Jan W Schrickel

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi Induction of atrial fibrillation in mice by rapid transesophageal atrial pacing
    Jan Wilko Schrickel
    Department of Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Basic Res Cardiol 97:452-60. 2002
  2. ncbi Cardiomyocyte-specific deletion of survivin causes global cardiac conduction defects
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Germany
    Basic Res Cardiol 107:299. 2012
  3. ncbi Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart
    Elke Winterhager
    Institut fur Anatomie, Universitat Duisburg Essen, 45122 Essen, Germany
    BMC Dev Biol 7:26. 2007
  4. ncbi Cardiac conduction disturbances and differential effects on atrial and ventricular electrophysiological properties in desmin deficient mice
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Interv Card Electrophysiol 28:71-80. 2010
  5. ncbi Incidence and predictors of silent cerebral embolism during pulmonary vein catheter ablation for atrial fibrillation
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    Europace 12:52-7. 2010
  6. ncbi Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Interv Card Electrophysiol 26:3-10. 2009
  7. ncbi Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice
    Jan W Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Mol Cell Cardiol 46:644-52. 2009
  8. ncbi Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice
    Jan W Schrickel
    Department of Medicine Cardiology, University of Bonn, Germany
    Cardiovasc Res 76:257-68. 2007
  9. ncbi Amiodarone-associated "torsade de pointes". Relevance of concomitant cardiovascular medication in a patient with atrial fibrillation and structural heart disease
    J Schrickel
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Z Kardiol 92:889-92. 2003
  10. ncbi Pro-arrhythmic effects of amiodarone and concomitant rate-control medication
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
    Europace 8:403-7. 2006

Collaborators

Detail Information

Publications25

  1. ncbi Induction of atrial fibrillation in mice by rapid transesophageal atrial pacing
    Jan Wilko Schrickel
    Department of Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Basic Res Cardiol 97:452-60. 2002
    ..We therefore evaluated a transesophageal rapid atrial stimulation protocol for the induction of AF in C57Bl/6 mice...
  2. ncbi Cardiomyocyte-specific deletion of survivin causes global cardiac conduction defects
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Germany
    Basic Res Cardiol 107:299. 2012
    ..Lack of susceptibility to AF and VT suggests that reduced cardiomyocyte number and increased size constitute determinants of electrical stableness in the heart and counteract potentially proarrhythmogenic connexin43 loss in Surv(-/-)...
  3. ncbi Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart
    Elke Winterhager
    Institut fur Anatomie, Universitat Duisburg Essen, 45122 Essen, Germany
    BMC Dev Biol 7:26. 2007
    ..In order to further distinguish unique from general functions of connexin43, we have generated mice in which the coding region of connexin43 was replaced by that of connexin26...
  4. ncbi Cardiac conduction disturbances and differential effects on atrial and ventricular electrophysiological properties in desmin deficient mice
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Interv Card Electrophysiol 28:71-80. 2010
    ..The aim of the present study was to characterize electrophysiological cardiac properties in a desmin-deficient mouse model...
  5. ncbi Incidence and predictors of silent cerebral embolism during pulmonary vein catheter ablation for atrial fibrillation
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    Europace 12:52-7. 2010
    ..We aimed to investigate the incidence and predictors of silent cerebral embolism associated with PV catheter ablation, detected by diffusion-weighted magnetic resonance imaging (DW-MRI)...
  6. ncbi Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Interv Card Electrophysiol 26:3-10. 2009
    ..Gelsolin (gsn) is involved in the reorganization of the cytoskeleton, thereby modulating cardiomyocytal L-type Ca(2+) channels. We investigated global cardiac electrophysiological characteristics in a gsn-deficient (gsn(-/-)) mouse strain...
  7. ncbi Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice
    Jan W Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Mol Cell Cardiol 46:644-52. 2009
    ..We suggest that Cx30.2 and Cx40 act as counterparts in the AV-node and His-bundle, decreasing or increasing, respectively, electrical coupling and conduction velocity in these areas...
  8. ncbi Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice
    Jan W Schrickel
    Department of Medicine Cardiology, University of Bonn, Germany
    Cardiovasc Res 76:257-68. 2007
    ..We investigated the impact of annexin A7 on cardiac electrophysiological properties using an annexin A7-deficient mouse strain (annexin A7(-/-))...
  9. ncbi Amiodarone-associated "torsade de pointes". Relevance of concomitant cardiovascular medication in a patient with atrial fibrillation and structural heart disease
    J Schrickel
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Z Kardiol 92:889-92. 2003
    ..This points towards an elevated risk for proarrhythmia under this triple therapy...
  10. ncbi Pro-arrhythmic effects of amiodarone and concomitant rate-control medication
    Jan Wilko Schrickel
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
    Europace 8:403-7. 2006
    ..Although pro-arrhythmic effects of amiodarone therapy are rare, the aim of the present study was to identify clinical constellations which may lead to amiodarone-associated pro-arrhythmia...
  11. ncbi "Torsade de pointes" in patients with structural heart disease and atrial fibrillation treated with amiodarone, beta-blockers, and digitalis
    Jan W Schrickel
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Pacing Clin Electrophysiol 29:363-6. 2006
    ..The present case reports imply that amiodarone in combination with beta-blocker/digitalis therapy may be associated with an elevated proarrhythmic risk in selected patients with structural heart disease and AF...
  12. ncbi In vitro comparison of platinum-iridium and gold tip electrodes: lesion depth in 4 mm, 8 mm, and irrigated-tip radiofrequency ablation catheters
    Markus Linhart
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Europace 11:565-70. 2009
    ..We compared a newly developed irrigated gold tip electrode ablation catheter and a gold tip 4 and 8 mm catheter with the corresponding platinum-iridium (Pt) tip catheters in an in vitro setting...
  13. ncbi Comparison of cryoballoon and radiofrequency ablation of pulmonary veins in 40 patients with paroxysmal atrial fibrillation: a case-control study
    Markus Linhart
    Medizinische Klinik und Poliklinik II, University of Bonn, Bonn, Germany
    J Cardiovasc Electrophysiol 20:1343-8. 2009
    ..Radiofrequency (RF) is currently the most widespread energy source for PV ablation. Cryothermal energy applied with a cryoballoon technique as an alternative has recently evolved...
  14. ncbi The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans
    Radoslaw Dobrowolski
    Institute of Genetics, University of Bonn, Germany
    Hum Mol Genet 17:539-54. 2008
    ..Our results suggest that the increased activity of ATP-releasing channels in Cx43G138R mutated cardiomyocytes may further reduce the already decreased gap junctional communication and thus aggravate arrhythmogenesis in the mouse mutant...
  15. ncbi Connexin45 provides optimal atrioventricular nodal conduction in the adult mouse heart
    Marina Frank
    LIMES Institute, Molecular Genetics, University of Bonn, Bonn, Germany
    Circ Res 111:1528-38. 2012
    ..The function of Cx45 in the adult mouse has not yet been cleared...
  16. ncbi Left atrial deformation imaging with ultrasound based two-dimensional speckle-tracking predicts the rate of recurrence of paroxysmal and persistent atrial fibrillation after successful ablation procedures
    Christoph Hammerstingl
    Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany
    J Cardiovasc Electrophysiol 23:247-55. 2012
    ....
  17. ncbi Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs
    Julia Otten
    Department of Molecular Cell Biology, Institute for Cell Biology, University of Bonn, Ulrich Haberland Str 61a, Bonn D 53121, Germany
    Cardiovasc Res 85:739-50. 2010
    ..To further investigate the function of Xin variants in the mammalian heart, we generated XinABC(-/-) mice deficient in all Xin isoforms...
  18. ncbi Prevalence of asymptomatic upper extremity venous obstruction in 302 patients undergoing first implantation of cardioverter defibrillator
    Markus Linhart
    Medizinische Klinik und Poliklinik II, University of Bonn, Bonn, Germany
    Pacing Clin Electrophysiol 34:684-9. 2011
    ..It remains unclear in which patients contrast venography is warranted before implantation procedure...
  19. ncbi Gold-tip electrodes--a new "deep lesion" technology for catheter ablation? In vitro comparison of a gold alloy versus platinum-iridium tip electrode ablation catheter
    Thorsten Lewalter
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    J Cardiovasc Electrophysiol 16:770-2. 2005
    ....
  20. ncbi Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia
    Wilhelm Roell
    Institute of Physiology I, Life and Brain Center, University of Bonn, Bonn 53105, Germany
    Nature 450:819-24. 2007
    ..Thus, engraftment of Cx43-expressing myocytes has the potential to reduce life-threatening post-infarct arrhythmias through the augmentation of intercellular coupling, suggesting autologous strategies for cardiac cell-based therapy...
  21. ncbi Influence of the point of origin on heart rate turbulence after stimulated ventricular and atrial premature beats
    Jörg O Schwab
    Basic Res Cardiol 99:56-60. 2004
    ..Therefore, we conducted a study consisting of 25 patients (pts) with premature beats generating from 2 different sites in the atrium and ventricle...
  22. ncbi Automatic p wave analysis over 24 hours in patients with paroxysmal or persistent atrial fibrillation
    Alexander Bitzen
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Ann Noninvasive Electrocardiol 12:306-15. 2007
    ..We examined a novel method for automatic P wave analysis in the 24-hour-Holter-ECG of 60 patients with paroxysmal or persistent AF and 12 healthy subjects...
  23. ncbi Atrioesophageal fistula after cryoballoon pulmonary vein isolation
    Florian Stöckigt
    Department of Medicine Cardiology, University Hospital of Bonn, Bonn, Germany
    J Cardiovasc Electrophysiol 23:1254-7. 2012
    ..We suggest that even when using cryothermal ablation technique, an imaging modality to assess the proximity of esophagus and left atrium should be routinely performed to avoid this fatal complication...
  24. ncbi Left phrenic nerve injury during cryoballoon ablation of the left superior pulmonary vein
    René P Andrié
    Department of Cardiology, University of Bonn, Bonn, Germany
    Pacing Clin Electrophysiol 35:e334-6. 2012
    ..This case report describes a left-sided PNI after cryoballoon ablation of the left superior PV...
  25. ncbi Role of high frequency atrial pacing for the termination of acute atrial fibrillation and atypical atrial flutter
    Nikolay Shlevkov
    Russian Cardiology Research Center, Moscow, Russia
    Pacing Clin Electrophysiol 30:322-32. 2007
    ....