A H Schmitt-Graeff

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint [Myelodysplastic syndromes. Epidemiology, molecular and morphological characteristics and risk stratification]
    A H Schmitt-Graeff
    Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstr 115a, 79106, Freiburg, Deutschland
    Pathologe 34:45-55. 2013
  2. pmc Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus
    Barbara Huck
    Department of Virology, Freiburg University Medical Center, Freiburg, Germany
    Respir Res 8:6. 2007
  3. doi request reprint [Chronic myeloid neoplasms. Diagnostic criteria and current therapeutic concepts]
    A H Schmitt-Graeff
    Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstrasse 115a, Freiburg
    Pathologe 31:29-41. 2010
  4. ncbi request reprint The Ki67+ proliferation index correlates with increased cellular retinol-binding protein-1 and the coordinated loss of plakophilin-1 and desmoplakin during progression of cervical squamous lesions
    A Schmitt-Graeff
    Institute of Pathology, University Hospital, Freiburg, Germany
    Histopathology 51:87-97. 2007
  5. ncbi request reprint Effects of the tyrosine kinase inhibitor imatinib mesylate (STI571) on bone marrow features in patients with chronic myelogenous leukemia
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 19:1277-88. 2004
  6. ncbi request reprint Immunophenotype as prognostic factor for diffuse large B-cell lymphoma in patients undergoing clinical risk-adapted therapy
    H Veelken
    Department of Internal Medicine I Hematology Oncology, Freiburg University Medical Center, Freiburg, Germany
    Ann Oncol 18:931-9. 2007
  7. ncbi request reprint [Hematological side effects of tyrosine kinase inhibition using imatinib]
    A Schmitt-Graeff
    Pathologisches Institut, Universitat Freiburg, Postfach 214, 79002 Freiburg
    Pathologe 27:40-6. 2006
  8. ncbi request reprint Bone marrow histopathology following cytoreductive therapy in chronic idiopathic myelofibrosis
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histopathology 43:470-9. 2003
  9. ncbi request reprint CD117 (c-kit) expression in human hepatocellular carcinoma
    G Becker
    Department of Medicine II, Freiburg University Hospital, Freiburg, Germany
    Clin Oncol (R Coll Radiol) 19:204-8. 2007
  10. ncbi request reprint Bone marrow features improve prognostic efficiency in multivariate risk classification of chronic-phase Ph(1+) chronic myelogenous leukemia: a multicenter trial
    H M Kvasnicka
    Institutes of Pathology, Universities of Cologne, Freiburg, Germany
    J Clin Oncol 19:2994-3009. 2001

Collaborators

Detail Information

Publications18

  1. doi request reprint [Myelodysplastic syndromes. Epidemiology, molecular and morphological characteristics and risk stratification]
    A H Schmitt-Graeff
    Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstr 115a, 79106, Freiburg, Deutschland
    Pathologe 34:45-55. 2013
    ..Mutations affecting growth factor receptors, cell cycle and apoptosis regulators, intracellular signaling, transcription factors, epigenetic regulation and the splicosome are involved in MDS pathogenesis and progression...
  2. pmc Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus
    Barbara Huck
    Department of Virology, Freiburg University Medical Center, Freiburg, Germany
    Respir Res 8:6. 2007
    ..In this study, HMPV and RSV were compared for replication, pathogenesis and immune induction in BALB/c mice infected with equivalent inocula of either virus...
  3. doi request reprint [Chronic myeloid neoplasms. Diagnostic criteria and current therapeutic concepts]
    A H Schmitt-Graeff
    Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstrasse 115a, Freiburg
    Pathologe 31:29-41. 2010
    ..JAK2 inhibitor drugs are currently being tested in clinical trials. The development of pathogenesis-targeted diagnostic and therapeutic approaches to the various MPNs will continue in the future...
  4. ncbi request reprint The Ki67+ proliferation index correlates with increased cellular retinol-binding protein-1 and the coordinated loss of plakophilin-1 and desmoplakin during progression of cervical squamous lesions
    A Schmitt-Graeff
    Institute of Pathology, University Hospital, Freiburg, Germany
    Histopathology 51:87-97. 2007
    ....
  5. ncbi request reprint Effects of the tyrosine kinase inhibitor imatinib mesylate (STI571) on bone marrow features in patients with chronic myelogenous leukemia
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histol Histopathol 19:1277-88. 2004
    ..Data on proliferative activity and apoptosis in general supported in vitro findings concerning the inhibitory effect of this agent on growth associated with a tendency for stimulated apoptosis, at least in responding patients...
  6. ncbi request reprint Immunophenotype as prognostic factor for diffuse large B-cell lymphoma in patients undergoing clinical risk-adapted therapy
    H Veelken
    Department of Internal Medicine I Hematology Oncology, Freiburg University Medical Center, Freiburg, Germany
    Ann Oncol 18:931-9. 2007
    ..Biological parameters, including expression of Bcl-6, Bcl-2, CD10, major histocompatibility complex class II, and categorization as germinal center (GC) type have been described as IPI-independent prognostic factors...
  7. ncbi request reprint [Hematological side effects of tyrosine kinase inhibition using imatinib]
    A Schmitt-Graeff
    Pathologisches Institut, Universitat Freiburg, Postfach 214, 79002 Freiburg
    Pathologe 27:40-6. 2006
    ..Current questions involve the molecular mechanisms of hematological side effects of tyrosine kinase inhibitors with special regard to the emergence of distinct aberrant clones...
  8. ncbi request reprint Bone marrow histopathology following cytoreductive therapy in chronic idiopathic myelofibrosis
    J Thiele
    Institute of Pathology, University of Cologne, Cologne, Germany
    Histopathology 43:470-9. 2003
    ..To analyse systematically therapy-induced lesions of haematopoiesis in chronic idiopathic myelofibrosis (IMF)...
  9. ncbi request reprint CD117 (c-kit) expression in human hepatocellular carcinoma
    G Becker
    Department of Medicine II, Freiburg University Hospital, Freiburg, Germany
    Clin Oncol (R Coll Radiol) 19:204-8. 2007
    ....
  10. ncbi request reprint Bone marrow features improve prognostic efficiency in multivariate risk classification of chronic-phase Ph(1+) chronic myelogenous leukemia: a multicenter trial
    H M Kvasnicka
    Institutes of Pathology, Universities of Cologne, Freiburg, Germany
    J Clin Oncol 19:2994-3009. 2001
    ....
  11. ncbi request reprint Prognostic impact of bone marrow erythropoietic precursor cells and myelofibrosis at diagnosis of Ph1+ chronic myelogenous leukaemia--a multicentre study on 495 patients
    H M Kvasnicka
    Institute of Pathology, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
    Br J Haematol 112:727-39. 2001
    ..In this context, the generally clinical-based multivariate risk classification can be improved by consideration of morphological variables that are acting independently of treatment modalities...
  12. ncbi request reprint Therapy-related changes of CD34+ progenitor cells in chronic myeloid leukemia: a morphometric study on sequential trephine biopsies
    J Thiele
    Institute of Pathology, University of Cologne, Germany
    J Hematother Stem Cell Res 10:827-36. 2001
    ....
  13. ncbi request reprint Chronic colitis due to an epithelial barrier defect: the role of kindlin-1 isoforms
    J S Kern
    Department of Dermatology, University Medical Center, Freiburg, Germany
    J Pathol 213:462-70. 2007
    ..The different clinical intestinal manifestations in Kindler syndrome patients may be explained by partial functional compensation of kindlin-1 deficiency by the intestinal isoform or by the presence of truncated mutant kindlin-1...
  14. pmc Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer
    M Pfeiffer
    Department of Internal Medicine, Freiburg University Hospital, Freiburg, Germany
    Br J Cancer 100:1949-56. 2009
    ..Taken together, these data indicate that STAT3 is constitutively phosphorylated in SCLC and is important in SCLC growth and spreading thus presenting an interesting target for therapy...
  15. ncbi request reprint Bone marrow changes in chronic myelogenous leukaemia after long-term treatment with the tyrosine kinase inhibitor STI571: an immunohistochemical study on 75 patients
    J Thiele
    Institutes of Pathology, University of Cologne, Germany
    Histopathology 46:540-50. 2005
    ..To carry out an immunohistochemical study on bone marrow (BM) biopsy specimens in 75 patients with chronic myelogenous leukaemia (CML) on long-term STI571 therapy...
  16. ncbi request reprint [Therapy-related changes of angiogenesis in Philadelphia chromosome positive chronic myelogenous leukemia]
    H M Kvasnicka
    Zentrum für Pathologie, Universitat Koln, Joseph Stelzmann Strasse 9, 50924 Köln, Germany
    Pathologe 25:127-34. 2004
    ....
  17. ncbi request reprint Dynamics of fibrosis in chronic idiopathic (primary) myelofibrosis during therapy: a follow-up study on 309 patients
    J Thiele
    Institutes of Pathology, University of Cologne, Joseph Stelzmannstr 9, D 50924 Cologne, Germany
    Leuk Lymphoma 44:949-53. 2003
    ..In conclusion, persuasive evidence has been produced that myelofibrosis in IMF is characterized by a stepwise progression and that this process is not significantly influenced by current treatment strategies...
  18. ncbi request reprint Acquired pure megakaryocytic aplasia: a separate haematological disease entity or a syndrome with multiple causes?
    P Felderbauer
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Eur J Haematol 72:451-4. 2004
    ..Furthermore, this case report presents an example for a possible disease progression...