G Schmitz

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint E-LDL and Ox-LDL differentially regulate ceramide and cholesterol raft microdomains in human Macrophages
    Margot Grandl
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042 Regensburg, Germany
    Cytometry A 69:189-91. 2006
  2. ncbi request reprint Drug evaluation: OGX-011, a clusterin-inhibiting antisense oligonucleotide
    Gerd Schmitz
    University of Regensburg, Institute of Clinical Chemistry and Laboratory Medicine, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Curr Opin Mol Ther 8:547-54. 2006
  3. pmc Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090, Osnabruck, Germany
    Nutr J 12:103. 2013
  4. pmc ATP-binding cassette transporters in immortalised human brain microvascular endothelial cells in normal and hypoxic conditions
    Christian Lindner
    Department of Neurology, University of Regensburg, Bezirksklinikum Regensburg, Regensburg, Germany
    Exp Transl Stroke Med 4:9. 2012
  5. pmc The surfactant protein C mutation A116D alters cellular processing, stress tolerance, surfactant lipid composition, and immune cell activation
    Ralf Zarbock
    Childrens Hospital of the Ludwig Maximilians University, Lindwurmstr, 4, 80337 Munich, Germany
    BMC Pulm Med 12:15. 2012
  6. pmc Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090 Osnabrück, Germany
    Nutr Metab (Lond) 8:41. 2011
  7. pmc A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling
    Markus Woischnik
    Department of Pneumology, Dr von Hauner Children s Hospital, Ludwig Maximilians University, Lindwurmstr 4, Munich 80337, Germany
    BMC Cell Biol 11:88. 2010
  8. pmc Analyzing M-CSF dependent monocyte/macrophage differentiation: expression modes and meta-modes derived from an independent component analysis
    Dominik Lutter
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, D 93042 Regensburg, Germany
    BMC Bioinformatics 9:100. 2008
  9. ncbi request reprint Pharmacogenomics: implications for laboratory medicine
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, D 93042 Regensburg, Germany
    Clin Chim Acta 308:43-53. 2001
  10. ncbi request reprint Metabolic learning in the intestine: adaptation to nutrition and luminal factors
    G Schmitz
    Institute of Clinical Chemistry, University of Regensburg, Regensburg, Germany
    Horm Metab Res 38:452-4. 2006

Collaborators

Detail Information

Publications144 found, 100 shown here

  1. ncbi request reprint E-LDL and Ox-LDL differentially regulate ceramide and cholesterol raft microdomains in human Macrophages
    Margot Grandl
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042 Regensburg, Germany
    Cytometry A 69:189-91. 2006
    ..Formation of different rafts may have consequences for raft associated signaling in cholesterol homeostasis and apoptosis in human macrophages...
  2. ncbi request reprint Drug evaluation: OGX-011, a clusterin-inhibiting antisense oligonucleotide
    Gerd Schmitz
    University of Regensburg, Institute of Clinical Chemistry and Laboratory Medicine, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Curr Opin Mol Ther 8:547-54. 2006
    ..Phase II clinical trials of OGX-011 in combination with chemotherapeutic drugs are underway in NSCLC, prostate and breast cancer...
  3. pmc Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090, Osnabruck, Germany
    Nutr J 12:103. 2013
    ....
  4. pmc ATP-binding cassette transporters in immortalised human brain microvascular endothelial cells in normal and hypoxic conditions
    Christian Lindner
    Department of Neurology, University of Regensburg, Bezirksklinikum Regensburg, Regensburg, Germany
    Exp Transl Stroke Med 4:9. 2012
    ..abstract:..
  5. pmc The surfactant protein C mutation A116D alters cellular processing, stress tolerance, surfactant lipid composition, and immune cell activation
    Ralf Zarbock
    Childrens Hospital of the Ludwig Maximilians University, Lindwurmstr, 4, 80337 Munich, Germany
    BMC Pulm Med 12:15. 2012
    ..In this study, we investigated the effects of the mutation A116D in the BRICHOS domain of SP-C on cellular homeostasis. We also evaluated the ability of drugs currently used in ILD therapy to counteract these effects...
  6. pmc Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090 Osnabrück, Germany
    Nutr Metab (Lond) 8:41. 2011
    ....
  7. pmc A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling
    Markus Woischnik
    Department of Pneumology, Dr von Hauner Children s Hospital, Ludwig Maximilians University, Lindwurmstr 4, Munich 80337, Germany
    BMC Cell Biol 11:88. 2010
    ..The most frequent SFTPC mutation in ILD patients leads to a threonine for isoleucine substitution at position 73 (I73T) of the SP-C preprotein (proSP-C), however little is known about the cellular consequences of SP-CI73T expression...
  8. pmc Analyzing M-CSF dependent monocyte/macrophage differentiation: expression modes and meta-modes derived from an independent component analysis
    Dominik Lutter
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, D 93042 Regensburg, Germany
    BMC Bioinformatics 9:100. 2008
    ..In this study, we investigate the relevance of ICA in gaining new insights into well characterized regulatory mechanisms of M-CSF dependent macrophage differentiation...
  9. ncbi request reprint Pharmacogenomics: implications for laboratory medicine
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, D 93042 Regensburg, Germany
    Clin Chim Acta 308:43-53. 2001
    ..Therefore, this review focuses on the implications of pharmacogenomics on the clinical laboratory...
  10. ncbi request reprint Metabolic learning in the intestine: adaptation to nutrition and luminal factors
    G Schmitz
    Institute of Clinical Chemistry, University of Regensburg, Regensburg, Germany
    Horm Metab Res 38:452-4. 2006
    ....
  11. ncbi request reprint Molecular defects in the ABCA1 pathway affect platelet function
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Pathophysiol Haemost Thromb 35:166-74. 2006
    ..It is concluded that the presence of ABCA1 and ABCG1 in the AP-3 pathway will have major impact for membrane phospholipid processing and HDL metabolism and their relation to disorders of lysosome-related organelles...
  12. ncbi request reprint CD14 signalling in lipid rafts: new ligands and co-receptors
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Curr Opin Lipidol 13:513-21. 2002
    ..The purpose of this review is to summarize the recent advances in our understanding of CD14-dependent receptor clustering and its relevance in atherogenesis...
  13. ncbi request reprint Lipidomic strategies to study structural and functional defects of ABC-transporters in cellular lipid trafficking
    Gerd Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93053, Germany
    FEBS Lett 580:5597-610. 2006
    ....
  14. ncbi request reprint ABC transporters and cholesterol metabolism
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042 Regensburg, Germany
    Front Biosci 6:D505-14. 2001
    ..Expression of a large number of ABC transporters in monocytes/macrophages and their regulation by cholesterol flux render these transporter molecules potentially critical players in chronic inflammatory diseases such as atherosclerosis...
  15. ncbi request reprint Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene
    W E Kaminski
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, D 93042, Germany
    Biochem Biophys Res Commun 278:782-9. 2000
    ..3...
  16. ncbi request reprint Pharmacogenomics of cholesterol-lowering therapy
    Gerd Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Straub Allee 11, 93042 Regensburg, Germany
    Vascul Pharmacol 44:75-89. 2006
    ..In the future, pharmacogenomic testing may allow risk stratification of patients to avoid serious side effects and enable clinicians to select lipid-lowering drugs with the highest efficacy resulting in the best response to therapy...
  17. ncbi request reprint Role of ABCG1 and other ABCG family members in lipid metabolism
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    J Lipid Res 42:1513-20. 2001
    ..In addition, new implications for the transcriptional control, as well as the intracellular routing and localization, of these proteins are presented...
  18. ncbi request reprint ABCA2: a candidate regulator of neural transmembrane lipid transport
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Cell Mol Life Sci 59:1285-95. 2002
    ..The unique expression profile together with available structural data suggest roles for this largest known ABC protein in neural transmembrane lipid export...
  19. ncbi request reprint ABCA1: regulation, trafficking and association with heteromeric proteins
    Gerd Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Ann Med 34:334-47. 2002
    ..Distinct prebeta-HDL ligand-specific receptor-clusters are involved that may modulate specific signaling pathways with varying outcomes related to prebeta-HDL particle composition, the cell-type and the cellular response status...
  20. ncbi request reprint Pharmacogenomics and pharmacogenetics of cholesterol-lowering therapy
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Clin Chem Lab Med 41:581-9. 2003
    ..This review summarizes current knowledge of the pharmacology and the pharmacogenomics of statin therapy...
  21. ncbi request reprint ATP-binding cassette (ABC) transporters in atherosclerosis
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, Germany
    Curr Atheroscler Rep 4:243-51. 2002
    ....
  22. ncbi request reprint ATP-binding cassette transporters in macrophages: promising drug targets for treatment of cardiovascular disease
    Gerd Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Curr Opin Investig Drugs 3:853-8. 2002
    ..Future studies clarifying the processes involved in the ABCA1 pathway at the cellular level are expected to identify new and possibly more specific pharmaceutical targets...
  23. ncbi request reprint Zinc finger protein ZNF202 structure and function in transcriptional control of HDL metabolism
    Gerd Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Curr Opin Lipidol 15:199-208. 2004
    ..Here we summarize the structure, regulation and modulation of ZNF202 function by protein interactions...
  24. ncbi request reprint Transcriptional regulatory networks in lipid metabolism control ABCA1 expression
    Gerd Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Biochim Biophys Acta 1735:1-19. 2005
    ..Thus, a highly sophisticated transcriptional network controls the balanced expression of ABCA1...
  25. ncbi request reprint High-density lipoproteins and ATP-binding cassette transporters as targets for cardiovascular drug therapy
    Gerd Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Curr Opin Investig Drugs 6:907-19. 2005
    ....
  26. ncbi request reprint Intracellular cholesterol and phospholipid trafficking: comparable mechanisms in macrophages and neuronal cells
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Neurochem Res 26:1045-68. 2001
    ....
  27. ncbi request reprint ABC transporters in cellular lipid trafficking
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Curr Opin Lipidol 11:493-501. 2000
    ....
  28. ncbi request reprint The Danubian Biobank project
    Gerd Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Stud Health Technol Inform 134:143-59. 2008
    ..In addition to local centers three regional DNA, plasma, and tissue banks in Regensburg, Vienna, and Budapest store samples and encrypted patient data for scientific purposes...
  29. ncbi request reprint Scavenging, signalling and adhesion coupling in macrophages: implications for atherogenesis
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Curr Opin Lipidol 8:287-300. 1997
    ....
  30. doi request reprint Update on lipid membrane microdomains
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Curr Opin Clin Nutr Metab Care 11:106-12. 2008
    ..This review provides an update of membrane microdomain abnormalities...
  31. ncbi request reprint Are circulating monocytes as microglia orthologues appropriate biomarker targets for neuronal diseases?
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg, Germany
    Cent Nerv Syst Agents Med Chem 9:307-30. 2009
    ..They are suitable biomarker targets for diagnosis and prognosis and maybe also therapy of central nervous system disease...
  32. doi request reprint Endolysosomal phospholipidosis and cytosolic lipid droplet storage and release in macrophages
    Gerd Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93049 Regensburg, Germany
    Biochim Biophys Acta 1791:524-39. 2009
    ....
  33. doi request reprint Metabolism and atherogenic disease association of lysophosphatidylcholine
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Atherosclerosis 208:10-8. 2010
    ....
  34. doi request reprint The molecular mechanisms of HDL and associated vesicular trafficking mechanisms to mediate cellular lipid homeostasis
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Arterioscler Thromb Vasc Biol 29:1718-22. 2009
    ..This review summarizes the current knowledge of the molecular mechanisms of HDL and associated vesicular trafficking mechanisms to mediate cellular lipid homeostasis...
  35. ncbi request reprint A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1
    G Schmiedeknecht
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, D 93042, Germany
    Biochem Biophys Res Commun 241:59-67. 1997
    ..These data indicate that the 102 bp region between p14.5 and hPOP1 can act as a bidirectional promoter. The p14.5-hPOP1-cluster was mapped to chromosome 8q22 using in situ hybridization technique...
  36. ncbi request reprint Analytical capillary isotachophoresis of human serum lipoproteins
    G Schmitz
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitat Regensburg, Germany
    Electrophoresis 18:1807-13. 1997
    ..With these characteristics analytical capillary isotachophoresis may be a helpful tool for a fast and reliable automated quantitation of lipoprotein subpopulations in the clinical laboratory...
  37. ncbi request reprint Recent advances in molecular genetics of cardiovascular disorders. Implications for atherosclerosis and diseases of cellular lipid metabolism
    G Schmitz
    University of Regensburg, Institute for Clinical Chemistry and Laboratory Medicine, Regensburg, Germany
    Pathol Oncol Res 4:152-60. 1998
    ..This will reduce the overall costs of health care without reducing the quality...
  38. doi request reprint Lipid homeostasis in macrophages - implications for atherosclerosis
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Rev Physiol Biochem Pharmacol 160:93-125. 2008
    ....
  39. ncbi request reprint Role of redox regulation and lipid rafts in macrophages during Ox-LDL-mediated foam cell formation
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Antioxid Redox Signal 9:1499-518. 2007
    ....
  40. ncbi request reprint ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism?
    G Schmitz
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Pathobiology 67:236-40. 1999
    ..Our results indicate a dual regulatory function for ABCA1 in macrophage lipid metabolism and inflammation...
  41. doi request reprint The opposing effects of n-3 and n-6 fatty acids
    Gerd Schmitz
    Institute of Clinical Chemistry, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Prog Lipid Res 47:147-55. 2008
    ..In addition, the n-3/n-6 PUFA content of cell and organelle membranes, as well as membrane microdomains strongly influences membrane function and numerous cellular processes such as cell death and survival...
  42. ncbi request reprint Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages
    W E Kaminski
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, 93042, Germany
    Biochem Biophys Res Commun 281:249-58. 2001
    ..Our results suggest a potential role for ABCA2 in macrophage lipid metabolism and neural development...
  43. pmc ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport
    J Klucken
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042 Regensburg, Germany
    Proc Natl Acad Sci U S A 97:817-22. 2000
    ..Our results demonstrating a regulator function for ABCG1 in cholesterol and phospholipid transport define a biologic activity for ABC transporters in macrophages...
  44. ncbi request reprint ABCA6, a novel a subclass ABC transporter
    W E Kaminski
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, 93042, Germany
    Biochem Biophys Res Commun 285:1295-301. 2001
    ..2. Based on its structural features and its cholesterol-responsive regulation ABCA6 is potentially involved in macrophage lipid homeostasis...
  45. ncbi request reprint Identification of regulatory elements in the human adipose most abundant gene transcript-1 ( apM-1) promoter: role of SP1/SP3 and TNF-alpha as regulatory pathways
    N Barth
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Diabetologia 45:1425-33. 2002
    ..Our aim was to characterize the tissue-specific regulation of the recently cloned apM-1 promoter and the mechanisms of TNF-alpha-induced downregulation of the apM-1 gene...
  46. ncbi request reprint Structural organization and characterization of the promoter region of a human carboxylesterase gene
    T Langmann
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Biochim Biophys Acta 1350:65-74. 1997
    ....
  47. ncbi request reprint Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli
    C Buechler
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Klinikum der Universitat Regensburg, Germany
    J Leukoc Biol 67:97-103. 2000
    ..This expression pattern implies a functional role of CD 163 in the antiinflammatory response of monocytes...
  48. ncbi request reprint Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages
    T Langmann
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, 93042, Germany
    Biochem Biophys Res Commun 257:29-33. 1999
    ..Our data, demonstrating sterol-dependent regulation of hABC1 in human monocytes/macrophages, suggest a novel role for this transporter molecule in membrane lipid transport...
  49. ncbi request reprint Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice
    E Orso
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Nat Genet 24:192-6. 2000
    ....
  50. ncbi request reprint Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts
    A Pfeiffer
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Eur J Immunol 31:3153-64. 2001
    ..The different receptor complexes may be linked to ligand-specific cellular responses initiated by CD14...
  51. ncbi request reprint Mutation analysis of the human adipocyte-specific apM-1 gene
    A Schaffler
    Department of Internal Medicine I, Institute of Clinical Chemistry, University of Regensburg, Germany
    Eur J Clin Invest 30:879-87. 2000
    ..The aim of this study was to analyse the human adipocyte-specific apM-1 gene for sequence variations...
  52. ncbi request reprint Genetic and biochemical evidence that CESD and Wolman disease are distinguished by residual lysosomal acid lipase activity
    C Aslanidis
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, 93042, Germany
    Genomics 33:85-93. 1996
    ....
  53. ncbi request reprint Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients
    B Zietz
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Exp Clin Endocrinol Diabetes 110:60-6. 2002
    ..Pro12Ala polymorphism of PPAR(gamma2) gene is not associated with diabetic retinopathy but is associated with dyslipidemia in male type 2 diabetic patients...
  54. ncbi request reprint Enzymatically degraded LDL preferentially binds to CD14(high) CD16(+) monocytes and induces foam cell formation mediated only in part by the class B scavenger-receptor CD36
    M Kapinsky
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Arterioscler Thromb Vasc Biol 21:1004-10. 2001
    ....
  55. ncbi request reprint Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene
    A Pietzsch
    Institute for Clinical Chemistry, University of Regensburg, Germany
    Biochem Biophys Res Commun 245:651-7. 1998
    ..The Dif-2 gene was mapped to chromosome 6p21.3 using in situ hybridization technique...
  56. ncbi request reprint The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux
    M Porsch-Ozcurumez
    Institute for Clinical Chemistry, University of Regensburg, Germany
    J Biol Chem 276:12427-33. 2001
    ..7 cells stably expressing ZNF202m1. In conclusion, we have identified ABCA1 and ABCG1 as target genes for ZNF202-mediated repression and thus, provide evidence for a functional linkage between ZNF202 and hypoalphalipoproteinemia...
  57. ncbi request reprint Gly15Gly polymorphism within the human adipocyte-specific apM-1gene but not Tyr111His polymorphism is associated with higher levels of cholesterol and LDL-cholesterol in caucasian patients with type 2 diabetes
    B Zietz
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Exp Clin Endocrinol Diabetes 109:320-5. 2001
    ..The recently described mutations within the human adipocyte-specific apM-1 gene might play a role in the pathogenesis of obesity, type 2 diabetes and related metabolic disorders...
  58. ncbi request reprint Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)
    W E Kaminski
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, D 93042, Germany
    Biochem Biophys Res Commun 273:532-8. 2000
    ..In macrophages, both the ABCA7 mRNA and protein expression are upregulated in the presence of modified low density lipoprotein and downregulated by HDL(3). Our results suggest a role for ABCA7 in macrophage transmembrane lipid transport...
  59. ncbi request reprint Adipophilin is a sensitive marker for lipid loading in human blood monocytes
    C Buechler
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93053, Regensburg, Germany
    Biochim Biophys Acta 1532:97-104. 2001
    ....
  60. ncbi request reprint Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis
    J A Hubacek
    Institute for Clinical Chemistry and Laboratory Medicine, The University of Regensburg, Germany
    Crit Care Med 29:557-61. 2001
    ....
  61. ncbi request reprint The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidaemia (FCH)
    A Schaffler
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Biochem Biophys Res Commun 260:416-25. 1999
    ..Exon- and intron-specific primer sequences are presented as a basis for mutation screening of patients affected with FCH...
  62. ncbi request reprint ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism
    W Drobnik
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, D 93042 Regensburg, Germany
    Gastroenterology 120:1203-11. 2001
    ..Our aim was to further analyze the role of ABCA1 in cholesterol metabolism...
  63. ncbi request reprint Nitrous oxide impairs the neutrophil oxidative response
    D Frohlich
    Department of Anesthesiology, University of Regensburg, Germany
    Anesthesiology 88:1281-90. 1998
    ..The choice of the stimulus, receptor agonists, or stimuli acting independent of receptors seems to determine whether nitrous oxide impairs the oxidative functions, suggesting an interference with the cytosolic signaling of neutrophils...
  64. ncbi request reprint Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine
    A Pietzsch
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Biochem Biophys Res Commun 235:4-9. 1997
    ..Our results indicate that DIF-2 represents a gene which is regulated in differentiation processes and strongly responsive to lipopolysaccharide, ceramide and lysophosphatidylcholine...
  65. ncbi request reprint Altered mononuclear phagocyte differentiation associated with genetic defects of the lysosomal acid lipase
    G Rothe
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Atherosclerosis 130:215-21. 1997
    ..In conclusion, our data suggest that these monogenetic defects of lysosomal lipoprotein metabolism are associated with complex alterations of mononuclear phagocyte differentiation and extravasation...
  66. ncbi request reprint Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene
    T Langmann
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93042, Regensburg, Germany
    Biochim Biophys Acta 1494:175-80. 2000
    ..The TATA-less proximal promoter contains multiple Sp1 binding sites and a consensus sequence for sterol regulatory element binding protein...
  67. ncbi request reprint Rapid quantification of human ABCA1 mRNA in various cell types and tissues by real-time reverse transcription-PCR
    D Kielar
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042 Regensburg, Germany
    Clin Chem 47:2089-97. 2001
    ..We developed a rapid, sensitive, specific, and reproducible real-time reverse transcription-PCR (RT-PCR) method for detection and quantification of ABCA1 transcripts in total RNA isolated from cultured human cells and tissues...
  68. ncbi request reprint Post-hoc analysis on the CD14 C(-260)T promoter polymorphism and coronary heart disease
    M Porsch-Ozcurumez
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Physiol Res 56:727-33. 2007
    ..Due to the small sample size and post-hoc character of the study large-scale prospective studies that monitor patients with proven CHD are needed to confirm these findings...
  69. ncbi request reprint Acyl-CoA binding protein (ACBP) regulates acyl-CoA:cholesterol acyltransferase (ACAT) in human mononuclear phagocytes
    C Kerkhoff
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Klinikum der Universitat Regensburg, Germany
    Biochim Biophys Acta 1346:163-72. 1997
    ..This common binding site is suggested to be responsible for the transfer from ACBP-bound oleoyl-CoA to ACAT and, therefore, to be essential for the microsomal cholesterol esterification...
  70. ncbi request reprint Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains
    Wolfgang Drobnik
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Traffic 3:268-78. 2002
    ..In summary, we provide evidence for the existence of compositionally distinct membrane microdomains in human cells and their modulation by apo AI/ABCA1-dependent and HDL3-mediated lipid efflux...
  71. ncbi request reprint Beta-amyloid (Abeta40, Abeta42) binding to modified LDL accelerates macrophage foam cell formation
    Berta Schulz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042 Regensburg, Germany
    Biochim Biophys Acta 1771:1335-44. 2007
    ..In summary, our results suggest that Abeta42 and Abeta40 act as potent opsonins for LDL, E-LDL and Ox-LDL and enhance cellular cholesterol accumulation as well as Abeta-deposition in vessel wall macrophages...
  72. doi request reprint HIF-1beta determines ABCA1 expression under hypoxia in human macrophages
    Peter Ugocsai
    Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Franz Josef Strauss Allee 11, Regensburg, Germany
    Int J Biochem Cell Biol 42:241-52. 2010
    ..These results demonstrate that HIF-1beta availability determines ABCA1 expression and cholesterol efflux in macrophages under hypoxia and may contribute to the interpersonal variability of atherosclerotic lesion progression...
  73. ncbi request reprint ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter
    Jürgen J Wenzel
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg D 93042, Germany
    Biochem Biophys Res Commun 306:1089-98. 2003
    ..Our results identify ABCA10 as a novel member of the group of ABCA6-like transporters and suggest its involvement in macrophage lipid homeostasis...
  74. ncbi request reprint Ezetimib influences the expression of raft-associated antigens in human monocytes
    Evelyn Orso
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Cytometry A 69:206-8. 2006
    ..Ezetimib significantly decreased the surface expression of CD13, CD16, CD64, and CD36; furthermore, it induced a shift of CD13 from plasma membrane to intracellular vesicles, and thus it quite likely modulated monocytic raft-assembly...
  75. ncbi request reprint Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily
    M Ritter
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, D 93042, Germany
    Biochem Biophys Res Commun 260:466-74. 1999
    ..In addition, we identified a L1 element located 1.4 kb upstream of the major transcription initiation site...
  76. ncbi request reprint Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes
    Thomas Langmann
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Gastroenterology 127:26-40. 2004
    ....
  77. ncbi request reprint Monocyte cholesterol homeostasis correlates with the presence of detergent resistant membrane microdomains
    Zsuzsanna Wolf
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Cytometry A 71:486-94. 2007
    ..Lipid membrane microdomains are involved in the regulation of biological functions of monocyte membrane proteins. These microdomains show a relative resistance to non-ionic detergents providing an easy analytical tool to study them...
  78. doi request reprint Changes in HDL-associated apolipoproteins relate to mortality in human sepsis and correlate to monocyte and platelet activation
    Stefan Barlage
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042, Regensburg, Germany
    Intensive Care Med 35:1877-85. 2009
    ..In this study, we analyzed whether plasma concentrations of lipoproteins and apolipoproteins in human sepsis are related to patient survival and the activation of blood monocytes and platelets...
  79. doi request reprint Fluorescent high-content imaging allows the discrimination and quantitation of E-LDL-induced lipid droplets and Ox-LDL-generated phospholipidosis in human macrophages
    Margot Grandl
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Cytometry A 77:231-42. 2010
    ..Therefore, fluorescent high-content imaging is a useful tool to discriminate between and quantify lipid storage compartments in macrophages also in response to drugs affecting cellular lipid metabolism...
  80. ncbi request reprint Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C
    M Ritter
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Eur J Immunol 31:999-1009. 2001
    ..Inhibition studies using specific kinase inhibitors reveal that both CKII and PKC are involved in the CD163 signaling mechanism resulting in the secretion of proinflammatory cytokines...
  81. ncbi request reprint Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation
    G Schmiedeknecht
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Eur J Biochem 242:339-51. 1996
    ..g. a differentiation-dependent regulation of protein synthesis in hepatocytes, renal tubular epithelial cells, smooth muscle cells and MNP...
  82. ncbi request reprint Evaluation of a high-content screening fluorescence-based assay analyzing the pharmacological modulation of lipid homeostasis in human macrophages
    Tobias Werner
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Cytometry A 69:200-2. 2006
    ..For understanding cholesterol and phospholipid efflux pathways there is a need for cellular fluorescence-based high-content screens (HCS) to investigated the cholesterol and phospholipid content in human macrophages...
  83. ncbi request reprint Molecular and functional interaction of the ATP-binding cassette transporter A1 with Fas-associated death domain protein
    Christa Buechler
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    J Biol Chem 277:41307-10. 2002
    ..The association of FADD with ABCA1 provides an unexpected link between high density lipoprotein metabolism and an adaptor molecule mainly described in death receptor signal transduction...
  84. ncbi request reprint High density lipoprotein modulates platelet function
    Stefan Barlage
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Cytometry A 69:196-9. 2006
    ..Platelet activation by atherogenic lipoproteins can be antagonized by high density lipoprotein (HDL), probably via interaction with the ATP-binding cassette transporter A1 (ABCA1)...
  85. ncbi request reprint Gene expression profiling identifies retinoids as potent inducers of macrophage lipid efflux
    Thomas Langmann
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Biochim Biophys Acta 1740:155-61. 2005
    ..We observed a strong induction of apoA-I-dependent lipid efflux in stimulated macrophages, implicating an important role for retinoids in cellular functions of macrophages...
  86. ncbi request reprint Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome
    Mariann Harangi
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, D 93042 Regensburg, Germany
    Eur J Immunol 35:305-17. 2005
    ..Our results suggest that the HA-1 168His variant is associated with reduced susceptibility to primary Sjögren's syndrome...
  87. doi request reprint Novel sphingolipid derivatives promote keratinocyte differentiation
    Gyorgy Paragh
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Exp Dermatol 17:1004-16. 2008
    ..Taken together, these results demonstrate the gene regulatory potential of sphingolipid species that could be valuable for dermatological or cosmetic applications...
  88. pmc Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells
    Salim Maa Bared
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93040 Regensburg, Germany
    Mol Biol Cell 15:5399-407. 2004
    ..It is concluded that ABCA1 forms a complex with syntaxin 13 and flotillin-1, residing at the plasma membrane and in phagosomes that are partially located in raft microdomains...
  89. ncbi request reprint Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages
    Chinh Quoc Duong
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93042, Regensburg, Germany
    Biochim Biophys Acta 1682:112-9. 2004
    ..Altogether, these data give insights into the expression and regulation of lysophospholipid receptors in primary human monocytes, macrophages and foam cells...
  90. ncbi request reprint Definition and characterization of relative hypo- and hyperleptinemia in a large Caucasian population
    R Buettner
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    J Endocrinol 175:745-56. 2002
    ..In conclusion, we report the first percentile curves for serum leptin by BMI in a large Caucasian population. Relatively low leptin values may be associated with a lower metabolic risk than relatively high serum leptin values...
  91. ncbi request reprint Lipoprotein (a) downregulates lysosomal acid lipase and induces interleukin-6 in human blood monocytes
    Christa Buechler
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Straubeta Allee 11, D 93042 Regensburg, Germany
    Biochim Biophys Acta 1642:25-31. 2003
    ..In addition, increased levels of IL-6 also predict future cardiovascular events and IL-6 secretion was also induced by purified Lp(a)...
  92. pmc Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes
    Josef Ecker
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042 Regensburg, Germany
    Proc Natl Acad Sci U S A 107:7817-22. 2010
    ..Therefore induction of fatty acid synthesis is a key requirement for phagocyte development and function...
  93. ncbi request reprint Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9
    Armin Piehler
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93042, Regensburg, Germany
    Biochem Biophys Res Commun 295:408-16. 2002
    ..Based on this information, ABCA9 is likely involved in monocyte differentiation and macrophage lipid homeostasis...
  94. ncbi request reprint Expression of tumor necrosis factor alpha and its receptors during cellular differentiation
    Petra Schling
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Cytokine 33:239-45. 2006
    ..Non-signaling TNF-receptors may protect chondrocytes and osteocytes from the anti-differentiation effects of local TNFalpha production...
  95. ncbi request reprint Alterations in intestinal fatty acid metabolism in inflammatory bowel disease
    Susanne Heimerl
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Biochim Biophys Acta 1762:341-50. 2006
    ..Observed alterations in expression of genes of fatty acid metabolism may contribute to the pathophysiology of ulcerative colitis...
  96. ncbi request reprint The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex
    Christa Buechler
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Biochem Biophys Res Commun 293:759-65. 2002
    ....
  97. doi request reprint Mass spectrometric analysis of lipid species of human circulating blood cells
    Katharina Leidl
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Biochim Biophys Acta 1781:655-64. 2008
    ..This work could be a reference for studies in different patient cohorts directed towards discovery of novel lipid biomarkers in circulating blood cells...
  98. ncbi request reprint Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells
    Susanne Heimerl
    Institute of Clinical Chemistry, University of Regensburg, Regensburg, Germany
    Melanoma Res 17:265-73. 2007
    ....
  99. ncbi request reprint Analysis of prothrombotic effects of two human monoclonal IgG antiphospholipid antibodies of apparently similar specificity
    K J Lackner
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Thromb Haemost 83:583-8. 2000
    ..Furthermore, the binding specificity of APA is perhaps not suited to predict the biological effects of the antibodies...
  100. ncbi request reprint Structure, function and regulation of the ABC1 gene product
    G Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
    Curr Opin Lipidol 12:129-40. 2001
    ..This suggests that a network of ABC transporters involved in cellular lipid transport exists, which is under the tight control of energy pathways directly linked to high density lipoprotein metabolism and atherogenesis...
  101. ncbi request reprint The satiety factor apolipoprotein A-IV modulates intestinal epithelial permeability through its interaction with alpha-catenin: implications for inflammatory bowel diseases
    E Orso
    Institute for Clinical Chemistry and Laboratory Medicine, University Clinic of Regensburg, Regensburg, and Medical Clinic III, University Hospital Carl Gustav Carus, Dresden, Germany
    Horm Metab Res 39:601-11. 2007
    ..ApoA-IV was also analyzed in the intestinal mucosa of patients with inflammatory bowel diseases (IBD), together with other genes involved in epithelial junctional integrity...