Roland E Schmieder

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Increased wall:lumen ratio of retinal arterioles in male patients with a history of a cerebrovascular event
    Joanna M Harazny
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 50:623-9. 2007
  2. doi request reprint A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease
    Raoul Zeltner
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Nephron Clin Pract 108:c169-75. 2008
  3. doi request reprint A guide for easy- and difficult-to-treat hypertension
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen, Germany Electronic address
    Int J Cardiol 172:17-22. 2014
  4. doi request reprint Effects of saxagliptin on early microvascular changes in patients with type 2 diabetes
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Ulmenweg 18, Erlangen, Germany
    Cardiovasc Diabetol 13:19. 2014
  5. pmc Achievement of recommended glucose and blood pressure targets in patients with type 2 diabetes and hypertension in clinical practice - study rationale and protocol of DIALOGUE
    Anselm K Gitt
    Stiftung Institut für Herzinfarktforschung Ludwigshafen, Bremser Strasse 79, 67063, Ludwigshafen, Germany
    Cardiovasc Diabetol 11:148. 2012
  6. pmc EARLY Treatment with azilsartan compared to ACE-inhibitors in anti-hypertensive therapy--rationale and design of the EARLY hypertension registry
    Anselm K Gitt
    Stiftung Institut für Herzinfarktforschung, Bremser Strasse 79, 67063 Ludwigshafen, Germany
    BMC Cardiovasc Disord 13:46. 2013
  7. doi request reprint Updated ESH position paper on interventional therapy of resistant hypertension
    Roland E Schmieder
    University Hospital Erlangen, Nephrology and Hypertension, Erlangen, Germany
    EuroIntervention 9:R58-66. 2013
  8. doi request reprint Optimizing blood pressure control in hypertension: the need to use ABPM
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany
    Blood Press 22:65-72. 2013
  9. pmc Barriers to cardiovascular risk prevention and management in Germany--an analysis of the EURIKA study
    Roland E Schmieder
    Nephrology and Hypertension, University Hospital Erlangen, Germany
    Vasc Health Risk Manag 8:177-86. 2012
  10. doi request reprint ESH position paper: renal denervation - an interventional therapy of resistant hypertension
    Roland E Schmieder
    University Hospital Erlangen, Nephrology and Hypertension, Erlangen, Germany
    J Hypertens 30:837-41. 2012

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Increased wall:lumen ratio of retinal arterioles in male patients with a history of a cerebrovascular event
    Joanna M Harazny
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 50:623-9. 2007
    ..40+/-0.13 versus 0.31+/-0.13; P=0.025). Thus, assessment of wall:lumen ratio of retinal arterioles emerged as an attractive tool to identify treated patients with hypertension with increased cerebrovascular risk...
  2. doi request reprint A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease
    Raoul Zeltner
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Nephron Clin Pract 108:c169-75. 2008
    ..We investigated whether the -414 T/C polymorphism in the promoter region of the alpha 8 integrin chain gene (ITGA8) is associated with the progression of renal disease in ADPKD...
  3. doi request reprint A guide for easy- and difficult-to-treat hypertension
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen, Germany Electronic address
    Int J Cardiol 172:17-22. 2014
    ..With intensive pharmacotherapy, many patients with difficult-to-treat hypertension can achieve BP control. If it fails, interventional strategies (e.g., renal denervation) are a valid option to get BP controlled. ..
  4. doi request reprint Effects of saxagliptin on early microvascular changes in patients with type 2 diabetes
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Ulmenweg 18, Erlangen, Germany
    Cardiovasc Diabetol 13:19. 2014
    ..g. in the retina and kidney) and increased pulse wave reflection leading to increased aortic pressure. We investigated the effects of the DPP-4-inhibitor saxagliptin on early retinal microvascular changes...
  5. pmc Achievement of recommended glucose and blood pressure targets in patients with type 2 diabetes and hypertension in clinical practice - study rationale and protocol of DIALOGUE
    Anselm K Gitt
    Stiftung Institut für Herzinfarktforschung Ludwigshafen, Bremser Strasse 79, 67063, Ludwigshafen, Germany
    Cardiovasc Diabetol 11:148. 2012
    ..In addition, DIALOGUE is the first registry to determine treatment success based on the new individualized treatment targets recommended by the ADA and the EASD...
  6. pmc EARLY Treatment with azilsartan compared to ACE-inhibitors in anti-hypertensive therapy--rationale and design of the EARLY hypertension registry
    Anselm K Gitt
    Stiftung Institut für Herzinfarktforschung, Bremser Strasse 79, 67063 Ludwigshafen, Germany
    BMC Cardiovasc Disord 13:46. 2013
    ..Therefore, we aimed to test whether these can be verified under clinical practice conditions...
  7. doi request reprint Updated ESH position paper on interventional therapy of resistant hypertension
    Roland E Schmieder
    University Hospital Erlangen, Nephrology and Hypertension, Erlangen, Germany
    EuroIntervention 9:R58-66. 2013
    ....
  8. doi request reprint Optimizing blood pressure control in hypertension: the need to use ABPM
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany
    Blood Press 22:65-72. 2013
    ..This article reviews the benefits of ABPM and discusses the importance of selecting long-acting antihypertensive agents for optimizing BP control...
  9. pmc Barriers to cardiovascular risk prevention and management in Germany--an analysis of the EURIKA study
    Roland E Schmieder
    Nephrology and Hypertension, University Hospital Erlangen, Germany
    Vasc Health Risk Manag 8:177-86. 2012
    ..Using EURIKA data we compared risk factor control in Germany with that of 11 other European countries (rest of Europe [ROE]) to identify differences and opportunities for improvement...
  10. doi request reprint ESH position paper: renal denervation - an interventional therapy of resistant hypertension
    Roland E Schmieder
    University Hospital Erlangen, Nephrology and Hypertension, Erlangen, Germany
    J Hypertens 30:837-41. 2012
    ..This position statement intends to facilitate a better understanding of the effectiveness, safety, limitations and issues still to be addressed with RDN...
  11. doi request reprint [Chronobiology of blood pressure and chronopharmacotherapy of arterial hypertension]
    R E Schmieder
    Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitatsklinikum Erlangen
    Dtsch Med Wochenschr 137:317-21. 2012
    ..The present manuscript reviews the chronopharmacotherapy of arterial hypertension and grant practical recommendations for their translation into clinical practice...
  12. doi request reprint Efficacy and safety of olmesartan medoxomil plus amlodipine in age, gender and hypertension severity defined subgroups of hypertensive patients
    R E Schmieder
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Krankenhausstrasse 12, Erlangen, Germany
    J Hum Hypertens 25:354-63. 2011
    ..Small differences in responsiveness between females and males may exist, which require further investigation...
  13. doi request reprint Cerebral microangiopathy in treatment-resistant hypertension
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany
    J Clin Hypertens (Greenwich) 13:582-7. 2011
    ....
  14. doi request reprint Renal protection with angiotensin receptor blockers: where do we stand
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    J Nephrol 24:569-80. 2011
    ..After a decade of research, there is now substantial evidence to show that the use of ARBs provides an efficacious treatment option for the prevention of renal disease progression in patients with hypertension and/or diabetes...
  15. pmc Changes in albuminuria predict mortality and morbidity in patients with vascular disease
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Am Soc Nephrol 22:1353-64. 2011
    ..This suggests that monitoring albuminuria is a useful strategy to help predict cardiovascular risk...
  16. pmc Significance of initial blood pressure and comorbidity for the efficacy of a fixed combination of an angiotensin receptor blocker and hydrochlorothiazide in clinical practice
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital of Erlangen, Germany
    Vasc Health Risk Manag 5:991-1000. 2009
    ..Fixed combinations have high efficacy and result in high patient compliance. 300 mg irbesartan plus 25 mg hydrochlorothiazide (HCTZ) has been investigated only in clinical trials but not in daily practice...
  17. pmc Angiotensin blockade to reduce microvascular damage in diabetes mellitus
    Roland E Schmieder
    Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitatsklinikum, Erlangen, 91054 Erlangen, Germany
    Dtsch Arztebl Int 106:556-62. 2009
    ..Diabetic retinopathy and microalbuminuria are often thought of as distinct disease entities despite their common pathophysiology. Many studies have addressed the prognostic significance of these conditions and their treatment...
  18. pmc End organ damage in hypertension
    Roland E Schmieder
    Nephrologie und Hypertensiologie, Universitatsklinikum Erlangen, 91054 Erlangen, Germany
    Dtsch Arztebl Int 107:866-73. 2010
    ..End organ damage in hypertension can be detected early, reflects accurately the hypertensive patient's overall cardiovascular risk, and should be prevented and treated with antihypertensive treatment...
  19. doi request reprint Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Kidney Dis 53:281-9. 2009
    ..Basal nitric oxide (NO) activity has a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments, its alteration has been associated with morphological changes characteristic of diabetic nephropathy...
  20. pmc Reversibility of the effects of aliskiren in the renal versus systemic circulation
    Markus P Schneider
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Clin J Am Soc Nephrol 7:258-64. 2012
    ..The BP-lowering effects of the renin inhibitor aliskiren are sustained 3-4 weeks after withdrawal. In this study, the reversibility of the renal hemodynamic effects of aliskiren was tested...
  21. doi request reprint Influence of blood flow on arteriolar wall-to-lumen ratio in the human retinal circulation in vivo
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Microvasc Res 83:111-7. 2012
    ..We hypothesized that blood flow impacts on arteriolar wall-to-lumen ratio and that vasodilatory capacity is negatively related to arteriolar wall-to-lumen ratio in the human retinal vascular bed...
  22. doi request reprint Does renal artery supply indicate treatment success of renal denervation?
    Axel Schmid
    Department of Radiology, University of Erlangen Nuremberg, Maximiliansplatz 1, 91054, Erlangen, Germany
    Cardiovasc Intervent Radiol 36:987-91. 2013
    ..With the exception of pretreatment blood pressure (BP) level, no other clear predictor for treatment efficacy is yet known. We analyzed whether the presence of multiple renal arteries has an impact on BP reduction after RDN...
  23. pmc Vascular and renal hemodynamic changes after renal denervation
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Clin J Am Soc Nephrol 8:1195-201. 2013
    ..However, the consequences on renal perfusion and renal vascular resistance (RVR), as well as central hemodynamics, are unknown...
  24. doi request reprint Impaired increase of retinal capillary blood flow to flicker light exposure in arterial hypertension
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Hypertension 60:871-6. 2012
    ..29±18%; P=0.607). The increase of RCF to flicker light exposure is impaired in arterial hypertension. In the subgroup of the total study cohort, nitric oxide was not a major determinant of the increase of RCF to flicker light exposure...
  25. ncbi request reprint Rosuvastatin does not affect intrarenal hemodynamics in patients with hypercholesterolemia
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    J Nephrol 22:675-81. 2009
    ..However, the potential renoprotective effects of statin treatment have not been fully elucidated and so far no study has analyzed the effects of statin treatment on intrarenal hemodynamics...
  26. doi request reprint Renal denervation in moderate treatment-resistant hypertension
    Christian Ott
    Department of Nephrology and Hypertension, University Hospital at the University of Erlangen Nuremberg, Erlangen, Germany
    J Am Coll Cardiol 62:1880-6. 2013
    ....
  27. ncbi request reprint Rosuvastatin improves basal nitric oxide activity of the renal vasculature in patients with hypercholesterolemia
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Atherosclerosis 196:704-11. 2008
    ..Whether this also holds true in the renal circulation has not yet been adequately addressed...
  28. doi request reprint Effect of angiotensin receptor blockade on central haemodynamics in essential hypertension: results of a randomised trial
    Markus P Schneider
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Germany
    J Renin Angiotensin Aldosterone Syst 9:49-56. 2008
    ..We tested whether this is also true for long-term treatment with an angiotensin receptor blocker (ARB)...
  29. doi request reprint Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes
    Christian Delles
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 21:1330-6. 2008
    ..We examined adiponectin levels in patients with type 2 diabetes who participated in the Telmisartan vs. Ramipril in Renal Endothelial Dysfunction (TRENDY) study...
  30. doi request reprint Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension
    Bernd Klanke
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 23:3456-63. 2008
    ..We examined the contribution of high blood pressure versus direct mineralocorticoid effects to the progression of kidney inflammation and fibrosis in established experimental deoxycorticosterone-acetate (DOCA)-salt hypertension...
  31. doi request reprint Renal resistive index--a valid tool to assess renal endothelial function in humans?
    Ulrike Raff
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Nephrol Dial Transplant 25:1869-74. 2010
    ..We hypothesized that Doppler sonographic measurements of the renal resistive index in response to inhibition of nitric oxide synthase offer a new methodological approach for testing renal endothelial function...
  32. doi request reprint Wall-to-lumen ratio of retinal arterioles and arteriole-to-venule ratio of retinal vessels in patients with cerebrovascular damage
    Delia Baleanu
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:4351-9. 2009
    ..The primary objective was to test the association between WLR and AVR in a distinct cohort of patients with cerebrovascular damage...
  33. ncbi request reprint Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension
    Markus P Schneider
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 18:1111-7. 2005
    ..We therefore compared the acute superoxide scavenging efficacy of NAC against vitamin C (VITC) on impaired endothelium-dependent vasodilation in subjects with essential hypertension...
  34. doi request reprint Wall-to-lumen ratio of retinal arterioles is related with urinary albumin excretion and altered vascular reactivity to infusion of the nitric oxide synthase inhibitor N-monomethyl-L-arginine
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    J Hypertens 27:2201-8. 2009
    ....
  35. ncbi request reprint Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Diabetes Care 30:1351-6. 2007
    ..The aim of this study was to analyze the effects of renin-angiotensin system (RAS) blockade on renal endothelial function...
  36. ncbi request reprint Elevation of sympathetic activity by eprosartan in young male subjects
    Karsten Heusser
    Department of Medicine IV Nephrology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Am J Hypertens 16:658-64. 2003
    ..We examined the effects of AT1 receptor blockade on the sympathetic nervous system in humans...
  37. doi request reprint Gender is related to alterations of renal endothelial function in type 2 diabetes
    Markus P Schneider
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Germany
    Nephrol Dial Transplant 24:3354-9. 2009
    ..We hypothesized that renal vascular nitric oxide (NO) availability is higher, and oxidative stress lower, in female compared to male patients with type 2 diabetes...
  38. ncbi request reprint Valsartan and retinal endothelial function in elderly hypertensive patients
    Sebastian Oehmer
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Blood Press 15:185-91. 2006
    ..The aim of this study was to investigate the impact of short-term treatment with the angiotensin II receptor blocker (ARB) valsartan on retinal endothelial function in elderly patients with mild to moderate essential hypertension...
  39. doi request reprint Impact of the endothelial nitric oxide synthase gene G894T polymorphism on renal endothelial function in patients with type 2 diabetes
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Pharmacogenet Genomics 18:699-707. 2008
    ....
  40. doi request reprint Folic acid treatment normalizes NOS-dependence of vascular tone in the metabolic syndrome
    Markus P Schneider
    Department of Nephrology and Hypertension, University of Erlangen, Nuremberg, Erlangen, Germany
    Obesity (Silver Spring) 19:960-7. 2011
    ..Future trials should test whether these effects translate into a reduction of microvascular complications...
  41. ncbi request reprint AT1 antagonism by eprosartan lowers heart rate variability and baroreflex gain
    Karsten Heusser
    Department of Medicine IV Nephrology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054, Erlangen, Germany
    Auton Neurosci 107:45-51. 2003
    ..We sought to assess the effects of the angiotensin type 1 (AT1) receptor blocker eprosartan on HRV and BRG...
  42. doi request reprint Effects of angiotensin II type 1-receptor blockade on retinal endothelial function
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    J Hypertens 26:516-22. 2008
    ..We tested whether AT1-receptor blockade improved endothelial function of the retinal vasculature in normocholesterolemic and hypercholesterolemic subjects...
  43. doi request reprint Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Krankenhausstrasse 12, Erlangen, Germany
    Pharmacogenet Genomics 21:347-9. 2011
    ..05). These findings indicate that C-allele carriers have lower systolic BP than T-allele carriers. Thus, our data suggest that (P)RR influences BP regulation in Caucasian men, potentially through altered aldosterone release...
  44. doi request reprint 25-hydroxyvitamin D insufficiency is associated with impaired renal endothelial function and both are improved with rosuvastatin treatment
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Clin Res Cardiol 102:299-304. 2013
    ..We tested the hypotheses that vitamin D deficiency impairs the endothelial function of renal vasculature and whether vitamin D levels and endothelial function can be improved by the treatment with statins...
  45. doi request reprint Central pulse pressure is an independent determinant of vascular remodeling in the retinal circulation
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Hypertension 61:1340-5. 2013
    ..Such a relationship indicates a coupling and crosstalk between the microvascular and macrovascular changes attributable to hypertension...
  46. doi request reprint Effect of the rs168924 single-nucleotide polymorphism in the SLC6A2 catecholamine transporter gene on blood pressure in Caucasians
    Oliver Zolk
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Clin Hypertens (Greenwich) 14:293-8. 2012
    ..Unlike previous findings in a Japanese population, in our Caucasian study cohort the presence of the minor rs168924 G allele was associated with lower prevalence of hypertension...
  47. doi request reprint Salt intake determines retinal arteriolar structure in treatment resistant hypertension independent of blood pressure
    Ulrike Raff
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Atherosclerosis 222:235-40. 2012
    ..The role of sodium in end organ damage is gaining interest and an independent association of sodium and cardiovascular morbidity and mortality has been described...
  48. doi request reprint Prevention of atrial fibrillation by Renin-Angiotensin system inhibition a meta-analysis
    Markus P Schneider
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Am Coll Cardiol 55:2299-307. 2010
    ..The authors reviewed published clinical trial data on the effects of renin-angiotensin system (RAS) inhibition for the prevention of atrial fibrillation (AF), aiming to define when RAS inhibition is most effective...
  49. doi request reprint Measurement of kidney perfusion by magnetic resonance imaging: comparison of MRI with arterial spin labeling to para-aminohippuric acid plasma clearance in male subjects with metabolic syndrome
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 25:1126-33. 2010
    ....
  50. ncbi request reprint Rapid nongenomic effects of aldosterone on the renal vasculature in humans
    Bernhard M W Schmidt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Hypertension 47:650-5. 2006
    ..Antagonizing the endothelial NO synthase unmasks these effects. Therefore, rapid nongenomic aldosterone effects increase renal vascular resistance and thereby mediate arterial hypertension if endothelial dysfunction is present...
  51. doi request reprint Analysis of retinal arteriolar structure in never-treated patients with essential hypertension
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Hypertens 26:1427-34. 2008
    ..We aimed to analyze retinal arteriolar structure in never-treated patients with essential hypertension and to test whether elevated blood pressure is associated with an increased wall-to-lumen ratio of retinal arterioles...
  52. doi request reprint Haemoglobin and vascular function in the human retinal vascular bed
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Bavaria, Germany
    J Hypertens 31:775-81. 2013
    ..Haemoglobin is associated with blood viscosity and the red blood cell free layer width of microvessels that impact on shear stress in the microcirculation. We hypothesized that haemoglobin modulates retinal vascular function...
  53. pmc Effects of manidipine vs. amlodipine on intrarenal haemodynamics in patients with arterial hypertension
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Germany
    Br J Clin Pharmacol 75:129-35. 2013
    ..The aim of this study was to investigate the effects of manidipine and amlodipine treatment on intragomerular pressure (P(glom)) in patients with mild to moderate essential hypertension...
  54. doi request reprint The Fcγ receptor IIA R131H gene polymorphism is associated with endothelial function in patients with hypercholesterolaemia
    Markus P Schneider
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Germany
    Atherosclerosis 218:411-5. 2011
    ..FcγRIIa is also expressed on endothelial cells, and we hypothesized this polymorphism would be associated with alterations of endothelial function...
  55. ncbi request reprint Effect of irbesartan versus atenolol on left ventricular mass and voltage: results of the CardioVascular Irbesartan Project
    Markus P Schneider
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Germany
    Hypertension 44:61-6. 2004
    ..Because voltage criteria for LVH have been shown to predict cardiovascular outcome independently from LVM, we suggest that both methods should be used to accurately assess the benefits of antihypertensive treatment...
  56. pmc Reduction in basal nitric oxide activity causes albuminuria
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Diabetes 60:572-6. 2011
    ..Albuminuria reflects a malfunction of this barrier, and in animals dysfunctional endothelial nitric-oxide (NO) synthase results in albuminuria. We aimed to analyze the importance of NO for the glomerular barrier function in humans...
  57. doi request reprint Nitric oxide and reactive hyperemia: role of location and duration of ischemia
    Ulrike Raff
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Germany
    Am J Hypertens 23:865-9. 2010
    ....
  58. doi request reprint Basal nitric oxide activity is an independent determinant of arteriolar structure in the human retinal circulation
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    J Hypertens 29:123-9. 2011
    ..Experimental data indicate that nitric oxide might play a role in structure and remodeling of peripheral small arteries and arterioles. We hypothesized that retinal arteriolar structure is modulated by basal nitric oxide activity...
  59. doi request reprint Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Circulation 119:417-25. 2009
    ..This randomized, double-blind, multicenter study assessed the long-term efficacy and safety of the direct renin inhibitor aliskiren in comparison with the diuretic hydrochlorothiazide in patients with essential hypertension...
  60. ncbi request reprint Endothelial dysfunction: how can one intervene at the beginning of the cardiovascular continuum?
    Roland E Schmieder
    University of Erlangen Nuremberg, Germany
    J Hypertens Suppl 24:S31-5. 2006
    ..Intervention at the beginning of the renal and cardiovascular continuum offers the opportunity to prevent the fatal development towards renal and cardiac failure...
  61. ncbi request reprint Mechanisms for the clinical benefits of angiotensin II receptor blockers
    Roland E Schmieder
    Medizinische Klinik IV, Universität Erlangen Nuernberg, Erlangen, Germany
    Am J Hypertens 18:720-30. 2005
    ..In addition, both recent and ongoing clinical trials help to clarify further the mechanisms for the benefits of using ARB across the cardiovascular continuum...
  62. doi request reprint Reduced incidence of new-onset atrial fibrillation with angiotensin II receptor blockade: the VALUE trial
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Erlangen Nuremberg, Erlangen, Germany
    J Hypertens 26:403-11. 2008
    ..Therefore, in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) a prespecified objective was to compare the effects of valsartan and amlodipine on new-onset AF...
  63. ncbi request reprint Renin-angiotensin system and cardiovascular risk
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Lancet 369:1208-19. 2007
    ..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
  64. ncbi request reprint MDR1 genotype-dependent regulation of the aldosterone system in humans
    Oliver Zolk
    Institute of Clinical and Experimental Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenet Genomics 17:137-44. 2007
    ....
  65. ncbi request reprint Left-ventricular structure and function are influenced by angiotensinogen gene polymorphism (-20 A/C) in young male patients
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 20:974-80. 2007
    ..Therefore, we questioned whether left-ventricular (LV) structure and function are influenced by the -20 A/C variant of the angiotensinogen (AGT) gene in young normotensive or mildly hypertensive patients...
  66. ncbi request reprint High sodium intake modulates left ventricular mass in patients with G expression of +1675 G/A angiotensin II receptor type 2 gene
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Nuremberg, Germany
    J Hypertens 25:1627-32. 2007
    ..Hypertension and LVH are often aggravated by salt intake. Our objective was to assess the relationship between AT2R gene variation and salt intake and their impact on left ventricular mass (LVM)...
  67. ncbi request reprint CYP3A5 genotype is associated with elevated blood pressure
    Martin F Fromm
    Institute of Clinical and Experimental Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenet Genomics 15:737-41. 2005
    ..We interpret the lower serum aldosterone concentration in the genotype group with the elevated systolic blood pressure as a counter-regulatory mechanism to attenuate the increased blood pressure associated with the CYP3A5*3/*3 genotype...
  68. ncbi request reprint Additional antiproteinuric effect of ultrahigh dose candesartan: a double-blind, randomized, prospective study
    Roland E Schmieder
    Universitatsklinikum Erlangen, Medizinische Klinik IV, Krankenhausstrasse 12, Erlangen 91054, Germany
    J Am Soc Nephrol 16:3038-45. 2005
    ..57]; NS). No change in BP was noticed in response to the different doses of candesartan. These data indicate an additive antiproteinuric effect of ultrahigh dose of the angiotensin receptor blocker candesartan compared with standard dose...
  69. ncbi request reprint Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate-salt hypertension
    Andrea Hartner
    Hospital for Children and Adolescents, Erlangen, Germany
    J Hypertens 27:376-85. 2009
    ..We examined the effects of fluvastatin treatment on the development of kidney injury in experimental deoxycorticosterone-acetate (DOCA)-salt hypertension...
  70. ncbi request reprint Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients
    Stefan John
    Department of Medicine IV, University of Erlangen Nurnberg, Erlangen, Germany
    Am Heart J 149:473. 2005
    ..We investigated whether improvement in NO availability in hypercholesterolemia can be achieved rapidly with statins before lipid-lowering therapy is complete...
  71. doi request reprint Renal resistive index in addition to low-grade albuminuria complements screening for target organ damage in therapy-resistant hypertension
    Ulrike Raff
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    J Hypertens 28:608-14. 2010
    ..We examined the value of renal resistive index (RRI) for prevalence of cardiovascular target organ damage in therapy-resistant hypertension in comparison to low-grade albuminuria...
  72. doi request reprint Renal denervation in a hypertensive patient with end-stage renal disease and small arteries: a direction for future research
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Clin Hypertens (Greenwich) 14:799-801. 2012
    ..The authors report that renal denervation seems to be effective in controlling hypertension in patients with ESRD, even in cases of small renal arteries...
  73. doi request reprint Postchallenge hyperglycemia is closely related with early vascular damage in overweight and obese patients
    Markus P Schneider
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Hypertens 30:147-52. 2012
    ..We examined the relationship between screening methods for diabetes and indices of vascular damage in young individuals at high risk of type 2 diabetes...
  74. doi request reprint The role of fixed-dose combination therapy with drugs that target the renin-angiotensin system in the hypertension paradigm
    Roland E Schmieder
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Germany
    Clin Exp Hypertens 32:35-42. 2010
    ..This review aims to highlight the simplicity, tolerability, and convenience of fixed-dose combinations targeting the renin-angiotensin system, which can lead to improved compliance and more patients achieving BP goals...
  75. ncbi request reprint Effects of nitric oxide synthase inhibition and L-arginine on renal haemodynamics in young patients at high cardiovascular risk
    Markus P Schlaich
    Department of Medicine 4 Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Atherosclerosis 192:155-60. 2007
    ..Whether such an association is already evident in the renal vascular bed in young patients at high cardiovascular risk has not yet been determined...
  76. ncbi request reprint Low-grade albuminuria and cardiovascular risk : what is the evidence?
    Roland E Schmieder
    Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitatsklinikum Erlangen, Krankenhausstrasse 12, 91054, Erlangen, Germany
    Clin Res Cardiol 96:247-57. 2007
    ..MA is modifiable, and the inhibition of the renin-angiotensin system by ACE inhibitors and AT1 receptor antagonists has been shown to result in a lower incidence of cardiovascular events...
  77. doi request reprint New software analyses increase the reliability of measurements of retinal arterioles morphology by scanning laser Doppler flowmetry in humans
    Joanna M Harazny
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Hypertens 29:777-82. 2011
    ..We analyzed the reliability of assessing retinal arteriolar morphology with our new version of the software analyses for scanning laser Doppler flowmetry...
  78. ncbi request reprint Renal and cardiac effects of antihypertensive treatment with ramipril vs metoprolol in autosomal dominant polycystic kidney disease
    Raoul Zeltner
    Department of Nephrology and Hypertension, University of Erlangen Nuernberg, Nuernberg, Germany
    Nephrol Dial Transplant 23:573-9. 2008
    ..This prospective randomized double-blind study was performed to compare the renal and cardiac effects of the ACE inhibitor ramipril and the beta-blocker metoprolol as first line therapy in ADPKD patients with hypertension...
  79. ncbi request reprint Effect of erythropoietin on cardiovascular prognosis parameters in hemodialysis patients
    Helga Frank
    Medical Clinic IV, Department of Nephrology, University of Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 66:832-40. 2004
    ..In addition, an autonomic dysfunction is associated with the uremic state and influences the cardiovascular risk in patients with end-stage renal disease (ESRD)...
  80. ncbi request reprint Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice
    Johannes Jacobi
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Physiol Heart Circ Physiol 294:H1058-66. 2008
    ..However, an overexpression of DDAH1 alleviates ANG II-induced renal interstitial fibrosis and vascular oxidative stress, suggesting a blood pressure-independent effect of ADMA on ANG II-induced target organ damage...
  81. ncbi request reprint Renin inhibitors: optimal strategy for renal protection
    Roland E Schmieder
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Curr Hypertens Rep 9:415-21. 2007
    ..Aliskiren is a new orally active DRI with proven BP-lowering effects. Animal studies indicate that aliskiren may provide renal protection, and data from human studies are anticipated...
  82. ncbi request reprint Dihydropyridine calcium antagonists are associated with increased albuminuria in treatment-resistant hypertensives
    Diana Hummel
    Medical Department 4, Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Nephrol 23:563-8. 2010
    ..Since increases of albuminuria even in the low range are associated with increased cardiovascular risk, detection of albuminuria should influence the choice of antihypertensive drugs in hypertensive patients with albuminuria...
  83. doi request reprint Remodeling of retinal small arteries in hypertension
    Marina V Lehmann
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 24:1267-73. 2011
    ..Thus, SLDF emerged as a noninvasive research tool to assess early vascular changes in the retinal circulation...
  84. ncbi request reprint Impaired endothelial function of the retinal vasculature in hypertensive patients
    Christian Delles
    Department of Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Stroke 35:1289-93. 2004
    ..Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation...
  85. ncbi request reprint The role of statins in the treatment of the metabolic syndrome
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Curr Hypertens Rep 11:143-9. 2009
    ..Thus, evidence is accumulating that statins are very effective therapeutic agents in the treatment of individuals with the metabolic syndrome...
  86. pmc Renal protection in diabetes: lessons from ONTARGET
    Eberhard Ritz
    Universitat Erlangen, Medizinische Klinik IV, Erlangen, Germany
    Cardiovasc Diabetol 9:60. 2010
    ....
  87. ncbi request reprint Blood pressure control in patients with comorbidities
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany
    J Clin Hypertens (Greenwich) 10:624-31. 2008
    ..Not all available antihypertensives are equally effective in controlling BP over 24 hours, and some may exacerbate underlying metabolic abnormalities...
  88. doi request reprint Serum levels of the Th1 chemoattractant interferon-gamma-inducible protein (IP) 10 are elevated in patients with essential hypertension
    Christian Stumpf
    Department of Cardiology Medical Clinic II, University of Erlangen Nuremberg, Erlangen, Germany
    Hypertens Res 34:484-8. 2011
    ..01). In conclusion, our study provides new insights into the pathophysiological mechanisms in EH linking inflammation and IP-10. However, these preliminary results need to be confirmed in larger trials...
  89. ncbi request reprint Fourier analysis of the envelope of the ophthalmic artery blood flow velocity: age- and blood pressure related impact
    Georg Michelson
    Department of Ophthalmology and Nephrology, University Erlangen Nurnberg, Erlangen, Germany
    Hypertension 50:964-9. 2007
    ..The SI of the ophthalmic artery allows an assessment of the ocular circulation in consideration of age and arterial blood pressure in contrast to the resistance index...
  90. ncbi request reprint Analysis of NO-synthase expression and clinical risk factors in human diabetic nephropathy
    Bernd Hohenstein
    Roland E Schmieder, Department of Nephrology and Hypertension, University Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany Tel 49 9131 8536245 Fax 49 9131 8539209 E mail
    Nephrol Dial Transplant 23:1346-54. 2008
    ..It is still not yet specified whether the regulation and activity of NOS is changed in human diabetic nephropathy...
  91. doi request reprint Effects of statin treatment on endothelial function, oxidative stress and inflammation in patients with arterial hypertension and normal cholesterol levels
    Markus P Schneider
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Hypertens 29:1757-64. 2011
    ..We tested whether fluvastatin reduces oxidative stress and inflammation, and improves endothelial function in patients with arterial hypertension and normal LDL-cholesterol...
  92. doi request reprint Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in obese patients with hypertension: sub-analysis of a 52-week, randomized, double-blind trial
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    J Hypertens 27:1493-501. 2009
    ..To compare the long-term efficacy, safety and tolerability of the direct renin inhibitor aliskiren against the diuretic hydrochlorothiazide (HCTZ) in obese patients with hypertension...
  93. ncbi request reprint Effects of angiotensin II receptor antagonism on the renal hemodynamic response to cardiovascular stress
    Helga Frank
    Medical Clinic IV, Department of Internal Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 63:617-23. 2003
    ....
  94. ncbi request reprint Enhanced levels of platelet P-selectin and circulating cytokines in young patients with mild arterial hypertension
    Christian Stumpf
    Medical Clinic II, University of Erlangen Nuremberg, Erlangen, Germany
    J Hypertens 23:995-1000. 2005
    ..Therefore, the present pilot study was designed to examine the role of platelet P-selectin and various inflammatory mediators in young patients with moderate AH without signs of target organ damage...
  95. ncbi request reprint Optimizing therapeutic strategies to achieve renal and cardiovascular risk reduction in diabetic patients with angiotensin receptor blockers
    Roland E Schmieder
    Department of Medicine and Nephrology, University Erlangen Nuernberg, Erlangen, Germany
    J Hypertens 23:905-11. 2005
    ....
  96. ncbi request reprint The role of nitric oxide in the regulation of glomerular haemodynamics in humans
    Christian Delles
    Department of Medicine IV 4, University of Erlangen Nuremburg, Erlangen, Germany
    Nephrol Dial Transplant 19:1392-7. 2004
    ..According to experimental data, the afferent glomerular arteriole is particularly under control of nitric oxide (NO). By use of pharmacological manoeuvres, we examined whether this finding holds true in the human renal circulation in vivo...
  97. ncbi request reprint Effects of sympathetic nerves and angiotensin II on renal sodium and water handling in rats with common bile duct ligature
    Roland Veelken
    Dept of Medicine IV, Univ of Erlangen Nürnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 288:F1267-75. 2005
    ..We speculate that similar changes may contribute to long-term volume retention in liver cirrhosis...