Affiliation: University of Cologne
Albanna W, Lüke J, Schubert G, Dibué Adjei M, Kotliar K, Hescheler J, et al
. Modulation of Cav2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity. Mol Cell Neurosci. 2019;96:35-46 pubmed publisher
..3 channels at clinically relevant U/A molar ratios and indicate that supersaturation of albumin is not required for modulation but associated with a loss of channel functional that could contribute to chronic neuronal dysfunction. ..
Neumaier F, DibuÃ© Adjei M, Hescheler J, Schneider T. Voltage-gated calcium channels: Determinants of channel function and modulation by inorganic cations. Prog Neurobiol. 2015;129:1-36 pubmed publisher
..The fact that these ions can often traverse VGCCs can contribute to the detrimental intracellular accumulation of metal ions following excessive release of endogenous Cu(2+) and Zn(2+) or exposure to non-physiological toxic metal ions. ..
Schneider T, Dibué Adjei M, Neumaier F, Akhtar I, Hescheler J, Kamp M, et al
. R-Type Voltage-Gated CaÂ²âº Channels in Cardiac and Neuronal Rhythmogenesis. Curr Mol Pharmacol. 2015;8:102-8 pubmed
Siapich S, Akhtar I, Hescheler J, Schneider T, LÃ¼ke M. Low concentrations of ethanol but not of dimethyl sulfoxide (DMSO) impair reciprocal retinal signal transduction. Graefes Arch Clin Exp Ophthalmol. 2015;253:1713-9 pubmed publisher
..Ethanol itself but not DMSO may block GABA receptors and cause an amplitude increase by itself, so that reciprocal signaling is impaired. ..
Drobinskaya I, Neumaier F, Pereverzev A, Hescheler J, Schneider T. Diethyldithiocarbamate-mediated zinc ion chelation reveals role of Cav2.3 channels in glucagon secretion. Biochim Biophys Acta. 2015;1853:953-64 pubmed publisher
..Especially under conditions of Zn2+ deficiency, ablation or dysfunction of Cav2.3 channels may lead to severe disturbances in glucose homeostasis. ..
Tevoufouet E, Nembo E, Distler F, Neumaier F, Hescheler J, Nguemo F, et al
. Multiple nickel-sensitive targets elicit cardiac arrhythmia in isolated mouse hearts after pituitary adenylate cyclase-activating polypeptide-mediated chronotropy. Pharmacol Res. 2017;117:140-147 pubmed publisher