Research Topics
Genomes and Genes | U Schlötzer-SchrehardtSummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplaninClaus Cursiefen
Department of Ophthalmology and Nikolaus Fiebiger Zentrum for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 43:2127-35. 2002..To determine whether lymphatic vessels exist in vascularized human corneas, by using immunohistochemistry with novel markers for lymphatic endothelium...
Mitochondria-rich epithelioid leiomyoma of the ciliary bodyUrsula Schlötzer-Schrehardt
Department of Ophthalmology, University Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
Arch Ophthalmol 120:77-82. 2002
Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissuesUrsula Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
Invest Ophthalmol Vis Sci 43:1475-87. 2002..To determine the expression and precise cellular and subcellular localization of the EP prostanoid receptor subtypes EP(1) through EP(4) and the FP receptor in normal human ocular tissues on the protein and mRNA levels...
[Oxidative stress and pseudoexfoliation glaucoma]U Schlötzer-Schrehardt
Augenklinik, Universitat Erlangen Nurnberg
Klin Monbl Augenheilkd 227:108-13. 2010..Oxidative stress, therefore, appears to represent a modifiable risk factor in the management of patients with PEX syndrome/glaucoma...
Dose-related structural effects of photodynamic therapy on choroidal and retinal structures of human eyesUrsula Schlötzer-Schrehardt
Department of Ophthalmology, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
Graefes Arch Clin Exp Ophthalmol 240:748-57. 2002..To determine the effects of photodynamic therapy (PDT) on choroidal and retinal structures of human eyes...
Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucomaUrsula Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 44:1117-25. 2003....
Multifocal corneal argyrosis after an explosion injuryU Schlötzer-Schrehardt
Department of Ophthalmology, University Nürnberg, Erlangen, Germany
Cornea 20:553-7. 2001..To document the clinical and histopathologic corneal features of a patient who developed multifocal corneal argyrosis after a chemical explosion injury with unusual involvement of the corneal stroma and keratocytes...
Energy-filtering transmission electron microscopy (EFTEM) in the elemental analysis of pseudoexfoliative materialU Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Curr Eye Res 22:154-62. 2001..To obtain more information on the basic nature of the pathological matrix product accumulating in pseudoexfoliation (PEX) syndrome by analyzing its elemental composition at the subcellular level...
The Pathogenesis of floppy eyelid syndrome: involvement of matrix metalloproteinases in elastic fiber degradationUrsula Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Ophthalmology 112:694-704. 2005....
[Functional significance of adenosine receptors in the eye and their dysregulation in pseudoexfoliation syndrome]U Schlötzer-Schrehardt
Augenklinik der Friedrich Alexander Universität Erlangen Nürnberg
Ophthalmologe 102:1074-80, 1082. 2005..We investigated the expression of the receptor isoforms in eyes with PEX syndrome, which is associated with anterior chamber hypoxia and elevated intraocular pressure...
Selective upregulation of the A3 adenosine receptor in eyes with pseudoexfoliation syndrome and glaucomaUrsula Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Germany
Invest Ophthalmol Vis Sci 46:2023-34. 2005..In the current study, the role of the adenosine system in the pathophysiology of pseudoexfoliation (PEX) syndrome, which is typically associated with anterior chamber hypoxia and elevated intraocular pressure, was examined...
Role of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndromeU Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Exp Eye Res 73:765-80. 2001..Future therapeutic strategies might focus on TGF-beta1 antagonistic approaches...
Adenoma of the nonpigmented ciliary epithelium mimicking a malignant melanoma of the irisC Cursiefen
Department of Ophthalmology, University Eye Hospital, Friedrich Alexander University Erlangen Nurnberg, Germany
Arch Ophthalmol 117:113-6. 1999..Postoperative visual acuity was 20/40 OD after 6 weeks. An adenoma of the nonpigmented ciliary epithelium may mimic an amelanotic malignant melanoma of the iris and should be considered in its differential diagnosis...
Elastic fiber proteins in the glomerular mesangium in vivo and in cell cultureR B Sterzel
Medizinische Klinik IV and Augenklinik mit Poliklinik, Universitat Erlangen Nurnberg, Erlangen, Germany
Kidney Int 58:1588-602. 2000..The aim of this study was to clarify the exact glomerular localization, composition, and cellular production of these proteins...
Ocular findings in ichthyosis follicularis, atrichia, and photophobia syndromeC Cursiefen
Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
Arch Ophthalmol 117:681-4. 1999..A defective tear film, recurrent atopic keratoconjunctival inflammations, or a primary anomaly of corneal epithelial adhesion are potential causes for the corneal defects. Photophobia is most likely due to corneal abnormalities...
Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyesC Maihofner
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
Invest Ophthalmol Vis Sci 42:2616-24. 2001....
Pseudoexfoliation syndrome in eyes with ischemic central retinal vein occlusion. A histopathologic and electron microscopic studyC Cursiefen
Department of Ophthalmology, University Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
Acta Ophthalmol Scand 79:476-8. 2001..These deposits could explain an association of CRVO and PEX...
Corneal stromal calcification after topical steroid-phosphate therapyU Schlötzer-Schrehardt
Department of Ophthalmology, University Erlangen Nurnberg, Germany
Arch Ophthalmol 117:1414-8. 1999....
Characterization of extracellular matrix components in the limbal epithelial stem cell compartmentU Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
Exp Eye Res 85:845-60. 2007..Identification of specific niche parameters might not only help to understand limbal stem cell regulation, but also to improve their selective enrichment and in vitro expansion for therapeutic strategies...
Effect of latanoprost and timolol on the histopathology of the human conjunctivaN Terai
Department of Ophthalmology, Carl Gustav Carus University Hospital, Fetscherstrasse 74, Dresden, Germany
Br J Ophthalmol 93:219-24. 2009....
Persisting retinal ganglion cell axons in blind atrophic human eyesC Cursiefen
Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
Graefes Arch Clin Exp Ophthalmol 239:158-64. 2001..To evaluate enucleated blind atrophic human eyes for the persistence of retinal ganglion cell axons. This might be of relevance for contact to an electronic prosthesis in the future...
Analysis of aqueous humour proteins of eyes with and without pseudoexfoliation syndromeJ Berlau
Department of Ophthalmology, University of Rostock, Germany
Graefes Arch Clin Exp Ophthalmol 239:743-6. 2001..However, our findings support the theory that the pseudoexfoliation syndrome is associated with an amyloid of a serum protein...
Immunohistochemical classification of primary and recurrent macular corneal dystrophy in Germany: subclassification of immunophenotype I A using a novel keratan sulfate antibodyC Cursiefen
Department of Ophthalmology and University Eye Hospital, University of Erlangen Nurnberg, Erlangen, Germany
Exp Eye Res 73:593-600. 2001..The mAb 3D12/H7 allows a further subclassification of immunophenotype I A into type I A1 and 2. This points to a broader spectrum of MCD immunophenotypes and indirectly to a broader corneal proteoglycan pathology in MCD...
"Masked" pseudoexfoliation syndrome in unoperated eyes with circular posterior synechiae: clinical-electron microscopic correlationC Y Mardin
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Arch Ophthalmol 119:1500-3. 2001..To investigate the prevalence of "masked" pseudoexfoliation (PEX) syndrome in eyes with circular posterior synechiae receiving antiglaucomatous therapy with miotics...
Merkel cell carcinoma: clinicopathologic correlation, management, and follow-up in five patientsF Colombo
Department of Ophthalmology and Eye Hospital, University Erlangen Nurnberg, Erlangen, Germany
Ophthal Plast Reconstr Surg 16:453-8. 2000..To review the clinicopathologic features, management and follow-up in five patients with periocular Merkel cell carcinoma (MCC)...
Pericyte recruitment in human corneal angiogenesis: an ultrastructural study with clinicopathological correlationC Cursiefen
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Br J Ophthalmol 87:101-6. 2003..This study analyses whether, and if so when, pathological vessels in human corneal neovascularisation (CN) acquire pericyte coverage. This can be of importance for future angioregressive therapeutic strategies...
The C5 domain of Col6A3 is cleaved off from the Col6 fibrils immediately after secretionT Aigner
Cartilage Research Group, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Federal Republic of Germany
Biochem Biophys Res Commun 290:743-8. 2002....
Orbital lymphangioma with positive immunohistochemistry of lymphatic endothelial markers (vascular endothelial growth factor receptor 3 and podoplanin)C Cursiefen
Department of Ophthalmology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Graefes Arch Clin Exp Ophthalmol 239:628-32. 2001..Existence of true orbital lymphangiomas has been questioned in recent years. Therefore an orbital lymphangioma was analyzed with two new specific markers of lymphatic endothelium...
Increased homocysteine levels in tear fluid of patients with primary open-angle glaucomaJ B Roedl
Department of Ophthalmology, University Eye Hospital, Erlangen Nuremberg, Germany
Ophthalmic Res 40:249-56. 2008..We assessed homocysteine (Hcy) levels in tear fluid and plasma of patients with primary open-angle glaucoma (POAG). We determined the association between Hcy levels, dry eye syndrome and B vitamin status...
Early conjunctival changes following treatment with metipranolol and preservatives are not reversible with dexamethasoneH Mietz
Department of Ophthalmology, University of Cologne, Germany
Graefes Arch Clin Exp Ophthalmol 235:452-9. 1997..We sought to determine whether, after short-term use of metipranolol with preservatives, subsequent application of steroids or metipranolol without preservatives affects these conjunctival changes...
Ocular findings in Fryns syndromeC Cursiefen
Department of Ophthalmology, University Eye Hospital, Friedrich Alexander University Erlangen Nurnberg, Germany
Acta Ophthalmol Scand 78:710-3. 2000..The prevalence is about 0.7 per 10,000 births. Reported ocular features include microphthalmus, "cloudy cornea", irregularities of Bowman's layer, thickened posterior lens capsule and retinal dysplasia...
Intraocular lymphangiogenesis in malignant melanomas of the ciliary body with extraocular extensionLudwig M Heindl
Department of Ophthalmology and Eye Hospital, Ophthalmic Pathology Laboratory, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 50:1988-95. 2009....
Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucomaMatthias Zenkel
Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
Am J Pathol 176:2868-79. 2010..These findings support a role for a stress-induced, spatially, and temporally restricted subclinical inflammation in the onset of the fibrotic matrix process characteristic of PEX syndrome/glaucoma...
The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprostMichaela E Kraft
Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 51:2504-11. 2010....
Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucomaMatthias Zenkel
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 48:5558-66. 2007..The expression of stress-related genes in eyes from patients with and without PEX syndrome/glaucoma was investigated to determine whether PEX syndrome is associated with an altered cellular stress response...
Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cellsEwa Anna Blazejewska
Department of Ophthalmology, University of Erlangen Nuremberg, Germany
Stem Cells 27:642-52. 2009..Therefore, the HF may be an easily accessible alternative therapeutic source of autologous adult stem cells for replacement of the corneal epithelium and restoration of visual function in patients with ocular surface disorders...
Homocysteine in tear fluid of patients with pseudoexfoliation glaucomaJohannes B Roedl
Department of Ophthalmology and University Eye Hospital, Germany
J Glaucoma 16:234-9. 2007..To evaluate homocysteine (Hcy) concentrations in tear fluid and plasma and their association with B-vitamin levels in patients with pseudoexfoliation glaucoma (PEXG)...
Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative materialMatthias Zenkel
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 47:1982-90. 2006....
Nonmechanical posterior lamellar keratoplasty using the femtosecond laser (femto-plak) for corneal endothelial decompensationBerthold Seitz
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Am J Ophthalmol 136:769-72. 2003..To assess the potential of a short pulsed laser to cut a posterior graft and bed for posterior lamellar keratoplasty (PLAK)...
Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early developmentErnst Poschl
Department of Experimental Medicine I, University Erlangen Nurnberg, 91054 Erlangen, Germany
Development 131:1619-28. 2004....
Inverse mushroom-shaped nonmechanical penetrating keratoplasty using a femtosecond laserBerthold Seitz
Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
Am J Ophthalmol 139:941-4. 2005..To demonstrate the feasibility of an inverse mushroom-shaped nonmechanical corneal trephination using a femtosecond laser in a noncontact manner...
Elevated homocysteine levels in aqueous humor of patients with pseudoexfoliation glaucomaStefan Bleich
Dept of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
Am J Ophthalmol 138:162-4. 2004..To determine total homocysteine levels in aqueous humor of pseudoexfoliation open-angle glaucoma patients...
[Nodular fasciitis of the eyelid and anterior orbit in children: case report and review of the literature]R W Damasceno
Augenklinik mit Poliklinik, Universitat Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen
Ophthalmologe 106:829-31. 2009..Five years after surgery, there is no evidence of local recurrence, and the result is aesthetically satisfactory...
[Postoperative opacification of 12 hydrogel foldable lenses (Hydroview(R))]M J Groh
Augenklinik mit Poliklinik der Universität Erlangen Nürnberg, Schwabachanlage 6, 91054 Erlangen
Klin Monbl Augenheilkd 218:645-8. 2001..To evaluate postoperative lens opacifications in foldable hydrophilic intraocular lenses...
Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucomaMandy Krumbiegel
Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 50:2796-801. 2009..This study was focused on six functional candidate genes involved in PEX material deposition and the analysis of their potential association with PEX syndrome and PEX glaucoma (PEXG)...
Histologic analysis of descemet stripping in posterior lamellar keratoplastyLudwig M Heindl
Department of Ophthalmology and University Eye Hospital, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
Arch Ophthalmol 126:461-4. 2008..To investigate how precise Descemet stripping works in posterior lamellar keratoplasty (Descemet stripping automated endothelial keratoplasty [DSAEK]) for the treatment of corneal endothelial disorders...
Safety profile of topical VEGF neutralization at the corneaFelix Bock
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 50:2095-102. 2009..Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface...
Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patientsUrsula Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Am J Pathol 173:1724-35. 2008..Alterations of LOXL1 activation, processing, and/or substrate specificity may contribute to the abnormal aggregation of elastic fiber components into characteristic PEX fibrils...
Preservation of the limbal stem cell phenotype by appropriate culture techniquesEwa Anna Meyer-Blazejewska
Department of Ophthalmology, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 51:765-74. 2010....
Molecular pathology of pseudoexfoliation syndrome/glaucoma--new insights from LOXL1 gene associationsUrsula Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
Exp Eye Res 88:776-85. 2009....
Carcinoma-associated retinopathy-an electrophysiological and immunohistochemical correlationBarbara Link
Department of Ophthalmology, University of Erlangen Nuernberg, Erlangen, Germany
Retina 29:69-72. 2009..To correlate the clinical, electrophysiological, and immunohistochemical findings in patients suffering from carcinoma-associated retinopathy...
Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucomaFrancesca Pasutto
Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Invest Ophthalmol Vis Sci 49:1459-63. 2008..In this study, the genetic association of these variants was investigated in patients with PEX or PEXG of German and Italian descent...
Borrelia-associated crystalline keratopathy with intracorneal detection of Borrelia garinii by electron microscopy and polymerase chain reactionTina Dietrich
Department of Ophthalmology, Immunology and Hygiene, University Erlangen Nurnberg, Erlangen, Germany
Cornea 27:498-500. 2008..First report of a patient with Borrelia-associated crystalline keratopathy with intracorneal evidence of Borrelia garinii by polymerase chain reaction (PCR) and electron microscopy (EM)...
Histopathology of corneal changes in lecithin-cholesterol acyltransferase deficiencyArne Viestenz
Department of Ophthalmology, University Eye Hospital, University of Erlangen Nurnberg, Erlangen, Germany
Cornea 21:834-7. 2002..Lecithin-cholesterol acyltransferase (LCAT) deficiency is a rare entity. This dyslipoproteinemia may lead to corneal opacity, renal failure, and arteriosclerosis...
Pseudoexfoliation syndrome: pathological manifestations of relevance to intraocular surgeryR Max Conway
Department of Ophthalmology and Eye Hospital, University of Erlangen Nurnberg, Erlangen, Germany
Clin Experiment Ophthalmol 32:199-210. 2004..In this short review, current reports relating to PEX pathological changes of practical interest to the intraocular surgeon are summarized...
Ucma, a novel secreted cartilage-specific protein with implications in osteogenesisCordula Surmann-Schmitt
Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
J Biol Chem 283:7082-93. 2008..These findings suggest that Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface...
Heterologous expression of wildtype and mutant myocilin in High Five insect cells shows comparable effects to cultivated trabecular meshwork cellsSevinc Oezbey
University Hospital Erlangen, Institute of Human Genetics, Schwabachanlage 10, 91054, Erlangen, Germany
Biomol Eng 24:313-7. 2007..A direct attachment of ribosomes to these growing vesicles preceding the cell death was observed by electron microscopy. Our observations indicate that this system is suitable to trace the intracellular effects of MYOC mutants...
Immunohistochemical identification of kynurenine aminotransferases in corpora amylacea in the human retina and optic nerveRobert Rejdak
Friedrich Alexander University of Erlangen Nuremberg, Department of Ophthalmology, Schwabachanlage 6, D 91054 Erlangen, Germany
Folia Neuropathol 45:66-71. 2007..This study examines KAT I and II immunoreactivity in CAm in the human retina and optic nerve...
