R E Schmieder

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Renin uptake by the endothelium mediates vascular angiotensin formation
    K F Hilgers
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 38:243-8. 2001
  2. ncbi request reprint Additional antiproteinuric effect of ultrahigh dose candesartan: a double-blind, randomized, prospective study
    Roland E Schmieder
    Universitatsklinikum Erlangen, Medizinische Klinik IV, Krankenhausstrasse 12, Erlangen 91054, Germany
    J Am Soc Nephrol 16:3038-45. 2005
  3. ncbi request reprint Effects of nitric oxide synthase inhibition and L-arginine on renal haemodynamics in young patients at high cardiovascular risk
    Markus P Schlaich
    Department of Medicine 4 Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Atherosclerosis 192:155-60. 2007
  4. ncbi request reprint Low-grade albuminuria and cardiovascular risk : what is the evidence?
    Roland E Schmieder
    Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitatsklinikum Erlangen, Krankenhausstrasse 12, 91054, Erlangen, Germany
    Clin Res Cardiol 96:247-57. 2007
  5. doi request reprint Effects of angiotensin II type 1-receptor blockade on retinal endothelial function
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    J Hypertens 26:516-22. 2008
  6. pmc Renal protection in diabetes: lessons from ONTARGET
    Eberhard Ritz
    Universitat Erlangen, Medizinische Klinik IV, Erlangen, Germany
    Cardiovasc Diabetol 9:60. 2010
  7. ncbi request reprint Optimizing therapeutic strategies to achieve renal and cardiovascular risk reduction in diabetic patients with angiotensin receptor blockers
    Roland E Schmieder
    Department of Medicine and Nephrology, University Erlangen Nuernberg, Erlangen, Germany
    J Hypertens 23:905-11. 2005
  8. ncbi request reprint Telmisartan/hydrochlorothiazide combination therapy in the treatment of essential hypertension
    Roland E Schmieder
    University Erlangen Nuremberg, Department of Medicine IV, Germany
    Expert Opin Pharmacother 5:2303-10. 2004
  9. ncbi request reprint Blood pressure control in patients with comorbidities
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany
    J Clin Hypertens (Greenwich) 10:624-31. 2008
  10. ncbi request reprint Effect of irbesartan versus atenolol on left ventricular mass and voltage: results of the CardioVascular Irbesartan Project
    Markus P Schneider
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Germany
    Hypertension 44:61-6. 2004

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Renin uptake by the endothelium mediates vascular angiotensin formation
    K F Hilgers
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 38:243-8. 2001
    ..The effects of endothelium destruction on Ang I formation support the notion that the endothelium mediates vascular angiotensin formation by taking up renin...
  2. ncbi request reprint Additional antiproteinuric effect of ultrahigh dose candesartan: a double-blind, randomized, prospective study
    Roland E Schmieder
    Universitatsklinikum Erlangen, Medizinische Klinik IV, Krankenhausstrasse 12, Erlangen 91054, Germany
    J Am Soc Nephrol 16:3038-45. 2005
    ..57]; NS). No change in BP was noticed in response to the different doses of candesartan. These data indicate an additive antiproteinuric effect of ultrahigh dose of the angiotensin receptor blocker candesartan compared with standard dose...
  3. ncbi request reprint Effects of nitric oxide synthase inhibition and L-arginine on renal haemodynamics in young patients at high cardiovascular risk
    Markus P Schlaich
    Department of Medicine 4 Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Atherosclerosis 192:155-60. 2007
    ..Whether such an association is already evident in the renal vascular bed in young patients at high cardiovascular risk has not yet been determined...
  4. ncbi request reprint Low-grade albuminuria and cardiovascular risk : what is the evidence?
    Roland E Schmieder
    Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitatsklinikum Erlangen, Krankenhausstrasse 12, 91054, Erlangen, Germany
    Clin Res Cardiol 96:247-57. 2007
    ..MA is modifiable, and the inhibition of the renin-angiotensin system by ACE inhibitors and AT1 receptor antagonists has been shown to result in a lower incidence of cardiovascular events...
  5. doi request reprint Effects of angiotensin II type 1-receptor blockade on retinal endothelial function
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    J Hypertens 26:516-22. 2008
    ..We tested whether AT1-receptor blockade improved endothelial function of the retinal vasculature in normocholesterolemic and hypercholesterolemic subjects...
  6. pmc Renal protection in diabetes: lessons from ONTARGET
    Eberhard Ritz
    Universitat Erlangen, Medizinische Klinik IV, Erlangen, Germany
    Cardiovasc Diabetol 9:60. 2010
    ....
  7. ncbi request reprint Optimizing therapeutic strategies to achieve renal and cardiovascular risk reduction in diabetic patients with angiotensin receptor blockers
    Roland E Schmieder
    Department of Medicine and Nephrology, University Erlangen Nuernberg, Erlangen, Germany
    J Hypertens 23:905-11. 2005
    ....
  8. ncbi request reprint Telmisartan/hydrochlorothiazide combination therapy in the treatment of essential hypertension
    Roland E Schmieder
    University Erlangen Nuremberg, Department of Medicine IV, Germany
    Expert Opin Pharmacother 5:2303-10. 2004
    ....
  9. ncbi request reprint Blood pressure control in patients with comorbidities
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany
    J Clin Hypertens (Greenwich) 10:624-31. 2008
    ..Not all available antihypertensives are equally effective in controlling BP over 24 hours, and some may exacerbate underlying metabolic abnormalities...
  10. ncbi request reprint Effect of irbesartan versus atenolol on left ventricular mass and voltage: results of the CardioVascular Irbesartan Project
    Markus P Schneider
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Germany
    Hypertension 44:61-6. 2004
    ..Because voltage criteria for LVH have been shown to predict cardiovascular outcome independently from LVM, we suggest that both methods should be used to accurately assess the benefits of antihypertensive treatment...
  11. ncbi request reprint Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Diabetes Care 30:1351-6. 2007
    ..The aim of this study was to analyze the effects of renin-angiotensin system (RAS) blockade on renal endothelial function...
  12. doi request reprint Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Circulation 119:417-25. 2009
    ..This randomized, double-blind, multicenter study assessed the long-term efficacy and safety of the direct renin inhibitor aliskiren in comparison with the diuretic hydrochlorothiazide in patients with essential hypertension...
  13. doi request reprint Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in obese patients with hypertension: sub-analysis of a 52-week, randomized, double-blind trial
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    J Hypertens 27:1493-501. 2009
    ..To compare the long-term efficacy, safety and tolerability of the direct renin inhibitor aliskiren against the diuretic hydrochlorothiazide (HCTZ) in obese patients with hypertension...
  14. doi request reprint Gender is related to alterations of renal endothelial function in type 2 diabetes
    Markus P Schneider
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Germany
    Nephrol Dial Transplant 24:3354-9. 2009
    ..We hypothesized that renal vascular nitric oxide (NO) availability is higher, and oxidative stress lower, in female compared to male patients with type 2 diabetes...
  15. ncbi request reprint [Left ventricular hypertrophy. Recent aspects of diagnosis and therapy]
    Roland E Schmieder
    Universität Erlangen Nürnberg Medizinische Klinik IV 4 Klinikum Nürnberg Süd Breslauer Strasse 201 90471 Nürnberg
    MMW Fortschr Med 144:45-6. 2002
  16. doi request reprint Reduced incidence of new-onset atrial fibrillation with angiotensin II receptor blockade: the VALUE trial
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Erlangen Nuremberg, Erlangen, Germany
    J Hypertens 26:403-11. 2008
    ..Therefore, in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) a prespecified objective was to compare the effects of valsartan and amlodipine on new-onset AF...
  17. ncbi request reprint [Observational study of blood pressure control and microalbuminuria in type 2 diabetics on Irbesartan or Irbesartan/HCTZ]
    R E Schmieder
    Universitätsklinikum Erlangen Medizinische Klinik IV, Erlangen
    MMW Fortschr Med 147:43. 2005
  18. ncbi request reprint Renin-angiotensin system and cardiovascular risk
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Lancet 369:1208-19. 2007
    ..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
  19. ncbi request reprint [Subclinical albuminuria, microalbuminuria and proteinuria--accepted cardiovascular risk markers?]
    R E Schmieder
    Medizinische Klinik 4 der Universität Erlangen Nürnberg
    Dtsch Med Wochenschr 131:2665-71. 2006
  20. ncbi request reprint The potential role of prorenin in diabetic nephropathy
    Roland E Schmieder
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Germany
    J Hypertens 25:1323-6. 2007
  21. ncbi request reprint [Albuminuria: an indicator of cardiovascular risk]
    Peter Bramlage
    Institut fur Klinische Pharmakologie, Medizinische Fakultat, TU Dresden, Dresden
    Med Klin (Munich) 102:833-43; quiz 844-5. 2007
    ..The appearance of albumin in the urine is pathologic and should be evaluated within the context of the accompanying cardiovascular risk...
  22. ncbi request reprint [Guidelines 2007 of the European Societies of Hypertension and of Cardiology: what has changed?]
    R E Schmieder
    Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitatsklinikum Erlangen, Erlangen
    Dtsch Med Wochenschr 132:2463-6. 2007
  23. ncbi request reprint Analysis of NO-synthase expression and clinical risk factors in human diabetic nephropathy
    Bernd Hohenstein
    Roland E Schmieder, Department of Nephrology and Hypertension, University Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany Tel 49 9131 8536245 Fax 49 9131 8539209 E mail
    Nephrol Dial Transplant 23:1346-54. 2008
    ..It is still not yet specified whether the regulation and activity of NOS is changed in human diabetic nephropathy...
  24. ncbi request reprint Endothelial dysfunction: how can one intervene at the beginning of the cardiovascular continuum?
    Roland E Schmieder
    University of Erlangen Nuremberg, Germany
    J Hypertens Suppl 24:S31-5. 2006
    ..Intervention at the beginning of the renal and cardiovascular continuum offers the opportunity to prevent the fatal development towards renal and cardiac failure...
  25. ncbi request reprint Renin inhibitors: optimal strategy for renal protection
    Roland E Schmieder
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Curr Hypertens Rep 9:415-21. 2007
    ..Aliskiren is a new orally active DRI with proven BP-lowering effects. Animal studies indicate that aliskiren may provide renal protection, and data from human studies are anticipated...
  26. ncbi request reprint Are all antihypertensive drug classes equal in reducing left ventricular hypertrophy?
    Erwin H Fleischmann
    Department of Internal Medicine 4 IV, University of Erlangen Nuremberg, Breslauer Strasse 201, 90475 Nuremberg, Germany
    Curr Cardiol Rep 4:474-8. 2002
    ..It also proves for the first time that regression of LVH is associated with better cardiovascular outcome...
  27. ncbi request reprint Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans
    R E Schmieder
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Germany
    J Am Coll Cardiol 37:175-82. 2001
    ..Our study goal was to analyze whether gene variants of angiotensin II type 2-receptor (AT2-R) modulate the effects of angiotensin II on the left ventricle (LV)...
  28. ncbi request reprint Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase
    M P Schneider
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Germany
    J Hypertens 18:1767-73. 2000
    ..To test whether the Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene is of functional relevance in humans by altering endothelium-dependent vasodilation...
  29. ncbi request reprint Impaired sodium excretion during mental stress in mild essential hypertension
    M P Schneider
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Germany
    Hypertension 37:923-7. 2001
    ..This abnormality in sodium handling during activation of the sympathetic nervous system appears to be mediated by angiotensin II...
  30. ncbi request reprint Hypertension and the heart
    R E Schmieder
    Department of Medicine IV, University of Erlangen Nurnberg, Germany
    J Hum Hypertens 14:597-604. 2000
    ..Various aspects of LV hypertrophy including its prevalence, determinants, prognosis and regression are discussed in this article...
  31. ncbi request reprint Diuretic therapy and the risk for renal cell carcinoma
    R E Schmieder
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Germany
    J Nephrol 13:343-6. 2000
    ..In general, in many clinical conditions, the reduction of mortality with diuretic therapy outweighs a potential risk of renal cell carcinoma. However, in certain conditions, alternative medical treatment should be considered...
  32. ncbi request reprint Effect of AT1 receptor blockade on endothelial function in essential hypertension
    Arnfried U Klingbeil
    Department of Medicine IV, University of Erlangen Nümberg, Erlangen Nurnberg, Germany
    Am J Hypertens 16:123-8. 2003
    ..Angiotensin II adversely affects endothelial function and NO availability. We analyzed the effect of AT(1) receptor blockade on endothelium-dependent vasodilation and basal nitric oxide (NO) production and release in hypertensive patients...
  33. ncbi request reprint Impaired basal NO activity in patients with glomerular disease and the influence of oxidative stress
    T G Schäufele
    Department of Medicine 4 Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Kidney Int 70:1177-81. 2006
    ..This might be in part related to increased oxidative stress...
  34. ncbi request reprint The effect of statins on angiotensin II-induced hemodynamic changes in young, mildly hypercholesterolemic men
    E H Fleischmann
    Department of Medicine 4 IV, University Erlangen Nuremberg, 90475 Nuremberg, Germany
    Am J Hypertens 17:1120-6. 2004
    ..We analyzed to what extent statins and AT(1) receptor antagonists diminish the vasoconstrictive response to Ang II infusion in hypercholesterolemic patients...
  35. ncbi request reprint Lack of association between polymorphisms of angiotensin II receptor genes and response to short-term angiotensin II infusion
    C Delles
    Department of Medicine and Nephrology, University of Erlangen Nurnberg, Germany
    J Hypertens 18:1573-8. 2000
    ..In this study, we examined the short-term effects of genetic polymorphisms of the angiotensin II AT1 - and AT2-receptor subtypes in humans by means of angiotensin II infusion...
  36. ncbi request reprint Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks
    S John
    Department of Medicine IV, , , , Germany
    J Am Coll Cardiol 37:1351-8. 2001
    ..CONCLUSIONS: Short-term lipid-lowering therapy with cerivastatin can improve endothelial function and NO bioavailability after two weeks in patients with hypercholesterolemia...
  37. doi request reprint Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Kidney Dis 53:281-9. 2009
    ..Basal nitric oxide (NO) activity has a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments, its alteration has been associated with morphological changes characteristic of diabetic nephropathy...
  38. ncbi request reprint Elevation of sympathetic activity by eprosartan in young male subjects
    Karsten Heusser
    Department of Medicine IV Nephrology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Am J Hypertens 16:658-64. 2003
    ..We examined the effects of AT1 receptor blockade on the sympathetic nervous system in humans...
  39. ncbi request reprint Rosuvastatin improves basal nitric oxide activity of the renal vasculature in patients with hypercholesterolemia
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Atherosclerosis 196:704-11. 2008
    ..Whether this also holds true in the renal circulation has not yet been adequately addressed...
  40. ncbi request reprint Impaired endothelial function of the retinal vasculature in hypertensive patients
    Christian Delles
    Department of Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Stroke 35:1289-93. 2004
    ..Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation...
  41. doi request reprint Efficacy and safety of olmesartan medoxomil plus amlodipine in age, gender and hypertension severity defined subgroups of hypertensive patients
    R E Schmieder
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Krankenhausstrasse 12, Erlangen, Germany
    J Hum Hypertens 25:354-63. 2011
    ..Small differences in responsiveness between females and males may exist, which require further investigation...
  42. pmc Significance of initial blood pressure and comorbidity for the efficacy of a fixed combination of an angiotensin receptor blocker and hydrochlorothiazide in clinical practice
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Hospital of Erlangen, Germany
    Vasc Health Risk Manag 5:991-1000. 2009
    ..Fixed combinations have high efficacy and result in high patient compliance. 300 mg irbesartan plus 25 mg hydrochlorothiazide (HCTZ) has been investigated only in clinical trials but not in daily practice...
  43. doi request reprint Renal resistive index--a valid tool to assess renal endothelial function in humans?
    Ulrike Raff
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Nephrol Dial Transplant 25:1869-74. 2010
    ..We hypothesized that Doppler sonographic measurements of the renal resistive index in response to inhibition of nitric oxide synthase offer a new methodological approach for testing renal endothelial function...
  44. ncbi request reprint Gender-specific cardiovascular adaptation due to circadian blood pressure variations in essential hypertension
    R E Schmieder
    Department of Medicine IV, University of Erlangen-Nuremberg, Nuremberg, Germany
    Am J Hypertens 8:1160-6. 1995
    ....
  45. ncbi request reprint Angiotensinases restrict locally generated angiotensin II to the blood vessel wall
    K F Hilgers
    Department of Medicine IV, University of Erlangen, Germany
    Hypertension 31:368-72. 1998
    ..We conclude that the major part of locally generated angiotensins is not released into the circulation but degraded by angiotensinases within the tissue compartment...
  46. doi request reprint Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes
    Christian Delles
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 21:1330-6. 2008
    ..We examined adiponectin levels in patients with type 2 diabetes who participated in the Telmisartan vs. Ramipril in Renal Endothelial Dysfunction (TRENDY) study...
  47. ncbi request reprint AT1-receptor blockade improves augmentation index: a double-blind, randomized, controlled study
    Arnfried U Klingbeil
    Department of Medicine IV, University of Erlangen Nurnberg, Germany
    J Hypertens 20:2423-8. 2002
    ..Arterial hypertension leads to vascular structural and functional adaptive processes that are influenced by angiotensin II. To analyze the effects of AT receptor blockade on vascular function we determined augmentation index...
  48. ncbi request reprint The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia
    Markus P Schneider
    Universitat Erlangen Nurnberg, Medizinische Klinik IV 4, Klinikum Nürnberg Süd, Breslauer Strasse 201, D 90471 Nuremberg, Germany
    Clin Sci (Lond) 105:97-103. 2003
    ....
  49. ncbi request reprint AT1 antagonism by eprosartan lowers heart rate variability and baroreflex gain
    Karsten Heusser
    Department of Medicine IV Nephrology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054, Erlangen, Germany
    Auton Neurosci 107:45-51. 2003
    ..We sought to assess the effects of the angiotensin type 1 (AT1) receptor blocker eprosartan on HRV and BRG...
  50. ncbi request reprint The role of nitric oxide in the regulation of glomerular haemodynamics in humans
    Christian Delles
    Department of Medicine IV 4, University of Erlangen Nuremburg, Erlangen, Germany
    Nephrol Dial Transplant 19:1392-7. 2004
    ..According to experimental data, the afferent glomerular arteriole is particularly under control of nitric oxide (NO). By use of pharmacological manoeuvres, we examined whether this finding holds true in the human renal circulation in vivo...
  51. ncbi request reprint Efficacy, safety and tolerability of valsartan 80 mg compared to irbesartan 150 mg in hypertensive patients on long-term hemodialysis (VALID study)
    M Leidig
    Department of Medicine IV Nephrology and Hypertension, University of Erlangen Nurnberg, Bad Muender, Germany
    Clin Nephrol 69:425-32. 2008
    ....
  52. ncbi request reprint Renal and systemic hemodynamics in black and white hypertensive patients
    J K Rockstroh
    Department of Medicine IV, , , Germany
    Am J Hypertens 10:971-8. 1997
    ..When defining arterial pressure by 24-h ambulatory monitoring, no differences in early target organ damage can be found between black and white patients with mild essential hypertension...
  53. ncbi request reprint Renal and cardiac effects of antihypertensive treatment with ramipril vs metoprolol in autosomal dominant polycystic kidney disease
    Raoul Zeltner
    Department of Nephrology and Hypertension, University of Erlangen Nuernberg, Nuernberg, Germany
    Nephrol Dial Transplant 23:573-9. 2008
    ..This prospective randomized double-blind study was performed to compare the renal and cardiac effects of the ACE inhibitor ramipril and the beta-blocker metoprolol as first line therapy in ADPKD patients with hypertension...
  54. doi request reprint Measurement of kidney perfusion by magnetic resonance imaging: comparison of MRI with arterial spin labeling to para-aminohippuric acid plasma clearance in male subjects with metabolic syndrome
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 25:1126-33. 2010
    ....
  55. ncbi request reprint Rapid nongenomic effects of aldosterone on the renal vasculature in humans
    Bernhard M W Schmidt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Hypertension 47:650-5. 2006
    ..Antagonizing the endothelial NO synthase unmasks these effects. Therefore, rapid nongenomic aldosterone effects increase renal vascular resistance and thereby mediate arterial hypertension if endothelial dysfunction is present...
  56. ncbi request reprint Valsartan and retinal endothelial function in elderly hypertensive patients
    Sebastian Oehmer
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Blood Press 15:185-91. 2006
    ..The aim of this study was to investigate the impact of short-term treatment with the angiotensin II receptor blocker (ARB) valsartan on retinal endothelial function in elderly patients with mild to moderate essential hypertension...
  57. ncbi request reprint A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension
    Arnfried U Klingbeil
    Department of Medicine IV, University of Erlangen Nurnberg, Nuremberg, Germany
    Am J Med 115:41-6. 2003
    ..Antihypertensive medications have different effects on left ventricular mass. We conducted a meta-analysis of double-blind trials that measured the effects of antihypertensive therapy on left ventricular mass...
  58. ncbi request reprint Rosuvastatin does not affect intrarenal hemodynamics in patients with hypercholesterolemia
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    J Nephrol 22:675-81. 2009
    ..However, the potential renoprotective effects of statin treatment have not been fully elucidated and so far no study has analyzed the effects of statin treatment on intrarenal hemodynamics...
  59. ncbi request reprint Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension
    Markus P Schneider
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 18:1111-7. 2005
    ..We therefore compared the acute superoxide scavenging efficacy of NAC against vitamin C (VITC) on impaired endothelium-dependent vasodilation in subjects with essential hypertension...
  60. doi request reprint Effect of angiotensin receptor blockade on central haemodynamics in essential hypertension: results of a randomised trial
    Markus P Schneider
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Germany
    J Renin Angiotensin Aldosterone Syst 9:49-56. 2008
    ..We tested whether this is also true for long-term treatment with an angiotensin receptor blocker (ARB)...
  61. doi request reprint Rosuvastatin improves pulse wave reflection by restoring endothelial function
    C Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Microvasc Res 84:60-4. 2012
    ..Overall, in patients without CV disease, rosuvastatin exerted beneficially effect on vascular dysfunction, one of the earliest manifestation of atherosclerosis...
  62. ncbi request reprint Subthreshold stimulation of a serotonin 5-HT3 reflex attenuates cardiovascular reflexes
    R Veelken
    Department of Internal Medicine, University of Erlangen Nurnberg, Germany
    Am J Physiol 271:R1500-6. 1996
    ..We conclude that 5-HT3-serotonergic cardiopulmonary chemoreceptors blunt the RSNA decrease to volume loading. This mechanism may facilitate volume retention when cardiac serotonin is increased...
  63. ncbi request reprint [Proven and new parameters of hypertensive target organ damage]
    B M Schmidt
    Medizinische Klinik 4 Nephrologie und Hypertensiologie, Clinical Research Center, Universitat Erlangen Nurnberg, Erlangen, Germany
    Dtsch Med Wochenschr 131:H20-3. 2006
  64. ncbi request reprint CYP3A5 genotype is associated with elevated blood pressure
    Martin F Fromm
    Institute of Clinical and Experimental Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenet Genomics 15:737-41. 2005
    ..We interpret the lower serum aldosterone concentration in the genotype group with the elevated systolic blood pressure as a counter-regulatory mechanism to attenuate the increased blood pressure associated with the CYP3A5*3/*3 genotype...
  65. ncbi request reprint Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia
    Stefan John
    Department of Medicine IV, University of Erlangen Nurnberg, Klinikum Nürnberg Süd, Breslauerstr 201, 90471 Nürnberg, Germany
    Curr Hypertens Rep 5:199-207. 2003
    ..Statins and blockers of the renin-angiotensin system seem to have such antioxidative effects independent from their effects on lipid profiles or blood pressure control...
  66. doi request reprint [Chronobiology of blood pressure and chronopharmacotherapy of arterial hypertension]
    R E Schmieder
    Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitatsklinikum Erlangen
    Dtsch Med Wochenschr 137:317-21. 2012
    ..The present manuscript reviews the chronopharmacotherapy of arterial hypertension and grant practical recommendations for their translation into clinical practice...
  67. ncbi request reprint Angiotensinogen gene core promoter variants and non-modulating hypertension
    K F Hilgers
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Nurnberg, Germany
    Hypertension 38:1250-4. 2001
    ..We conclude that the -20 C variant or the -20 C/-6 A haplotype of the angiotensinogen core promoter is associated with a blunted aldosterone response to Ang II and may thus contribute to the non-modulating phenotype...
  68. doi request reprint Change in augmentation index during NOS inhibition, an index of basal NO production, is an independent determinant of large-artery function
    M P Schneider
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen Nuremberg, Germany
    Kidney Blood Press Res 33:343-51. 2010
    ..Arterial wave reflection, measured as augmentation index (AIx), and central pulse pressure (PP) closely predict cardiovascular events. We hypothesized that basal nitric oxide (NO) production would be a determinant of AIx and central PP...
  69. ncbi request reprint [Combination therapy: used too little and too late?]
    R Veelken
    Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitat Erlangen Nurnberg
    MMW Fortschr Med 150:27-8, 30. 2008
  70. doi request reprint Wall-to-lumen ratio of retinal arterioles and arteriole-to-venule ratio of retinal vessels in patients with cerebrovascular damage
    Delia Baleanu
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:4351-9. 2009
    ..The primary objective was to test the association between WLR and AVR in a distinct cohort of patients with cerebrovascular damage...
  71. ncbi request reprint Altered aldosterone response to salt intake and angiotensin II infusion in young normotensive men with parental history of arterial hypertension
    Markus P Schlaich
    Department of Medicine IV Nephrology, University of Erlangen Nurnberg, Breslauer Strasse 201, D 90471 Nürnberg, Germany
    J Hypertens 20:117-24. 2002
    ....
  72. doi request reprint Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension
    Bernd Klanke
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 23:3456-63. 2008
    ..We examined the contribution of high blood pressure versus direct mineralocorticoid effects to the progression of kidney inflammation and fibrosis in established experimental deoxycorticosterone-acetate (DOCA)-salt hypertension...
  73. ncbi request reprint Left ventricular hypertrophy and its regression: pathophysiology and therapeutic approach: focus on treatment by antihypertensive agents
    M P Schlaich
    Department of Medicine IV, , , Germany
    Am J Hypertens 11:1394-404. 1998
    ..Further prospective controlled trials will be required to finally evaluate whether the excellent reduction of LVH with ACE inhibitors and calcium channel blockers can be transferred into improved cardiovascular prognosis...
  74. ncbi request reprint 825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension
    J Jacobi
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Germany
    J Hypertens 17:1457-62. 1999
    ..In this study, we investigated the impact of the 825T allele on left ventricular structure and function in mild to moderate essential hypertensive subjects...
  75. ncbi request reprint Efficacy and drug interactions of the new HMG-CoA reductase inhibitors cerivastatin and atorvastatin in CsA-treated renal transplant recipients
    L Renders
    Medizinische Klinik IV, , Erlangen, Germany
    Nephrol Dial Transplant 16:141-6. 2001
    ..Further research in a larger study is necessary in order to confirm these results and to investigate the possible reasons for this drug interaction...
  76. ncbi request reprint [Observational study of blood pressure control and microalbuminuria in type 2 diabetics on irbesartan or irbesartan/HCTZ]
    R E Schmieder
    Medizinische Klinik IV der Universität Erlangen Nürnberg
    MMW Fortschr Med 147:97-101. 2005
    ..Inclusion criteria were type 2 diabetes, hypertension > 140/90 mmHg and current treatment with irbesartan or irbesartan/hydrochlorothiazide (HTCZ). The observational study covered a period of 6 months...
  77. ncbi request reprint [Control of systolic blood pressure in the VALUE trial after 12 months]
    R E Schmieder
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Nuremberg
    Dtsch Med Wochenschr 128:485-6. 2003
  78. ncbi request reprint [A model project on shared decision-making in the treatment of arterial hypertension]
    A Deinzer
    Institut für Präventive Medizin, Klinikum Nürnberg, Universitat Erlangen Nurnberg
    MMW Fortschr Med 146:48-50. 2004
  79. ncbi request reprint Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients
    Stefan John
    Department of Medicine IV, University of Erlangen Nurnberg, Erlangen, Germany
    Am Heart J 149:473. 2005
    ..We investigated whether improvement in NO availability in hypercholesterolemia can be achieved rapidly with statins before lipid-lowering therapy is complete...
  80. ncbi request reprint The role of statins in the treatment of the metabolic syndrome
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Curr Hypertens Rep 11:143-9. 2009
    ..Thus, evidence is accumulating that statins are very effective therapeutic agents in the treatment of individuals with the metabolic syndrome...
  81. ncbi request reprint Effects of sympathetic nerves and angiotensin II on renal sodium and water handling in rats with common bile duct ligature
    Roland Veelken
    Dept of Medicine IV, Univ of Erlangen Nürnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 288:F1267-75. 2005
    ..We speculate that similar changes may contribute to long-term volume retention in liver cirrhosis...
  82. ncbi request reprint Renal endothelial effects of antihypertensive therapy
    Christian Delles
    Department of Medicine IV, University of Erlangen Nurnberg, Germany
    Curr Opin Nephrol Hypertens 13:489-93. 2004
    ..To review the influence of antihypertensive therapy on the contribution of nitric oxide (NO) to renal perfusion in essential hypertension...
  83. ncbi request reprint Effect of erythropoietin on cardiovascular prognosis parameters in hemodialysis patients
    Helga Frank
    Medical Clinic IV, Department of Nephrology, University of Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 66:832-40. 2004
    ..In addition, an autonomic dysfunction is associated with the uremic state and influences the cardiovascular risk in patients with end-stage renal disease (ESRD)...
  84. doi request reprint Impact of the endothelial nitric oxide synthase gene G894T polymorphism on renal endothelial function in patients with type 2 diabetes
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Pharmacogenet Genomics 18:699-707. 2008
    ....
  85. doi request reprint Prevention of atrial fibrillation by Renin-Angiotensin system inhibition a meta-analysis
    Markus P Schneider
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Am Coll Cardiol 55:2299-307. 2010
    ..The authors reviewed published clinical trial data on the effects of renin-angiotensin system (RAS) inhibition for the prevention of atrial fibrillation (AF), aiming to define when RAS inhibition is most effective...
  86. ncbi request reprint Effects of angiotensin II receptor antagonism on the renal hemodynamic response to cardiovascular stress
    Helga Frank
    Medical Clinic IV, Department of Internal Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 63:617-23. 2003
    ....
  87. ncbi request reprint Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate-salt hypertension
    Andrea Hartner
    Hospital for Children and Adolescents, Erlangen, Germany
    J Hypertens 27:376-85. 2009
    ..We examined the effects of fluvastatin treatment on the development of kidney injury in experimental deoxycorticosterone-acetate (DOCA)-salt hypertension...
  88. doi request reprint The role of fixed-dose combination therapy with drugs that target the renin-angiotensin system in the hypertension paradigm
    Roland E Schmieder
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Germany
    Clin Exp Hypertens 32:35-42. 2010
    ..This review aims to highlight the simplicity, tolerability, and convenience of fixed-dose combinations targeting the renin-angiotensin system, which can lead to improved compliance and more patients achieving BP goals...
  89. ncbi request reprint Mechanisms for the clinical benefits of angiotensin II receptor blockers
    Roland E Schmieder
    Medizinische Klinik IV, Universität Erlangen Nuernberg, Erlangen, Germany
    Am J Hypertens 18:720-30. 2005
    ..In addition, both recent and ongoing clinical trials help to clarify further the mechanisms for the benefits of using ARB across the cardiovascular continuum...
  90. ncbi request reprint The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Anesth Analg 103:1170-6. 2006
    ..Further studies are warranted to determine adverse renal effects of longer-lasting therapy with these drugs, especially in patients with renal impairment or concomitant diseases...
  91. ncbi request reprint Increased wall:lumen ratio of retinal arterioles in male patients with a history of a cerebrovascular event
    Joanna M Harazny
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 50:623-9. 2007
    ..40+/-0.13 versus 0.31+/-0.13; P=0.025). Thus, assessment of wall:lumen ratio of retinal arterioles emerged as an attractive tool to identify treated patients with hypertension with increased cerebrovascular risk...
  92. ncbi request reprint Effect of nos inhibition on retinal arterial and capillary circulation in early arterial hypertension
    Georg Michelson
    Augenklinik mit Poliklinik, Universitat Erlangen Nurnberg, Schwabachanlage 6, D 91053 Erlangen, Germany
    Retina 26:437-44. 2006
    ..This study analyzes changes of retinal and systemic NO-dependent circulation parameters by inhibiting nitric oxide synthase (NOS) in both hypertensive and normotensive individuals...
  93. ncbi request reprint Fourier analysis of the envelope of the ophthalmic artery blood flow velocity: age- and blood pressure related impact
    Georg Michelson
    Department of Ophthalmology and Nephrology, University Erlangen Nurnberg, Erlangen, Germany
    Hypertension 50:964-9. 2007
    ..The SI of the ophthalmic artery allows an assessment of the ocular circulation in consideration of age and arterial blood pressure in contrast to the resistance index...
  94. doi request reprint Elevated VEGF-plasma levels in young patients with mild essential hypertension
    C Stumpf
    Department of Cardiology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Clin Invest 39:31-6. 2009
    ..To investigate the hypothesis that VEGF plays a role as an inflammatory mediator in EH we performed the present pilot study of young patients in a very early stage of EH...
  95. ncbi request reprint Effects of continuous haemofiltration vs intermittent haemodialysis on systemic haemodynamics and splanchnic regional perfusion in septic shock patients: a prospective, randomized clinical trial
    S John
    Department of Medicine IV, , , , Germany
    Nephrol Dial Transplant 16:320-7. 2001
    ..s.). CONCLUSIONS: Despite different changes of systemic haemodynamics between CVVH and IHD, CVVH did not improve parameters of splanchnic regional perfusion like pHi, pCO(2)i or pCO(2) gap in septic shock patients...
  96. ncbi request reprint Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in rats
    J Jacobi
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Kidney Int 69:2013-21. 2006
    ..Impaired angioadaptation may contribute to the poor prognosis of patients with renal failure suffering from peripheral arterial disease...
  97. ncbi request reprint [Are COX-2 inhibitors a risk factor for cardiovascular disease?]
    S John
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Germany
    Dtsch Med Wochenschr 127:156-9. 2002
  98. ncbi request reprint Hypercholesterolaemia and treatment with statins do not alter L-arginine-induced changes of renal haemodynamics
    Erwin H Fleischmann
    Department of Medicine IV 4 Nephrology, University of Erlangen Nurnberg, Germany
    Nephrol Dial Transplant 17:1758-65. 2002
    ..Hypercholesterolaemia has been found to impair endothelial function in the systemic and coronary circulations and lipid-lowering therapy with statins has been shown to improve this abnormality...
  99. ncbi request reprint Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension
    Christian Delles
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Nurnberg, Germany
    Am J Hypertens 15:590-3. 2002
    ..Asymmetrical N(G), N(G)-dimethylarginine (ADMA) is associated with impaired endothelium-dependent vasodilation in humans...
  100. ncbi request reprint Assessment of endothelial function of the renal vasculature in human subjects
    Christian Delles
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Germany
    Am J Hypertens 15:3-9. 2002
    ..However, little is known about the appropriate dose of L-arginine to be used and the duration of action of L-arginine and L-NMMA...
  101. ncbi request reprint Impact of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects
    Johannes Jacobi
    Department of Medicine Nephrology, University of Erlangen Nurnberg, Germany
    J Hypertens 20:525-30. 2002
    ..To examine the acute effects of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjects...