Research Topics
Species | Paul SchnitzlerSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Detail Information
Publications
Mechanism of herpes simplex virus type 2 suppression by propolis extractsSilke Nolkemper
Department of Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
Phytomedicine 17:132-8. 2010..Selectivity indices were determined at 80 and 42.5 for the aqueous and ethanolic extract, respectively, thus propolis extracts might be suitable for topical therapy in recurrent herpetic infection...
Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case reportAnnika Gauss
Department of Infectious Diseases, Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany
J Med Case Rep 6:334. 2012..abstract:..- Melissa officinalis oil affects infectivity of enveloped herpesvirusesP Schnitzler
Department of Virology, Hygiene Institute, University of Heidelberg, 69120 Heidelberg, Germany
Phytomedicine 15:734-40. 2008..Considering the lipophilic nature of lemon balm essential oil, which enables it to penetrate the skin, and a high selectivity index, Melissa officinalis oil might be suitable for topical treatment of herpetic infections... - [Efficacy of plant products against herpetic infections]P Schnitzler
Department für Infektiologie, Virologie, Universitat Heidelberg, Deutschland
HNO 59:1176-84. 2011..Some companies have marketed plant products, e.g. from Melissa, for the treatment of recurrent herpetic infections... - Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwoodPaul Schnitzler
Hygiene Institute, Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, Heidelberg, Germany
Antimicrob Agents Chemother 51:1859-62. 2007..All essential oils exhibited high levels of virucidal activity against acyclovir-sensitive strain KOS and acyclovir-resistant HSV-1 clinical isolates and reduced plaque formation significantly... - Antiviral activity and mode of action of propolis extracts and selected compoundsPaul Schnitzler
Department of Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
Phytother Res 24:S20-8. 2010..Propolis extracts might be suitable for topical application against herpes infection... - Efficacy of an aqueous Pelargonium sidoides extract against herpesvirusP Schnitzler
Department of Virology, Hygiene Institute, University of Heidelberg, 69120 Heidelberg, Germany
Phytomedicine 15:1108-16. 2008..Hence this extract is capable of exerting an antiviral effect on herpes simplex virus and might be suitable for topical therapeutic use as antiviral drug both in labial and genital herpes infection... 
Virucidal activity of a beta-triketone-rich essential oil of Leptospermum scoparium (manuka oil) against HSV-1 and HSV-2 in cell cultureJürgen Reichling
Institute of Pharmacy and Molecular Biotechnology, Department of Biology, University of Heidelberg, Heidelberg, Germany
Planta Med 71:1123-7. 2005..When added at non-cytotoxic concentrations to the virus 1 h prior to cell infection, plaque formation was reduced by 99.1 % and 79.7 % for flavesone and leptospermone, respectively...- Efficacy of anise oil, dwarf-pine oil and chamomile oil against thymidine-kinase-positive and thymidine-kinase-negative herpesvirusesChristine Koch
Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
J Pharm Pharmacol 60:1545-50. 2008.... - Pharmacodynamic monitoring of cyclosporin A reveals risk of opportunistic infections and malignancies in renal transplant recipients 65 years and olderClaudia Sommerer
Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
Ther Drug Monit 33:694-8. 2011..Measuring the residual nuclear factor of activated T-cell (NFAT)-regulated gene expression (RGE) is a promising pharmacodynamic tool to individually monitor cyclosporin A (CsA) therapy... - Anti-herpetic properties of hydroalcoholic extracts and pressed juice from Echinacea pallidaSven Schneider
Department of Virology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
Planta Med 76:265-72. 2010..Different types of Echinacea preparations, such as commercial tinctures, tablets, and teas, are expected to offer different antiviral profiles... - Strong association of phenylalanine and tryptophan metabolites with activated cytomegalovirus infection in kidney transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, D 69117 Heidelberg, Germany
Hum Immunol 73:186-92. 2012..Moreover, tryptophan metabolite levels correlate with disease severity. Measurement of these amino acids is an inexpensive and fast method expected to complete conventional diagnostic assays... - Impact of ethanolic lamiaceae extracts on herpesvirus infectivity in cell cultureJürgen Reichling
Institute of Pharmacy and Molecular Biotechnology, Department of Biology, University of Heidelberg, Germany
Forsch Komplementmed 15:313-20. 2008..Extracts of medicinal plants are increasingly of interest as novel drugs for antimicrobial and antiviral agents, since microorganisms might develop resistance to commonly used antimicrobial or antiviral agents... - Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitroSilke Nolkemper
Institute of Pharmacy and Molecular Biotechnology, Department of Biology, University of Heidelberg, Heidelberg, Germany
Planta Med 72:1378-82. 2006..Therefore, the extracts exert their antiviral effect on free HSV and offer a chance to use them for topical therapeutic application against recurrent HERPES infections... - Melissa officinalis extract inhibits attachment of herpes simplex virus in vitroAkram Astani
Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany
Chemotherapy 58:70-7. 2012..Extracts and essential oils of medicinal plants are increasingly of interest as novel drugs for antiherpetic agents, since the herpes simplex virus (HSV) might develop resistance to commonly used antiviral drugs... - Cytokine expression during early and late phase of acute Puumala hantavirus infectionMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
BMC Immunol 12:65. 2011..An immune-mediated pathogenesis is discussed for both syndromes. The aim of our study was to investigate cytokine expression during the course of acute Puumala hantavirus infection... - Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruriaMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 88:1109-16. 2009..BKV-associated nephropathy develops in approximately 5% to 8% of renal transplant recipients, and its prognosis is poor. The relationship between urine cytokines and BK viruria in kidney recipients has not been defined... - Comparative study on the antiviral activity of selected monoterpenes derived from essential oilsAkram Astani
Department of Virology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
Phytother Res 24:673-9. 2010..However, mixtures of different monoterpenes present in natural tea tree essential oil revealed a ten-fold higher selectivity index and a lower toxicity than its isolated single monoterpenes... - Essential oils of aromatic plants with antibacterial, antifungal, antiviral, and cytotoxic properties--an overviewJürgen Reichling
Institute of Pharmacy and Molecular Biotechnology, Department of Biology, University of Heidelberg, Im Neuenheimer Feld 364, Heidelberg, Germany
Forsch Komplementmed 16:79-90. 2009..The progress of this expanding scientific field will be documented by the most important results published in the last decade... - (Val-)Ganciclovir prophylaxis reduces Epstein-Barr virus primary infection in pediatric renal transplantationBritta Höcker
University Children s Hospital, Heidelberg, Germany
Transpl Int 25:723-31. 2012..Chemoprophylaxis with VGCV/GCV is associated with a reduced incidence of EBV viremia in high-risk pediatric kidney allograft recipients in the first year post-transplant. (ClinicalTrials.gov number: NCT00963248)... - Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patientsSylvia Brost
Department of Gastroenterology and Infectious Diseases, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
World J Gastroenterol 16:5447-51. 2010..To study the efficacy and safety of entecavir (ETV) as first-line therapy for hepatitis B virus (HBV) reactivation due to immunosuppression... - Viral infections in septic shock (VISS-trial)-crosslinks between inflammation and immunosuppressionThorsten Brenner
Department of Anaesthesiology, University of Heidelberg, Heidelberg, Germany
J Surg Res 176:571-82. 2012..However, at this time, it remains unclear whether these viral infections are of real pathogenetic relevance or represent innocent bystanders... - Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejectionImad Lahdou
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Hum Immunol 71:1067-72. 2010..Although informative in overall terms, at the present stage, Kyn levels do not allow the concise risk differentiation of individual patients... - Effects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patientsAndreas O Doesch
Department of Cardiology, University of Heidelberg, Heidelberg
Drug Des Devel Ther 6:289-95. 2012..This study (June 2003-January 2010) retrospectively assessed the effects of oral valganciclovir prophylaxis in adult heart transplant recipients during the first year after transplantation... - Hepatitis B virus infection is associated with deletion of chromosome 8p in multiple myelomaNikolaus Becker
Clinical Cancer Registry, National Center of Tumor Diseases and German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany
Eur J Haematol 90:279-85. 2013..36-5.50, P = 0.0048) and for loss of 13q14 non-significantly increased (OR = 1.40, 95% CL = 0.74-2.65) in anti-HBc positive patients. The results provide further support for a role of HBV infection in the pathogenesis of MM... - Delayed detection of cytomegalovirus-specific T-helper cells in a preterm infant following intrauterine exposure to tacrolimusMaximilian Von Au
Department of Infectious Diseases, Virology, University of Heidelberg, Germany
Clin Lab 58:811-5. 2012..Thus, exposure to tacrolimus in utero caused a transitional T-cell activation defect which did not compromise viral clearance... - Herpes simplex virus encephalitis despite normal cell count in the cerebrospinal fluidNurith J Jakob
Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
Crit Care Med 40:1304-8. 2012..To describe herpes simplex virus encephalitis despite normal cell count in the cerebrospinal fluid in patients with malignoma after whole brain irradiation... - Pharmacodynamic disparities in tacrolimus-treated patients developing cytomegalus virus viremiaClaudia Sommerer
Department of Nephrology, University Hospital, Heidelberg, Germany
Ther Drug Monit 33:373-9. 2011..The quantification of nuclear factor of activated T cell (NFAT)-regulated gene expression may provide a tool to monitor the individual susceptibility to Tac... - Epstein-Barr virus load in whole blood is associated with immunosuppression, but not with post-transplant lymphoproliferative disease in stable adult heart transplant patientsAndreas O Doesch
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Transpl Int 21:963-71. 2008..EBV DNA viral load determination does not appear to be useful for risk prediction or early diagnosis of PTLD in adults after HTX, but an association of EBV DNA load with qualitative and quantitative immunosuppression is demonstrated... - Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4BKatharina Esser-Nobis
Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany
Hepatology 57:953-63. 2013..This novel mode of action renders SIL an attractive candidate for combination therapies with other directly acting antiviral drugs, particularly in difficult-to-treat patient cohorts... - Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study EpilymphNikolaus Becker
Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
J Cancer Res Clin Oncol 138:1993-2001. 2012.... - Dysregulated cytokine responses during cytomegalovirus infection in renal transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 86:275-85. 2008..The aim of this study was to examine whether there are differences in plasma cytokine levels pretransplant, before and during CMV replication in renal transplant recipients... - Adenovirus infection and treatment with cidofovir in children after liver transplantationGuido Engelmann
Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
Pediatr Transplant 13:421-8. 2009..Immunosuppression was reduced in this patient immediately and the antiviral drug cidofovir administered intravenously followed by viral suppression and clinical improvement of the child... - Screening for antiviral activities of isolated compounds from essential oilsAkram Astani
Department of Infectious Diseases, Virology, University of Heidelberg, 69120 Heidelberg, Germany
Evid Based Complement Alternat Med 2011:253643. 2011..These results indicate that phenylpropanoids and sesquiterpenes present in essential oils contribute to their antiviral activity against HSV... - Immunogenicity and safety of H1N1 vaccination in anorexia nervosa--results from a pilot studyArne Zastrow
Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Int J Eat Disord 45:146-9. 2012..Currently, no recommendation can be given on the safety and immunogenicity of indicated vaccinations in this malnourished population... - Immunogenicity and efficacy in hemodialysis patients of an AS03(A)-adjuvanted vaccine for 2009 pandemic influenza A(H1N1): a nonrandomized trialRalf Dikow
Department of Nephrology, University Hospital of Heidelberg, Heidelberg, Germany
Am J Kidney Dis 57:716-23. 2011..To increase the immunogenicity of vaccines, antigens can be formulated with adjuvants. The new tocopherol-containing adjuvant system AS03(A) has not been tested yet in patients with end-stage renal disease... - Mutations in the BC-loop of the BKV VP1 region do not influence viral load in renal transplant patientsEllen Krautkrämer
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
J Med Virol 81:75-81. 2009..These in vivo results demonstrate that high replication rates which serve as a predictive marker for BKVAN are not caused by altered receptor binding or affinity via mutated BC-loops... - Sudden death of an immunocompetent young adult caused by novel (swine origin) influenza A/H1N1-associated myocarditisGeorg Gdynia
Institute of Pathology, University Hospital, Im Neuenheimer Feld 220 221, 69120, Heidelberg, Germany
Virchows Arch 458:371-6. 2011..In conclusion, sudden death by myocarditis may be a rare complication of novel influenza A/H1N1 infection in otherwise healthy individuals, even in the absence of significant respiratory tract infection... - Combination of native and recombinant cytomegalovirus antigens in a new ELISA for detection of CMV-specific antibodiesClemens Busse
Applied Tumor Virology, German Cancer Research Center, University of Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Clin Virol 43:137-41. 2008..Serological detection of cytomegalovirus (CMV)-specific antibodies varies greatly due to antigen composition and the lack of antigen standardization... - An update on swine-origin influenza virus A/H1N1: a reviewSebastian U Schnitzler
Department of Virology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
Virus Genes 39:279-92. 2009..This review summarizes the current information on the new pandemic swine-origin influenza virus A/H1N1... - An outbreak of epidemic keratoconjunctivtis in a pediatric unit due to adenovirus type 8Iris E Chaberny
Department of Medical Microbiology and Hygiene, Institute of Hygiene, University of Heidelberg, Germany
Infect Control Hosp Epidemiol 24:514-9. 2003..Ophthalmologists who have had contact with known EKC cases should use antiseptics and disinfectants with virucidal activity before contact with newborns or abstain from examining newborns... - Prevalence of hepatitis B virus infection among women at reproductive age at a German university hospitalBritta Knorr
Department of Hygiene and Medical Microbiology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
J Clin Virol 42:422-4. 2008..Mother to infant transmission of hepatitis B virus (HBV) represents a major factor in maintaining chronic infection and depends on the degree of maternal infectivity status... - Fatal circumstances of human herpesvirus 6 infection: transcriptosome data analysis suggests caution in implicating HHV-6 in the cause of deathConsolato Sergi
Institute of Pathology, Medical University of Innsbruck, Austria
J Clin Pathol 60:1173-7. 2007