Affiliation: University of Munich
Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callen E, et al
. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev. 2008;22:2048-61 pubmed publisher
..Thus, conversion to an H4K20me1 state results in compromised chromatin that is insufficient to protect genome integrity and to process a DNA-rearranging differentiation program in the mouse. ..
Sadic D, Schmidt K, Groh S, Kondofersky I, Ellwart J, Fuchs C, et al
. Atrx promotes heterochromatin formation atÂ retrotransposons. EMBO Rep. 2015;16:836-50 pubmed publisher
..In summary, we demonstrate a direct role of Atrx in the establishment and robust maintenance of heterochromatin. ..
Pasquarella A, Ebert A, Pereira de Almeida G, Hinterberger M, Kazerani M, Nuber A, et al
. Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells. Development. 2016;143:1788-99 pubmed publisher
..Production of MLV proteins leads to activation of the unfolded protein response pathway and apoptosis. Thus, our data demonstrate that B cell development depends on the proper repression of retrotransposon sequences through Setdb1. ..
Groh S, Schotta G. Silencing of endogenous retroviruses by heterochromatin. Cell Mol Life Sci. 2017;74:2055-2065 pubmed publisher
..In this review, we discuss the major pathways leading to efficient establishment of robust and inaccessible heterochromatin across ERVs. ..