Peter Schönknecht

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. pmc Development and evaluation of an algorithm for the computer-assisted segmentation of the human hypothalamus on 7-Tesla magnetic resonance images
    Stephanie Schindler
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany
    PLoS ONE 8:e66394. 2013
  2. pmc A critical review of the recent literature and selected therapy guidelines since 2006 on the use of lamotrigine in bipolar disorder
    Anja Tränkner
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany
    Neuropsychiatr Dis Treat 9:101-11. 2013
  3. doi request reprint Diffusion imaging-based subdivision of the human hypothalamus: a magnetic resonance study with clinical implications
    Peter Schönknecht
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Semmelweisstr 10, 04103, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 263:497-508. 2013
  4. doi request reprint Indeterminacy of translation and impaired intersubjectivity in schizophrenia
    Peter Schönknecht
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany
    Psychopathology 46:88-93. 2013
  5. ncbi request reprint Between phenomenological and community psychiatry: the Comprehending Anthropology of Jürg Zutt
    Peter Schönknecht
    Ruprecht Karls University, Heidelberg, Germany
    Hist Psychiatry 23:182-93. 2012
  6. doi request reprint Neural correlates of delayed episodic memory in patients with mild cognitive impairment--a FDG PET study
    Oskar Dieter Peter Schönknecht
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Neurosci Lett 467:100-4. 2009
  7. ncbi request reprint Bihemispheric cerebral FDG PET correlates of cognitive dysfunction as assessed by the CERAD in Alzheimer's disease
    Oskar Dieter Peter Schönknecht
    Department of Psychiatry, University Hospital Leipzig, Leipzig, Germany
    Clin EEG Neurosci 42:71-6. 2011
  8. doi request reprint [Symptoms and imaging diagnostics of neurodegenerative dementia]
    P Schonknecht
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Leipzig, AöR, Semmelweisstr 10, 04103 Leipzig, Deutschland
    Radiologe 51:278-84. 2011
  9. doi request reprint Impaired cerebral glucose metabolism in prodromal Alzheimer's disease differs by regional intensity normalization
    Anika Küntzelmann
    Psychiatry and Psychotherapy, University Hospital Leipzig, Germany
    Neurosci Lett 534:12-7. 2013
  10. ncbi request reprint Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy
    Peter Schönknecht
    Department of Psychiatry, Section of Geriatric Psychiatry, University of Heidelberg, Voss Street 4, Heidelberg D 69115, Germany
    Psychiatry Res 120:231-8. 2003

Detail Information

Publications41

  1. pmc Development and evaluation of an algorithm for the computer-assisted segmentation of the human hypothalamus on 7-Tesla magnetic resonance images
    Stephanie Schindler
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany
    PLoS ONE 8:e66394. 2013
    ..Providing very high test-retest and inter-rater reliabilities, it outperforms former procedures established at 1.5T and 3T magnetic resonance images and thus can serve as a gold standard for future automated procedures. ..
  2. pmc A critical review of the recent literature and selected therapy guidelines since 2006 on the use of lamotrigine in bipolar disorder
    Anja Tränkner
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany
    Neuropsychiatr Dis Treat 9:101-11. 2013
    ..In conclusion, the findings of the present review article on treatment guidelines for bipolar disorder question the role of LTG in acute depressive states, and critically discusses its use, particularly in acute depressive states...
  3. doi request reprint Diffusion imaging-based subdivision of the human hypothalamus: a magnetic resonance study with clinical implications
    Peter Schönknecht
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Semmelweisstr 10, 04103, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 263:497-508. 2013
    ..When applied in a larger sample of neuropsychiatric patients, a structural analysis of hypothalamic subnuclei should contribute to a better understanding of the pathogenesis of neuropsychiatric conditions such as affective disorders. ..
  4. doi request reprint Indeterminacy of translation and impaired intersubjectivity in schizophrenia
    Peter Schönknecht
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany
    Psychopathology 46:88-93. 2013
    ..Indulgence and coherence are hypothesized as reflecting an approximation process of reconstructing intersubjectivity in conditions where it is severely disturbed such as schizophrenia...
  5. ncbi request reprint Between phenomenological and community psychiatry: the Comprehending Anthropology of Jürg Zutt
    Peter Schönknecht
    Ruprecht Karls University, Heidelberg, Germany
    Hist Psychiatry 23:182-93. 2012
    ..However, it cannot be concluded from the existing evidence that the reform of psychiatric services necessarily resulted from the anthropological approach...
  6. doi request reprint Neural correlates of delayed episodic memory in patients with mild cognitive impairment--a FDG PET study
    Oskar Dieter Peter Schönknecht
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Neurosci Lett 467:100-4. 2009
    ..Since not all patients with MCI will further deteriorate, AD specific mechanism may not be concluded from the present study but warrant longitudinal investigations...
  7. ncbi request reprint Bihemispheric cerebral FDG PET correlates of cognitive dysfunction as assessed by the CERAD in Alzheimer's disease
    Oskar Dieter Peter Schönknecht
    Department of Psychiatry, University Hospital Leipzig, Leipzig, Germany
    Clin EEG Neurosci 42:71-6. 2011
    ..The findings of our study for the first time demonstrate that in AD neuropsychological deficits as assessed by the CERAD refer to different cerebral sites of both hemispheres...
  8. doi request reprint [Symptoms and imaging diagnostics of neurodegenerative dementia]
    P Schonknecht
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Leipzig, AöR, Semmelweisstr 10, 04103 Leipzig, Deutschland
    Radiologe 51:278-84. 2011
    ....
  9. doi request reprint Impaired cerebral glucose metabolism in prodromal Alzheimer's disease differs by regional intensity normalization
    Anika Küntzelmann
    Psychiatry and Psychotherapy, University Hospital Leipzig, Germany
    Neurosci Lett 534:12-7. 2013
    ..Unexpected hypermetabolism in patients was only revealed using global normalization and has to be regarded as an artifact of intensity normalization to a reference region affected by the disease...
  10. ncbi request reprint Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy
    Peter Schönknecht
    Department of Psychiatry, Section of Geriatric Psychiatry, University of Heidelberg, Voss Street 4, Heidelberg D 69115, Germany
    Psychiatry Res 120:231-8. 2003
    ..A subgroup of AD patients without increased tau levels was characterized by a significantly larger percentage of patients with presenile onset...
  11. doi request reprint [CSF levels of total tau protein in patients with mild cognitive impairment and Alzheimer's disease]
    Johannes Schroder
    Sektion Gerontopsychiatrie, Psychiatrische Universitatsklinik, Vossstrasse 4, 69115, Heidelberg, Germany
    Z Gerontol Geriatr 41:497-501. 2008
    ....
  12. ncbi request reprint Hippocampal glucose metabolism is associated with cerebrospinal fluid estrogen levels in postmenopausal women with Alzheimer's disease
    Peter Schönknecht
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Heidelberg, Voss Str 4, D 69115 Heidelberg, Germany
    Psychiatry Res 124:125-7. 2003
    ..This is the first clinical study indicating an association between CSF E(2) concentration and hippocampal glucose metabolism in postmenopausal women with AD...
  13. ncbi request reprint Levels of total tau and tau protein phosphorylated at threonine 181 in patients with incipient and manifest Alzheimer's disease
    Peter Schönknecht
    Department of Psychiatry, University of Heidelberg, Voss Strasse 4, D 69115, Heidelberg, Germany
    Neurosci Lett 339:172-4. 2003
    ..These findings suggest that total and phosphorylated tau protein may facilitate early detection and differential diagnosis of AD...
  14. doi request reprint Structural studies of the hypothalamus and its nuclei in mood disorders
    Stephanie Schindler
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany
    Psychiatry Res 201:1-9. 2012
    ..We discuss the implications of these findings and provide directions for future research...
  15. doi request reprint Test-retest stability of the Onset of Depression Inventory
    Maria Strauss
    Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany
    Psychopathology 47:45-50. 2014
    ..The aim of this study was to evaluate the test-retest stability of the ODI. Patients were asked concerning the speed of onset at the time of hospitalization and again before discharge...
  16. ncbi request reprint Influence of delayed CSF storage on concentrations of phospho-tau protein (181), total tau protein and beta-amyloid (1-42)
    Elmar Kaiser
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Heidelberg, Germany
    Neurosci Lett 417:193-5. 2007
    ..These results indicate that CSF samples for the evaluation of total tau and phospho-tau protein may be kept at room temperature for up to 24h whereas CSF samples for beta-amyloid (1-42) need to be frozen immediately...
  17. pmc Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease
    Philipp A Thomann
    Section of Geriatric Psychiatry, University of Heidelberg, Heidelberg, Germany
    J Psychiatry Neurosci 34:136-42. 2009
    ....
  18. doi request reprint Impact of EEG-vigilance on brain glucose uptake measured with [(18)F]FDG and PET in patients with depressive episode or mild cognitive impairment
    Thomas Guenther
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Neuroimage 56:93-101. 2011
    ..For the first time, the present study exploratively investigated this association in a routine diagnostic work-up...
  19. pmc Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease
    Frank M Schmidt
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany
    PLoS ONE 8:e63136. 2013
    ..Histochemical and actigraphic explorations are warranted to further elucidate alterations of hypothalamic transmitter regulation in AD...
  20. pmc Prestimulus vigilance predicts response speed in an easy visual discrimination task
    Juliane Minkwitz
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstr, 10, 04103 Leipzig, Germany
    Behav Brain Funct 7:31. 2011
    ..We hypothesised that a low EEG-vigilance state immediately before a reaction task would entail a longer RT. Shorter RTs were expected for a high EEG-vigilance state...
  21. ncbi request reprint Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurobiol Aging 29:812-8. 2008
    ..9 pg/mL. These cutoff values were also applied to discriminate between MCI-AD and MCI-O subjects. Simultaneous measurement of the biomarkers significantly improves management of the samples and quality control of the assays' performance...
  22. ncbi request reprint International quality control survey of neurochemical dementia diagnostics
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurosci Lett 409:1-4. 2006
    ..Although the results of this quality control survey are promising, the quality of measurements has to be further optimized...
  23. doi request reprint Onset of Depression Inventory (ODI)--assessment of the speed of onset of depressive episodes
    Maria Strauss
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstraße 10, 04103 Leipzig, Germany
    J Affect Disord 142:156-60. 2012
    ..Apart from a replication of these findings, the present study aimed to investigate the speed of onset in patients with BD compared to UD patients with either a depressive episode (DE) or recurrent depressive disorder (RD)...
  24. doi request reprint Unstable EEG-vigilance in patients with cancer-related fatigue (CRF) in comparison to healthy controls
    Sebastian Olbrich
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany
    World J Biol Psychiatry 13:146-52. 2012
    ..Therefore the goal of this study is to compare the electroencephalographic (EEG)-vigilance regulation of patients with CRF and healthy controls...
  25. doi request reprint Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    Psychiatry Res 182:244-50. 2010
    ..Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for cross-sectional diagnostic studies, and they replicate essential findings from smaller scale monocentre studies...
  26. doi request reprint Cognitive activity, education and socioeconomic status as preventive factors for mild cognitive impairment and Alzheimer's disease
    Christine Sattler
    University of Heidelberg, Heidelberg, Germany
    Psychiatry Res 196:90-5. 2012
    ..Our results confirm the hypothesis that a high level of CLA acts as a protective factor against the development of MCI and AD by increasing cognitive reserve. This effect is not accounted for by important potential confounders...
  27. ncbi request reprint In vivo quantification of brain volumes in subcortical vascular dementia and Alzheimer's disease. An MRI-based study
    J Pantel
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Heidelberg, Heidelberg, Germany
    Dement Geriatr Cogn Disord 9:309-16. 1998
    ....
  28. ncbi request reprint Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls
    Peter Schönknecht
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Heidelberg, Voss Strasse 4, 69115, Germany
    Neurosci Lett 324:83-5. 2002
    ..Our results demonstrate that CSF 24S-hydroxycholesterol is increased in AD. This effect does not seem to be triggered by plasma cholesterol levels since the latter did not significantly differ between groups...
  29. doi request reprint CSF-hypocretin-1 levels in patients with major depressive disorder compared to healthy controls
    Frank Martin Schmidt
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany
    Psychiatry Res 190:240-3. 2011
    ..Whether hcrt-1 levels are altered in depressive patients exhibiting impaired vigilance regulation has to be investigated in further studies combining measures of CSF-hcrt-1 with electroencephalography...
  30. doi request reprint Type II diabetes in mild cognitive impairment and Alzheimer's disease: results from a prospective population-based study in Germany
    Pablo Toro
    Section for Geriatric Psychiatry, University of Heidelberg, Heidelberg, Germany
    J Alzheimers Dis 16:687-91. 2009
    ..Our findings indicate that T2DM is involved in MCI and may aggravate the clinical picture as a concomitant factor...
  31. ncbi request reprint Increased tau protein differentiates mild cognitive impairment from geriatric depression and predicts conversion to dementia
    Peter Schönknecht
    Section of Geriatric Psychiatry, University of Heidelberg, Heidelberg, Germany
    Neurosci Lett 416:39-42. 2007
    ..Our findings demonstrate that both, CSF t-tau and p-tau levels facilitate the differential diagnosis of MCI and are of prognostic value...
  32. ncbi request reprint Elevated levels of cerebrospinal fluid neuron-specific enolase (NSE) in Alzheimer's disease
    Frank Martin Schmidt
    University Hospital Leipzig, Department of Psychiatry and Psychotherapy, Semmelweisstr 10, 04103 Leipzig, Germany Electronic address
    Neurosci Lett 570:81-5. 2014
    ..87, p<0.000001) and P-tau (r ≥ 0.88, p<0.000001) in both AD and HS. Our results indicate elevated CSF-NSE levels to reflect altered neuronal metabolism in AD that may be used in supporting AD diagnostics...
  33. ncbi request reprint Impairment in basal limbic function in schizophrenia during affect recognition
    Albrecht Hempel
    Department of Psychiatry, University of Heidelberg, Vossstrasse 2, D 69115 Heidelberg, Germany
    Psychiatry Res 122:115-24. 2003
    ..It is suggested that the latter may reflect a compensatory effort for deficits in more basal limbic functions...
  34. doi request reprint Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings
    Susanne Graef
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Psychopharmacology (Berl) 215:205-29. 2011
    ..The cholinergic system has long been linked to cognitive processes. Two main classes of acetylcholine (ACh) receptors exist in the human brain, namely muscarinic and nicotinic receptors, of which several subtypes occur...
  35. ncbi request reprint Functional connectivity in major depression: increased phase synchronization between frontal cortical EEG-source estimates
    Sebastian Olbrich
    Clinic for Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany LIFE Leipzig Research Center for Civilization Diseases, University Leipzig, Semmelweisstraße 10, 04103 Leipzig, Germany Electronic address
    Psychiatry Res 222:91-9. 2014
    ..MDD is characterized by increased EEG functional connectivity within frontal brain areas. These EEG markers of disturbed neuronal communication might have potential value as biomarkers. ..
  36. doi request reprint Cerebrospinal fluid hypocretin-1 (orexin A) levels in mania compared to unipolar depression and healthy controls
    Frank M Schmidt
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Neurosci Lett 483:20-2. 2010
    ..For the first time, in the present study hcrt levels were investigated in patients with a manic episode and compared with age-matched patients with MDD and controls...
  37. ncbi request reprint Topography of callosal atrophy reflects distribution of regional cerebral volume reduction in Alzheimer's disease
    J Pantel
    Department of Psychiatry, Section of Geriatric Psychiatry, University of Heidelberg, Germany
    Psychiatry Res 90:181-92. 1999
    ..Correlations between regional callosal atrophy and severity of dementia indicate that interhemispheric cortico-cortical disconnection may contribute to the dementia syndrome...
  38. doi request reprint Tissue transglutaminase is not a biochemical marker for Alzheimer's disease
    Johannes Wolf
    Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany
    Neurobiol Aging 34:2495-8. 2013
    ..Only in rare cases, tTG was detectable in CSF samples. This could be attributed to liberation from erythrocytes. Our data contradict the view that tTG is a potential biochemical marker for AD...
  39. ncbi request reprint Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Neurobiol Aging 27:10-5. 2006
    ..Our findings indicate a dissociation in the direction of change in CSF levels of t-tau and p-tau231 in CJD when compared to AD...
  40. ncbi request reprint Laboratory parameters and appetite regulators in patients with anorexia nervosa
    Hubertus Himmerich
    Department of Psychiatry, University of Leipzig, 04103 Leipzig, Germany
    J Psychiatr Pract 16:82-92. 2010
    ..To date, despite these associated laboratory alterations, the diagnosis of anorexia is a clinical one, based on weight and specific psychopathology...
  41. doi request reprint Are antidepressants useful in the treatment of minor depression: a critical update of the current literature
    Ulrich Hegerl
    Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany
    Curr Opin Psychiatry 25:1-6. 2012
    ....