Munich, Munich, Germany
    Neuropsychobiology 49:58-63. 2004
    ..Apparently, WS 5570 at the dosages given in this study inconsistently causes endocrinological effects in healthy subjects by influencing central neurotransmitters...
  27. ncbi request reprint Combined action of the ACE D- and the G-protein beta3 T-allele in major depression: a possible link to cardiovascular disease?
    B Bondy
    Psychiatric Department of University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Mol Psychiatry 7:1120-6. 2002
    ..Nevertheless our study reports for the first time that the same allelic combination of two genes that have been shown to increase the risk for myocardial infarction (Naber et al, 2000) increase the vulnerability for depressive disorder...
  28. ncbi request reprint SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Munich D 80336, Germany
    Mol Psychiatry 9:1030-6. 2004
    ..These results may open up new research strategies for the analysis of the observed disturbances in the serotonergic system in patients suffering from several other psychiatric disorders...
  29. ncbi request reprint Influence of mirtazapine on salivary cortisol in depressed patients
    G Laakmann
    Department of Psychiatry, University of Munich, Munich, Germany
    Neuropsychobiology 47:31-6. 2003
    ..However, the importance of the acute inhibitory effects of mirtazapine on cortisol secretion for its antidepressant efficacy has to be further clarified...
  30. ncbi request reprint Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects
    G Laakmann
    Psychiatrische Klinik, Ludwig Maximilians Universitat, Munchen, Germany
    Psychoneuroendocrinology 24:769-84. 1999
    ..86 micrograms/100 ml x 240 min). Further studies have to elucidate the question whether the demonstrated inhibition of COR secretion after application of 15 mg mirtazapine is caused by central or peripheral effects of this substance...
  31. ncbi request reprint Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 61:177-83. 2004
    ..Several studies have found reciprocal interactions between the serotonergic system and both brain-derived neurotrophic factor and glutamate, which are known to modulate or affect hippocampal morphologic characteristics...
  32. ncbi request reprint Neuroendocrine effects of Hypericum extract WS 5570 in 12 healthy male volunteers
    C Schule
    Department of Psychiatry, University of Munich, Germany
    Pharmacopsychiatry 34:S127-33. 2001
    ..300 mg of WS 5570 did not show any effects on COR secretion. We propose that the Hypericum extract WS 5570 is able to influence central neurotransmitters, thereby causing COR stimulation in a dose-dependent manner...
  33. ncbi request reprint Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity
    C Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Mol Psychiatry 11:261-72. 2006
    ..However, the changes in neuroactive steroid concentrations more likely reflect direct pharmacological effects of this antidepressant rather than clinical improvement in general...
  34. ncbi request reprint C-type natriuretic peptide exerts stimulatory effects on the corticotropin-releasing hormone-induced secretion of hormones in normal man
    M Kellner
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Endocrinol 136:388-93. 1997
    ..Our data suggest stimulatory effects of C-type natriuretic peptide on corticotropin-releasing hormone-induced hormone release and offer further evidence for a complex role of different natriuretic peptides in endocrine regulation...
  35. doi request reprint [Core symptoms of depression. Effectiveness of antidepressant therapy]
    J Damm
    Klinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat, Nussbaumstrasse 7, 80336, Munchen
    Nervenarzt 80:515-6, 518, 520 passim. 2009
    ..Because the positive diagnosis of the core symptoms of depression may include clinical consequences, it would be useful to integrate all these concepts into the upcoming new versions of the diagnostic systems DSM-V and ICD-11...
  36. doi request reprint Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs?
    C Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Neuroscience 191:55-77. 2011
    ..This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain...
  37. ncbi request reprint Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide
    B Bondy
    Psychiatric Clinic, University of Munich, Munich, Germany
    Am J Med Genet 96:831-5. 2000
    ..Thus, our results suggest that this polymorphism may not commonly be involved in the susceptibility to suicidality. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:831-835, 2000...
  38. ncbi request reprint Independent component analysis applied to pharmacological magnetic resonance imaging (phMRI): new insights into the functional networks underlying panic attacks as induced by CCK-4
    A C Dieler
    Ludwig Maximilians Universitat, Department of Psychiatry and Psychotherapy, Munich, Germany
    Curr Pharm Des 14:3492-507. 2008
    ..In conclusion, group ICA is a promising tool for phMRI studies that allows quantifying and visualizing the modulation of neural networks by pharmacological interventions...
  39. ncbi request reprint Treatment of mitral valve prolapse and panic disorder with metoprolol
    P Zwanzger
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 1:124-5. 2000
    ..This case report suggests that betablockers might represent a useful tool in the treatment of panic disorder and mitral valve prolapse...
  40. ncbi request reprint Plasma gamma-amino-butyric acid (GABA) levels in cholecystokinine-tetrapeptide (CCK-4) induced anxiety
    P Zwanzger
    Department of Psychiatry, University of Munich, Munich, Germany
    J Neural Transm 110:313-6. 2003
    ..To evaluate a possible relationship between plasma GABA and CCK-4 induced panic plasma GABA levels in healthy volunteers were investigated...
  41. ncbi request reprint [Hypericum perforatum extract in treatment of mild to moderate depression. Clinical and pharmacological aspects]
    G Laakmann
    Psychiatrische Klinik der Universität München, Nussbaumstrasse 7, 80336 Munchen
    Nervenarzt 73:600-12. 2002
    ..However, interactions in combination treatments are possible by interference with the cytochrom P450 system, thereby changing plasma levels of other medications...
  42. ncbi request reprint The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 126:82-7. 2004
    ....
  43. ncbi request reprint Neuroactive steroids as endogenous modulators of anxiety
    Daniela Eser
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Curr Pharm Des 14:3525-33. 2008
    ..In conclusion, neuroactive steroids are important endogenous modulators of depression and anxiety and may provide a basis for development of novel therapeutic agents in the treatment of affective disorders...
  44. ncbi request reprint Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine
    Cornelius Schule
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Psychopharmacology (Berl) 166:271-5. 2003
    ..Mirtazapine acts as an antagonist at presynaptic alpha(2)-receptors and at postsynaptic 5-hydroxytryptamine (5-HT)(2), 5-HT(3) and histamine H(1) receptors. It has been shown acutely to inhibit cortisol secretion in healthy subjects...
  45. ncbi request reprint The angiotensin I converting enzyme insertion/deletion polymorphism influences therapeutic outcome in major depressed women, but not in men
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 363:38-42. 2004
    ..Our investigation gives the first hint that the speed of onset of antidepressant therapies may be dependent on both variants of the ACE genes and the gender of the patients...
  46. doi request reprint The influence of anaesthetic medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 11:447-56. 2010
    ..Furthermore, most anaesthetics have anticonvulsant properties and therefore might additionally influence the efficacy of ECT...
  47. doi request reprint Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects
    Rainer Rupprecht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany
    Science 325:490-3. 2009
    ..Thus, translocator protein (18 kD) ligands are promising candidates for fast-acting anxiolytic drugs with less severe side effects than benzodiazepines...
  48. ncbi request reprint Hypothalamic-pituitary-adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 328:299-303. 2002
    ..The HPA axis stimulating properties of higher ACE and consecutively higher AT-II and/or lower substance P concentrations may be crucial factors for the HPA system hyperactivity during major depressive episodes...
  49. ncbi request reprint Saccadic eye velocity after selective GABAergic treatment with tiagabine in healthy volunteers
    Peter Zwanzger
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
    Neuropsychobiology 52:147-50. 2005
    ..Tiagabine is a new antiepileptic drug which acts via selective blockade of GABA reuptake. Therefore, we examined the effects of tiagabine on saccade parameters...
  50. doi request reprint Influence of age on effectiveness and tolerability of electroconvulsive therapy
    Julia Damm
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    J ECT 26:282-8. 2010
    ..Nevertheless, age-specific adverse effects such as greater cognitive impairment and higher somatic risks due to medical comorbidities and concomitant medication may be limiting factors in geriatric patients...
  51. ncbi request reprint The influence of concomitant antidepressant medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 7:82-90. 2006
    ..Also, a concomitant pharmacotherapy can be utilized to augment therapeutic effectiveness. Surprisingly, data in this field are widely lacking and only few studies showed advantages of an ECT/tricyclic antidepressant combination...
  52. ncbi request reprint Genetic variants in the angiotensin I-converting-enzyme (ACE) and angiotensin II receptor (AT1) gene and clinical outcome in depression
    Brigitta Bondy
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1094-9. 2005
    ..Our data might further suggest that patients with a haplotype combining the CC and DD/ID genotypes respond better to treatment than those with either single allele. These results should however be replicated in future research...
  53. ncbi request reprint Mirtazapine acutely inhibits salivary cortisol concentrations in depressed patients
    Gregor Laakmann
    Department of Psychiatry, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Ann N Y Acad Sci 1032:279-82. 2004
    ..However, the importance of the acute inhibitory effects of mirtazapine on cortisol secretion for its antidepressant efficacy has to be further clarified...
  54. ncbi request reprint Influence of a functional polymorphism within the angiotensin I-converting enzyme gene on partial sleep deprivation in patients with major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 339:223-6. 2003
    ..This should result in earlier and more intense additional therapeutic interventions in this group of patients...
  55. ncbi request reprint Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychopharmacology (Berl) 192:479-87. 2007
    ..However, assessment of CCK-4-induced panic does not follow consistent rules...
  56. ncbi request reprint Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
    ..Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression...
  57. ncbi request reprint Effects of tiagabine on cholecystokinin-tetrapeptide (CCK-4)-induced anxiety in healthy volunteers
    Peter Zwanzger
    Department of Psychiatry, University of Munich, Munich, Germany
    Depress Anxiety 18:140-3. 2003
    ..Our results suggest anxiolytic properties of tiagabine in humans, which provide sufficient rationale to assess its putative anxiolytic effects in patients with panic disorder under controlled conditions...
  58. ncbi request reprint Influence of mirtazapine on urinary free cortisol excretion in depressed patients
    Cornelius Schule
    Department of Psychiatry, University of Munich, Nussbaumstr 7, Munich 80336, Germany
    Psychiatry Res 120:257-64. 2003
    ..Apparently, the mirtazapine-induced rapid reduction of cortisol secretion in depressed patients is not necessarily correlated with a favorable therapeutic response...
  59. ncbi request reprint No Influence of a functional polymorphism within the serotonin transporter gene on partial sleep deprivation in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 4:111-4. 2003
    ..Thus, the previously reported influence of the serotonin transporter gene on PSD outcome in bipolar depression could not be confirmed in unipolar depressed patients...
  60. ncbi request reprint Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Hum Brain Mapp 30:511-22. 2009
    ..In conclusion, while overall brain activation patterns are not related to the subjective anxiety response to CCK-4, amygdala activation may be involved in the subjective perception of CCK-4-induced fear...
  61. doi request reprint Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1003-7. 2008
    ....
  62. doi request reprint Impact of state and trait anxiety on the panic response to CCK-4
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    J Neural Transm 115:917-20. 2008
    ..In conclusion, psychological factors are not major determinants for the subjective panic response to CCK-4 thus emphasising the importance of neurobiological factors...
  63. ncbi request reprint Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 120:85-9. 2003
    ..05). However, after correction for multiple testing (Bonferroni) these results did not remain significant. Nevertheless, these findings suggest that the presence of the C allele might be an indicator for antidepressant treatment response...
  64. ncbi request reprint The dysbindin gene in major depression: an association study
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 129:55-8. 2004
    ..Further analysis are needed to confirm these results...
  65. doi request reprint Impact of loudness dependency of auditory evoked potentials on the panic response to CCK-4
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 43:393-400. 2009
    ..The analysis of the loudness dependency of the auditory evoked potentials (LDAEP) is a valid non-invasive indicator of central serotonergic activity...
  66. doi request reprint Translocator protein (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile
    C Nothdurfter
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    J Neuroendocrinol 24:82-92. 2012
    ..In this review, we focus on the pathophysiology of anxiety disorders and TSPO ligands as a novel pharmacological approach in the treatment of these disorders...