Gunnar Schotta

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callen E, et al. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev. 2008;22:2048-61 pubmed publisher
    ..Thus, conversion to an H4K20me1 state results in compromised chromatin that is insufficient to protect genome integrity and to process a DNA-rearranging differentiation program in the mouse. ..
  2. Sadic D, Schmidt K, Groh S, Kondofersky I, Ellwart J, Fuchs C, et al. Atrx promotes heterochromatin formation at retrotransposons. EMBO Rep. 2015;16:836-50 pubmed publisher
    ..In summary, we demonstrate a direct role of Atrx in the establishment and robust maintenance of heterochromatin. ..
  3. Pasquarella A, Ebert A, Pereira de Almeida G, Hinterberger M, Kazerani M, Nuber A, et al. Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells. Development. 2016;143:1788-99 pubmed publisher
    ..Production of MLV proteins leads to activation of the unfolded protein response pathway and apoptosis. Thus, our data demonstrate that B cell development depends on the proper repression of retrotransposon sequences through Setdb1. ..
  4. Groh S, Schotta G. Silencing of endogenous retroviruses by heterochromatin. Cell Mol Life Sci. 2017;74:2055-2065 pubmed publisher
    ..In this review, we discuss the major pathways leading to efficient establishment of robust and inaccessible heterochromatin across ERVs. ..