Peter Schnuelle

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Open randomized trial comparing early withdrawal of either cyclosporine or mycophenolate mofetil in stable renal transplant recipients initially treated with a triple drug regimen
    Peter Schnuelle
    University Hospital Mannheim, Ruperto Carola, Heidelberg, Germany
    J Am Soc Nephrol 13:536-43. 2002
  2. doi request reprint Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial
    Peter Schnuelle
    University Medical Centre Mannheim, 5th Department of Medicine, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    JAMA 302:1067-75. 2009
  3. ncbi request reprint Impact of donor dopamine on immediate graft function after kidney transplantation
    P Schnuelle
    Vth Medical Clinic Department of Nephrology and Endocrinology, University Hospital Mannheim, Mannheim, Germany
    Am J Transplant 4:419-26. 2004
  4. ncbi request reprint Perioperative fluid management in renal transplantation: a narrative review of the literature
    Peter Schnuelle
    Medical Clinic V, Medical Faculty of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Transpl Int 19:947-59. 2006
  5. ncbi request reprint Comparison of early renal function parameters for the prediction of 5-year graft survival after kidney transplantation
    Peter Schnuelle
    University Hospital Mannheim, Vth Medical Clinic, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Nephrol Dial Transplant 22:235-45. 2007
  6. doi request reprint Donor dopamine treatment in brain dead rats is associated with an improvement in renal function early after transplantation and a reduction in renal inflammation
    Simone Hoeger
    Department of Medicine V, Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Transpl Int 21:1072-80. 2008
  7. ncbi request reprint Atorvastatin donor pre-treatment in a model of brain death and allogeneic kidney transplantation in rat
    Simone Hoeger
    5th Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Ann Transplant 17:79-85. 2012
  8. doi request reprint Donor desmopressin is associated with superior graft survival after kidney transplantation
    Urs Benck
    5th Department of Medicine, University Medical Centre Mannheim, Mannheim, Germany
    Transplantation 92:1252-8. 2011
  9. ncbi request reprint Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in rats
    Uwe Gottmann
    Fifth Department of Medicine, Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Transplantation 79:1344-50. 2005
  10. doi request reprint UW is superior compared with HTK after prolonged preservation of renal grafts
    Simone Hoeger
    Department of Medicine V Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Surg Res 170:e149-57. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Open randomized trial comparing early withdrawal of either cyclosporine or mycophenolate mofetil in stable renal transplant recipients initially treated with a triple drug regimen
    Peter Schnuelle
    University Hospital Mannheim, Ruperto Carola, Heidelberg, Germany
    J Am Soc Nephrol 13:536-43. 2002
    ....
  2. doi request reprint Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial
    Peter Schnuelle
    University Medical Centre Mannheim, 5th Department of Medicine, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    JAMA 302:1067-75. 2009
    ..Kidney graft function after transplantation can be improved through pharmacological donor pretreatment to limit organ injury from cold preservation...
  3. ncbi request reprint Impact of donor dopamine on immediate graft function after kidney transplantation
    P Schnuelle
    Vth Medical Clinic Department of Nephrology and Endocrinology, University Hospital Mannheim, Mannheim, Germany
    Am J Transplant 4:419-26. 2004
    ..The beneficial effect of dopamine is achievable without side-effects for the recipients, and correlates with superior long-term graft survival...
  4. ncbi request reprint Perioperative fluid management in renal transplantation: a narrative review of the literature
    Peter Schnuelle
    Medical Clinic V, Medical Faculty of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Transpl Int 19:947-59. 2006
    ..This review article should provide better guidance for fluid management in kidney transplantation until best-evidence guidelines can be established based upon more research...
  5. ncbi request reprint Comparison of early renal function parameters for the prediction of 5-year graft survival after kidney transplantation
    Peter Schnuelle
    University Hospital Mannheim, Vth Medical Clinic, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Nephrol Dial Transplant 22:235-45. 2007
    ..Early graft function (EGF) has an enduring effect on the subsequent course after kidney transplantation. This study compares quantitative parameters of EGF for the prediction of graft survival...
  6. doi request reprint Donor dopamine treatment in brain dead rats is associated with an improvement in renal function early after transplantation and a reduction in renal inflammation
    Simone Hoeger
    Department of Medicine V, Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Transpl Int 21:1072-80. 2008
    ..No difference for macrophage chemoattractant protein 1 and IL-10 were found. These findings may explain the salutary effect of donor dopamine treatment in renal transplantation...
  7. ncbi request reprint Atorvastatin donor pre-treatment in a model of brain death and allogeneic kidney transplantation in rat
    Simone Hoeger
    5th Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Ann Transplant 17:79-85. 2012
    ..The aim of the present study was to evaluate the effect of donor pre-treatment with atorvastatin in a model of brain death followed by prolonged cold preservation and allogeneic kidney transplantation in rats...
  8. doi request reprint Donor desmopressin is associated with superior graft survival after kidney transplantation
    Urs Benck
    5th Department of Medicine, University Medical Centre Mannheim, Mannheim, Germany
    Transplantation 92:1252-8. 2011
    ..gov Identifier: NCT00115115). This study determines whether donor exposure to desmopressin (1-deamino-8-d-arginine-vasopressin [DDAVP]) before organ retrieval affects renal transplant outcome...
  9. ncbi request reprint Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in rats
    Uwe Gottmann
    Fifth Department of Medicine, Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Transplantation 79:1344-50. 2005
    ..In the present study, the authors investigated the influence of dopamine donor pretreatment before prolonged cold storage on short- and long-term graft outcome after allogeneic kidney transplantation...
  10. doi request reprint UW is superior compared with HTK after prolonged preservation of renal grafts
    Simone Hoeger
    Department of Medicine V Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Surg Res 170:e149-57. 2011
    ..In recent clinical studies, the efficacy of histidine-tryptophan-ketoglutarate (HTK) in kidney transplantation was questioned. This study compares the efficacy of University of Wisconsin (UW) and HTK solutions on transplantation outcome...
  11. ncbi request reprint Donor dopamine pretreatment inhibits tubulitis in renal allografts subjected to prolonged cold preservation
    Zhenzi Liu
    Fifth Medical Clinic, Klinikum Mannheim, University of Heidelberg, Heidelberg, Germany
    Transplantation 83:297-303. 2007
    ..In the present study, we used the Brown-Norway (BN) to Lewis model as a model for acute rejection, to test the hypothesis that dopamine (DA) treatment of BN donors significantly reduces the inflammatory response after renal transplantation...
  12. doi request reprint The additional detrimental effects of cold preservation on transplantation-associated injury in kidneys from living and brain-dead donor rats
    Simone Hoeger
    Department of Medicine V Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Transplantation 87:52-8. 2009
    ..The present study was conducted to assess the influence of these factors on transplantation-associated injury independently or in combination...
  13. ncbi request reprint Atorvastatin donor pretreatment prevents ischemia/reperfusion injury in renal transplantation in rats: possible role for aldose-reductase inhibition
    Uwe Gottmann
    Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Transplantation 84:755-62. 2007
    ..The aim of the present study was to evaluate the effect of donor pretreatment with atorvastatin on ischemia/reperfusion (I/R) injury in renal transplantation in rats...
  14. ncbi request reprint Effect of dopamine on inflammatory status in kidneys of brain-dead rats
    Meike Schaub
    Fifth Medical Clinic, University Hospital Mannheim, Mannheim, Germany
    Transplantation 77:1333-40. 2004
    ..To elucidate the mechanisms underlying the protective effect of dopamine on kidneys of brain-dead donors, we studied a model for brain death in rats...
  15. pmc N-octanoyl dopamine, a non-hemodyanic dopamine derivative, for cell protection during hypothermic organ preservation
    Ralf M Losel
    Department of Clinical Pharmacology, University Medical Centre Mannheim, Mannheim, Germany
    PLoS ONE 5:e9713. 2010
    ..We hypothesized that variation of the molecular structure would yield more efficacious compounds avoid of any hemodynamic effects...
  16. doi request reprint Dopamine and lipophilic derivates protect cardiomyocytes against cold preservation injury
    Christiane Vettel
    Institute of Experimental and Clinical Pharmacology and Toxicology C V, T W, Fifth Medical Clinic M C H, R S, U B, P S, B K K, S H, B A Y, and Department of Anesthesiology C T, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany and Institute of Pharmacology, University Medical Center Gottingen, Heart Center, Georg August University Medical School Göttingen, Gottingen, Germany C V, A E A
    J Pharmacol Exp Ther 348:77-85. 2014
    ..The beneficial effects are independent of β-adrenoceptor or dopaminergic receptor stimulation but correlate with redox potential and lipophilic properties. ..
  17. ncbi request reprint Influence of hypersulfated and low molecular weight heparins on ischemia/reperfusion: injury and allograft rejection in rat kidneys
    Uwe Gottmann
    V Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Transpl Int 20:542-9. 2007
    ..Chemically modified heparins without anticoagulatory effects may offer a new treatment option in preventing I/R injury and CAN in human kidney transplantation...
  18. doi request reprint Hypothermic injury: the mitochondrial calcium, ATP and ROS love-hate triangle out of balance
    Paul Thomas Brinkkoetter
    Vth Medical Department, University Hospital of Mannheim, University of Heidelberg, Mannheim, Germany
    Cell Physiol Biochem 22:195-204. 2008
    ..Here, we identified cellular processes which govern hypothermia-mediated cell death in endothelial cells and how they are influenced by dopamine...
  19. doi request reprint Effects of N-acetylcysteine on renal hemodynamics in contrast media-induced nephropathy
    Stefan Krzossok
    Fifth Medical Department, Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Kidney Blood Press Res 34:125-34. 2011
    ..Conclusions: Renal perfusion is not affected by NAC application in a model of experimental contrast nephropathy in rats. Other effects of NAC might thus account for the presumed renoprotective properties...
  20. doi request reprint CORMs protect endothelial cells during cold preservation, resulting in inhibition of intimal hyperplasia after aorta transplantation in rats
    Hui Song
    Vth Medical Clinic, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Transpl Int 23:1144-53. 2010
    ..Hence, our findings might offer a novel strategy to prevent vascular damage during CP...
  21. doi request reprint Effects of donor pre-treatment with dopamine on survival after heart transplantation: a cohort study of heart transplant recipients nested in a randomized controlled multicenter trial
    Urs Benck
    University Medical Centre Mannheim, Mannheim, Germany
    J Am Coll Cardiol 58:1768-77. 2011
    ..We determined the outcome of cardiac allografts from multiorgan donors enrolled in a randomized trial of donor pre-treatment with dopamine...
  22. ncbi request reprint Preconditioning strategies to limit graft immunogenicity and cold ischemic organ injury
    Fokko J van der Woude
    Vth Medical University Clinic Nephrology, Endocrinology, Rheumatology, Klinikum Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim, Germany
    J Investig Med 52:323-9. 2004
    ..It is important to underscore that donor pretreatment will have great advantages for the recipient because an improved long-term graft survival could thus be achieved cost-efficiently and without great effort or side effects...
  23. doi request reprint Vagal stimulation in brain dead donor rats decreases chronic allograft nephropathy in recipients
    Simone Hoeger
    Department of Medicine V Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Nephrol Dial Transplant 29:544-9. 2014
    ..In the present study, we assessed the influence of donor vagus nerve stimulation on survival, renal function and histology in a chronic allograft model...
  24. ncbi request reprint Hypothermia-induced loss of endothelial barrier function is restored after dopamine pretreatment: role of p42/p44 activation
    Paul Thomas Brinkkoetter
    Department of Medicine Nephrology, University Hospital Mannheim, University of Heidelberg, Germany
    Transplantation 82:534-42. 2006
    ..Although prolonged cold preservation results in an increased vascular permeability, the present study was conducted to examine in vitro and in vivo if dopamine pretreatment influences endothelial barrier function under such conditions...
  25. pmc N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates ischemia-induced [corrected] acute kidney injury in rat
    Charalambos Tsagogiorgas
    Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    PLoS ONE 7:e43525. 2012
    ..Although NOD mitigates deterioration in renal function after AKI, further studies are required to assess to what extend this is causally related to TRPV1 activation and/or desensitization...
  26. doi request reprint ANCA-associated vasculitis following influenza vaccination: causal association or mere coincidence?
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Germany
    J Clin Rheumatol 15:289-91. 2009
    ..Although our report does not prove a causal association between vaccination and vasculitis, it seems possible that in rare cases vaccination might induce vasculitic disease...
  27. ncbi request reprint Total parathyroidectomy without autotransplantation as a standard procedure in the treatment of secondary hyperparathyroidism
    Stefan Ockert
    Department of Surgery, University Hospital of Mannheim, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Langenbecks Arch Surg 387:204-9. 2002
    ..However, a considerable recurrence rate following these procedures ranges from 5% to 80%. We present a retrospective analysis of the results of parathyroidectomy with autotransplantation to the forearm versus parathyroidectomy alone...
  28. ncbi request reprint Dopamine treatment in brain-dead rats mediates anti-inflammatory effects: the role of hemodynamic stabilization and D-receptor stimulation
    Simone Hoeger
    Department of Medicine V, University Medical Center Mannheim, University of Heidelberg, Germany, and Départment de Médecine, Interne et Néphrologie, Centre Hospitalier Kirchberg, Luxembourg
    Transpl Int 20:790-9. 2007
    ..Hence, DA might reduce BD-induced monocyte infiltration possibly by hemodynamic stabilization, D-receptor activation, or a combination of both...
  29. ncbi request reprint Prevention of cold-preservation injury of cultured endothelial cells by catecholamines and related compounds
    Benito Yard
    V Medizinische Universitätsklinik, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Am J Transplant 4:22-30. 2004
    ..In conclusion we have demonstrated that catecholamines protect cells against preservation injury either by scavenging of ROS or by inhibition of ROS production...
  30. ncbi request reprint Fluorescence-guided minimally invasive parathyroidectomy: a novel surgical therapy for secondary hyperparathyroidism
    Ruediger L Prosst
    Department of Surgery and Fifth Medical Clinic Nephrology, Endocrinology, University Hospital Mannheim, Ruprecht Karls University, Heidelberg, Germany
    Am J Kidney Dis 48:327-31. 2006
    ..The technique serves as an additional tool requiring only moderate technical and clinical expenditure...