Research Topics
Genomes and Genes | Susanne SchochSummaryAffiliation: University of Bonn Country: Germany Publications
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Publications
Molecular organization of the presynaptic active zoneSusanne Schoch
Emmy Noether Research Group, Institute of Neuropathology and Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Cell Tissue Res 326:379-91. 2006..These multidomain proteins are instrumental for the diverse functions performed by the presynaptic active zone...
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter releaseSusanne Schoch
Emmy Noether Research Group, Institute of Neuropathology, Department of Epileptology, University Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
EMBO J 25:5852-63. 2006..Our data thus demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis...- Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST)Karen M J Van Loo
Department of Neuropathology, University of Bonn Medical Center, D 53105 Bonn, Germany
J Biol Chem 287:15489-501. 2012..This mechanism has critical implications for the regulation of neuronal and cardiac Ca(2+) homeostasis under physiological conditions and in episodic disorders such as arrhythmias and epilepsy... 
Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsyAlbert J Becker
Departments of Neuropathology, University of Bonn Medical Center, University of Bonn, Bonn, Germany
J Neurosci 28:13341-53. 2008..In addition, the appearance of spontaneous seizures was dramatically reduced in these mice. Together, these data establish transcriptional induction of Ca(v)3.2 as a critical step in epileptogenesis and neuronal vulnerability...- The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticusJulika Pitsch
Department of Neuropathology, University of Bonn, 53105 Bonn, Germany
J Neurosci 32:12384-95. 2012..In summary, our results suggest that presynaptic plasticity and proper function of RIM1α play an important part in a neuron's adaptive response to aberrant electrical activity... - Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitisPitt Niehusmann
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Epilepsia 51:2478-83. 2010..Our data argue against HHV-6 as a major local pathogenetic factor in MTS hippocampi after CFS. The high detection rate of HHV-6 DNA suggests a potential pathogenetic role of HHV-6 in TLE patients with a history of encephalitis... - RIM3γ and RIM4γ are key regulators of neuronal arborizationElena Alvaréz-Baron
Department of Neuropathology, Department of Epileptology, Laboratory for Experimental Epileptology and Cognition Research, University of Bonn, 53105 Bonn, Germany
J Neurosci 33:824-39. 2013.... - RIM proteins and their role in synapse functionTobias Mittelstaedt
Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
Biol Chem 391:599-606. 2010..Here, we summarize recent findings about the specific roles of the various RIM isoforms in basic synaptic vesicle release as well as long- and short-term presynaptic plasticity... - Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampiKatharina Pernhorst
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
J Neuropathol Exp Neurol 70:1080-8. 2011..This might contribute to the episodic onset of symptoms and point to new targets for pharmacotherapies... - Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brainTobias Mittelsteadt
Institute of Neuropathology, University of Bonn, 53105 Bonn, Germany
J Comp Neurol 512:514-28. 2009..This study therefore supports the hypothesis that the functional properties of individual neurons and astrocytes are conferred by the specific subset of synaptotagmins expressed in a cell... - Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitroCéline Lugnier
Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, Bonn, Germany
J Neuropathol Exp Neurol 68:1136-46. 2009..Future studies will be needed to characterize the roles of these TSC1 sequence variants in the genesis of dysplastic epileptogenic developmental brain lesions... - Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursorsJana Fassunke
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Brain 131:3034-50. 2008..The present data characterize novel molecular mechanisms operating in gangliogliomas that contribute to the development of dysplastic neurons and an aberrant neuronal network... - Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticusTimo Kirschstein
Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
J Neurosci 27:7696-704. 2007..Thus, we conclude that the reduction of mGluR LTD after pilocarpine-induced status epilepticus is the result of the subtype-specific downregulation of mGluR5 and associated downstream signaling components... - Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitisElena Alvaréz-Baron
Department of Neuropathology, University Bonn Medical School, Sigmund Freud Str 25, 53105 Bonn, Germany
Epilepsy Res 80:93-7. 2008.... - Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissueMichael Majores
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Epilepsia 48:4-12. 2007..Here, we will discuss experimental approaches to unravel molecular-neuropathological aspects of TLE and highlight characteristics and potential of molecular studies in human and/or experimental TLE... - Structure and evolution of RIM-BP genes: identification of a novel family memberTobias Mittelstaedt
Department of Neuropathology and Epileptology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Gene 403:70-9. 2007..The modular domain structure of RIM-BPs, their expression pattern and the conservative expansion during evolution shown here support their potential role as important molecular adaptors... - Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiationYan You Huang
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York, NY 10032, USA
Proc Natl Acad Sci U S A 102:9365-70. 2005..Thus Rab3A and its effectors are general modules for four distinct types of PKA-dependent LTP in the brain... - Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter releaseNicole Calakos
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
Neuron 42:889-96. 2004..These results suggest that RIM1alpha modulates sequential steps in synaptic vesicle exocytosis through serial protein-protein interactions and that this modulation is the basis for RIM1alpha's role in synaptic plasticity... - The presynaptic active zone protein RIM1alpha is critical for normal learning and memoryCraig M Powell
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neuron 42:143-53. 2004.... - Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapsesGYORGY LONART
Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 115:49-60. 2003..Our findings suggest that PKA-mediated phosphorylation of the active zone protein RIM1alpha at a single N-terminal site induces presynaptic LTP... - RIM1alpha is required for presynaptic long-term potentiationPablo E Castillo
Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304, USA
Nature 415:327-30. 2002.... - RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zoneSusanne Schoch
The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
Nature 415:321-6. 2002..These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release... - Deletion of CASK in mice is lethal and impairs synaptic functionDeniz Atasoy
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Proc Natl Acad Sci U S A 104:2525-30. 2007.... - Synaptobrevin is essential for fast synaptic-vesicle endocytosisFerenc Deak
Center for Basic Neuroscience, Howard Hughes Medical Institute, USA
Nat Cell Biol 6:1102-8. 2004..Thus, synaptobrevin is essential for two fast synapse-specific membrane trafficking reactions: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid reuse of synaptic vesicles...