M L Schmitz

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. Weber A, Dam S, Saul V, Kuznetsova I, Müller C, Fritz Wolf K, et al. Phosphoproteome analysis of cells infected with adapted and non-adapted influenza A virus reveals novel pro- and antiviral signaling networks. J Virol. 2019;: pubmed publisher
    ..Our global characterization of IAV-triggered patterns of phospho-proteins provides a rich resource to further understand host responses to infection at the level of phosphorylation-dependent signaling networks. ..
  2. López M, Soriano Sarabia N, Bruges G, Marquez M, Preissner K, Schmitz M, et al. Expression pattern of protease activated receptors in lymphoid cells. Cell Immunol. 2014;288:47-52 pubmed publisher
    ..Analyses of the cell surface PARs expression by flow cytometry were consistent with the mRNA data and also between different donors. PAR₁ is the most abundant member of the PAR family present in lymphocytes. ..
  3. Ritter O, Schmitz M. Differential intracellular localization and dynamic nucleocytoplasmic shuttling of homeodomain-interacting protein kinase family members. Biochim Biophys Acta Mol Cell Res. 2019;: pubmed publisher
  4. Seibert M, Kruger M, Watson N, Sen O, Daum J, Slotman J, et al. CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol. 2019;218:1164-1181 pubmed publisher
    ..As H2B S6ph is important for faithful chromosome separation, this modification may contribute to the prevention chromosomal instability and aneuploidy which frequently occur in cancer cells. ..
  5. Schmitz M, Kracht M, Saul V. The intricate interplay between RNA viruses and NF-κB. Biochim Biophys Acta. 2014;1843:2754-2764 pubmed publisher
    ..We will discuss at the examples of influenza and HTLV-1 viruses how a fascinating diversity of biochemical mechanisms is employed by viral proteins to control the NF-κB pathway at all levels. ..
  6. Schmitz M, Shaban M, Albert B, Gökçen A, Kracht M. The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-?B: Complex Mechanisms Relevant for Cancer, Inflammation and Infection. Biomedicines. 2018;6: pubmed publisher
    ..This crosstalk provides ample opportunities to fine-tune cellular stress responses and could also be exploited therapeutically in the future. ..
  7. Riedlinger T, Haas J, Busch J, van De Sluis B, Kracht M, Schmitz M. The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice. Biomedicines. 2018;6: pubmed publisher
    ..As NF-κB's central role in human physiology prohibits its global inhibition, these auxiliary or cell type-specific NF-κB regulating pathways are potential therapeutic targets. ..
  8. Rodriguez Gil A, Riedlinger T, Ritter O, Saul V, Schmitz M. Formaldehyde-assisted Isolation of Regulatory Elements to Measure Chromatin Accessibility in Mammalian Cells. J Vis Exp. 2018;: pubmed publisher
    ..The regions with a looser chromatin structure are enriched in the free DNA sample, thus allowing the identification of genomic regions with lower chromatin compaction. ..
  9. Rodriguez Gil A, Ritter O, Hornung J, Stekman H, Kruger M, Braun T, et al. HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell. 2016;27:1969-80 pubmed publisher
    ..HIPKs are well known regulators of transcription, but the mutual regulation between CCR4-NOT and HIPKs extends the regulatory potential of these kinases by enabling posttranscriptional gene regulation. ..

More Information

Publications14

  1. request reprint
    Hagenbucher J, Stekman H, Rodriguez Gil A, Kracht M, Schmitz M. Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases. Methods Mol Biol. 2017;1510:297-312 pubmed
    ..The impact of SIAH expression on the relative amounts of target proteins and their mRNAs can be quantified by Western blotting and quantitative PCR (qPCR) as described here. ..
  2. request reprint
    Schmitz M, Krappmann D. Controlling NF-kappaB activation in T cells by costimulatory receptors. Cell Death Differ. 2006;13:834-42 pubmed
    ..Recent studies indicate that coreceptor pathways influence the threshold activities of many signalling mediators and thus act on multiple layers of the NF-kappaB pathway. ..
  3. Saul V, Niedenthal R, Pich A, Weber F, Schmitz M. SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity. Biochim Biophys Acta. 2015;1853:136-43 pubmed publisher
    ..SUMO modification at K694 contributes to the antiviral function of TBK1 and accordingly the viral protein Gam1 antagonizes this posttranslational modification. ..
  4. Dam S, Kracht M, Pleschka S, Schmitz M. The Influenza A Virus Genotype Determines the Antiviral Function of NF-?B. J Virol. 2016;90:7980-90 pubmed publisher
    ..Second, we found that perturbation of NF-?B function greatly improved the growth of a nonadapted IAV, suggesting that NF-?B may contribute to the maintenance of the host species barrier. ..
  5. Rodriguez Gil A, Ritter O, Saul V, Wilhelm J, Yang C, Grosschedl R, et al. The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Sci Rep. 2017;7:3547 pubmed publisher
    ..These results expand the known repertoire of CCR4-NOT members for immune regulation and identify CNOT proteins as a novel group of corepressors restricting class II expression. ..