Research Topics
| M SchmelzSummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Active "itch fibers" in chronic pruritusM Schmelz
Department of Clinical Neurophysiology, University of Uppsala, Sweden
Neurology 61:564-6. 2003..quot; Itch may be caused by activity in a specific subpopulation of C-fiber afferents...- Topical acetyl salicylate and dipyrone attenuate neurogenic protein extravasation in rat skin in vivoM Schmelz
Department of Physiology and Experimental Pathophysiology, Universitatsstrasse 17, 91054 Erlangen, Nurnberg, Germany
Neurosci Lett 290:57-60. 2000..ASA and dipyrone antagonized the excitatory effects of capsaicin on skin nociceptors and thus suppressed the neurogenic protein extravasation... - Itch--mediators and mechanismsM Schmelz
Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Universitaetsstrasse 17, D 91054, Erlangen, Germany
J Dermatol Sci 28:91-6. 2002..After the discovery of itch-specific neurons has dramatically improved our understanding of itch mechanisms under experimental conditions, the present task is to correlate these new findings to the clinical situation of itch patients... - The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reactionW Koppert
Department of Anesthesiology, University of Erlangen Nuremberg, Erlangen, Germany
Anesth Analg 89:1521-7. 1999..In large concentrations, the opioid diminished axon-reflex flare without effects on secondary hyperalgesia. We found no evidence for the involvement of endogenous glutamate in secondary hyperalgesia or axon reflex flare... 
Microneurographic assessment of C-fibre function in aged healthy subjectsB Namer
Department of Physiology and Pathophysiology, University of Erlangen, Erlangen, Germany
J Physiol 587:419-28. 2009..These findings are important for the understanding and differential diagnoses regarding pathological processes and normal ageing...- Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in manA Bickel
Department of Physiology I, University of Erlangen Nurnberg, Erlangen, Germany
Pain 76:317-25. 1998..b) Since mechanical and thermal hyperalgesia is induced by UVB, drug effects can be tested upon both forms of hyperalgesia... - Chemical response pattern of different classes of C-nociceptors to pruritogens and algogensM Schmelz
Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Germany
J Neurophysiol 89:2441-8. 2003.... - Nociceptor activation and protein extravasation induced by inflammatory mediators in human skinG Lischetzki
Department of Physiology and Experimental Pathophysiology, , Erlangen, Germany
Eur J Pain 5:49-57. 2001..It is concluded that there is no link between nociceptor activation and protein extravasation induced by inflammatory mediators in healthy human skin... - A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaineW Koppert
Department of Anesthesiology, University of Erlangen Nuremberg, Germany
Anesthesiology 95:395-402. 2001..The authors used the analgesics alfentanil, S(+)-ketamine, and systemic lidocaine to examine a new human model of experimental pain and hyperalgesia... - Action potential conduction in the terminal arborisation of nociceptive C-fibre afferentsC Weidner
Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
J Physiol 547:931-40. 2003..This indicates that the terminal branches are equipped with membrane proteins that are different from those of the parent axon... - Innervation territories of mechano-insensitive C nociceptors in human skinR Schmidt
Department of Clinical Neurophysiology, University of Uppsala, 751 85 Uppsala, Sweden
J Neurophysiol 88:1859-66. 2002..The widely branched terminals underlying the large fields are consistent with a role of this nociceptor class in axon reflex flare and preclude a role in exact spatial discrimination of noxious stimuli... - Peripheral antihyperalgesic effect of morphine to heat, but not mechanical, stimulation in healthy volunteers after ultraviolet-B irradiationW Koppert
Department of Anesthesiology, University of Erlangen Nuremberg, Germany
Anesth Analg 88:117-22. 1999..01% diminished heat, but not primary mechanical, hyperalgesia. Therefore, suppression of mechanical hyperalgesia seen in previous studies could be predominantly due to inhibition of secondary (central) mechanical hyperalgesia... - Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesiaM Schmelz
Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
Neurosci Lett 214:72-4. 1996..In contrast, capsaicin-induced heat hyperalgesia was unaffected by ASA. It is concluded that ASA counteracts the excitatory effects of capsaicin on nociceptors and mechanical hyperalgesia but not its sensitizing action to heat... - Density of sympathetic axons in sural nerve biopsies of neuropathy patients is related to painfulnessA Bickel
Department of Neurology, University of Erlangen Nuremberg, 91054, Erlangen, Germany
Pain 84:413-9. 2000..We conclude that an imbalance between afferent and sympathetic nerve fiber density in the periphery may contribute to neuropathic pain even in those patients without obvious clinical autonomic disturbances... - Injection pain of rocuronium and vecuronium is evoked by direct activation of nociceptive nerve endingsJ A Blunk
Friedrich-Alexander University, Department of Anaesthesiology, Erlangen, Germany
Eur J Anaesthesiol 20:245-53. 2003..CONCLUSIONS: The algogenic effect of aminosteroidal neuromuscular blocking drugs can be attributed to a direct activation of C-nociceptors... - Influence of vagus nerve stimulation on histamine-induced itchingA Kirchner
Neurologische Klinik, Friedrich Alexander Universität Erlangen, Germany
Neurology 59:108-12. 2002..To investigate whether vagus nerve stimulation (VNS) reduces pruritus in humans... - Different lipid profiles as constituencies of liquid formula diets do not influence pain perception and the efficacy of opioids in a human model of acute pain and hyperalgesiaI R Pahl
Department of Anesthesiology, University of Erlangen, 91054 Erlangen, Germany
Pain 104:519-27. 2003..In our studies, liquid formula diets did not influence acute pain perception or the efficacy of opioids in a human model of pain... - Neurogenic inflammation in human and rodent skinM Schmelz
Department of Physiology, University of Erlangen, 91054 Erlangen, Germany
News Physiol Sci 16:33-7. 2001..Dermal microdialysis has considerably increased our knowledge about neurogenic inflammation in human skin, including the involvement of mast cells... - Dermal microdialysis provides evidence for hypersensitivity to noradrenaline in patients with familial dysautonomiaA Bickel
Neurologische Klinik, , Schwabachanlage 6, 91054 Erlangen, Germany
J Neurol Neurosurg Psychiatry 73:299-302. 2002..This may be one mechanism contributing to the major hypertension that frequently occurs during "dysautonomic crises" in FD... - [Interactions between itch and pain]M Schmelz
Karl Feuerstein Professur, Klinik fur Anasthesiologie und Operative Intensivmedizin, Fakultät für Klinische Medizin Mannheim, Ruprecht Karls Universitat Heidelberg, Mannheim
Hautarzt 57:385-6, 388-9. 2006..The presumed similarities in underlying sensitizing mechanisms between itch and pain has major therapeutic consequences as successful therapies for chronic pain might be used also in chronic itch... - Inhibition of neutral endopeptidase (NEP) facilitates neurogenic inflammationH H Kramer
Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
Exp Neurol 195:179-84. 2005..Our findings suggest that NEP but not ACE is most important for CGRP degradation in human skin. This may be of particular importance for the understanding of pain disorders like migraine or complex regional pain syndrome... - Neurophysiological evidence for altered sensory function caused by storage of hydroxyethyl starch in cutaneous nerve fibresS Ständer
Br J Dermatol 152:1085-6. 2005 - Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itchA Ikoma
Department of Dermatology, Kyoto University, Japan
Neurology 62:212-7. 2004..In contrast to the well-known A-fiber-mediated alloknesis and hyperknesis, this type of central sensitization appears to be elicited by C-nociceptors... - Facilitated neurogenic inflammation in complex regional pain syndromeM Weber
Neurologische Klinik, , , D-91054 Erlangen, Germany
Pain 91:251-7. 2001..We conclude that neurogenic inflammation is facilitated in CRPS. Our results suggest an increased releasability of neuropeptides in CRPS... - Botulinum Toxin A reduces neurogenic flare but has almost no effect on pain and hyperalgesia in human skinH H Kramer
Neurologische Klinik, Universitat Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
J Neurol 250:188-93. 2003..In contrast, the analgesic effect of BoNT/A was very limited. Therefore we assume that other than neuropeptide mechanisms must be important for BoNT/A induced pain relief in clinical pain syndromes... - Sudomotor function in familial dysautonomiaA Bickel
Department of Neurology, University Erlangen-Nuremberg, Germany
J Neurol Neurosurg Psychiatry 75:275-9. 2004..This might explain excessive episodic hyperhidrosis in situations with increased central sympathetic outflow... - Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteersB A Chizh
Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2GG, UK
Br J Anaesth 98:246-54. 2007..Furthermore, we explored if combinations of either of these drugs with the COX-2 inhibitor parecoxib could improve its efficacy... - Complex interactions between pain and itchM Schmelz
Pain 124:9-10. 2006 - Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputeesM Schley
Department of Anaesthesiology and Intensive Care Medicine, Experimental Pain Research Pain Centre, University of Heidelberg, Faculty of Clinical Medicine, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Eur J Pain 11:299-308. 2007..Hyperexcitability of N-methyl-d-aspartate acid (NMDA) receptors may play an important role in the development of phantom limb pain (PLP)... - [Clinical classification of chronic pruritus. Interdisciplinary consensus proposal for a diagnostic algorithm]S Ständer
Abteilung für klinische Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
Hautarzt 57:390-4. 2006..The proposed clinical classification is oriented at the clinical appearance of the patients and differentiates between disorders with or without primary or secondary skin lesions... - [Mechanisms in the development of pain. Key issue in the periphery]C Konrad
Klinik fur Anasthesiologie und Operative Intensivmedizin, Fakultät Klinische Medizin Mannheim der Universität Heidelberg
Internist (Berl) 46:1115-21. 2005..Learning processes and extinction of aversive memory are of major importance for the development, but also the therapy of chronic pain states... - Differential effects of surgical sympathetic block on sudomotor and vasoconstrictor functionC H Schick
Department of Surgery, , Germany
Neurology 60:1770-6. 2003..Recurrent and enhanced vasoconstrictor function 3 months following endoscopic sympathetic block has major implications for its use to treat enhanced vasoconstriction... - How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approachesT Biro
Department of Physiology, University of Debrecen, Medical and Health Sciences Center, H 4012 Debrecen, PO Box 22, Hungary
Exp Dermatol 14:225-40. 2005.... - Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled studyP N Nielsen
The Allergy Unit, National University Hospital, University of Copenhagen, Copenhagen, Denmark
Clin Exp Allergy 31:1378-84. 2001..It did not inhibit any of the late-phase mediators, but it reduced the late skin reaction. These data suggest that mediators other than those actually measured may play a significant role in the clinical late-phase reaction... - Different patterns of mast cell activation by muscle relaxants in human skinW Koppert
Department of Anesthesiology, University of Erlangen-Nuremberg, Germany
Anesthesiology 95:659-67. 2001..The different pattern of tryptase release by isoquinolines and aminosteroids suggests different mechanisms of mast cell activation...