Research Topics
| Peter SchnuelleSummaryAffiliation: University of Heidelberg Country: Germany Publications
| Collaborators
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Detail Information
Publications
Open randomized trial comparing early withdrawal of either cyclosporine or mycophenolate mofetil in stable renal transplant recipients initially treated with a triple drug regimenPeter Schnuelle
University Hospital Mannheim, Ruperto Carola, Heidelberg, Germany
J Am Soc Nephrol 13:536-43. 2002....- Impact of donor dopamine on immediate graft function after kidney transplantationP Schnuelle
Vth Medical Clinic Department of Nephrology and Endocrinology, University Hospital Mannheim, Mannheim, Germany
Am J Transplant 4:419-26. 2004..The beneficial effect of dopamine is achievable without side-effects for the recipients, and correlates with superior long-term graft survival... - Perioperative fluid management in renal transplantation: a narrative review of the literaturePeter Schnuelle
Medical Clinic V, Medical Faculty of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
Transpl Int 19:947-59. 2006..This review article should provide better guidance for fluid management in kidney transplantation until best-evidence guidelines can be established based upon more research... 
Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trialPeter Schnuelle
University Medical Centre Mannheim, 5th Department of Medicine, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
JAMA 302:1067-75. 2009..Kidney graft function after transplantation can be improved through pharmacological donor pretreatment to limit organ injury from cold preservation...- Comparison of early renal function parameters for the prediction of 5-year graft survival after kidney transplantationPeter Schnuelle
University Hospital Mannheim, Vth Medical Clinic, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
Nephrol Dial Transplant 22:235-45. 2007..Early graft function (EGF) has an enduring effect on the subsequent course after kidney transplantation. This study compares quantitative parameters of EGF for the prediction of graft survival... - Donor dopamine treatment in brain dead rats is associated with an improvement in renal function early after transplantation and a reduction in renal inflammationSimone Hoeger
Department of Medicine V, Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Transpl Int 21:1072-80. 2008..No difference for macrophage chemoattractant protein 1 and IL-10 were found. These findings may explain the salutary effect of donor dopamine treatment in renal transplantation... - Atorvastatin donor pre-treatment in a model of brain death and allogeneic kidney transplantation in ratSimone Hoeger
5th Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
Ann Transplant 17:79-85. 2012..The aim of the present study was to evaluate the effect of donor pre-treatment with atorvastatin in a model of brain death followed by prolonged cold preservation and allogeneic kidney transplantation in rats... - Donor desmopressin is associated with superior graft survival after kidney transplantationUrs Benck
5th Department of Medicine, University Medical Centre Mannheim, Mannheim, Germany
Transplantation 92:1252-8. 2011..gov Identifier: NCT00115115). This study determines whether donor exposure to desmopressin (1-deamino-8-d-arginine-vasopressin [DDAVP]) before organ retrieval affects renal transplant outcome... - Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in ratsUwe Gottmann
Fifth Department of Medicine, Nephrology/Endocrinology/Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
Transplantation 79:1344-50. 2005..The authors' experimental data demonstrate that donor treatment is a simple and effective approach for preventing long-term graft loss after kidney transplantation... - UW is superior compared with HTK after prolonged preservation of renal graftsSimone Hoeger
Department of Medicine V Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
J Surg Res 170:e149-57. 2011..In recent clinical studies, the efficacy of histidine-tryptophan-ketoglutarate (HTK) in kidney transplantation was questioned. This study compares the efficacy of University of Wisconsin (UW) and HTK solutions on transplantation outcome... - Donor dopamine pretreatment inhibits tubulitis in renal allografts subjected to prolonged cold preservationZhenzi Liu
Fifth Medical Clinic, Klinikum Mannheim, University of Heidelberg, Heidelberg, Germany
Transplantation 83:297-303. 2007..In the present study, we used the Brown-Norway (BN) to Lewis model as a model for acute rejection, to test the hypothesis that dopamine (DA) treatment of BN donors significantly reduces the inflammatory response after renal transplantation... - The additional detrimental effects of cold preservation on transplantation-associated injury in kidneys from living and brain-dead donor ratsSimone Hoeger
Department of Medicine V Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Transplantation 87:52-8. 2009..The present study was conducted to assess the influence of these factors on transplantation-associated injury independently or in combination... - Atorvastatin donor pretreatment prevents ischemia/reperfusion injury in renal transplantation in rats: possible role for aldose-reductase inhibitionUwe Gottmann
Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
Transplantation 84:755-62. 2007..The aim of the present study was to evaluate the effect of donor pretreatment with atorvastatin on ischemia/reperfusion (I/R) injury in renal transplantation in rats... - Effect of dopamine on inflammatory status in kidneys of brain-dead ratsMeike Schaub
Fifth Medical Clinic, University Hospital Mannheim, Mannheim, Germany
Transplantation 77:1333-40. 2004..To elucidate the mechanisms underlying the protective effect of dopamine on kidneys of brain-dead donors, we studied a model for brain death in rats... - Hypothermia-induced loss of endothelial barrier function is restored after dopamine pretreatment: role of p42/p44 activationPaul-Thomas Brinkkoetter
Department of Medicine (Nephrology, University Hospital Mannheim, University of Heidelberg, Germany
Transplantation 82:534-42. 2006..This may contribute to the positive effects of catecholamines on immediate graft function of renal allografts in men... - Effects of N-acetylcysteine on renal hemodynamics in contrast media-induced nephropathyStefan Krzossok
Fifth Medical Department, Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
Kidney Blood Press Res 34:125-34. 2011..Conclusions: Renal perfusion is not affected by NAC application in a model of experimental contrast nephropathy in rats. Other effects of NAC might thus account for the presumed renoprotective properties... 
N-octanoyl dopamine, a non-hemodyanic dopamine derivative, for cell protection during hypothermic organ preservationRalf M Losel
Department of Clinical Pharmacology, University Medical Centre Mannheim, Mannheim, Germany
PLoS ONE 5:e9713. 2010..We hypothesized that variation of the molecular structure would yield more efficacious compounds avoid of any hemodynamic effects...- Hypothermic injury: the mitochondrial calcium, ATP and ROS love-hate triangle out of balancePaul Thomas Brinkkoetter
Vth Medical Department, University Hospital of Mannheim, University of Heidelberg, Mannheim, Germany
Cell Physiol Biochem 22:195-204. 2008..Here, we identified cellular processes which govern hypothermia-mediated cell death in endothelial cells and how they are influenced by dopamine... - Influence of hypersulfated and low molecular weight heparins on ischemia/reperfusion: injury and allograft rejection in rat kidneysUwe Gottmann
V Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
Transpl Int 20:542-9. 2007..Chemically modified heparins without anticoagulatory effects may offer a new treatment option in preventing I/R injury and CAN in human kidney transplantation... - Preconditioning strategies to limit graft immunogenicity and cold ischemic organ injuryFokko J van der Woude
Vth Medical University Clinic Nephrology, Endocrinology, Rheumatology, Klinikum Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim, Germany
J Investig Med 52:323-9. 2004..It is important to underscore that donor pretreatment will have great advantages for the recipient because an improved long-term graft survival could thus be achieved cost-efficiently and without great effort or side effects... - Effects of donor pre-treatment with dopamine on survival after heart transplantation: a cohort study of heart transplant recipients nested in a randomized controlled multicenter trialUrs Benck
University Medical Centre Mannheim, Mannheim, Germany
J Am Coll Cardiol 58:1768-77. 2011..We determined the outcome of cardiac allografts from multiorgan donors enrolled in a randomized trial of donor pre-treatment with dopamine... - CORMs protect endothelial cells during cold preservation, resulting in inhibition of intimal hyperplasia after aorta transplantation in ratsHui Song
Vth Medical Clinic, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
Transpl Int 23:1144-53. 2010..Hence, our findings might offer a novel strategy to prevent vascular damage during CP... - ANCA-associated vasculitis following influenza vaccination: causal association or mere coincidence?Rainer Birck
Fifth Department of Medicine, University Hospital Mannheim, Germany
J Clin Rheumatol 15:289-91. 2009..Although our report does not prove a causal association between vaccination and vasculitis, it seems possible that in rare cases vaccination might induce vasculitic disease... - Total parathyroidectomy without autotransplantation as a standard procedure in the treatment of secondary hyperparathyroidismStefan Ockert
Department of Surgery, University Hospital of Mannheim, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
Langenbecks Arch Surg 387:204-9. 2002..However, a considerable recurrence rate following these procedures ranges from 5% to 80%. We present a retrospective analysis of the results of parathyroidectomy with autotransplantation to the forearm versus parathyroidectomy alone... - Dopamine treatment in brain-dead rats mediates anti-inflammatory effects: the role of hemodynamic stabilization and D-receptor stimulationSimone Hoeger
Department of Medicine V, University Medical Center Mannheim, University of Heidelberg, Germany, and Départment de Médecine, Interne et Néphrologie, Centre Hospitalier Kirchberg, Luxembourg
Transpl Int 20:790-9. 2007..Hence, DA might reduce BD-induced monocyte infiltration possibly by hemodynamic stabilization, D-receptor activation, or a combination of both... - N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates is chemia-induced acute kidney injury in ratCharalambos Tsagogiorgas
Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
PLoS ONE 7:e43525. 2012..Although NOD mitigates deterioration in renal function after AKI, further studies are required to assess to what extend this is causally related to TRPV1 activation and/or desensitization... - Prevention of cold-preservation injury of cultured endothelial cells by catecholamines and related compoundsBenito Yard
V Medizinische Universitätsklinik, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Am J Transplant 4:22-30. 2004..In conclusion we have demonstrated that catecholamines protect cells against preservation injury either by scavenging of ROS or by inhibition of ROS production... - Fluorescence-guided minimally invasive parathyroidectomy: a novel surgical therapy for secondary hyperparathyroidismRuediger L Prosst
Department of Surgery and Fifth Medical Clinic Nephrology, Endocrinology, University Hospital Mannheim, Ruprecht Karls University, Heidelberg, Germany
Am J Kidney Dis 48:327-31. 2006..The technique serves as an additional tool requiring only moderate technical and clinical expenditure...