M Schmelz

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen, Germany
    Eur J Pain 8:237-44. 2004
  2. ncbi request reprint Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo
    Otilia Obreja
    Institut fur Physiologie und Experimentelle Pathophysiologie, Universitatsstrasse 17, Erlangen, Germany
    Pain 96:57-62. 2002
  3. ncbi request reprint Itch and pain
    Martin Schmelz
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Dermatol Ther 18:304-7. 2005
  4. ncbi request reprint Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany
    Exp Dermatol 15:58-65. 2006
  5. doi request reprint Translating nociceptive processing into human pain models
    Martin Schmelz
    Department of Anesthesiology, University of Heidelberg, Mannheim, Germany
    Exp Brain Res 196:173-8. 2009
  6. doi request reprint Microneurographic single-unit recordings to assess receptive properties of afferent human C-fibers
    M Schmelz
    Department of Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Neurosci Lett 470:158-61. 2010
  7. ncbi request reprint [Interactions between itch and pain]
    M Schmelz
    Karl Feuerstein Professur, Klinik fur Anasthesiologie und Operative Intensivmedizin, Fakultät für Klinische Medizin Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim
    Hautarzt 57:385-6, 388-9. 2006
  8. doi request reprint [Opioid-induced pruritus. Mechanisms and treatment regimens]
    M Schmelz
    Institut fur Anasthesiologie und Operative Intensivmedizin, Klinische Fakultät Mannheim, Ruprecht Karls Universitat Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Deutschland
    Anaesthesist 58:61-5. 2009
  9. doi request reprint Itch and pain
    Martin Schmelz
    Department Anesthesiology and Intensive Care Medicine, Karl Feuerstein Professorship, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Neurosci Biobehav Rev 34:171-6. 2010
  10. ncbi request reprint Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Germany
    J Neurophysiol 89:2441-8. 2003

Detail Information

Publications90

  1. ncbi request reprint Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen, Germany
    Eur J Pain 8:237-44. 2004
    ....
  2. ncbi request reprint Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo
    Otilia Obreja
    Institut fur Physiologie und Experimentelle Pathophysiologie, Universitatsstrasse 17, Erlangen, Germany
    Pain 96:57-62. 2002
    ....
  3. ncbi request reprint Itch and pain
    Martin Schmelz
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Dermatol Ther 18:304-7. 2005
    ..It will be of major interest to reveal whether the underlying mechanism for sensitization in the itch and pain pathways are also similar, as this might have major implications for therapy...
  4. ncbi request reprint Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany
    Exp Dermatol 15:58-65. 2006
    ..Thrombin-induced PE and VD are mediated mainly by a non-neurogenic mechanism...
  5. doi request reprint Translating nociceptive processing into human pain models
    Martin Schmelz
    Department of Anesthesiology, University of Heidelberg, Mannheim, Germany
    Exp Brain Res 196:173-8. 2009
    ..Thus, although being helpful for proof of concept studies and dose finding, current human pain models cannot replace patient studies for testing efficacy of analgesic compounds...
  6. doi request reprint Microneurographic single-unit recordings to assess receptive properties of afferent human C-fibers
    M Schmelz
    Department of Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Neurosci Lett 470:158-61. 2010
    ..As subjects and patients are awake during the recording, microneurography provides a unique tool to correlate the discharge behaviour of afferent nerve fibers with the sensation evoked by certain stimuli...
  7. ncbi request reprint [Interactions between itch and pain]
    M Schmelz
    Karl Feuerstein Professur, Klinik fur Anasthesiologie und Operative Intensivmedizin, Fakultät für Klinische Medizin Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim
    Hautarzt 57:385-6, 388-9. 2006
    ..The presumed similarities in underlying sensitizing mechanisms between itch and pain has major therapeutic consequences as successful therapies for chronic pain might be used also in chronic itch...
  8. doi request reprint [Opioid-induced pruritus. Mechanisms and treatment regimens]
    M Schmelz
    Institut fur Anasthesiologie und Operative Intensivmedizin, Klinische Fakultät Mannheim, Ruprecht Karls Universitat Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Deutschland
    Anaesthesist 58:61-5. 2009
    ..Spinal triggering of itching is observed in particular by activation of mu-opioid receptors (mu-OR), while kappa-OR surprisingly suppress itch. The therapeutic implications of this interaction will be described...
  9. doi request reprint Itch and pain
    Martin Schmelz
    Department Anesthesiology and Intensive Care Medicine, Karl Feuerstein Professorship, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Neurosci Biobehav Rev 34:171-6. 2010
    ..These perspectives illustrate that itch and pain research no longer follows separate paths, but can be advantageously interconnected...
  10. ncbi request reprint Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Germany
    J Neurophysiol 89:2441-8. 2003
    ....
  11. ncbi request reprint Opioids and the skin: "itchy" perspectives beyond analgesia and abuse
    Martin Schmelz
    Department of Anesthesiology Mannheim, University of Heidelberg, Heidelberg, Germany
    J Invest Dermatol 127:1287-9. 2007
    ..Recent results, however, clearly indicate that opioids play a specific role in skin homeostasis by modulating keratinocyte differentiation, wound healing, and inflammatory responses...
  12. ncbi request reprint The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction
    W Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Erlangen, Germany
    Anesth Analg 89:1521-7. 1999
    ..Ketamine failed to inhibit both secondary hyperalgesia and axon reflex flare as long as nonlocal anesthetic concentrations were applied...
  13. ncbi request reprint A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine
    W Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Germany
    Anesthesiology 95:395-402. 2001
    ..The authors used the analgesics alfentanil, S(+)-ketamine, and systemic lidocaine to examine a new human model of experimental pain and hyperalgesia...
  14. ncbi request reprint Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin
    G Lischetzki
    Department of Physiology and Experimental Pathophysiology, , Erlangen, Germany
    Eur J Pain 5:49-57. 2001
    ..It is concluded that there is no link between nociceptor activation and protein extravasation induced by inflammatory mediators in healthy human skin...
  15. pmc Action potential conduction in the terminal arborisation of nociceptive C-fibre afferents
    C Weidner
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
    J Physiol 547:931-40. 2003
    ..This indicates that the terminal branches are equipped with membrane proteins that are different from those of the parent axon...
  16. doi request reprint Skin innervation at different depths correlates with small fibre function but not with pain in neuropathic pain patients
    M Schley
    Department of Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, Heidelberg University, Germany
    Eur J Pain 16:1414-25. 2012
    ..We aimed to link reduced skin nerve fibre density in different levels to layer-specific functional impairment in neuropathic pain patients and tried to identify pain-specific functional and structural markers...
  17. doi request reprint Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans
    B Weinkauf
    Department of Anesthesiology Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany
    Eur J Pain 16:543-9. 2012
    ..sensitization of TRPV1. NGF-evoked extreme mechanical impact pain indicates high action potential discharge frequencies, which might be more susceptible to lidocaine block...
  18. ncbi request reprint Peripheral antihyperalgesic effect of morphine to heat, but not mechanical, stimulation in healthy volunteers after ultraviolet-B irradiation
    W Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Germany
    Anesth Analg 88:117-22. 1999
    ..Morphine 0.01% significantly diminished thermal, but not mechanical, hyperalgesia by a peripheral mode of action, which suggests inhibition of effector pathways leading to heat, but not mechanical, sensitization...
  19. ncbi request reprint Central origin of secondary mechanical hyperalgesia
    Monika Klede
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    J Neurophysiol 90:353-9. 2003
    ..We conclude that the development of allodynia and punctate hyperalgesia in human skin is centrally mediated, whereas the axon reflex vasodilation is of peripheral origin...
  20. doi request reprint Comparison of electrically induced flare response patterns in human and pig skin
    M Dusch
    Department of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Inflamm Res 58:639-48. 2009
    ..We compared the characteristics of neurogenic flare responses in human and pig skin to establish a translational research animal model...
  21. ncbi request reprint Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
    Neurosci Lett 214:72-4. 1996
    ..In contrast, capsaicin-induced heat hyperalgesia was unaffected by ASA. It is concluded that ASA counteracts the excitatory effects of capsaicin on nociceptors and mechanical hyperalgesia but not its sensitizing action to heat...
  22. doi request reprint Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human
    Otilia Obreja
    Department of Anesthesiology Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Pain 148:59-69. 2010
    ..Notably, cold nociceptors with a distinct ADS pattern were first detected in pig. Our results therefore suggest that the pig is a suitable model to study nociceptor class-specific changes of ADS...
  23. ncbi request reprint Density of sympathetic axons in sural nerve biopsies of neuropathy patients is related to painfulness
    A Bickel
    Department of Neurology, University of Erlangen Nuremberg, 91054, Erlangen, Germany
    Pain 84:413-9. 2000
    ..We conclude that an imbalance between afferent and sympathetic nerve fiber density in the periphery may contribute to neuropathic pain even in those patients without obvious clinical autonomic disturbances...
  24. ncbi request reprint Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans
    Wolfgang Koppert
    Department of Anesthesiology, University Clinic of Erlangen, Germany
    Anesthesiology 99:152-9. 2003
    ....
  25. ncbi request reprint Sensitization to bradykinin B1 and B2 receptor activation in UV-B irradiated human skin
    Harald Eisenbarth
    Department of Physiology and Experimental Pathophysiology, University of Erlangen, Erlangen, Germany
    Pain 110:197-204. 2004
    ..The UV-B irradiation did not enhance B1 and B2 receptor-induced protein extravasation indicating a differential sensitization of the neuronal, but not the vascular response...
  26. doi request reprint Differential endogenous pain modulation in complex-regional pain syndrome
    Frank Seifert
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Brain 132:788-800. 2009
    ..Thus, we hypothesize that differential activity in endogenous pain modulating systems may be not only a result of CRPS, but a potential risk factor for its development...
  27. ncbi request reprint Rapid flare development evoked by current frequency-dependent stimulation analyzed by full-field laser perfusion imaging
    Martin Dusch
    Department of Anaesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Germany
    Neuroreport 18:1101-5. 2007
    ..The highest neuropeptide release at 5 Hz correlates to the discharge characteristics of mechanoinsensitive C-fibers, whereas the maximum pain intensity at 50 Hz may be attributed to the activation of A-delta fibers...
  28. ncbi request reprint Different patterns of mast cell activation by muscle relaxants in human skin
    W Koppert
    Department of Anesthesiology, University of Erlangen-Nuremberg, Germany
    Anesthesiology 95:659-67. 2001
    ..The different pattern of tryptase release by isoquinolines and aminosteroids suggests different mechanisms of mast cell activation...
  29. ncbi request reprint Itch--mediators and mechanisms
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Universitaetsstrasse 17, D 91054, Erlangen, Germany
    J Dermatol Sci 28:91-6. 2002
    ..After the discovery of itch-specific neurons has dramatically improved our understanding of itch mechanisms under experimental conditions, the present task is to correlate these new findings to the clinical situation of itch patients...
  30. ncbi request reprint Different lipid profiles as constituencies of liquid formula diets do not influence pain perception and the efficacy of opioids in a human model of acute pain and hyperalgesia
    I R Pahl
    Department of Anesthesiology, University of Erlangen, 91054 Erlangen, Germany
    Pain 104:519-27. 2003
    ..In our studies, liquid formula diets did not influence acute pain perception or the efficacy of opioids in a human model of pain...
  31. ncbi request reprint [Mechanisms in the development of pain. Key issue in the periphery]
    C Konrad
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Fakultät Klinische Medizin Mannheim der Universität Heidelberg
    Internist (Berl) 46:1115-21. 2005
    ..Learning processes and extinction of aversive memory are of major importance for the development, but also the therapy of chronic pain states...
  32. ncbi request reprint Nociceptor sensitization to mechanical and thermal stimuli in pig skin in vivo
    Roman Rukwied
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur J Pain 12:242-50. 2008
    ..Sensitization of primarily mechano-insensitive (silent) nociceptors, which are underlying the flare response in humans, most probably contributes to the observation presented here...
  33. doi request reprint Single-fiber recordings of unmyelinated afferents in pig
    Otilia Obreja
    Dept Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68137 Mannheim, Germany
    Neurosci Lett 470:175-9. 2010
    ..It is suggested that the pig is an attractive model for studying modulation of excitability in nociceptive and non-nociceptive C-fiber classes that correspond to those in man...
  34. doi request reprint NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin
    Roman Rukwied
    Department of Anaesthesiology and Intensive Care Medicine Mannheim, Heidelberg University, Germany
    Pain 148:407-13. 2010
    ..Intradermal NGF administration provokes a pattern of sensitization that can be used as experimental model for neuropathic pain...
  35. doi request reprint Nerve growth factor-evoked nociceptor sensitization in pig skin in vivo
    Roman Rukwied
    University Clinics of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurosci Res 88:2066-72. 2010
    ..Thus, long-lasting sensitization processes of nociceptor endings or axonal sodium channel desensitization mechanisms can be explored in the pig as a translational experimental animal model...
  36. ncbi request reprint Duration of effects of aspirin on platelet function in healthy volunteers: an analysis using the PFA-100
    Christoph J Konrad
    Clinical Pain Research and Pain Clinics, Institute of Anesthesiology and Intensive Care Medicine, University Clinics Mannheim, Ruprecht Karls University of Heidelberg, 68167 Mannheim, Germany
    J Clin Anesth 18:12-7. 2006
    ..The aim of the study was to determine the duration and effects of aspirin on platelet function...
  37. ncbi request reprint Reduction of pulmonary edema by short-acting local anesthetics
    Christoph J Konrad
    Department of Anesthesiology and Operative Intensive Care Medicine, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Reg Anesth Pain Med 31:254-9. 2006
    ..Therefore, an investigation of the influence of LAs on the inflammatory response of the isolated rat lung (n = 78) to an N-formyl-l-leucin-methionyl-l-phenylalanine (FMLP) stimulus was performed...
  38. ncbi request reprint Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2
    Roman Rukwied
    Department of Anesthesiology and Intensive Care Medicine, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Pain 8:443-51. 2007
    ..Intriguingly, when compared with skin, muscle pain was significantly lower in the initial phase (0 to 15 seconds) but significantly higher in the second phase (20 to 100 seconds after injection)...
  39. doi request reprint Painful and nonpainful phantom and stump sensations in acute traumatic amputees
    Marcus T Schley
    Department of Anesthesiology and Intensive Care, University of Heidelberg, Mannheim, Germany
    J Trauma 65:858-64. 2008
    ..The formation, prevalence, intensity, course, and predisposing factors of phantom limb pain were investigated to determine possible mechanisms of the origin of phantom limb pain in traumatic upper limb amputees...
  40. doi request reprint Experimental thermal lesions induce beta-thromboglobulin release from activated platelets
    James A Blunk
    Department of Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Eur J Pain 15:23-8. 2011
    ..We conclude that local platelet activation is induced by the heating stimulus. Platelet mediators, such as beta-TG might contribute to the subsequent inflammatory process which is also characterized by mechanical and heat hyperalgesia...
  41. ncbi request reprint Representation of UV-B-induced thermal and mechanical hyperalgesia in the human brain: a functional MRI study
    Frank Seifert
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Hum Brain Mapp 29:1327-42. 2008
    ..Finally, the data provide evidence for the existence of a common "sensitization network" consisting of ACC, bilateral anterior insula, and parts of the IFC...
  42. ncbi request reprint Neural activation during experimental allodynia: a functional magnetic resonance imaging study
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Eur J Neurosci 19:3211-8. 2004
    ..Furthermore, it demonstrates that the combined heat/capsaicin model can be used successfully in the exploration of brain processes underlying stimulus-evoked pain...
  43. ncbi request reprint [Cross-sectional field 14 pain medicine. Implementation of the German Pain Society (DGSS) core curriculum in the model study course MaReCuM]
    M Dusch
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Medizinische Fakultat Mannheim, Universitat Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Deutschland
    Schmerz 27:387-94. 2013
    ..The recent introduction of amendments to the medical licensure laws led to the introduction of the field of pain medicine into the study program "Human Medicine". The implementation has to be completed by all medical faculties before 2016...
  44. ncbi request reprint Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees
    M Schley
    Department of Anaesthesiology and Intensive Care Medicine, Experimental Pain Research Pain Centre, University of Heidelberg, Faculty of Clinical Medicine, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur J Pain 11:299-308. 2007
    ..Hyperexcitability of N-methyl-d-aspartate acid (NMDA) receptors may play an important role in the development of phantom limb pain (PLP)...
  45. ncbi request reprint Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief
    Marcus Schley
    Department of Anaesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Curr Med Res Opin 22:1269-76. 2006
    ..2 ms, current increase stepwise from 2.5-12.5 mA every 3 minutes) delivered via small surface electrodes, attached to the volar forearm skin...
  46. ncbi request reprint Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans
    Andreas Tröster
    Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
    Anesthesiology 105:1016-23. 2006
    ..The aim of the investigation was to determine analgesic and antihyperalgesic properties of the cyclooxygenase-2 inhibitor parecoxib on remifentanil-induced hypersensitivity in humans...
  47. ncbi request reprint Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 106:91-9. 2003
    ....
  48. ncbi request reprint The effect of the nitric oxide synthase inhibitor N-nitro-L-arginine-methyl ester on neuropeptide-induced vasodilation and protein extravasation in human skin
    Monika Klede
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Erlangen, Germany
    J Vasc Res 40:105-14. 2003
    ..Exogenously applied SP induces vasodilation and protein extravasation, which is partly NO mediated, whereas CGRP-induced vasodilation appears to be NO independent...
  49. ncbi request reprint Neural signal processing: the underestimated contribution of peripheral human C-fibers
    Christian Weidner
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    J Neurosci 22:6704-12. 2002
    ..The receptive class of a fiber only determines its susceptibility to accommodate. Thus, the time course of aftereffects and existence or absence of an SNP is fully explained by the amount of preexisting accommodation...
  50. ncbi request reprint Activation of naloxone-sensitive and -insensitive inhibitory systems in a human pain model
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
    J Pain 6:757-64. 2005
    ..The session effect was not reversed by naloxone. High-current-density electrical stimulation provokes central sensitization, but in addition inhibitory systems are activated that are only partly naloxone-sensitive...
  51. ncbi request reprint Topical acetyl salicylate and dipyrone attenuate neurogenic protein extravasation in rat skin in vivo
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, Universitatsstrasse 17, 91054 Erlangen, Nurnberg, Germany
    Neurosci Lett 290:57-60. 2000
    ..ASA and dipyrone antagonized the excitatory effects of capsaicin on skin nociceptors and thus suppressed the neurogenic protein extravasation...
  52. ncbi request reprint Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin
    Martin Steinhoff
    Department of Physiology and Experimental Pathophysiology, University of Erlangen, 91054 Erlangen, Germany
    J Neurosci 23:6176-80. 2003
    ..PAR-2 therefore represents a promising therapeutic target for the treatment of cutaneous neurogenic inflammation and pruritus...
  53. ncbi request reprint The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 108:148-53. 2004
    ..Thus, besides its well-known effects on inflamed peripheral tissues, inhibition of central COX provides an important mechanism of NSAID-mediated antihyperalgesia in humans...
  54. ncbi request reprint Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen, Erlangen, Germany
    Anesth Analg 98:1050-5, table of contents. 2004
    ....
  55. ncbi request reprint Opioid-induced mast cell activation and vascular responses is not mediated by mu-opioid receptors: an in vivo microdialysis study in human skin
    James A Blunk
    Department of Anesthesiology, University Hospital, Erlangen, Germany
    Anesth Analg 98:364-70, table of contents. 2004
    ..Because naloxone did not attenuate these effects, it is unlikely that mu-opioid receptors are involved in the activation of mast cells...
  56. ncbi request reprint Substance-P-induced protein extravasation is bilaterally increased in complex regional pain syndrome
    Stefan Leis
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Exp Neurol 183:197-204. 2003
    ..The underlying mechanism might be impaired SP inactivation. Thus, our results further support the hypothesis that neurogenic inflammation plays an important role in the initiation of CRPS...
  57. ncbi request reprint Sensitivity of human scalp skin to pruritic stimuli investigated by intradermal microdialysis in vivo
    Roman Rukwied
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
    J Am Acad Dermatol 47:245-50. 2002
    ..Although pruritus is common in scalp skin, the forearm has been the main site for investigation in previous experimental studies...
  58. ncbi request reprint Transcutaneous penetration of toluene in rat skin a microdialysis study
    Monika Klede
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
    Exp Dermatol 14:103-8. 2005
    ....
  59. doi request reprint A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels
    Otilia Obreja
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Eur J Pain 12:775-89. 2008
    ..In conclusion, in porcine dorsal root ganglion neurons there is a subset of capsaicin-positive, IB4-negative neurons lacking HCN-1 and/or HCN-2 channel isoforms...
  60. ncbi request reprint Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis
    Akihiko Ikoma
    Departments of Dermatology, Kyoto University, Kyoto, Japan
    Arch Dermatol 139:1455-8. 2003
    ..Lowered threshold of neurons (ie, neuronal sensitization) in atopic dermatitis was investigated by testing sensitivity to histamine...
  61. ncbi request reprint Neurophysiology of pruritus: cutaneous elicitation of itch
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Arch Dermatol 139:1463-70. 2003
    ..This review focuses on the peripheral generation of itch, including neurotransmitters, neuropeptides, and inflammatory mediators...
  62. ncbi request reprint Neurophysiology of pruritus: interaction of itch and pain
    Akihiko Ikoma
    Department of Dermatology, Kyoto University, Kyoto, Japan
    Arch Dermatol 139:1475-8. 2003
    ..Therapeutic antipruritic approaches therefore should target both local inflammation and spinal sensitization of itch processing...
  63. ncbi request reprint Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Pain 106:49-57. 2003
    ..This study also points to a differential susceptibility of different pain modalities for the expression of hyperalgesia associated with opioid administration...
  64. ncbi request reprint Chronic itch and pain--similarities and differences
    Sonja Ständer
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Eur J Pain 10:473-8. 2006
    ..Finally, itch and pain exhibit corresponding patterns of central sensitization. The knowledge of antagonistic interaction, but also of similar sensitization processes has major implication for antipruritic therapeutic approaches...
  65. ncbi request reprint ATP responses in human C nociceptors
    Marita Hilliges
    Department of Clinical Neurophysiology, University of Uppsala, S 75185 Uppsala, Sweden
    Pain 98:59-68. 2002
    ..ATP did not sensitise human C fibres for mechanical or heat stimuli. We discuss how various mechanisms might contribute to the observed responses to ATP...
  66. ncbi request reprint Prostaglandin E2 induces vasodilation and pruritus, but no protein extravasation in atopic dermatitis and controls
    Ulrich Neisius
    Department of Dermatology, University of Erlangen Nurnberg, Universitätstrasse 17, 91054 Erlangen, Germany
    J Am Acad Dermatol 47:28-32. 2002
    ..Prostaglandin E(2) (PGE(2)) has well-established vasodilatory effects, whereas its effects on protein extravasation and its sensory effects are less clear...
  67. ncbi request reprint No alpha-adrenoreceptor-induced C-fiber activation in healthy human skin
    Sebastian Zahn
    Department of Neurology, Friedrich Alexander Universität Erlangen, Erlangen, Germany
    J Appl Physiol 96:1380-4. 2004
    ..Our results indicate that, in healthy human skin, exogenously supplied alpha-adrenoreceptor agonists alone do not activate nociceptors sufficiently to induce axon reflex flare...
  68. ncbi request reprint Abnormal function of C-fibers in patients with diabetic neuropathy
    Kristin Ørstavik
    Faculty of Medicine, University of Oslo, 0027 Oslo, Norway
    J Neurosci 26:11287-94. 2006
    ..We conclude that small-fiber neuropathy in diabetes affects receptive properties of nociceptors that leads to an impairment of mechano-responsive nociceptors...
  69. ncbi request reprint Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model
    Wolfgang Koppert
    Department of Anaesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 118:15-22. 2005
    ..It will be of major clinical interest whether this difference will translate into improved treatment of pain states dominated by central sensitization...
  70. ncbi request reprint Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch
    Miwa Hosogi
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Pain 126:16-23. 2006
    ..It is concluded that serotonin and bradykinin, classic endogenous algogens, can turn into potent histamine-independent pruritogens in lesional skin of atopic dermatitis...
  71. ncbi request reprint Electrically evoked itch in humans
    Akihiko Ikoma
    Department of Dermatology, Kyoto University, Kyoto, Japan
    Pain 113:148-54. 2005
    ....
  72. ncbi request reprint Chemically and electrically induced sweating and flare reaction
    Barbara Namer
    Department of Neurology, Friedrich Alexander University, Erlangen, Germany
    Auton Neurosci 114:72-82. 2004
    ..31 vs. 0.21 microl/cm2/min, p<0.01), which might be attributed to an increased effectiveness of synchronized discharge in sympathetic fibers upon electrical stimulation...
  73. ncbi request reprint Catecholamine-induced excitation of nociceptors in sympathetically maintained pain
    Ellen Jørum
    Laboratory of Clinical Neurophysiology, Department of Neurology, Rikshospitalet University Hospital, Oslo, Norway
    Pain 127:296-301. 2007
    ..No evidence for ephaptic interaction between sympathetic efferent and nociceptive afferent fibers was found...
  74. ncbi request reprint Electrically stimulated axon reflexes are diminished in diabetic small fiber neuropathies
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University, Mainz, Germany
    Diabetes 53:769-74. 2004
    ..83, P < 0.004). Intracutaneous electrical stimulation of C-fibers and scanning the flare with LDI is a sensitive tool to reliably detect small fiber impairment in diabetic SFN subjects and even increased neuropeptide release in NO-Ns...
  75. ncbi request reprint The impact of opioid-induced hyperalgesia for postoperative pain
    Wolfgang Koppert
    Klinik fur Anasthesiologie, Universitatsklinikum Erlangen, Krankenhousstrasse 12, D 91054 Erlongen, Germany
    Best Pract Res Clin Anaesthesiol 21:65-83. 2007
    ....
  76. pmc Frontiers in pruritus research: scratching the brain for more effective itch therapy
    Ralf Paus
    Department of Dermatology and Allergy, University of Lubeck, Lubeck, Germany
    J Clin Invest 116:1174-86. 2006
    ....
  77. ncbi request reprint Itch
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University, Winston Salem, North Carolina 27517, USA
    Lancet 361:690-4. 2003
    ..We describe the clinical classification of itch, new findings on neuropathophysiology of itch, methods for assessment, and improved treatments...
  78. ncbi request reprint The neurobiology of itch
    Akihiko Ikoma
    Department of Dermatology, Kyoto University, Shogin Kawahara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Nat Rev Neurosci 7:535-47. 2006
    ..The antagonistic interaction between pain and itch is already exploited in pruritus therapy, and current research concentrates on the identification of common targets for future analgesic and antipruritic therapy...
  79. ncbi request reprint Facilitated neurogenic inflammation in unaffected limbs of patients with complex regional pain syndrome
    Stefan Leis
    Department of Neurology, University of Erlangen Nurnberg, Erlangen, Germany
    Neurosci Lett 359:163-6. 2004
    ..The lack of protein extravasation indicates that an initiating trauma is necessary to induce neuropeptide up-regulation in primary afferents...
  80. ncbi request reprint Effects of gender and level of surgical sympathetic block on vasoconstrictor function
    Kerstin S Fronek
    Dept of Surgery, University of Erlangen Nurnberg, Krankenhausstrasse 12, 91054, Erlangen, Germany
    Clin Auton Res 13:I74-8. 2003
    ..It remains to be established whether the quantification of vasoconstriction has some predictive value for the long-term prognosis of sudomotor blockade...
  81. ncbi request reprint High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator
    Victoria Rotter Sopasakis
    The Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Obes Res 12:454-60. 2004
    ..To examine the possibility that interleukin-6 (IL-6) can act as a paracrine regulator in adipose tissue by examining effects on adipogenic genes and measuring interstitial IL-6 concentrations in situ...
  82. ncbi request reprint Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Peptides 27:917-20. 2006
    ..These findings suggest that NEP and ACE do not have additive effects regarding neuropeptide degradation. In contrast, inhibition of ACE seems to augment CGRP catabolism...
  83. ncbi request reprint Catecholamine release in human skin--a microdialysis study
    Stefan Leis
    Department of Neurology, University of Erlangen Nurnberg, Germany
    Exp Neurol 188:86-93. 2004
    ..Additional to non-enzymatic oxidation, DA increase probably reflects metabolic degradation of tyramine by non-neuronal pathways and therefore does not reflect local sympathetic innervation...
  84. ncbi request reprint Pathophysiology and treatment of pain in joint disease
    Hans Georg Schaible
    Institut fur Physiologie, Universitat Jena, Teichgraben 8, D 07740 Jena, Germany
    Adv Drug Deliv Rev 58:323-42. 2006
    ..Therapeutic targets are also found among the axonal channels that set membrane potential and modulate discharge frequency such as voltage sensitive sodium channels and various potassium channels...
  85. ncbi request reprint Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo
    Stephan Seeliger
    Department of Pediatrics, University of Munster, Munster, Germany
    FASEB J 17:1871-85. 2003
    ..Thus, PAR-2 may be a beneficial therapeutic target for the treatment of inflammatory skin diseases...
  86. ncbi request reprint Altered central excitability and analgesic treatment in patients with restless legs syndrome
    Ulrich Leutgeb
    Brain 128:E34. 2005
  87. ncbi request reprint Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus
    Martin Steinhoff
    Department of Dermatology, IZKF Münster, Ludwig Boltzmann Institute for Immunobiology of the Skin, University Hospital Muenster, Muenster, Germany
    J Invest Dermatol 126:1705-18. 2006
    ..A deeper understanding of these circuits is required for the development of novel antipruritic strategies...
  88. ncbi request reprint Clinical classification of itch: a position paper of the International Forum for the Study of Itch
    Sonja Ständer
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Acta Derm Venereol 87:291-4. 2007
    ..It is intended to serve as a diagnostic route for better evaluation of patients with chronic pruritus and aims to improve patients' care...
  89. ncbi request reprint Differential sensitivity of thick and thin fibers to HIV and therapy-induced neuropathy
    Panagiotis Kokotis
    Academic Departments of Neurology Aeginition Hospital, Medical School of Athens, Athens, Greece
    Auton Neurosci 136:90-5. 2007
    ..The results suggest that HIV neuropathy preferably affects myelinated and anti-retroviral therapy unmyelinated fibers...
  90. ncbi request reprint Pathological C-fibres in patients with a chronic painful condition
    Kristin Ørstavik
    Department of Neurology, Ulleval University Hospital, Oslo, Norway
    Brain 126:567-78. 2003
    ..This is the first systematic study of single C-fibres in patients and it shows an active contribution of mechano-insensitive fibres to chronic pain...