Paul Schnitzler

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Mechanism of herpes simplex virus type 2 suppression by propolis extracts
    Silke Nolkemper
    Department of Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Phytomedicine 17:132-8. 2010
  2. pmc Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case report
    Annika Gauss
    Department of Infectious Diseases, Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany
    J Med Case Rep 6:334. 2012
  3. doi request reprint Melissa officinalis oil affects infectivity of enveloped herpesviruses
    P Schnitzler
    Department of Virology, Hygiene Institute, University of Heidelberg, 69120 Heidelberg, Germany
    Phytomedicine 15:734-40. 2008
  4. doi request reprint Antiviral activity and mode of action of propolis extracts and selected compounds
    Paul Schnitzler
    Department of Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Phytother Res 24:S20-8. 2010
  5. doi request reprint Efficacy of an aqueous Pelargonium sidoides extract against herpesvirus
    P Schnitzler
    Department of Virology, Hygiene Institute, University of Heidelberg, 69120 Heidelberg, Germany
    Phytomedicine 15:1108-16. 2008
  6. pmc Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood
    Paul Schnitzler
    Hygiene Institute, Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, Heidelberg, Germany
    Antimicrob Agents Chemother 51:1859-62. 2007
  7. doi request reprint [Efficacy of plant products against herpetic infections]
    P Schnitzler
    Department für Infektiologie, Virologie, Universitat Heidelberg, Deutschland
    HNO 59:1176-84. 2011
  8. ncbi request reprint Virucidal activity of a beta-triketone-rich essential oil of Leptospermum scoparium (manuka oil) against HSV-1 and HSV-2 in cell culture
    Jürgen Reichling
    Institute of Pharmacy and Molecular Biotechnology, Department of Biology, University of Heidelberg, Heidelberg, Germany
    Planta Med 71:1123-7. 2005
  9. doi request reprint Efficacy of anise oil, dwarf-pine oil and chamomile oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses
    Christine Koch
    Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
    J Pharm Pharmacol 60:1545-50. 2008
  10. doi request reprint Pharmacodynamic monitoring of cyclosporin A reveals risk of opportunistic infections and malignancies in renal transplant recipients 65 years and older
    Claudia Sommerer
    Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
    Ther Drug Monit 33:694-8. 2011

Detail Information

Publications46

  1. doi request reprint Mechanism of herpes simplex virus type 2 suppression by propolis extracts
    Silke Nolkemper
    Department of Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Phytomedicine 17:132-8. 2010
    ..Selectivity indices were determined at 80 and 42.5 for the aqueous and ethanolic extract, respectively, thus propolis extracts might be suitable for topical therapy in recurrent herpetic infection...
  2. pmc Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case report
    Annika Gauss
    Department of Infectious Diseases, Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany
    J Med Case Rep 6:334. 2012
    ..abstract:..
  3. doi request reprint Melissa officinalis oil affects infectivity of enveloped herpesviruses
    P Schnitzler
    Department of Virology, Hygiene Institute, University of Heidelberg, 69120 Heidelberg, Germany
    Phytomedicine 15:734-40. 2008
    ..Considering the lipophilic nature of lemon balm essential oil, which enables it to penetrate the skin, and a high selectivity index, Melissa officinalis oil might be suitable for topical treatment of herpetic infections...
  4. doi request reprint Antiviral activity and mode of action of propolis extracts and selected compounds
    Paul Schnitzler
    Department of Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Phytother Res 24:S20-8. 2010
    ..Propolis extracts might be suitable for topical application against herpes infection...
  5. doi request reprint Efficacy of an aqueous Pelargonium sidoides extract against herpesvirus
    P Schnitzler
    Department of Virology, Hygiene Institute, University of Heidelberg, 69120 Heidelberg, Germany
    Phytomedicine 15:1108-16. 2008
    ..Hence this extract is capable of exerting an antiviral effect on herpes simplex virus and might be suitable for topical therapeutic use as antiviral drug both in labial and genital herpes infection...
  6. pmc Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood
    Paul Schnitzler
    Hygiene Institute, Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, Heidelberg, Germany
    Antimicrob Agents Chemother 51:1859-62. 2007
    ..All essential oils exhibited high levels of virucidal activity against acyclovir-sensitive strain KOS and acyclovir-resistant HSV-1 clinical isolates and reduced plaque formation significantly...
  7. doi request reprint [Efficacy of plant products against herpetic infections]
    P Schnitzler
    Department für Infektiologie, Virologie, Universitat Heidelberg, Deutschland
    HNO 59:1176-84. 2011
    ..Some companies have marketed plant products, e.g. from Melissa, for the treatment of recurrent herpetic infections...
  8. ncbi request reprint Virucidal activity of a beta-triketone-rich essential oil of Leptospermum scoparium (manuka oil) against HSV-1 and HSV-2 in cell culture
    Jürgen Reichling
    Institute of Pharmacy and Molecular Biotechnology, Department of Biology, University of Heidelberg, Heidelberg, Germany
    Planta Med 71:1123-7. 2005
    ..When added at non-cytotoxic concentrations to the virus 1 h prior to cell infection, plaque formation was reduced by 99.1 % and 79.7 % for flavesone and leptospermone, respectively...
  9. doi request reprint Efficacy of anise oil, dwarf-pine oil and chamomile oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses
    Christine Koch
    Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
    J Pharm Pharmacol 60:1545-50. 2008
    ....
  10. doi request reprint Pharmacodynamic monitoring of cyclosporin A reveals risk of opportunistic infections and malignancies in renal transplant recipients 65 years and older
    Claudia Sommerer
    Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
    Ther Drug Monit 33:694-8. 2011
    ..Measuring the residual nuclear factor of activated T-cell (NFAT)-regulated gene expression (RGE) is a promising pharmacodynamic tool to individually monitor cyclosporin A (CsA) therapy...
  11. doi request reprint Anti-herpetic properties of hydroalcoholic extracts and pressed juice from Echinacea pallida
    Sven Schneider
    Department of Virology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
    Planta Med 76:265-72. 2010
    ..Different types of Echinacea preparations, such as commercial tinctures, tablets, and teas, are expected to offer different antiviral profiles...
  12. doi request reprint Strong association of phenylalanine and tryptophan metabolites with activated cytomegalovirus infection in kidney transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, D 69117 Heidelberg, Germany
    Hum Immunol 73:186-92. 2012
    ..Moreover, tryptophan metabolite levels correlate with disease severity. Measurement of these amino acids is an inexpensive and fast method expected to complete conventional diagnostic assays...
  13. doi request reprint Impact of ethanolic lamiaceae extracts on herpesvirus infectivity in cell culture
    Jürgen Reichling
    Institute of Pharmacy and Molecular Biotechnology, Department of Biology, University of Heidelberg, Germany
    Forsch Komplementmed 15:313-20. 2008
    ..Extracts of medicinal plants are increasingly of interest as novel drugs for antimicrobial and antiviral agents, since microorganisms might develop resistance to commonly used antimicrobial or antiviral agents...
  14. ncbi request reprint Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro
    Silke Nolkemper
    Institute of Pharmacy and Molecular Biotechnology, Department of Biology, University of Heidelberg, Heidelberg, Germany
    Planta Med 72:1378-82. 2006
    ..Therefore, the extracts exert their antiviral effect on free HSV and offer a chance to use them for topical therapeutic application against recurrent HERPES infections...
  15. doi request reprint Melissa officinalis extract inhibits attachment of herpes simplex virus in vitro
    Akram Astani
    Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany
    Chemotherapy 58:70-7. 2012
    ..Extracts and essential oils of medicinal plants are increasingly of interest as novel drugs for antiherpetic agents, since the herpes simplex virus (HSV) might develop resistance to commonly used antiviral drugs...
  16. pmc Cytokine expression during early and late phase of acute Puumala hantavirus infection
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    BMC Immunol 12:65. 2011
    ..An immune-mediated pathogenesis is discussed for both syndromes. The aim of our study was to investigate cytokine expression during the course of acute Puumala hantavirus infection...
  17. doi request reprint Hepatitis B virus infection is associated with deletion of chromosome 8p in multiple myeloma
    Nikolaus Becker
    Clinical Cancer Registry, National Center of Tumor Diseases and German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany
    Eur J Haematol 90:279-85. 2013
    ..36-5.50, P = 0.0048) and for loss of 13q14 non-significantly increased (OR = 1.40, 95% CL = 0.74-2.65) in anti-HBc positive patients. The results provide further support for a role of HBV infection in the pathogenesis of MM...
  18. doi request reprint Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 88:1109-16. 2009
    ..BKV-associated nephropathy develops in approximately 5% to 8% of renal transplant recipients, and its prognosis is poor. The relationship between urine cytokines and BK viruria in kidney recipients has not been defined...
  19. doi request reprint Comparative study on the antiviral activity of selected monoterpenes derived from essential oils
    Akram Astani
    Department of Virology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
    Phytother Res 24:673-9. 2010
    ..However, mixtures of different monoterpenes present in natural tea tree essential oil revealed a ten-fold higher selectivity index and a lower toxicity than its isolated single monoterpenes...
  20. doi request reprint Essential oils of aromatic plants with antibacterial, antifungal, antiviral, and cytotoxic properties--an overview
    Jürgen Reichling
    Institute of Pharmacy and Molecular Biotechnology, Department of Biology, University of Heidelberg, Im Neuenheimer Feld 364, Heidelberg, Germany
    Forsch Komplementmed 16:79-90. 2009
    ..The progress of this expanding scientific field will be documented by the most important results published in the last decade...
  21. doi request reprint (Val-)Ganciclovir prophylaxis reduces Epstein-Barr virus primary infection in pediatric renal transplantation
    Britta Höcker
    University Children s Hospital, Heidelberg, Germany
    Transpl Int 25:723-31. 2012
    ..Chemoprophylaxis with VGCV/GCV is associated with a reduced incidence of EBV viremia in high-risk pediatric kidney allograft recipients in the first year post-transplant. (ClinicalTrials.gov number: NCT00963248)...
  22. pmc Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patients
    Sylvia Brost
    Department of Gastroenterology and Infectious Diseases, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    World J Gastroenterol 16:5447-51. 2010
    ..To study the efficacy and safety of entecavir (ETV) as first-line therapy for hepatitis B virus (HBV) reactivation due to immunosuppression...
  23. doi request reprint Viral infections in septic shock (VISS-trial)-crosslinks between inflammation and immunosuppression
    Thorsten Brenner
    Department of Anaesthesiology, University of Heidelberg, Heidelberg, Germany
    J Surg Res 176:571-82. 2012
    ..However, at this time, it remains unclear whether these viral infections are of real pathogenetic relevance or represent innocent bystanders...
  24. doi request reprint Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejection
    Imad Lahdou
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 71:1067-72. 2010
    ..Although informative in overall terms, at the present stage, Kyn levels do not allow the concise risk differentiation of individual patients...
  25. pmc Changes in severity of influenza A(H1N1)pdm09 infection from pandemic to first postpandemic season, Germany
    Nicola Lehners
    University of Heidelberg, Heidelberg, Germany
    Emerg Infect Dis 19:748-55. 2013
    ..In summary, the proportion of patients with severe disease and fatal cases increased in the postpandemic season. Therefore, patients with suspected infections should be promptly identified and receive early treatment...
  26. pmc Effects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg
    Drug Des Devel Ther 6:289-95. 2012
    ..This study (June 2003-January 2010) retrospectively assessed the effects of oral valganciclovir prophylaxis in adult heart transplant recipients during the first year after transplantation...
  27. ncbi request reprint Delayed detection of cytomegalovirus-specific T-helper cells in a preterm infant following intrauterine exposure to tacrolimus
    Maximilian Von Au
    Department of Infectious Diseases, Virology, University of Heidelberg, Germany
    Clin Lab 58:811-5. 2012
    ..Thus, exposure to tacrolimus in utero caused a transitional T-cell activation defect which did not compromise viral clearance...
  28. doi request reprint Herpes simplex virus encephalitis despite normal cell count in the cerebrospinal fluid
    Nurith J Jakob
    Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany
    Crit Care Med 40:1304-8. 2012
    ..To describe herpes simplex virus encephalitis despite normal cell count in the cerebrospinal fluid in patients with malignoma after whole brain irradiation...
  29. doi request reprint Pharmacodynamic disparities in tacrolimus-treated patients developing cytomegalus virus viremia
    Claudia Sommerer
    Department of Nephrology, University Hospital, Heidelberg, Germany
    Ther Drug Monit 33:373-9. 2011
    ..The quantification of nuclear factor of activated T cell (NFAT)-regulated gene expression may provide a tool to monitor the individual susceptibility to Tac...
  30. doi request reprint Epstein-Barr virus load in whole blood is associated with immunosuppression, but not with post-transplant lymphoproliferative disease in stable adult heart transplant patients
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 21:963-71. 2008
    ..EBV DNA viral load determination does not appear to be useful for risk prediction or early diagnosis of PTLD in adults after HTX, but an association of EBV DNA load with qualitative and quantitative immunosuppression is demonstrated...
  31. pmc Varicella-like cutaneous toxoplasmosis in a patient with aplastic anemia
    Stefan Zimmermann
    Department of Infectious Diseases, University of Heidelberg, Heidelberg, Germany
    J Clin Microbiol 51:1341-4. 2013
    ..Cutaneous toxoplasmosis is a rare finding in immunocompromised patients and might mimic other infectious diseases, and vesicular lesions associated with toxoplasmosis have not been reported previously...
  32. pmc Molecular characterization of a respiratory syncytial virus outbreak in a hematology unit in Heidelberg, Germany
    Steffen Geis
    Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany
    J Clin Microbiol 51:155-62. 2013
    ..Prolonged viral shedding may have contributed to nosocomial transmission and should be taken into account in the infection control management of RSV outbreaks in settings with heavily immunosuppressed patients...
  33. pmc Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B
    Katharina Esser-Nobis
    Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany
    Hepatology 57:953-63. 2013
    ..This novel mode of action renders SIL an attractive candidate for combination therapies with other directly acting antiviral drugs, particularly in difficult-to-treat patient cohorts...
  34. doi request reprint Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph
    Nikolaus Becker
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    J Cancer Res Clin Oncol 138:1993-2001. 2012
    ....
  35. doi request reprint Dysregulated cytokine responses during cytomegalovirus infection in renal transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 86:275-85. 2008
    ..The aim of this study was to examine whether there are differences in plasma cytokine levels pretransplant, before and during CMV replication in renal transplant recipients...
  36. doi request reprint Adenovirus infection and treatment with cidofovir in children after liver transplantation
    Guido Engelmann
    Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    Pediatr Transplant 13:421-8. 2009
    ..Immunosuppression was reduced in this patient immediately and the antiviral drug cidofovir administered intravenously followed by viral suppression and clinical improvement of the child...
  37. pmc Screening for antiviral activities of isolated compounds from essential oils
    Akram Astani
    Department of Infectious Diseases, Virology, University of Heidelberg, 69120 Heidelberg, Germany
    Evid Based Complement Alternat Med 2011:253643. 2011
    ..These results indicate that phenylpropanoids and sesquiterpenes present in essential oils contribute to their antiviral activity against HSV...
  38. doi request reprint Immunogenicity and safety of H1N1 vaccination in anorexia nervosa--results from a pilot study
    Arne Zastrow
    Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Int J Eat Disord 45:146-9. 2012
    ..Currently, no recommendation can be given on the safety and immunogenicity of indicated vaccinations in this malnourished population...
  39. doi request reprint Immunogenicity and efficacy in hemodialysis patients of an AS03(A)-adjuvanted vaccine for 2009 pandemic influenza A(H1N1): a nonrandomized trial
    Ralf Dikow
    Department of Nephrology, University Hospital of Heidelberg, Heidelberg, Germany
    Am J Kidney Dis 57:716-23. 2011
    ..To increase the immunogenicity of vaccines, antigens can be formulated with adjuvants. The new tocopherol-containing adjuvant system AS03(A) has not been tested yet in patients with end-stage renal disease...
  40. doi request reprint Mutations in the BC-loop of the BKV VP1 region do not influence viral load in renal transplant patients
    Ellen Krautkrämer
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Med Virol 81:75-81. 2009
    ..These in vivo results demonstrate that high replication rates which serve as a predictive marker for BKVAN are not caused by altered receptor binding or affinity via mutated BC-loops...
  41. doi request reprint Sudden death of an immunocompetent young adult caused by novel (swine origin) influenza A/H1N1-associated myocarditis
    Georg Gdynia
    Institute of Pathology, University Hospital, Im Neuenheimer Feld 220 221, 69120, Heidelberg, Germany
    Virchows Arch 458:371-6. 2011
    ..In conclusion, sudden death by myocarditis may be a rare complication of novel influenza A/H1N1 infection in otherwise healthy individuals, even in the absence of significant respiratory tract infection...
  42. doi request reprint Combination of native and recombinant cytomegalovirus antigens in a new ELISA for detection of CMV-specific antibodies
    Clemens Busse
    Applied Tumor Virology, German Cancer Research Center, University of Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Clin Virol 43:137-41. 2008
    ..Serological detection of cytomegalovirus (CMV)-specific antibodies varies greatly due to antigen composition and the lack of antigen standardization...
  43. doi request reprint An update on swine-origin influenza virus A/H1N1: a review
    Sebastian U Schnitzler
    Department of Virology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
    Virus Genes 39:279-92. 2009
    ..This review summarizes the current information on the new pandemic swine-origin influenza virus A/H1N1...
  44. ncbi request reprint An outbreak of epidemic keratoconjunctivtis in a pediatric unit due to adenovirus type 8
    Iris E Chaberny
    Department of Medical Microbiology and Hygiene, Institute of Hygiene, University of Heidelberg, Germany
    Infect Control Hosp Epidemiol 24:514-9. 2003
    ..To investigate and control an outbreak of epidemic keratoconjunctivitis (EKC) occurring in a neonatal intensive care unit (NICU) and to determine signs specific for EKC in newborns...
  45. doi request reprint Prevalence of hepatitis B virus infection among women at reproductive age at a German university hospital
    Britta Knorr
    Department of Hygiene and Medical Microbiology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
    J Clin Virol 42:422-4. 2008
    ..Mother to infant transmission of hepatitis B virus (HBV) represents a major factor in maintaining chronic infection and depends on the degree of maternal infectivity status...
  46. pmc Fatal circumstances of human herpesvirus 6 infection: transcriptosome data analysis suggests caution in implicating HHV-6 in the cause of death
    Consolato Sergi
    Institute of Pathology, Medical University of Innsbruck, Austria
    J Clin Pathol 60:1173-7. 2007