Christoph Schramm

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Overlap syndromes of cholestatic liver diseases and auto-immune hepatitis
    Christoph Schramm
    Medizinische Klinik I, Universitätsulinikum Hamburg Eppendorf, Hamburg, Germany
    Clin Rev Allergy Immunol 28:105-14. 2005
  2. doi request reprint Characteristics and long-term prognosis of the autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome
    Stefan Lüth
    Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Clin Gastroenterol 43:75-80. 2009
  3. doi request reprint Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
    Antonella Carambia
    Department of Medicine I, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:112-8. 2013
  4. doi request reprint Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells
    Samuel Huber
    Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Immunol 182:4633-40. 2009
  5. ncbi request reprint Reduced FOXP3(+) regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms
    Marcial Sebode
    I Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 60:1010-6. 2014
  6. ncbi request reprint Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis
    Stefan Lüth
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Gastroenterol 42:926-30. 2008
  7. ncbi request reprint Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity
    Katrin Presser
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Immunol 181:7751-8. 2008
  8. ncbi request reprint Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis
    Christina Weiler-Normann
    I Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:529-34. 2013
  9. doi request reprint FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency
    Moritz Peiseler
    Department of Medicine I, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 57:125-32. 2012
  10. pmc Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs
    Stefan Lüth
    Department of Medicine I, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Invest 118:3403-10. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Overlap syndromes of cholestatic liver diseases and auto-immune hepatitis
    Christoph Schramm
    Medizinische Klinik I, Universitätsulinikum Hamburg Eppendorf, Hamburg, Germany
    Clin Rev Allergy Immunol 28:105-14. 2005
    ..This article focuses on the prevalence, diagnosis, and treatment of the overlap syndrome of AIH and PBC or PSC...
  2. doi request reprint Characteristics and long-term prognosis of the autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome
    Stefan Lüth
    Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Clin Gastroenterol 43:75-80. 2009
    ..Our aim was to assess the clinical characteristics and long-term prognosis of the AIH/PSC overlap syndrome...
  3. doi request reprint Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
    Antonella Carambia
    Department of Medicine I, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:112-8. 2013
    ..Here we investigated the role of liver sinusoidal endothelial cells (LSECs) in regulating the activity of inflammatory CD4 T cells...
  4. doi request reprint Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells
    Samuel Huber
    Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Immunol 182:4633-40. 2009
    ..Therefore, besides promoting inflammation, activin A may contribute to the regulation of inflammation via the expansion of peripheral Treg...
  5. ncbi request reprint Reduced FOXP3(+) regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms
    Marcial Sebode
    I Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 60:1010-6. 2014
    ..The aim of this study was to investigate Treg in patients with PSC and to associate their numbers with relevant gene polymorphisms...
  6. ncbi request reprint Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis
    Stefan Lüth
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Gastroenterol 42:926-30. 2008
    ..It is frequent clinical practice to follow disease by assessment of serologic markers. Here, we assessed the diagnostic fidelity of this clinical practice...
  7. ncbi request reprint Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity
    Katrin Presser
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Immunol 181:7751-8. 2008
    ..In conclusion, modulation of cytokine expression by Treg may have therapeutic potential for the treatment of AHR in asthma. The mechanisms of the effects of Treg on airway inflammation require further clarification...
  8. ncbi request reprint Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis
    Christina Weiler-Normann
    I Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 58:529-34. 2013
    ..We sought to analyze the safety and efficacy of off-label treatment with infliximab in a cohort of eleven patients with difficult-to-treat autoimmune hepatitis...
  9. doi request reprint FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency
    Moritz Peiseler
    Department of Medicine I, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Hepatol 57:125-32. 2012
    ..However, the role of Treg in AIH is not clear, since earlier studies reporting Treg impairment had used only CD25 as marker that cannot unambiguously distinguish Treg from activated effector T cells...
  10. pmc Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs
    Stefan Lüth
    Department of Medicine I, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Invest 118:3403-10. 2008
    ..Our findings indicate that autoantigen expression in the liver may generate autoantigen-specific Tregs. Thus, targeting of autoantigens to hepatocytes may be a novel approach to prevention or treatment of autoimmune diseases...
  11. doi request reprint Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis
    Janosch Katt
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Hepatology 58:1084-93. 2013
    ..These data should prompt further studies investigating the link between pathogen responses, inflammation, and fibrosis in patients with PSC...
  12. doi request reprint Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice
    Roja Barikbin
    Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Hepatology 55:553-62. 2012
    ..Moreover, hepatocellular proliferation and signs of dysplasia were decreased after HO-1 induction...
  13. ncbi request reprint Mycophenolate mofetil as second line therapy in autoimmune hepatitis?
    Elke M Hennes
    First Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Am J Gastroenterol 103:3063-70. 2008
    ..The aim of this study was to examine the possible role of mycophenolate mofetil (MMF) as second line treatment of autoimmune hepatitis (AIH)...
  14. pmc P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg
    Samuel Huber
    I Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 3:e3302. 2008
    ..Our findings indicate that signaling via p38 MAP kinase seems to be important for the peripheral generation of iTreg; p38 MAP kinase could thus be a therapeutic target to enhance immunity to chronic viral infection or cancer...
  15. doi request reprint Primary liver transplantation for autoimmune hepatitis: a comparative analysis of the European Liver Transplant Registry
    Christoph Schramm
    Department of Medicine I, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Liver Transpl 16:461-9. 2010
    ..It should be noted that not all risk factors relevant to patient and graft survival could be analyzed with the European Liver Transplant Registry database...
  16. ncbi request reprint Evaluation of F-actin ELISA for the diagnosis of autoimmune hepatitis
    Christian Frenzel
    The I Department of Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Am J Gastroenterol 101:2731-6. 2006
    ..We compared the diagnostic value of a new F-actin enzyme-linked immunosorbent assay (ELISA) with the current gold standard of detection of smooth muscle antibodies by indirect immunofluorescence (SMA-IFT)...
  17. doi request reprint Unmasking autoimmune hepatitis under immunomodulatory treatment of multiple sclerosis--not only beta interferon
    Vera von Kalckreuth
    Am J Gastroenterol 103:2147-8; author reply 2148. 2008
  18. doi request reprint Simplified criteria for the diagnosis of autoimmune hepatitis
    Elke M Hennes
    Department of Medicine, University Medical Centre Hamburg Eppendorf, Germany
    Hepatology 48:169-76. 2008
    ..Based on the ROC curves, two cutoff points were chosen. The score was found to have 88% sensitivity and 97% specificity (cutoff > or =6) and 81% sensitivity and 99% specificity (cutoff > or =7) in the validation set...
  19. ncbi request reprint Pregnancy in autoimmune hepatitis: outcome and risk factors
    Christoph Schramm
    Department of Medicine I, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Am J Gastroenterol 101:556-60. 2006
    ..Autoimmune hepatitis (AIH) may influence pregnancy outcome and pregnancy may affect AIH. We aimed at analyzing the disease course in pregnant AIH patients and at identifying disease-related risk factors for adverse pregnancy outcome...
  20. ncbi request reprint Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice
    Christoph Schramm
    First Department of Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
    Am J Physiol Gastrointest Liver Physiol 284:G525-35. 2003
    ..This suggests an important role for TGF-beta in immune homeostasis in the liver and may teleologically explain TGF-beta upregulation in response to T cell-mediated liver injury...