Susanne Schoch

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Molecular organization of the presynaptic active zone
    Susanne Schoch
    Emmy Noether Research Group, Institute of Neuropathology and Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Cell Tissue Res 326:379-91. 2006
  2. pmc Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release
    Susanne Schoch
    Emmy Noether Research Group, Institute of Neuropathology, Department of Epileptology, University Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    EMBO J 25:5852-63. 2006
  3. doi request reprint Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue
    Katharina Pernhorst
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, Bonn 53105, Germany
    Brain Res 1499:136-44. 2013
  4. doi request reprint RIM3γ and RIM4γ are key regulators of neuronal arborization
    Elena Alvaréz-Baron
    Department of Neuropathology, Department of Epileptology, Laboratory for Experimental Epileptology and Cognition Research, University of Bonn, 53105 Bonn, Germany
    J Neurosci 33:824-39. 2013
  5. pmc Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST)
    Karen M J Van Loo
    Department of Neuropathology, University of Bonn Medical Center, D 53105 Bonn, Germany
    J Biol Chem 287:15489-501. 2012
  6. doi request reprint Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy
    Albert J Becker
    Departments of Neuropathology, University of Bonn Medical Center, University of Bonn, Bonn, Germany
    J Neurosci 28:13341-53. 2008
  7. doi request reprint The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus
    Julika Pitsch
    Department of Neuropathology, University of Bonn, 53105 Bonn, Germany
    J Neurosci 32:12384-95. 2012
  8. doi request reprint Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis
    Pitt Niehusmann
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 51:2478-83. 2010
  9. doi request reprint RIM proteins and their role in synapse function
    Tobias Mittelstaedt
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    Biol Chem 391:599-606. 2010
  10. doi request reprint Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi
    Katharina Pernhorst
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    J Neuropathol Exp Neurol 70:1080-8. 2011

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Molecular organization of the presynaptic active zone
    Susanne Schoch
    Emmy Noether Research Group, Institute of Neuropathology and Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Cell Tissue Res 326:379-91. 2006
    ..These multidomain proteins are instrumental for the diverse functions performed by the presynaptic active zone...
  2. pmc Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release
    Susanne Schoch
    Emmy Noether Research Group, Institute of Neuropathology, Department of Epileptology, University Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    EMBO J 25:5852-63. 2006
    ..Our data thus demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis...
  3. doi request reprint Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue
    Katharina Pernhorst
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, Bonn 53105, Germany
    Brain Res 1499:136-44. 2013
    ..These data may point to a novel, i.e., rs6295 allelic variant and c-Jun dependent transcriptional 5HT1AR 'receptoropathy'...
  4. doi request reprint RIM3γ and RIM4γ are key regulators of neuronal arborization
    Elena Alvaréz-Baron
    Department of Neuropathology, Department of Epileptology, Laboratory for Experimental Epileptology and Cognition Research, University of Bonn, 53105 Bonn, Germany
    J Neurosci 33:824-39. 2013
    ....
  5. pmc Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST)
    Karen M J Van Loo
    Department of Neuropathology, University of Bonn Medical Center, D 53105 Bonn, Germany
    J Biol Chem 287:15489-501. 2012
    ..This mechanism has critical implications for the regulation of neuronal and cardiac Ca(2+) homeostasis under physiological conditions and in episodic disorders such as arrhythmias and epilepsy...
  6. doi request reprint Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy
    Albert J Becker
    Departments of Neuropathology, University of Bonn Medical Center, University of Bonn, Bonn, Germany
    J Neurosci 28:13341-53. 2008
    ..In addition, the appearance of spontaneous seizures was dramatically reduced in these mice. Together, these data establish transcriptional induction of Ca(v)3.2 as a critical step in epileptogenesis and neuronal vulnerability...
  7. doi request reprint The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus
    Julika Pitsch
    Department of Neuropathology, University of Bonn, 53105 Bonn, Germany
    J Neurosci 32:12384-95. 2012
    ..In summary, our results suggest that presynaptic plasticity and proper function of RIM1α play an important part in a neuron's adaptive response to aberrant electrical activity...
  8. doi request reprint Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis
    Pitt Niehusmann
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 51:2478-83. 2010
    ..Our data argue against HHV-6 as a major local pathogenetic factor in MTS hippocampi after CFS. The high detection rate of HHV-6 DNA suggests a potential pathogenetic role of HHV-6 in TLE patients with a history of encephalitis...
  9. doi request reprint RIM proteins and their role in synapse function
    Tobias Mittelstaedt
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    Biol Chem 391:599-606. 2010
    ..Here, we summarize recent findings about the specific roles of the various RIM isoforms in basic synaptic vesicle release as well as long- and short-term presynaptic plasticity...
  10. doi request reprint Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi
    Katharina Pernhorst
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    J Neuropathol Exp Neurol 70:1080-8. 2011
    ..This might contribute to the episodic onset of symptoms and point to new targets for pharmacotherapies...
  11. doi request reprint Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain
    Tobias Mittelsteadt
    Institute of Neuropathology, University of Bonn, 53105 Bonn, Germany
    J Comp Neurol 512:514-28. 2009
    ..This study therefore supports the hypothesis that the functional properties of individual neurons and astrocytes are conferred by the specific subset of synaptotagmins expressed in a cell...
  12. doi request reprint Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitro
    Céline Lugnier
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, Bonn, Germany
    J Neuropathol Exp Neurol 68:1136-46. 2009
    ..Future studies will be needed to characterize the roles of these TSC1 sequence variants in the genesis of dysplastic epileptogenic developmental brain lesions...
  13. doi request reprint Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors
    Jana Fassunke
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Brain 131:3034-50. 2008
    ..The present data characterize novel molecular mechanisms operating in gangliogliomas that contribute to the development of dysplastic neurons and an aberrant neuronal network...
  14. doi request reprint Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 54:36-44. 2013
    ..Recent behavioral research indicates that personality traits may predispose to these side effects. To assess the genetic basis of the adverse psychotropic profile of LEV, a candidate gene-based two-stage association study was conducted...
  15. doi request reprint Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis
    Elena Alvaréz-Baron
    Department of Neuropathology, University Bonn Medical School, Sigmund Freud Str 25, 53105 Bonn, Germany
    Epilepsy Res 80:93-7. 2008
    ....
  16. ncbi request reprint Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus
    Timo Kirschstein
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    J Neurosci 27:7696-704. 2007
    ..Thus, we conclude that the reduction of mGluR LTD after pilocarpine-induced status epilepticus is the result of the subtype-specific downregulation of mGluR5 and associated downstream signaling components...
  17. ncbi request reprint Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue
    Michael Majores
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Epilepsia 48:4-12. 2007
    ..Here, we will discuss experimental approaches to unravel molecular-neuropathological aspects of TLE and highlight characteristics and potential of molecular studies in human and/or experimental TLE...
  18. ncbi request reprint RIM1alpha is required for presynaptic long-term potentiation
    Pablo E Castillo
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304, USA
    Nature 415:327-30. 2002
    ....
  19. ncbi request reprint Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses
    GYORGY LONART
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 115:49-60. 2003
    ..Our findings suggest that PKA-mediated phosphorylation of the active zone protein RIM1alpha at a single N-terminal site induces presynaptic LTP...
  20. ncbi request reprint The presynaptic active zone protein RIM1alpha is critical for normal learning and memory
    Craig M Powell
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 42:143-53. 2004
    ....
  21. ncbi request reprint Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release
    Nicole Calakos
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 42:889-96. 2004
    ..These results suggest that RIM1alpha modulates sequential steps in synaptic vesicle exocytosis through serial protein-protein interactions and that this modulation is the basis for RIM1alpha's role in synaptic plasticity...
  22. ncbi request reprint RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone
    Susanne Schoch
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Nature 415:321-6. 2002
    ..These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release...
  23. pmc Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation
    Yan You Huang
    Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:9365-70. 2005
    ..Thus Rab3A and its effectors are general modules for four distinct types of PKA-dependent LTP in the brain...
  24. ncbi request reprint Structure and evolution of RIM-BP genes: identification of a novel family member
    Tobias Mittelstaedt
    Department of Neuropathology and Epileptology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Gene 403:70-9. 2007
    ..The modular domain structure of RIM-BPs, their expression pattern and the conservative expansion during evolution shown here support their potential role as important molecular adaptors...
  25. pmc Deletion of CASK in mice is lethal and impairs synaptic function
    Deniz Atasoy
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 104:2525-30. 2007
    ....
  26. ncbi request reprint Synaptobrevin is essential for fast synaptic-vesicle endocytosis
    Ferenc Deak
    Center for Basic Neuroscience, Howard Hughes Medical Institute, USA
    Nat Cell Biol 6:1102-8. 2004
    ..Thus, synaptobrevin is essential for two fast synapse-specific membrane trafficking reactions: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid reuse of synaptic vesicles...