Research Topics
Genomes and Genes
| Paul M SchneiderSummaryAffiliation: University of Cologne Country: Germany Publications
| Collaborators
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Detail Information
Publications
A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagusJan Brabender
Department of Visceral and Vascular Surgery, University of Cologne, 50931 Germany
Oncogene 23:4780-8. 2004..Expression analysis of a limited number of highly selected genes may have clinical usefulness for the treatment of patients with this disease...
Histomorphologic tumor regression and lymph node metastases determine prognosis following neoadjuvant radiochemotherapy for esophageal cancer: implications for response classificationPaul M Schneider
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Ann Surg 242:684-92. 2005..We sought to quantitatively and objectively evaluate histomorphologic tumor regression and establish a relevant prognostic regression classification system for esophageal cancer patients receiving neoadjuvant radiochemotherapy...
ERCC1 RNA expression in peripheral blood predicts minor histopathological response to neoadjuvant radio-chemotherapy in patients with locally advanced cancer of the esophagusJan Brabender
Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50931, Cologne, Germany
J Gastrointest Surg 12:1815-21. 2008....- High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancerHuan Xi
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Clin Cancer Res 11:8341-7. 2005..01). CONCLUSION: High COX-2 protein expression following neoadjuvant radiochemotherapy in resection specimens is significantly associated with minor histopathologic response to neoadjuvant therapy and very poor prognosis... - Reduced incidence of nodal micrometastasis after major response to neoadjuvant chemoradiation in locally advanced esophageal cancerKlaus L Prenzel
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Ann Surg Oncol 14:954-9. 2007..The influence on nodal micrometastasis has not yet been evaluated... - Failure in downregulation of intratumoral survivin expression following neoadjuvant chemoradiation in esophageal cancerDaniel Vallbohmer
Department of Visceral and Vascular Surgery, University of Cologne, Kerpenerstrasse 62, 50937 Cologne, Germany
Pharmacogenomics 9:681-90. 2008..We aimed to examine the association of survivin protein expression, an inhibitor of apoptosis, with histopathologic response to neoadjuvant chemoradiation and prognosis in patients with esophageal cancer... - Skip metastasis in nonsmall cell lung carcinoma: predictive markers and isolated tumor cells in N1 lymph nodesKlaus L Prenzel
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Cancer 100:1909-17. 2004..In patients with pN2 skip metastases, micrometastases to N1 lymph nodes, which only mimic skip metastases, have not been investigated... - Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancerUte Warnecke-Eberz
Department of Visceral and Vascular Surgery, University of Cologne, Joseph-Stelzmann-Strasse 9, 50931 Cologne, Germany
Oncol Rep 13:1241-6. 2005..However, overexpression of survivin mRNA in pretreatment biopsies (T/N ratio >1) was associated with superior survival probabilities... - Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancerPeter P Grimminger
Department of General, Visceral and Cancer Surgery, University of Cologne, Germany
Clin Lung Cancer 11:114-9. 2010..Hence, the aim of this study was to explore the potential role of ODC mRNA expression as a prognostic biomarker in patients with curatively resected NSCLC... - Quantitative analysis of survivin RNA expression in blood as a non-invasive predictor of response to neoadjuvant radiochemotherapy in esophageal cancerPeter Grimminger
Department of General, Visceral, and Tumor Surgery, University of Cologne, 50931Cologne, Germany
J Surg Oncol 100:447-51. 2009..Analysis of survivin RNA expression in peripheral blood as a non-invasive molecular predictor of response to neoadjuvant radiochemotherapy in patients with locally advanced cancer of the esophagus... - Response evaluation by endoscopy, rebiopsy, and endoscopic ultrasound does not accurately predict histopathologic regression after neoadjuvant chemoradiation for esophageal cancerPaul M Schneider
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Ann Surg 248:902-8. 2008.... - Roles of thymidylate synthase and dihydropyrimidine dehydrogenase expression in blood as predictors of response to multimodal therapy in esophageal cancerJan Brabender
Department of General, Visceral and Tumor Surgery, University of Cologne, Cologne, Germany
Surgery 151:306-12. 2012.... - Death-associated protein kinase (DAPK) promoter methylation and response to neoadjuvant radiochemotherapy in esophageal cancerJan Brabender
Department of General, Visceral and Tumor Surgery, University of Cologne, Cologne, Germany
Ann Surg Oncol 16:1378-83. 2009.... - Staging of esophageal carcinoma: length of tumor and number of involved regional lymph nodes. Are these independent prognostic factors?Elfriede Bollschweiler
Department of Visceral and Vascular Surgery, University of Cologne, Germany
J Surg Oncol 94:355-63. 2006..The aim of this study was to analyze the prognostic relevance of tumor length as well as number of involved regional lymph nodes (LNM) in patients with esophageal carcinoma... - Dihydropyrimidine dehydrogenase mRNA expression in peripheral blood of rectal cancer patients is significantly associated with residual tumor and distant metastases following resectionAndreas Claudius Hoffmann
Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany
J Surg Oncol 99:296-301. 2009..Little is known about mRNA expression levels of TS and DPD in peripheral blood. The goals of this study were to test the feasibility of DPD and TS detection in blood and their associations to TNM staging and complete surgical resection... - Significant down-regulation of the plasminogen activator inhibitor 1 mRNA in pancreatic cancerUte Warnecke-Eberz
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Pancreas 36:173-7. 2008..Expression profiles were compared with paired uninvolved normal tissues to define a possible differential role of these genes in tumorigenesis of both tumor types... - β-catenin and Her2/neu expression in rectal cancer: association with histomorphological response to neoadjuvant therapy and prognosisUta Drebber
Institute of Pathology, University Hospital Cologne, Kerpener Str 62, 50937, Cologne, Germany
Int J Colorectal Dis 26:1127-34. 2011..We examined the association of β-catenin and Her2/neu protein expression with histopathologic response to neoadjuvant radiochemotherapy and prognosis in patients with locally advanced rectal cancer... - Expression of {beta}-catenin, MUC1 and c-met in diffuse-type gastric carcinomas: correlations with tumour progression and prognosisMonika F Retterspitz
Institute of Pathology, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Anticancer Res 30:4635-41. 2010..On the other hand, c-met expression did not exhibit any prognostic value in this study... - Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of VaterKlaus L Prenzel
Department of Visceral and Vascular Surgery, University of Cologne, 50931 Cologne, Germany
Oncol Rep 15:1397-401. 2006..In conclusion, SPARC mRNA overexpression is significantly more frequent in CP than CPV and adds further evidence that CP and CPV are biologically different tumor entities... - The role of the homeobox genes BFT and CDX2 in the pathogenesis of non-small cell lung cancerPeter Grimminger
Department of General, Visceral and Tumor Surgery, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
Anticancer Res 29:1281-6. 2009..The goal of this study was to investigate the mRNA expression of BFT and CDX2 in NSCLC and to determine the association with the pathogenesis and the potential as a biomarker of this disease... - COX-2 mRNA expression is significantly increased in acid-exposed compared to nonexposed squamous epithelium in gastroesophageal reflux diseaseGeorg Lurje
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
J Gastrointest Surg 11:1105-11. 2007..The objectives of this study were to further analyze COX-2 mRNA expression in patients with GERD compared to Barrett's esophagus (BE) and Barrett's cancer (BC)... - Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of VaterKlaus L Prenzel
Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
World J Gastroenterol 12:437-42. 2006.... - Down-regulation of Gadd45 expression is associated with tumor differentiation in non-small cell lung cancerHiroshi Higashi
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Anticancer Res 26:2143-7. 2006..The purpose of this study was to determine the gene expression patterns and clinical relevance of Gadd45 in tumor specimens of non-small cell lung cancer (NSCLC) patients... - Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosisJan Brabender
Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
Carcinogenesis 26:525-30. 2005..Quantitation of RAR and RXR mRNA expression levels in tumor tissue is a candidate prognostic marker and surrogate biomarker for chemopreventive trials in NSCLC... - High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancerUte Warnecke-Eberz
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Clin Cancer Res 10:3794-9. 2004.... - Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancerPeter P Grimminger
Department of General, Visceral and Tumor Surgery, University of Cologne, Germany
Clin Lung Cancer 11:328-34. 2010..The aim of this study was to investigate the mRNA expression of TS, TP, and DPD in tumor and nontumor lung tissue of patients with NSCLC and to determine the potential of these genes as molecular biomarkers... - The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinomaJan Brabender
Department of Visceral and Vascular Surgery, University of Cologne, Germany
Cancer Epidemiol Biomarkers Prev 14:2113-7. 2005.... - Leukocyte depletion in allogeneic blood transfusion does not change the negative influence on survival following transthoracic resection for esophageal cancerFrederike C Ling
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
J Gastrointest Surg 13:581-6. 2009..This study evaluates the association between receipt of leucocyte-depleted and non-depleted allogeneic blood and survival following esophagectomy for cancer... - HIF-1alpha mRNA is not associated with histopathological regression following neoadjuvant chemoradiation in esophageal cancerFrederike C Ling
Department of Visceral and Vascular Surgery, University of Cologne, 50931 Cologne, Germany
Anticancer Res 26:4505-9. 2006..CONCLUSION: HIF-1alpha mRNA expression is differentially upregulated in esophageal squamous cell carcinoma compared to adenocarcinomas, but does not predict tumor regression or prognosis... - Evaluation of quality indicators following implementation of total mesorectal excision in primarily resected rectal cancer changed future managementPaul M Schneider
Department of General, Visceral and Tumor Surgery, University of Cologne, Cologne, Germany
Int J Colorectal Dis 26:903-9. 2011..We evaluated the outcome of primarily resected rectal cancer patients immediately after the implementation of total meserectal excision (TME) based on potential quality indicators... - Role of retinoid X receptor mRNA expression in Barrett's esophagusJan Brabender
Department of Visceral and Vascular Surgery, University of Cologne, Cologne
J Gastrointest Surg 8:413-22. 2004.... - Clinical significance of nm23 gene expression in gastric cancerStefan P Monig
Department of Visceral and Vascular Surgery, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
Anticancer Res 27:3029-33. 2007..The expression of the putative metastasis-suppressor gene nm23 in gastric carcinoma is controversial. The aim of this study was the analysis of nm23 expression in a large series of gastric cancer patients... - Increased platelet counts after transthoracic en bloc resection for esophageal cancer is associated with significantly improved survivalFrederike C Ling
Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpener Straße 62, Cologne, 50937, Germany
World J Surg 34:2628-34. 2010..Recent data described preoperative thrombocytosis in malignancies to be associated with poor prognosis... - Lymph node size and metastatic infiltration in non-small cell lung cancerKlaus L Prenzel
Department of Visceral and Vascular Surgery, University of Cologne, Germany
Chest 123:463-7. 2003..Lymph nodes > 1 cm in size are regarded as metastatic nodes. The surgical approach and potential application of neoadjuvant therapy regimens are dependent on this evaluation... - Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinomaStephan E Baldus
Institute of Pathology and Center of Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
Ann Surg Oncol 9:887-93. 2002..MUC5AC represents a mucin peptide core expressed in normal gastric epithelia. Its presence in gastric carcinomas was previously described as a characteristic of gastric differentiation... - Laparoscopic ischemic conditioning of the stomach for esophageal replacementArnulf H Holscher
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Ann Surg 245:241-6. 2007..Therefore, this study was designed to improve gastric perfusion by laparoscopic ischemic conditioning of the stomach... - Localization of isolated lymph node metastases in esophageal cancer--does it influence the sentinel node concept?Wolfgang Schroder
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Hepatogastroenterology 54:1116-20. 2007..This study analyses the localization of single lymph node metastases in esophageal cancer and discusses the possible theoretical impact on SNL navigation... - Lymph node revealing solution in gastric carcinoma does not provide upstaging of the N-statusThomas Luebke
Department of Visceral and Vascular Surgery, University of Cologne, Joseph-Stelzmann Strasse 9, 50931 Cologne, Germany
Oncol Rep 13:361-5. 2005..Immunohistochemical techniques aid in identifying micrometastatic disease in lymph nodes missed in routine H&E staining in order to define the pN(i) status according to the TNM classification... - MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosisStephan E Baldus
Institute of Pathology, University of Cologne, Cologne, Germany
Clin Cancer Res 10:2790-6. 2004..We tried to elucidate the coexpression of both molecules in colorectal cancer to demonstrate possible correlations with clinical, pathological, and prognostic data... - Role of skip metastasis to mediastinal lymph nodes in non-small cell lung cancerKlaus L Prenzel
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
J Surg Oncol 82:256-60. 2003..It is still under discussion whether any prognostic differences exist between resected NSCLC with either skip metastases or continuous mediastinal lymph node metastases (N2)... - Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung CancerPeter P Grimminger
Department of General, Visceral and Tumor Surgery, University of Cologne, 50931 Cologne, Germany
J Oncol 2009:139590. 2009..The results suggest COX-2 926G>C SNP as a molecular marker for lymph node involvement in this disease... - p16, cyclin D1 and Rb expression in colorectal carcinomas: Correlations with clinico-pathological parameters and prognosisCaroline A S Von Stockmar-Von Wangenheim
Institute of Pathology, University of Cologne, Cologne, Germany
Mol Med Report 1:27-32. 2008..Further correlations with gender, growth pattern, staging, grading or prognosis were not revealed. The three cell cycle regulators do not represent useful markers of prognosis or predictors of colorectal carcinoma... - Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLCPeter P Grimminger
Department of General, Visceral and Cancer Surgery, University of Cologne, Germany
Lung Cancer 78:87-91. 2012..The aim of this study was to investigate the relevance of mRNA expression and DNA methylation of GST-PI in tumor and non-tumor lung tissue from NSCLC patients in terms of prognostic and pathogenetic value of this biomarker... - Topographical distribution of lymph node metastasis in adenocarcinoma of the gastroesophageal junctionStefan P Monig
Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
Hepatogastroenterology 49:419-22. 2002..The current discussion concerning the extent of resection in patients with adenocarcinoma of the gastroesophageal junction is focused beside the luminal extent of resection primarily on the value of lymphadenectomy... - PCR-screening of human esophageal and bronchial cancers reveals absence of adenoviral DNA sequencesYlva Mende
Institute of Genetics, University of Cologne, Weyertal 121, , Germany
Virus Res 104:81-5. 2004.... - Mutations in the mitochondrial DNA D-Loop region occur frequently in adenocarcinoma in Barrett's esophagusFutoshi Miyazono
Department of Visceral and Vascular Surgery, University of Cologne, Joseph-Stelzmann-Strasse 9, 50931 Cologne, Germany
Oncogene 21:3780-3. 2002..Since mutations were identified in tumor-associated dysplastic Barrett's epithelium, they also might become a marker for the malignant potential of Barrett's epithelium... - TaqMan low-density arrays and analysis by artificial neuronal networks predict response to neoadjuvant chemoradiation in esophageal cancerUte Warnecke-Eberz
Center for Integrated Oncology CIO, University Hospital of Cologne, Kerpener Strasse 62, 50937 Koln, Germany
Pharmacogenomics 11:55-64. 2010..A total of 17 genes were selected to predict histopathologic tumor response to chemoradiation (cisplatin, 5-fluorouracil, 36 Gy)... - Increased human telomerase reverse transcriptase (hTERT) mRNA expression but not telomerase activity is related to survival in curatively resected non-small cell lung cancerRalf Metzger
Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Joseph Stelzmann Strasse 9, D 50931 Cologne, Germany
Anticancer Res 29:1157-62. 2009..The purpose of this study was to evaluate the significance of human telomerase reverse transcriptase (hTERT) mRNA expression and telomerase activity as prognostic markers in non-small cell lung cancer (NSCLC)... - Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcomeJan Brabender
Department of Visceral and Vascular Surgery, University of Cologne, Cologne 50931, Germany
Clin Cancer Res 9:223-7. 2003..The purpose of this study was to determine the frequency and clinical relevance of MGMT gene promoter hypermethylation in curatively resected non-small cell lung cancer (NSCLC)... - Long-term results and gastroesophageal reflux in a series of laparoscopic adjustable gastric bandingChristian A Gutschow
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
J Gastrointest Surg 9:941-8. 2005..However, the reoperation rate is high and postoperative symptoms are frequent. The high incidence of gastroesophageal reflux and esophagitis remains a matter of concern... - Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancerSylke Schneider
Department of Molecular Biology and Biochemistry and Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
J Am Coll Surg 200:336-44. 2005..01). CONCLUSIONS: The expression levels of a set of genes that are possible determinants of 5-FU/cisplatin/radiation therapy antitumor activity are significantly downregulated by neoadjuvant radiochemotherapy in esophageal cancer... - Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinomaReginald V N Lord
Department of Surgery, University of Southern California Keck School of Medicine Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Surgery 138:924-31. 2005..This study was undertaken to investigate the expression pattern of these critical morphogenesis genes in the Barrett's multistage carcinogenesis model... - Glutathione S-transferase-pi expression is downregulated in patients with Barrett's esophagus and esophageal adenocarcinomaJan Brabender
Department of Biochemistry, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
J Gastrointest Surg 6:359-67. 2002..Loss of GSTPI expression may have an important role in the development and progression of this disease... - Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancerJan Brabender
Department of Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
Ann Surg 235:440-3. 2002..To investigate cyclooxygenase-2 (COX-2) mRNA expression in curatively resected non-small cell lung cancer (NSCLC) and to determine its association with prognosis... - The role of chemotherapy in patients with established gastric cancerAnna D Wagner
First Department of Medicine, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, Halle Saale, Germany
Best Pract Res Clin Gastroenterol 20:789-99. 2006..Neo-adjuvant chemotherapy has the ability to downsize gastric tumours and appears to improve R0-resection rates, but its potential to improve overall survival is still unclear... - The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancerJan Brabender
Department of Molecular Biology and Biochemistry, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Clin Cancer Res 8:438-43. 2002..We hypothesized that suppressed RXR expression might be a prognostic factor of worse clinical outcome in patients with NSCLC... - Methylenetetrahydrofolate reductase C677T polymorphism and risk of adenocarcinoma of the upper gastrointestinal tractMario Sarbia
Institute of Pathology, Technical University, Munich, Germany
Scand J Gastroenterol 40:109-11. 2005 - Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancerCarsten Muller-Tidow
Department of Medicine, Hematology Oncology, University of Munster, Germany
Cancer Res 65:1778-82. 2005..The identified RTKs represent promising novel candidates for further functional analyses... - Sex differences in the predictive power of the molecular prognostic factor HER2/neu in patients with non-small-cell lung cancerDaniel Vallbohmer
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
Clin Lung Cancer 7:332-7. 2006..Whereas considerable evidence indicates sex differences in epidemiologic, hormonal, biologic, and genetic factors in this disease, it has remained unknown whether HER2/neu has a diverse function as a prognostic factor in men and women... - Osteopontin but not osteonectin messenger RNA expression is a prognostic marker in curatively resected non-small cell lung cancerSylke Schneider
Department of Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Clin Cancer Res 10:1588-96. 2004.... - MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancerPing Ji
Department of Medicine, University of Munster, Germany
Oncogene 22:8031-41. 2003..Taken together, these data contribute to the identification of early-stage NSCLC patients that are at high risk to develop metastasis. The identification of MALAT-1 emphasizes the potential role of noncoding RNAs in human cancer...