M Schmelz

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Active "itch fibers" in chronic pruritus
    M Schmelz
    Department of Clinical Neurophysiology, University of Uppsala, Sweden
    Neurology 61:564-6. 2003
  2. ncbi request reprint Topical acetyl salicylate and dipyrone attenuate neurogenic protein extravasation in rat skin in vivo
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, Universitatsstrasse 17, 91054 Erlangen, Nurnberg, Germany
    Neurosci Lett 290:57-60. 2000
  3. ncbi request reprint Itch--mediators and mechanisms
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Universitaetsstrasse 17, D 91054, Erlangen, Germany
    J Dermatol Sci 28:91-6. 2002
  4. ncbi request reprint The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction
    W Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Erlangen, Germany
    Anesth Analg 89:1521-7. 1999
  5. pmc Microneurographic assessment of C-fibre function in aged healthy subjects
    B Namer
    Department of Physiology and Pathophysiology, University of Erlangen, Erlangen, Germany
    J Physiol 587:419-28. 2009
  6. ncbi request reprint Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man
    A Bickel
    Department of Physiology I, University of Erlangen Nurnberg, Erlangen, Germany
    Pain 76:317-25. 1998
  7. ncbi request reprint Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Germany
    J Neurophysiol 89:2441-8. 2003
  8. ncbi request reprint Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin
    G Lischetzki
    Department of Physiology and Experimental Pathophysiology, , Erlangen, Germany
    Eur J Pain 5:49-57. 2001
  9. ncbi request reprint A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine
    W Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Germany
    Anesthesiology 95:395-402. 2001
  10. pmc Action potential conduction in the terminal arborisation of nociceptive C-fibre afferents
    C Weidner
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
    J Physiol 547:931-40. 2003

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Active "itch fibers" in chronic pruritus
    M Schmelz
    Department of Clinical Neurophysiology, University of Uppsala, Sweden
    Neurology 61:564-6. 2003
    ..quot; Itch may be caused by activity in a specific subpopulation of C-fiber afferents...
  2. ncbi request reprint Topical acetyl salicylate and dipyrone attenuate neurogenic protein extravasation in rat skin in vivo
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, Universitatsstrasse 17, 91054 Erlangen, Nurnberg, Germany
    Neurosci Lett 290:57-60. 2000
    ..ASA and dipyrone antagonized the excitatory effects of capsaicin on skin nociceptors and thus suppressed the neurogenic protein extravasation...
  3. ncbi request reprint Itch--mediators and mechanisms
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Universitaetsstrasse 17, D 91054, Erlangen, Germany
    J Dermatol Sci 28:91-6. 2002
    ..After the discovery of itch-specific neurons has dramatically improved our understanding of itch mechanisms under experimental conditions, the present task is to correlate these new findings to the clinical situation of itch patients...
  4. ncbi request reprint The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction
    W Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Erlangen, Germany
    Anesth Analg 89:1521-7. 1999
    ..Ketamine failed to inhibit both secondary hyperalgesia and axon reflex flare as long as nonlocal anesthetic concentrations were applied...
  5. pmc Microneurographic assessment of C-fibre function in aged healthy subjects
    B Namer
    Department of Physiology and Pathophysiology, University of Erlangen, Erlangen, Germany
    J Physiol 587:419-28. 2009
    ..These findings are important for the understanding and differential diagnoses regarding pathological processes and normal ageing...
  6. ncbi request reprint Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man
    A Bickel
    Department of Physiology I, University of Erlangen Nurnberg, Erlangen, Germany
    Pain 76:317-25. 1998
    ..b) Since mechanical and thermal hyperalgesia is induced by UVB, drug effects can be tested upon both forms of hyperalgesia...
  7. ncbi request reprint Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Germany
    J Neurophysiol 89:2441-8. 2003
    ....
  8. ncbi request reprint Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin
    G Lischetzki
    Department of Physiology and Experimental Pathophysiology, , Erlangen, Germany
    Eur J Pain 5:49-57. 2001
    ..It is concluded that there is no link between nociceptor activation and protein extravasation induced by inflammatory mediators in healthy human skin...
  9. ncbi request reprint A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine
    W Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Germany
    Anesthesiology 95:395-402. 2001
    ..The authors used the analgesics alfentanil, S(+)-ketamine, and systemic lidocaine to examine a new human model of experimental pain and hyperalgesia...
  10. pmc Action potential conduction in the terminal arborisation of nociceptive C-fibre afferents
    C Weidner
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
    J Physiol 547:931-40. 2003
    ..This indicates that the terminal branches are equipped with membrane proteins that are different from those of the parent axon...
  11. ncbi request reprint Innervation territories of mechano-insensitive C nociceptors in human skin
    R Schmidt
    Department of Clinical Neurophysiology, University of Uppsala, 751 85 Uppsala, Sweden
    J Neurophysiol 88:1859-66. 2002
    ..The widely branched terminals underlying the large fields are consistent with a role of this nociceptor class in axon reflex flare and preclude a role in exact spatial discrimination of noxious stimuli...
  12. ncbi request reprint Peripheral antihyperalgesic effect of morphine to heat, but not mechanical, stimulation in healthy volunteers after ultraviolet-B irradiation
    W Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Germany
    Anesth Analg 88:117-22. 1999
    ..Morphine 0.01% significantly diminished thermal, but not mechanical, hyperalgesia by a peripheral mode of action, which suggests inhibition of effector pathways leading to heat, but not mechanical, sensitization...
  13. ncbi request reprint Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
    Neurosci Lett 214:72-4. 1996
    ..In contrast, capsaicin-induced heat hyperalgesia was unaffected by ASA. It is concluded that ASA counteracts the excitatory effects of capsaicin on nociceptors and mechanical hyperalgesia but not its sensitizing action to heat...
  14. ncbi request reprint Density of sympathetic axons in sural nerve biopsies of neuropathy patients is related to painfulness
    A Bickel
    Department of Neurology, University of Erlangen Nuremberg, 91054, Erlangen, Germany
    Pain 84:413-9. 2000
    ..We conclude that an imbalance between afferent and sympathetic nerve fiber density in the periphery may contribute to neuropathic pain even in those patients without obvious clinical autonomic disturbances...
  15. ncbi request reprint Injection pain of rocuronium and vecuronium is evoked by direct activation of nociceptive nerve endings
    J A Blunk
    Friedrich Alexander University, Department of Anaesthesiology, Erlangen, Germany
    Eur J Anaesthesiol 20:245-53. 2003
    ..Dermal microdialysis in human and electrophysiological recordings of nociceptors in mouse skin were used to elucidate the underlying mechanisms of pain induction...
  16. ncbi request reprint Influence of vagus nerve stimulation on histamine-induced itching
    A Kirchner
    Neurologische Klinik, Friedrich Alexander Universität Erlangen, Germany
    Neurology 59:108-12. 2002
    ..To investigate whether vagus nerve stimulation (VNS) reduces pruritus in humans...
  17. ncbi request reprint Different lipid profiles as constituencies of liquid formula diets do not influence pain perception and the efficacy of opioids in a human model of acute pain and hyperalgesia
    I R Pahl
    Department of Anesthesiology, University of Erlangen, 91054 Erlangen, Germany
    Pain 104:519-27. 2003
    ..In our studies, liquid formula diets did not influence acute pain perception or the efficacy of opioids in a human model of pain...
  18. ncbi request reprint Neurogenic inflammation in human and rodent skin
    M Schmelz
    Department of Physiology, University of Erlangen, 91054 Erlangen, Germany
    News Physiol Sci 16:33-7. 2001
    ..Dermal microdialysis has considerably increased our knowledge about neurogenic inflammation in human skin, including the involvement of mast cells...
  19. pmc Dermal microdialysis provides evidence for hypersensitivity to noradrenaline in patients with familial dysautonomia
    A Bickel
    Neurologische Klinik, Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    J Neurol Neurosurg Psychiatry 73:299-302. 2002
    ..To use the technique of dermal microdialysis to examine sensitivity of skin vessels to noradrenaline (NA) in patients with familial dysautonomia (FD) and in healthy controls...
  20. ncbi request reprint [Interactions between itch and pain]
    M Schmelz
    Karl Feuerstein Professur, Klinik fur Anasthesiologie und Operative Intensivmedizin, Fakultät für Klinische Medizin Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim
    Hautarzt 57:385-6, 388-9. 2006
    ..The presumed similarities in underlying sensitizing mechanisms between itch and pain has major therapeutic consequences as successful therapies for chronic pain might be used also in chronic itch...
  21. ncbi request reprint Inhibition of neutral endopeptidase (NEP) facilitates neurogenic inflammation
    H H Kramer
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Exp Neurol 195:179-84. 2005
    ..Our findings suggest that NEP but not ACE is most important for CGRP degradation in human skin. This may be of particular importance for the understanding of pain disorders like migraine or complex regional pain syndrome...
  22. ncbi request reprint Neurophysiological evidence for altered sensory function caused by storage of hydroxyethyl starch in cutaneous nerve fibres
    S Ständer
    Br J Dermatol 152:1085-6. 2005
  23. ncbi request reprint Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch
    A Ikoma
    Department of Dermatology, Kyoto University, Japan
    Neurology 62:212-7. 2004
    ..Central sensitization for pain is important for patients with chronic pain. The authors investigated a possible role of central sensitization for itch in patients with chronic pruritus...
  24. ncbi request reprint Facilitated neurogenic inflammation in complex regional pain syndrome
    M Weber
    Neurologische Klinik, , , D-91054 Erlangen, Germany
    Pain 91:251-7. 2001
    ..We conclude that neurogenic inflammation is facilitated in CRPS. Our results suggest an increased releasability of neuropeptides in CRPS...
  25. ncbi request reprint Botulinum Toxin A reduces neurogenic flare but has almost no effect on pain and hyperalgesia in human skin
    H H Kramer
    Neurologische Klinik, Universitat Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Neurol 250:188-93. 2003
    ..In contrast, the analgesic effect of BoNT/A was very limited. Therefore we assume that other than neuropeptide mechanisms must be important for BoNT/A induced pain relief in clinical pain syndromes...
  26. pmc Sudomotor function in familial dysautonomia
    A Bickel
    Department of Neurology, University Erlangen Nuremberg, Germany
    J Neurol Neurosurg Psychiatry 75:275-9. 2004
    ..We assessed peripheral sudomotor nerve fibre and sweat gland function to determine if this symptom was due to peripheral denervation hypersensitivity...
  27. ncbi request reprint Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers
    B A Chizh
    Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2GG, UK
    Br J Anaesth 98:246-54. 2007
    ..Furthermore, we explored if combinations of either of these drugs with the COX-2 inhibitor parecoxib could improve its efficacy...
  28. ncbi request reprint Complex interactions between pain and itch
    M Schmelz
    Pain 124:9-10. 2006
  29. ncbi request reprint Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees
    M Schley
    Department of Anaesthesiology and Intensive Care Medicine, Experimental Pain Research Pain Centre, University of Heidelberg, Faculty of Clinical Medicine, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur J Pain 11:299-308. 2007
    ..Hyperexcitability of N-methyl-d-aspartate acid (NMDA) receptors may play an important role in the development of phantom limb pain (PLP)...
  30. ncbi request reprint [Clinical classification of chronic pruritus. Interdisciplinary consensus proposal for a diagnostic algorithm]
    S Ständer
    Abteilung für klinische Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    Hautarzt 57:390-4. 2006
    ..The proposed clinical classification is oriented at the clinical appearance of the patients and differentiates between disorders with or without primary or secondary skin lesions...
  31. ncbi request reprint [Mechanisms in the development of pain. Key issue in the periphery]
    C Konrad
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Fakultät Klinische Medizin Mannheim der Universität Heidelberg
    Internist (Berl) 46:1115-21. 2005
    ..Learning processes and extinction of aversive memory are of major importance for the development, but also the therapy of chronic pain states...
  32. ncbi request reprint Differential effects of surgical sympathetic block on sudomotor and vasoconstrictor function
    C H Schick
    Department of Surgery, University of Erlangen Nurnberg, Germany
    Neurology 60:1770-6. 2003
    ..To assess the effects of a surgical block of the sympathetic chain at the T2 level on vasoconstriction and palmar sweating in patients with palmar hyperhidrosis...
  33. ncbi request reprint How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches
    T Biro
    Department of Physiology, University of Debrecen, Medical and Health Sciences Center, H 4012 Debrecen, PO Box 22, Hungary
    Exp Dermatol 14:225-40. 2005
    ....
  34. ncbi request reprint Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study
    P N Nielsen
    The Allergy Unit, National University Hospital, University of Copenhagen, Copenhagen, Denmark
    Clin Exp Allergy 31:1378-84. 2001
    ..It did not inhibit any of the late-phase mediators, but it reduced the late skin reaction. These data suggest that mediators other than those actually measured may play a significant role in the clinical late-phase reaction...
  35. ncbi request reprint Different patterns of mast cell activation by muscle relaxants in human skin
    W Koppert
    Department of Anesthesiology, University of Erlangen-Nuremberg, Germany
    Anesthesiology 95:659-67. 2001
    ..The different pattern of tryptase release by isoquinolines and aminosteroids suggests different mechanisms of mast cell activation...