Ursula Schlötzer-Schrehardt

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Genetics and genomics of pseudoexfoliation syndrome/glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Middle East Afr J Ophthalmol 18:30-6. 2011
  2. doi request reprint Reproducibility of graft preparations in Descemet's membrane endothelial keratoplasty
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 120:1769-77. 2013
  3. doi request reprint LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 119:1832-43. 2012
  4. doi request reprint [New pathogenetic insights into pseudoexfoliation syndrome/glaucoma. Therapeutically relevant?]
    U Schlötzer-Schrehardt
    Augenklinik, Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen
    Ophthalmologe 109:944-51. 2012
  5. ncbi request reprint Characterization of extracellular matrix components in the limbal epithelial stem cell compartment
    U Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Exp Eye Res 85:845-60. 2007
  6. doi request reprint Molecular pathology of pseudoexfoliation syndrome/glaucoma--new insights from LOXL1 gene associations
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 88:776-85. 2009
  7. pmc Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 173:1724-35. 2008
  8. doi request reprint Characterization of the cleavage plane in DESCemet's membrane endothelial keratoplasty
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 118:1950-7. 2011
  9. doi request reprint Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
    Francesca Pasutto
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:1459-63. 2008
  10. ncbi request reprint Differential gene expression in pseudoexfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 46:3742-52. 2005

Detail Information

Publications71

  1. pmc Genetics and genomics of pseudoexfoliation syndrome/glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Middle East Afr J Ophthalmol 18:30-6. 2011
    ..Ultimately, both detection and functional characterization of yet unidentified genetic and non-genetic factors may lead to the development of more precise screening tools for the risk of PEX glaucoma...
  2. doi request reprint Reproducibility of graft preparations in Descemet's membrane endothelial keratoplasty
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 120:1769-77. 2013
    ..To assess the reproducibility of manual graft preparation and evaluate the incidence rate and nature of structural anomalies of Descemet's membrane (DM) preventing successful graft preparation in DM endothelial keratoplasty (DMEK)...
  3. doi request reprint LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 119:1832-43. 2012
    ....
  4. doi request reprint [New pathogenetic insights into pseudoexfoliation syndrome/glaucoma. Therapeutically relevant?]
    U Schlötzer-Schrehardt
    Augenklinik, Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen
    Ophthalmologe 109:944-51. 2012
    ..The findings may have direct consequences for the clinical management of PEX patients underlining the need for an exact diagnosis, a strict IOP-reducing therapy and a close and regular follow-up...
  5. ncbi request reprint Characterization of extracellular matrix components in the limbal epithelial stem cell compartment
    U Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Exp Eye Res 85:845-60. 2007
    ..Identification of specific niche parameters might not only help to understand limbal stem cell regulation, but also to improve their selective enrichment and in vitro expansion for therapeutic strategies...
  6. doi request reprint Molecular pathology of pseudoexfoliation syndrome/glaucoma--new insights from LOXL1 gene associations
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 88:776-85. 2009
    ....
  7. pmc Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Pathol 173:1724-35. 2008
    ..Alterations of LOXL1 activation, processing, and/or substrate specificity may contribute to the abnormal aggregation of elastic fiber components into characteristic PEX fibrils...
  8. doi request reprint Characterization of the cleavage plane in DESCemet's membrane endothelial keratoplasty
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 118:1950-7. 2011
    ..To define the cleavage plane between Descemet's membrane (DM) and posterior corneal stroma in Descemet's membrane endothelial keratoplasty (DMEK) concerning its ultrastructural and immunohistochemical characteristics...
  9. doi request reprint Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
    Francesca Pasutto
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:1459-63. 2008
    ..In this study, the genetic association of these variants was investigated in patients with PEX or PEXG of German and Italian descent...
  10. ncbi request reprint Differential gene expression in pseudoexfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 46:3742-52. 2005
    ..To identify and characterize genes differentially expressed in anterior segment tissues of eyes with pseudoexfoliation (PEX) syndrome and glaucoma...
  11. ncbi request reprint Comparative effects of TGF-beta 1 and TGF-beta 2 on extracellular matrix production, proliferation, migration, and collagen contraction of human Tenon's capsule fibroblasts in pseudoexfoliation and primary open-angle glaucoma
    Ulrike B Kottler
    Department of Ophthalmology, University Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 80:121-34. 2005
    ....
  12. ncbi request reprint Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 47:1982-90. 2006
    ....
  13. ncbi request reprint Nonmechanical Q-switched erbium:YAG laser trephination for penetrating keratoplasty: experimental study on human donor corneas
    Milenko Stojkovic
    Department of Ophthalmology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Arch Ophthalmol 121:1415-22. 2003
    ..To assess the alterations in human donor corneal tissue induced by Q-switched erbium (Er):YAG laser corneal trephination...
  14. doi request reprint Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 52:8488-95. 2011
    ..The aim of this study was to analyze the effect of various PEX-associated pathogenic factors on the genotype-correlated expression of LOXL1 and elastin-related genes...
  15. doi request reprint Apolipoprotein E genotypes in pseudoexfoliation syndrome and pseudoexfoliation glaucoma
    Mandy Krumbiegel
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    J Glaucoma 19:561-5. 2010
    ..In this study, we therefore investigated whether APOE alleles are associated with PEX syndrome and/or PEX glaucoma (PEXG) in 2 large cohorts of German and Italian origin...
  16. doi request reprint Donor tissue culture conditions and outcome after descemet membrane endothelial keratoplasty
    Kathrin Laaser
    Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany
    Am J Ophthalmol 151:1007-1018.e2. 2011
    ..To investigate the effect of culture conditions of donor tissue on functional outcome after Descemet membrane endothelial keratoplasty...
  17. ncbi request reprint Selective upregulation of the A3 adenosine receptor in eyes with pseudoexfoliation syndrome and glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 46:2023-34. 2005
    ..In the current study, the role of the adenosine system in the pathophysiology of pseudoexfoliation (PEX) syndrome, which is typically associated with anterior chamber hypoxia and elevated intraocular pressure, was examined...
  18. ncbi request reprint Q-Switched 2.94-microm Er:YAG laser trephination with convergent and divergent cut angles for penetrating keratoplasty
    Renate Ferreira De Souza
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Cornea 22:562-8. 2003
    ..To study the morphologic properties of perpendicular (P), convergent (C), and divergent (D) cut angles using different speeds of rotations during donor and recipient nonmechanical trephination for experimental penetrating keratoplasty...
  19. pmc Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome
    Mandy Krumbiegel
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Hum Genet 19:186-93. 2011
    ..Confirming efficiency of GWAS with DNA-pooling approach by detection of the known LOXL1 locus, our study data show evidence for association of CNTNAP2 with PEX syndrome and PEXG in German patients...
  20. ncbi request reprint A stepwise approach to donor preparation and insertion increases safety and outcome of Descemet membrane endothelial keratoplasty
    Friedrich E Kruse
    Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany
    Cornea 30:580-7. 2011
    ..However, wide-spread use of DMEK is currently limited because of problems with donor preparation namely the tearing of the Descemet membrane and the difficulty to unfold the EDM graft in the anterior chamber (AC)...
  21. doi request reprint Preservation of the limbal stem cell phenotype by appropriate culture techniques
    Ewa Anna Meyer-Blazejewska
    Department of Ophthalmology, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 51:765-74. 2010
    ....
  22. doi request reprint Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
    Mandy Krumbiegel
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:2796-801. 2009
    ..This study was focused on six functional candidate genes involved in PEX material deposition and the analysis of their potential association with PEX syndrome and PEX glaucoma (PEXG)...
  23. pmc Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Am J Pathol 176:2868-79. 2010
    ..These findings support a role for a stress-induced, spatially, and temporally restricted subclinical inflammation in the onset of the fibrotic matrix process characteristic of PEX syndrome/glaucoma...
  24. ncbi request reprint Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin
    Claus Cursiefen
    Department of Ophthalmology and Nikolaus Fiebiger Zentrum for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 43:2127-35. 2002
    ..To determine whether lymphatic vessels exist in vascularized human corneas, by using immunohistochemistry with novel markers for lymphatic endothelium...
  25. ncbi request reprint Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucoma
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 44:1117-25. 2003
    ....
  26. ncbi request reprint Nonmechanical posterior lamellar keratoplasty using the femtosecond laser (femto-plak) for corneal endothelial decompensation
    Berthold Seitz
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Ophthalmol 136:769-72. 2003
    ..To assess the potential of a short pulsed laser to cut a posterior graft and bed for posterior lamellar keratoplasty (PLAK)...
  27. doi request reprint Cytokine-dependent ELAM-1 induction and concomitant intraocular pressure regulation in porcine anterior eye perfusion culture
    Marco T Birke
    Department of Anatomy II, University of Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 52:468-75. 2011
    ....
  28. pmc Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cells
    Ewa Anna Blazejewska
    Department of Ophthalmology, University of Erlangen Nuremberg, Germany
    Stem Cells 27:642-52. 2009
    ..Therefore, the HF may be an easily accessible alternative therapeutic source of autologous adult stem cells for replacement of the corneal epithelium and restoration of visual function in patients with ocular surface disorders...
  29. ncbi request reprint The Pathogenesis of floppy eyelid syndrome: involvement of matrix metalloproteinases in elastic fiber degradation
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Ophthalmology 112:694-704. 2005
    ....
  30. ncbi request reprint Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 48:5558-66. 2007
    ..The expression of stress-related genes in eyes from patients with and without PEX syndrome/glaucoma was investigated to determine whether PEX syndrome is associated with an altered cellular stress response...
  31. doi request reprint Four subunits (αβγδ) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations
    Bettina Krueger
    Department of Cellular and Molecular Physiology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 53:596-604. 2012
    ..However, the precise localization of ENaC in the human eye is still unclear. Here, the authors studied ENaC expression in 12 normal human donor eyes and in six eyes of patients with glaucoma...
  32. doi request reprint Safety profile of topical VEGF neutralization at the cornea
    Felix Bock
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:2095-102. 2009
    ..Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface...
  33. doi request reprint The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost
    Michaela E Kraft
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 51:2504-11. 2010
    ....
  34. pmc Variants in ASB10 are associated with open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, University Hospital Erlangen Nuremberg, Erlangen, Germany
    Hum Mol Genet 21:1336-49. 2012
    ..02). In conclusion, genetic and molecular analyses provide evidence for ASB10 as a glaucoma-causing gene...
  35. doi request reprint Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium
    Tina Dietrich-Ntoukas
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cornea 31:564-9. 2012
    ....
  36. doi request reprint Pathogenesis of involutional ectropion and entropion: the involvement of matrix metalloproteinases in elastic fiber degradation
    Renato W Damasceno
    Department of Ophthalmology and Eye Hospital, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Orbit 30:132-9. 2011
    ..To determine the elastic fiber content and ultrastructure as well as the expression of elastin-degrading enzymes in biopsy specimens from patients with involutional ectropion and entropion...
  37. ncbi request reprint Elevated homocysteine levels in aqueous humor of patients with pseudoexfoliation glaucoma
    Stefan Bleich
    Dept of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Am J Ophthalmol 138:162-4. 2004
    ..To determine total homocysteine levels in aqueous humor of pseudoexfoliation open-angle glaucoma patients...
  38. doi request reprint Myofibroblast metaplasia after descemet membrane endothelial keratoplasty
    Ludwig M Heindl
    Department of Ophthalmology and Eye Hospital, Friedrich Alexander University Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Am J Ophthalmol 151:1019-1023.e2. 2011
    ..To describe myofibroblastic metaplasia of corneal endothelial cells in 2 cases with impaired visual function despite complete graft adherence after Descemet membrane endothelial keratoplasty (DMEK)...
  39. pmc Levels of aqueous humor trace elements in patients with non-exsudative age-related macular degeneration: a case-control study
    Anselm G M Jünemann
    Department of Ophthalmology, University Hospital of Erlangen, Erlangen, Germany
    PLoS ONE 8:e56734. 2013
    ..Alterations of trace element levels support the hypothesis that cadmium, cobalt, iron, and copper are involved in the pathogenesis of AMD...
  40. ncbi request reprint Identification and characterization of limbal stem cells
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University Erlangen Nurnberg, Erlangen, Germany
    Exp Eye Res 81:247-64. 2005
    ....
  41. ncbi request reprint Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Invest Ophthalmol Vis Sci 43:1475-87. 2002
    ..To determine the expression and precise cellular and subcellular localization of the EP prostanoid receptor subtypes EP(1) through EP(4) and the FP receptor in normal human ocular tissues on the protein and mRNA levels...
  42. ncbi request reprint Isolated neurofibroma of the orbit with extensive myxoid changes: a clinicopathologic study including MRI and electron microscopic findings
    Ulrike B Kottler
    Department of Ophthalmology and Eye Hospital, Univeresity of Erlangen Nürnberg, Erlangen, Germany
    Orbit 23:59-64. 2004
    ....
  43. doi request reprint Histopathological changes after deep anterior lamellar keratoplasty using the 'big-bubble technique'
    Joachim M Braun
    Department of Ophthalmology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Acta Ophthalmol 91:78-82. 2013
    ..The aim of our study is to analyse histopathological changes in host corneal tissue caused by air insufflation in patients with keratoconus, their variability in 10 patients and their possible clinical implication...
  44. pmc From hair to cornea: toward the therapeutic use of hair follicle-derived stem cells in the treatment of limbal stem cell deficiency
    Ewa Anna Meyer-Blazejewska
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Stem Cells 29:57-66. 2011
    ..These data highlight the therapeutic properties of using HFSC to treat LSCD in a mouse model while demonstrating a strong translational potential and points to the niche as a key factor for determining stem cell differentiation...
  45. doi request reprint Plasma homocysteine levels in patients with normal tension glaucoma
    Christopher W Rössler
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    J Glaucoma 19:576-80. 2010
    ..To investigate whether there is an association of elevated plasma levels of homocysteine (Hcy) and normal tension glaucoma (NTG)...
  46. doi request reprint Clonal analysis of limbal epithelial stem cell populations
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Methods Mol Biol 1014:55-64. 2013
    ..The cultivation method described may be essential for long-term restoration of the damaged ocular surface in patients with limbal stem cell deficiency...
  47. ncbi request reprint Inverse mushroom-shaped nonmechanical penetrating keratoplasty using a femtosecond laser
    Berthold Seitz
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Am J Ophthalmol 139:941-4. 2005
    ..To demonstrate the feasibility of an inverse mushroom-shaped nonmechanical corneal trephination using a femtosecond laser in a noncontact manner...
  48. ncbi request reprint Mitochondria-rich epithelioid leiomyoma of the ciliary body
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Arch Ophthalmol 120:77-82. 2002
  49. ncbi request reprint Histopathology of corneal changes in lecithin-cholesterol acyltransferase deficiency
    Arne Viestenz
    Department of Ophthalmology, University Eye Hospital, University of Erlangen Nurnberg, Erlangen, Germany
    Cornea 21:834-7. 2002
    ..Lecithin-cholesterol acyltransferase (LCAT) deficiency is a rare entity. This dyslipoproteinemia may lead to corneal opacity, renal failure, and arteriosclerosis...
  50. ncbi request reprint Dose-related structural effects of photodynamic therapy on choroidal and retinal structures of human eyes
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 240:748-57. 2002
    ..To determine the effects of photodynamic therapy (PDT) on choroidal and retinal structures of human eyes...
  51. doi request reprint Histologic analysis of descemet stripping in posterior lamellar keratoplasty
    Ludwig M Heindl
    Department of Ophthalmology and University Eye Hospital, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Arch Ophthalmol 126:461-4. 2008
    ..To investigate how precise Descemet stripping works in posterior lamellar keratoplasty (Descemet stripping automated endothelial keratoplasty [DSAEK]) for the treatment of corneal endothelial disorders...
  52. doi request reprint Characterization of the mucocutaneous junction of the human eyelid margin and meibomian glands with different biomarkers
    Ozan Yüksel Tektas
    Department of Anatomy II, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Ann Anat 194:436-45. 2012
    ..To investigate the morphology of the human eyelid margin and the presence of different cytokeratins, mucins and stem cell markers within the skin epithelium, mucocutaneous junction (MCJ) and palpebral conjunctiva...
  53. doi request reprint Evaluation of lamina cribrosa and peripapillary sclera stiffness in pseudoexfoliation and normal eyes by atomic force microscopy
    Christoph Braunsmann
    Institute of Applied Physics, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 53:2960-7. 2012
    ..In this pilot study, the stiffness of LC and peripapillary sclera (ppSC) in eyes with and without PEX syndrome were analyzed by atomic force microscopy (AFM) nanoindentation...
  54. ncbi request reprint A stepwise approach to donor preparation and insertion increases safety and outcome of descemet membrane endothelial keratoplasty
    Friedrich E Kruse
    From the Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany
    Cornea 30:580-7. 2011
    ..However, widespread use of DMEK is currently limited because of problems with donor preparation namely the tearing of the Descemet membrane and the difficulty to unfold the EDM graft in the anterior chamber (AC)...
  55. doi request reprint Evidence of endothelial cell migration after descemet membrane endothelial keratoplasty
    Christina Jacobi
    Department of Ophthalmology, University of Erlangen Nuremberg, Germany
    Am J Ophthalmol 152:537-542.e2. 2011
    ..To investigate the hypothesis that adult corneal endothelial cells can migrate after Descemet membrane endothelial keratoplasty (DMEK)...
  56. ncbi request reprint Immunohistochemical identification of kynurenine aminotransferases in corpora amylacea in the human retina and optic nerve
    Robert Rejdak
    Friedrich Alexander University of Erlangen Nuremberg, Department of Ophthalmology, Schwabachanlage 6, D 91054 Erlangen, Germany
    Folia Neuropathol 45:66-71. 2007
    ..This study examines KAT I and II immunoreactivity in CAm in the human retina and optic nerve...
  57. ncbi request reprint Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development
    Ernst Poschl
    Department of Experimental Medicine I, University Erlangen Nurnberg, 91054 Erlangen, Germany
    Development 131:1619-28. 2004
    ....
  58. doi request reprint Stem cell-based therapy for corneal epithelial reconstruction: present and future
    Johannes Menzel-Severing
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    Can J Ophthalmol 48:13-21. 2013
    ....
  59. doi request reprint [Descemet's stripping automated endothelial keratoplasty (DSAEK)]
    C Cursiefen
    Augenklinik mit Poliklinik, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen
    Ophthalmologe 106:939-52; quiz 953. 2009
    ..Posterior lamellar keratoplasty techniques such as DSAEK may replace penetrating keratoplasty as the gold standard for treating a large proportion of corneal endothelial pathologies...
  60. doi request reprint Biomechanical and morphological differences between the sclera canal ring and a peripheral sclera ring in the porcine eye
    Naim Terai
    Department of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, Germany
    Ophthalmic Res 47:61-5. 2012
    ..To investigate a possible association between the biomechanical load and unload behaviour and the elastin content of the sclera canal ring (SCR) and a superiorly localized sclera ring (SPS) in the porcine eye...
  61. ncbi request reprint Pseudoexfoliation syndrome: pathological manifestations of relevance to intraocular surgery
    R Max Conway
    Department of Ophthalmology and Eye Hospital, University of Erlangen Nurnberg, Erlangen, Germany
    Clin Experiment Ophthalmol 32:199-210. 2004
    ..In this short review, current reports relating to PEX pathological changes of practical interest to the intraocular surgeon are summarized...
  62. ncbi request reprint Heterologous expression of wildtype and mutant myocilin in High Five insect cells shows comparable effects to cultivated trabecular meshwork cells
    Sevinc Oezbey
    University Hospital Erlangen, Institute of Human Genetics, Schwabachanlage 10, 91054, Erlangen, Germany
    Biomol Eng 24:313-7. 2007
    ..A direct attachment of ribosomes to these growing vesicles preceding the cell death was observed by electron microscopy. Our observations indicate that this system is suitable to trace the intracellular effects of MYOC mutants...
  63. doi request reprint Intraocular lymphangiogenesis in malignant melanomas of the ciliary body with extraocular extension
    Ludwig M Heindl
    Department of Ophthalmology and Eye Hospital, Ophthalmic Pathology Laboratory, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:1988-95. 2009
    ....
  64. ncbi request reprint Ocular and systemic pseudoexfoliation syndrome
    Ursula Schlötzer-Schrehardt
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Am J Ophthalmol 141:921-937. 2006
    ....
  65. pmc Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells
    Silke Meister
    IZKF N2, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Neoplasia 12:550-61. 2010
    ..Thus, the combination of bortezomib with verapamil may improve the efficacy of proteasome inhibitory therapy...
  66. pmc Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway
    Jochen Klucken
    Department of Molecular Neurology, University Hospital, Erlangen, Germany
    Autophagy 8:754-66. 2012
    ..Our data also suggest that protein aggregation may represent a detoxifying event rather than being causal for cellular toxicity...
  67. ncbi request reprint Solitary fibrous tumor of the orbit presenting 20 years after Hodgkin's disease
    Leonard M Holbach
    Department of Ophthalmology and Eye Hospital, University of Erlangen Nurnberg, Germany
    Orbit 21:49-54. 2002
    ..Only 11 other cases of orbital solitary fibrous tumor have been reported in the literature. To our knowledge, this is the first one presenting after Hodgkin's disease...
  68. doi request reprint Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
    Johannes Schödel
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 78:857-67. 2010
    ..Thus, FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms...
  69. doi request reprint Borrelia-associated crystalline keratopathy with intracorneal detection of Borrelia garinii by electron microscopy and polymerase chain reaction
    Tina Dietrich
    Department of Ophthalmology, Immunology and Hygiene, University Erlangen Nurnberg, Erlangen, Germany
    Cornea 27:498-500. 2008
    ..First report of a patient with Borrelia-associated crystalline keratopathy with intracorneal evidence of Borrelia garinii by polymerase chain reaction (PCR) and electron microscopy (EM)...
  70. doi request reprint Adhesion/growth-regulatory galectins in the human eye: localization profiles and tissue reactivities as a standard to detect disease-associated alterations
    Ursula Schlötzer-Schrehardt
    Universitatsaugenklinik, Friedrich Alexander Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Graefes Arch Clin Exp Ophthalmol 250:1169-80. 2012
    ....
  71. doi request reprint Carcinoma-associated retinopathy-an electrophysiological and immunohistochemical correlation
    Barbara Link
    Department of Ophthalmology, University of Erlangen Nuernberg, Erlangen, Germany
    Retina 29:69-72. 2009
    ..To correlate the clinical, electrophysiological, and immunohistochemical findings in patients suffering from carcinoma-associated retinopathy...