Thorsten Schlomm

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. doi request reprint Neurovascular structure-adjacent frozen-section examination (NeuroSAFE) increases nerve-sparing frequency and reduces positive surgical margins in open and robot-assisted laparoscopic radical prostatectomy: experience after 11,069 consecutive patients
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 62:333-40. 2012
  2. pmc TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling
    Jan C Brase
    Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany
    BMC Cancer 11:507. 2011
  3. pmc Increasing the sensitivity of reverse phase protein arrays by antibody-mediated signal amplification
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Proteome Sci 8:36. 2010
  4. ncbi request reprint [Identification and validation of clinically relevant molecular alterations in prostate cancer]
    T Schlomm
    Martini Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Deutschland
    Urologe A 47:1193-8. 2008
  5. ncbi request reprint From gene to clinic: TMA-based clinical validation of molecular markers in prostate cancer
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Methods Mol Biol 664:177-89. 2010
  6. ncbi request reprint Marked gene transcript level alterations occur early during radical prostatectomy
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Eur Urol 53:333-44. 2008
  7. doi request reprint [Identification and validation of clinically relevant molecular alterations in prostate cancer]
    T Schlomm
    Martini Klinik, Universitätsklinikum Hamburg Eppendorf UKE, Hamburg, Deutschland
    Pathologe 30:111-6. 2009
  8. ncbi request reprint [Molecular high throughput research in prostate carcinoma]
    T Schlomm
    Martini Klinik am UKE, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, Gebäude O46, 20246 Hamburg
    Urologe A 46:1097-100. 2007
  9. ncbi request reprint Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, Department of Pathology and Urology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Clin Cancer Res 13:6579-84. 2007
  10. doi request reprint [Role of lymph node dissection in prostate cancer]
    T Schlomm
    Martini Klinik, UKE Hamburg Eppendorf, Gebäude 046, Martinistrasse 52, 20246 Hamburg
    Urologe A 48:37-45. 2009

Detail Information

Publications100

  1. doi request reprint Neurovascular structure-adjacent frozen-section examination (NeuroSAFE) increases nerve-sparing frequency and reduces positive surgical margins in open and robot-assisted laparoscopic radical prostatectomy: experience after 11,069 consecutive patients
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 62:333-40. 2012
    ..Intraoperative frozen-section analysis allows real-time histologic assessment of surgical margins (SMs) and identification of candidates for nerve-sparing (NS) procedures...
  2. pmc TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling
    Jan C Brase
    Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany
    BMC Cancer 11:507. 2011
    ..Although TMPRSS2-ERG fusion seems to be a critical event in prostate cancer, the precise functional role in cancer development and progression is still unclear...
  3. pmc Increasing the sensitivity of reverse phase protein arrays by antibody-mediated signal amplification
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Proteome Sci 8:36. 2010
    ..Increasing the sensitivity of RPPA approaches is important since many signaling proteins or posttranslational modifications are present at a low level...
  4. ncbi request reprint [Identification and validation of clinically relevant molecular alterations in prostate cancer]
    T Schlomm
    Martini Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Deutschland
    Urologe A 47:1193-8. 2008
    ..For this venture the pivotal prerequisite is the availability of large, comprehensively annotated and standardized high-quality bioresources...
  5. ncbi request reprint From gene to clinic: TMA-based clinical validation of molecular markers in prostate cancer
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Methods Mol Biol 664:177-89. 2010
    ..This approach of integrating large-scale clinical and molecular variables may provide a new paradigm for the use of molecular profiling to predict the clinical outcome in prostate cancer...
  6. ncbi request reprint Marked gene transcript level alterations occur early during radical prostatectomy
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Eur Urol 53:333-44. 2008
    ..However, transcript level patterns and RNA quality could rapidly change in response to ischemic and mechanical stress. Studies have shown that this occurs both perioperatively and after surgical removal of organs...
  7. doi request reprint [Identification and validation of clinically relevant molecular alterations in prostate cancer]
    T Schlomm
    Martini Klinik, Universitätsklinikum Hamburg Eppendorf UKE, Hamburg, Deutschland
    Pathologe 30:111-6. 2009
    ..For this venture the pivotal prerequisite is the availability of large, comprehensively annotated and standardized high-quality bioresources...
  8. ncbi request reprint [Molecular high throughput research in prostate carcinoma]
    T Schlomm
    Martini Klinik am UKE, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, Gebäude O46, 20246 Hamburg
    Urologe A 46:1097-100. 2007
  9. ncbi request reprint Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, Department of Pathology and Urology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Clin Cancer Res 13:6579-84. 2007
    ..To determine its role in prostate cancer, we analyzed 2,497 prostate cancers on the DNA and protein level...
  10. doi request reprint [Role of lymph node dissection in prostate cancer]
    T Schlomm
    Martini Klinik, UKE Hamburg Eppendorf, Gebäude 046, Martinistrasse 52, 20246 Hamburg
    Urologe A 48:37-45. 2009
    ..Each patient should be individually counseled regarding his individual tumor features and the use of statistical prognostic tools such as nomograms...
  11. ncbi request reprint Extraction and processing of high quality RNA from impalpable and macroscopically invisible prostate cancer for microarray gene expression analysis
    Thorsten Schlomm
    Department of Urology, University Clinic Hamburg Eppendorf, D 20246 Hamburg, Germany
    Int J Oncol 27:713-20. 2005
    ..Among these were several known prostate cancer relevant genes, such as AMACR, TARP, LIM, GPR160 (all up-regulated), CAV1, NTN1, MT1X; CLU, TRIM29, SPARCL1 and HSPB8 (all down-regulated)...
  12. ncbi request reprint Molecular staging of prostate cancer in the year 2007
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    World J Urol 25:19-30. 2007
    ..for optimal clinical decision making in prostate cancer patients: which patients will not require local therapy? If local therapy is needed, what is the treatment of choice? What medications should be given if metastases are present?..
  13. ncbi request reprint Molecular cancer phenotype in normal prostate tissue
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center Hamburg Eppendorf, Germany
    Eur Urol 55:885-90. 2009
    ..Insufficient sensitivity and specificity of prostate biopsies for cancer detection...
  14. ncbi request reprint Clinical significance of p53 alterations in surgically treated prostate cancers
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Mod Pathol 21:1371-8. 2008
    ..The rate of p53 alterations increases with prostate cancer progression...
  15. doi request reprint Radical prostatectomy improves progression-free and cancer-specific survival in men with lymph node positive prostate cancer in the prostate-specific antigen era: a confirmatory study
    Thomas Steuber
    Martini Clinic, Prostate Cancer Center, Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 107:1755-61. 2011
    ..Therapy (outcomes research)...
  16. doi request reprint Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Centre, Hamburg Eppendorf, Germany
    Eur Urol 55:394-401. 2009
    ..The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP...
  17. ncbi request reprint External validation of a preoperative nomogram for prediction of the risk of recurrence after radical prostatectomy
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:788-92. 2010
    ..To test the validity of an updated version of the preoperative Kattan nomogram for prediction of recurrence after radical prostatectomy (RP), published by Stephenson et al...
  18. doi request reprint The novel nomogram of Gleason sum upgrade: possible application for the eligible criteria of low dose rate brachytherapy
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Urol 17:862-8. 2010
    ....
  19. ncbi request reprint Differences in histopathological and biochemical outcomes in patients with low Gleason score prostate cancer
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:818-23. 2010
    ..Study Type - Diagnosis (case series) Level of Evidence 4..
  20. doi request reprint Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion-positive prostate cancers
    Antje Krohn
    Institute of Pathology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    J Pathol 231:130-41. 2013
    ..In summary, our data show that deletion of 3p13 defines a distinct and aggressive molecular subset of ERG(+) prostate cancers, which is possibly driven by inactivation of multiple tumour suppressors...
  21. ncbi request reprint Strong expression of the neuronal transcription factor FOXP2 is linked to an increased risk of early PSA recurrence in ERG fusion-negative cancers
    Laura Stumm
    Institute of Pathology, University Medical Center, Hamburg Eppendorf, Germany
    J Clin Pathol 66:563-8. 2013
    ..Transcription factors of the forkhead box P (FOXP1-4) family have been implicated in various human cancer types before. The relevance and role of neuronal transcription factor FOXP2 in prostate cancer is unknown...
  22. doi request reprint Loss of pSer2448-mTOR expression is linked to adverse prognosis and tumor progression in ERG-fusion-positive cancers
    Julia Muller
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 132:1333-40. 2013
    ....
  23. doi request reprint Low activated leukocyte cell adhesion molecule expression is associated with advanced tumor stage and early prostate-specific antigen relapse in prostate cancer
    Sarah Minner
    Institute of Pathology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Hum Pathol 42:1946-52. 2011
    ..The abundant presence of activated leukocyte cell adhesion molecule and its membranous localization in prostate cancer epithelium make activated leukocyte cell adhesion molecule a potentially attractive structure for targeted therapy...
  24. ncbi request reprint Development and internal validation of preoperative transition zone prostate cancer nomogram
    Thomas Steuber
    Department of Urology, University of Hamburg, Hamburg, Germany
    Urology 68:1295-300. 2006
    ..TZ PCa may be associated with more favorable RP pathologic findings than peripheral zone (PZ) PCa. To identify these men, we developed a model capable of predicting the probability of TZ PCa at RP...
  25. ncbi request reprint Unilateral prostate cancer cannot be accurately predicted in low-risk patients
    Hendrik Isbarn
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 77:784-7. 2010
    ..We tested the accuracy of unilaterally unremarkable biopsy findings in cases of low-risk PCa patients who are potential candidates for HAT...
  26. doi request reprint Risk assessment of metastatic recurrence in patients with prostate cancer by using the Cancer of the Prostate Risk Assessment score: results from 2937 European patients
    Lars Budaus
    Department of Urology, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 110:1714-20. 2012
    ..2 and 78.5, respectively, in European patients. Therefore, the CAPRA score also allows reliable prediction of the examined endpoints in European patients...
  27. ncbi request reprint Biochemical recurrence after radical prostatectomy: multiplicative interaction between surgical margin status and pathological stage
    Lars Budaus
    Martiniclinic, Prostate Cancer Center Hamburg Eppendorf, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 184:1341-6. 2010
    ..We addressed the first degree of interaction between positive surgical margins and other established adverse predictors of biochemical recurrence after radical prostatectomy...
  28. ncbi request reprint High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series
    Jochen Walz
    Department of Urology, University Medical Centre Eppendorf, Hamburg, Germany
    Eur Urol 50:498-505. 2006
    ..We explored the yield of saturation biopsy and developed a nomogram predicting the probability of prostate cancer (PCa) on the basis of saturation biopsy...
  29. pmc High mitochondria content is associated with prostate cancer disease progression
    Katharina Grupp
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Martinistr, 52, 20246 Hamburg, Germany
    Mol Cancer 12:145. 2013
    ..Mitochondria are suggested to be important organelles for cancer initiation and promotion. This study was designed to evaluate the prognostic value of MTC02, a marker for mitochondrial content, in prostate cancer...
  30. doi request reprint Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence
    Maria Christina Tsourlakis
    Institute of Pathology, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Hum Pathol 44:1789-96. 2013
    ..Furthermore, DAXX appears to exert biologically different effects in ERG-positive and ERG-negative prostate cancers. ..
  31. doi request reprint High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer
    Anna Flammiger
    Department of Oncology and Hematology, University Medical Center Hamburg Eppendorf, Hubertus Wald Tumorzentrum University Cancer Center Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Eur J Cancer 49:1273-9. 2013
    ..Our study suggests that the intratumoural presence of regulatory T cells may have substantial functional impact and may confer an adverse clinical course in prostate cancer...
  32. doi request reprint Assessment of rates of lymph nodes and lymph node metastases in periprostatic fat pads in a consecutive cohort treated with retropubic radical prostatectomy
    Jens Hansen
    Martini Clinic, Prostate Cancer Center at University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Urology 80:877-82. 2012
    ....
  33. doi request reprint Blood transfusions in radical prostatectomy: a contemporary population-based analysis
    Jan Schmitges
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Urology 79:332-8. 2012
    ..To examine the homologous blood transfusion (HBT), autologous blood transfusion (ABT) and intraoperative blood conservation technique (IOBCT) rates and trends at open (ORP) and minimally invasive radical prostatectomy (MIRP)...
  34. ncbi request reprint Long-term data on the survival of patients with prostate cancer treated with radical prostatectomy in the prostate-specific antigen era
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 106:37-43. 2010
    ..Therapy (case series) Level of Evidence 4...
  35. doi request reprint The presence of prostate cancer on saturation biopsy can be accurately predicted
    Sascha A Ahyai
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 105:636-41. 2010
    ..To improve the ability of our previously reported saturation biopsy nomogram quantifying the risk of prostate cancer, as the use of office-based saturation biopsy has increased...
  36. ncbi request reprint Distinct subcellular expression patterns of neutral endopeptidase (CD10) in prostate cancer predict diverging clinical courses in surgically treated patients
    Achim Fleischmann
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 14:7838-42. 2008
    ..Neutral endopeptidase (CD10), an ectopeptidase bound to the cell surface, is thought to be a potential prognostic marker for prostate cancer...
  37. ncbi request reprint Functional and oncological outcomes of patients aged <50 years treated with radical prostatectomy for localised prostate cancer in a European population
    Andreas Becker
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada
    BJU Int 114:38-45. 2014
    ..To address the biochemical and functional outcomes after radical prostatectomy (RP) of men aged <50 years in a large European population...
  38. ncbi request reprint NY-ESO-1 expression is tightly linked to TMPRSS2-ERG fusion in prostate cancer
    Katharina Grupp
    General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg Eppendorf, Hamburg, Germany Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate 74:1012-22. 2014
    ..This study was undertaken to explore the relationship of NY-ESO-1 with tumor phenotype, biochemical recurrence, and molecular subgroups in hormone-naive prostate cancers...
  39. ncbi request reprint Frozen section for the management of intraoperatively detected palpable tumor lesions during nerve-sparing scheduled radical prostatectomy
    Christian Eichelberg
    Department of Urology, University Hospital Hamburg Eppendorf, Germany
    Eur Urol 49:1011-6; discussion 1016-8. 2006
    ..We investigated the use of frozen section (FS) analysis to monitor the safety and efficiency of NS during RP in patients with intraoperatively identified subcapsular tumor lesions...
  40. ncbi request reprint Development and internal validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy pathology
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 49:820-6. 2006
    ..We explored the rate of upgrading from biopsy to RP specimen in our contemporary cohort, and developed a model capable of predicting the probability of biopsy Gleason sum upgrading...
  41. doi request reprint Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer
    Anna Flammiger
    Departments of Oncology and Hematology, University Medical Center Hamburg Eppendorf, Hubertus Wald Tumorzentrum University Cancer Center Hamburg, Hamburg, Germany
    APMIS 120:901-8. 2012
    ..This study indicates that the density of T but not B cells plays a functional role in the biology of prostate cancer and may have an impact on clinical outcome in this frequent neoplasia...
  42. doi request reprint Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer
    Sarah Minner
    Institute of Pathology, Department of Urology, Prostate Cancer Center University Medical Center, Hamburg Eppendorf, Germany
    Clin Cancer Res 16:1553-60. 2010
    ..The purpose of this study was to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in prostate cancer...
  43. doi request reprint Importance of baseline potency rate assessment of men diagnosed with clinically localized prostate cancer prior to radical prostatectomy
    Georg Salomon
    Martini Clinic, Prostate Cancer Center, University of Hamburg, Hamburg, Germany
    J Sex Med 6:498-504. 2009
    ..Knowledge about baseline potency is highly important in men undergoing treatment for prostate cancer (PCa) as it might influence judgments about impact of treatment and thereby treatment decisions...
  44. doi request reprint Immunological microenvironment in prostate cancer: high mast cell densities are associated with favorable tumor characteristics and good prognosis
    Achim Fleischmann
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate 69:976-81. 2009
    ..Number of intratumoral mast cells predicts survival in various cancers. The prognostic significance of such mast cells in surgically treated prostate cancer is unknown...
  45. ncbi request reprint High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions
    Katharina Grupp
    General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg Eppendorf, Hamburg, Germany Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    Eur J Cancer 50:852-61. 2014
    ..The RNA-binding motif protein 3 (RBM3) has recently been suspected as a prognostic biomarker in several cancers...
  46. ncbi request reprint Anatomic radical retropubic prostatectomy-long-term recurrence-free survival rates for localized prostate cancer
    Felix K H Chun
    Department of Urology, University Medical Center Eppendorf, Hamburg, Germany
    World J Urol 24:273-80. 2006
    ..Our findings confirm excellent long-term biochemical cancer-control outcomes after RRP. High grade prostate cancer at final pathology and seminal vesicle invasion proved to be the strongest risk factors of BCR after surgery...
  47. ncbi request reprint Contemporary prostate cancer prevalence among T1c biopsy-referred men with a prostate-specific antigen level < or = 4.0 ng per milliliter
    Sascha A Ahyai
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 53:750-7. 2008
    ..To investigate the prostate cancer (PCa) prevalence and risk factors of men with prostate-specific antigen (PSA) level< or =4.0 ng/ml and an unsuspicious digital rectal examination (DRE) in a large biopsy referral cohort...
  48. doi request reprint Inverse stage migration in patients undergoing radical prostatectomy: results of 8916 European patients treated within the last decade
    Lars Budaus
    Martiniclinic, Prostate Cancer Centre, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 108:1256-61. 2011
    ..To investigate the stage migration patterns during the last decade in European men treated with radical prostatectomy (RP)...
  49. ncbi request reprint Effect of body mass index on histopathologic parameters: results of large European contemporary consecutive open radical prostatectomy series
    Hendrik Isbarn
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Urology 73:615-9. 2009
    ..Studies, predominantly derived from the United States, have suggested that an increased BMI is a significant predictor of adverse pathologic findings in patients treated with open RP...
  50. doi request reprint Current technique of open intrafascial nerve-sparing retropubic prostatectomy
    Lars Budaus
    Martini Clinic, Prostate Cancer Centre Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 56:317-24. 2009
    ..Even though the principles of the technique and its oncological efficacy have often been published, ongoing refinements allow further improvements in functional outcome and morbidity...
  51. ncbi request reprint High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers
    Katharina Grupp
    General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg Eppendorf, Germany Institute of Pathology, University Medical Center Hamburg Eppendorf, Germany Electronic address
    Mol Oncol 7:1001-11. 2013
    ..It is concluded, that LPCAT1 measurement, either alone or in combination, may be utilized for better clinical decision-making. These data also highlight the potentially important role of lipid metabolism in prostate cancer biology...
  52. doi request reprint SPINK1 expression is tightly linked to 6q15- and 5q21-deleted ERG-fusion negative prostate cancers but unrelated to PSA recurrence
    Katharina Grupp
    General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg Eppendorf, Hamburg, Germany Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate 73:1690-8. 2013
    ..It was the aim of this study to further study the clinical relevance of SPINK1 expression and its relationship with other key genomic alterations of prostate cancer...
  53. ncbi request reprint Significant upgrading affects a third of men diagnosed with prostate cancer: predictive nomogram and internal validation
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    BJU Int 98:329-34. 2006
    ....
  54. doi request reprint Marked heterogeneity of ERG expression in large primary prostate cancers
    Sarah Minner
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mod Pathol 26:106-16. 2013
    ..Marked heterogeneity also compromises the concept of analyzing ERG status for treatment decisions in diagnostic needle core biopsies...
  55. ncbi request reprint Venous thromboembolism after radical prostatectomy: the effect of surgical caseload
    Jan Schmitges
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Germany
    BJU Int 110:828-33. 2012
    ..Our findings suggest that VTE-specific processes of care need to be improved, with the intent of reaching the level recorded in patients treated by high ASC surgeons. Finally, MIRP seems to be no risk factor for VTE...
  56. doi request reprint CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer
    Lia Burkhardt
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Cancer Res 73:2795-805. 2013
    ..Our study establishes CHD1 as the 5q21 tumor suppressor gene in prostate cancer and shows a key role of this chromatin remodeling factor in prostate cancer biology...
  57. doi request reprint Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer
    Antje Krohn
    Institute of Pathology, Prostate Cancer Center and Section for Translational Prostate Cancer Research at the Clinic of Urology at University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 181:401-12. 2012
    ....
  58. ncbi request reprint Zonal origin of localized prostate cancer does not affect the rate of biochemical recurrence after radical prostatectomy
    Felix K H Chun
    Department of Urology, University of Hamburg, Hamburg, Germany
    Eur Urol 51:949-55; discussion 955. 2007
    ..To investigate whether transition zone (TZ) prostate cancers demonstrate different rates of biochemical recurrence after radical prostatectomy compared to peripheral zone (PZ) cancers...
  59. doi request reprint Full functional-length urethral sphincter preservation during radical prostatectomy
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Centre, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 60:320-9. 2011
    ..A key prerequisite for urinary continence after radical prostatectomy (RP) is the functional length of the urethral sphincter and the stabilisation of its anatomic position within the pelvic floor...
  60. doi request reprint The impact of the number of cores on tissue microarray studies investigating prostate cancer biomarkers
    Pierre Tennstedt
    Institute of Pathology, University Medical Center, Hamburg Eppendorf, Germany
    Int J Oncol 40:261-8. 2012
    ..Multiple cores may even lead to statistical problems if unequal amounts of tissue are analyzed per tumor...
  61. ncbi request reprint MALDI imaging on tissue microarrays identifies molecular features associated with renal cell cancer phenotype
    Stefan Steurer
    Institute of Clinical Chemistry, University Medical Center Hamburg Eppendorf, Bldg N27, Room 00 008, Martinistr 52, 20246 Hamburg, Germany
    Anticancer Res 34:2255-61. 2014
    ..To identify molecular features associated with clinico-pathological parameters in renal cell cancer...
  62. doi request reprint Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions
    Martina Kluth
    Institute of Pathology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Mod Pathol 26:975-83. 2013
    ....
  63. ncbi request reprint High level of Ets-related gene expression has high specificity for prostate cancer: a tissue microarray study of 11 483 cancers
    Sarah Minner
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Histopathology 61:445-53. 2012
    ..This study was undertaken to determine the prevalence of ERG overexpression in other tumour types as well as in normal tissues...
  64. pmc Is radical prostatectomy a useful therapeutic option for high-risk prostate cancer in older men?
    Markus Graefen
    Martini Clinic, Prostate Cancer Centre, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Oncologist 17:4-8. 2012
    ..If eligible, the patient should be offered radical prostatectomy as a potentially curative treatment, without a rigid restriction to a certain chronological age...
  65. doi request reprint Y chromosome losses are exceedingly rare in prostate cancer and unrelated to patient age
    Phillip R Stahl
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Prostate 72:898-903. 2012
    ..This study was undertaken to investigate the frequency of Y chromosome losses and this chromosomal abnormality might play a potential role in prostate cancer...
  66. doi request reprint Evaluation of prostate cancer detection with ultrasound real-time elastography: a comparison with step section pathological analysis after radical prostatectomy
    Georg Salomon
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 54:1354-62. 2008
    ..Conventional gray scale ultrasound has a low sensitivity and specificity for prostate cancer detection. Better imaging modalities are needed...
  67. doi request reprint Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer
    Alexander T El Gammal
    Departments of Gynecology, Institute of Pathology, Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg, Germany
    Clin Cancer Res 16:56-64. 2010
    ..Deletions of 8p and gains of 8q belong to the most frequent cytogenetic alterations in prostate cancer. The target genes of these alterations and their biological significance are unknown...
  68. doi request reprint Reduced CD147 expression is linked to ERG fusion-positive prostate cancers but lacks substantial impact on PSA recurrence in patients treated by radical prostatectomy
    Katharina Grupp
    General, Visceral and Thoracic Surgery Department and Clinic, Institute of Pathology, University Medical Center Hamburg Eppendorf, Martinistr 52, Germany Institute of Pathology, University Medical Center Hamburg Eppendorf, Martinistr 52, Germany Electronic address
    Exp Mol Pathol 95:227-34. 2013
    ..Despite a weak association with PSA recurrence, CD147 cannot be considered a relevant prognostic biomarker...
  69. ncbi request reprint A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer
    Olaf J C Hellwinkel
    Martini Klinik, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    BJU Int 101:1454-60. 2008
    ....
  70. doi request reprint Accuracy of HistoScanning™ for the prediction of a negative surgical margin in patients undergoing radical prostatectomy
    Georg Salomon
    Martini Clinic, Prostate Cancer Center, University Medical Center Eppendorf, Hamburg, Germany
    BJU Int 111:60-6. 2013
    ..To assess the accuracy of HistoScanning™ (HS) as a visualization tool for preoperative treatment planning for nerve-sparing (NS) radical prostatectomy (RP)...
  71. ncbi request reprint Nerve distribution along the prostatic capsule
    Christian Eichelberg
    Department of Urology, University Hospital Eppendorf, Hamburg, Germany
    Eur Urol 51:105-10; discussion 110-1. 2007
    ..The objective of this study therefore was to determine the typical pattern of nerve distribution along the prostatic capsule...
  72. doi request reprint Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro
    Ramesh Ummanni
    Department of Oncology, Haematology and Bone Marrow Transplantation, Section Pneumology, Hubertus Wald Tumour Zentrum, University Hospital Eppendorf, Hamburg, Germany
    J Proteome Res 11:2452-66. 2012
    ..Functional characterization of PRDX3 and PRDX4 activity in PCa cell lines suggests a role of these members of the peroxiredoxin family in the pathophysiology of this tumor entity...
  73. doi request reprint High level PSMA expression is associated with early PSA recurrence in surgically treated prostate cancer
    Sarah Minner
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prostate 71:281-8. 2011
    ..This study was undertaken, to gain more insight on the role of PSMA in early prostate cancer and its distribution in various normal tissues...
  74. ncbi request reprint Reasonable delay of surgical treatment in men with localized prostate cancer--impact on prognosis?
    Markus Graefen
    Department of Urology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Urol 47:756-60. 2005
    ..We investigated whether a reasonable delay from diagnosis to definitive treatment impact recurrence free survival rates in men undergoing radical prostatectomy (RP) for localized prostate cancer...
  75. pmc No detection of XMRV in blood samples and tissue sections from prostate cancer patients in Northern Europe
    Kristin Stieler
    Institute for Medical Microbiology and Virology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e25592. 2011
    ....
  76. doi request reprint A population-based analysis of temporal perioperative complication rates after minimally invasive radical prostatectomy
    Jan Schmitges
    Martini Clinic, Prostate Cancer Center Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 60:564-71. 2011
    ..Existing population-based reports on complication rates after minimally invasive radical prostatectomy (MIRP) did not address temporal trends...
  77. doi request reprint Cysteine-rich secretory protein 3 overexpression is linked to a subset of PTEN-deleted ERG fusion-positive prostate cancers with early biochemical recurrence
    Katharina Grupp
    General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mod Pathol 26:733-42. 2013
    ..The tight link of strong CRISP3 expression to the ERG fusion-positive prostate cancers with PTEN deletions provides further evidence for the existence of molecularly distinct subgroups of prostate cancers...
  78. doi request reprint ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy
    Sarah Minner
    Institute of Pathology and Departments of Clinical Chemistry, Bone Marrow Transplantation with Section, Pneumology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 17:5878-88. 2011
    ..A secondary aim was to search for differences between these tumor classes...
  79. pmc Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation
    Ramesh Ummanni
    Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumour Zentrum UCCH, University Hospital Eppendorf UKE, Hamburg, Germany
    Mol Cancer 10:129. 2011
    ..Furthermore, we present evidences that UCHL1 expression can affect the behavior of prostate cancer cells in different ways...
  80. ncbi request reprint Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer
    Nicole Fischer
    Institute for Medical Microbiology and Virology, University Medical Center Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Clin Virol 43:277-83. 2008
    ....
  81. pmc Identification of clinically relevant protein targets in prostate cancer with 2D-DIGE coupled mass spectrometry and systems biology network platform
    Ramesh Ummanni
    Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumor Zentrum, University Hospital Eppendorf, Hamburg, Germany
    PLoS ONE 6:e16833. 2011
    ..Further functional validation of individual proteins is ongoing and might provide new insights in PCa progression potentially leading to the design of novel diagnostic and therapeutic strategies...
  82. doi request reprint Expression and prognostic relevance of annexin A3 in prostate cancer
    Jens Kollermann
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 54:1314-23. 2008
    ..The aim of this study was to thoroughly analyze ANXA3 expression patterns and its potential as a prognostic marker in a large set of benign, preneoplastic, and neoplastic prostate tissue samples...
  83. doi request reprint Human prostate cancer in a clinically relevant xenograft mouse model: identification of β(1,6)-branched oligosaccharides as a marker of tumor progression
    Tobias Lange
    Department of Anatomy and Experimental Morphology, University Cancer Center Hamburg, Hamburg, Germany
    Clin Cancer Res 18:1364-73. 2012
    ..To establish xenograft mouse models of metastatic and nonmetastatic human prostate cancer and to apply these models to the search for aberrant glycosylation patterns associated with tumor progression in vivo and in patients...
  84. ncbi request reprint [Selection criteria for the expected management of localised prostate cancer]
    M Graefen
    Martini Klinik, Prostatazentrum an der Universitätsklinik Hamburg Eppendorf
    Urologe A 44:1277-8, 1280-6. 2005
    ..In general, expected management is a suitable option for elderly patients with low grade cancers. Young patients and those with intermediate or high-grade cancers are most likely to benefit from active local treatment...
  85. ncbi request reprint [Active surveillance for prostate cancer]
    M Graefen
    Martini Klinik, Prostatazentrum an der Universitätsklinik Hamburg Eppendorf, Hamburg, Germany
    Urologe A 47:261-9. 2008
    ..Active surveillance has the potential to lead to undertreatment as there is some evidence that prolonged treatment delay might adversely affect outcome of definitive therapy...
  86. ncbi request reprint Prostate cancers in the transition zone: Part 1; pathological aspects
    Andreas Erbersdobler
    Institute of Pathology, University of Hamburg, Hamburg, Germany
    BJU Int 94:1221-5. 2004
  87. doi request reprint The potential role of G2- but not of G0-radiosensitivity for predisposition of prostate cancer
    Kerstin Borgmann
    Laboratory of Radiobiology and Experimental Radiooncology, University Medical Center Hamburg Eppendorf, Germany
    Radiother Oncol 96:19-24. 2010
    ..Comparing the chromosomal radiosensitivity of prostate cancer patients with that of healthy donors...
  88. ncbi request reprint Effects of chemotherapy on the cytogenetic constitution of Wilms' tumor
    Thorsten Schlomm
    Department of Urology, University of Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 11:4382-7. 2005
    ....
  89. doi request reprint [F(18)]-fluoroethylcholine combined in-line PET-CT scan for detection of lymph-node metastasis in high risk prostate cancer patients prior to radical prostatectomy: Preliminary results from a prospective histology-based study
    T Steuber
    Martini Clinic, Prostate Cancer Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur J Cancer 46:449-55. 2010
    ..To evaluate the diagnostic potential of PET/CT using ([F(18)]fluorethylcholine (FEC) for lymph node (LN) staging in high risk prostate cancer (PCa) patients prior to radical prostatectomy (RP)...
  90. ncbi request reprint Simultaneous tumour-like, atypical basal cell hyperplasia and acinar adenocarcinoma of the prostate: a comparative morphological and genetic approach
    A M Luebke
    Department of Urology, University of Hamburg, Martinistrasse 52, 22081 Hamburg, Germany
    Virchows Arch 446:338-41. 2005
    ..The pathological findings favoured the diagnosis of an atypical basal cell hyperplasia...
  91. ncbi request reprint Effect of autologous blood transfusion on the rate of biochemical recurrence after radical prostatectomy
    Andrea Gallina
    Department of Urology, Vita Salute University San Raffaele, Milan, Italy
    BJU Int 100:1249-53. 2007
    ..To test the association between autologous blood transfusion (ABT) and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large group of contemporary patients...
  92. ncbi request reprint Health-insurance status is a determinant of the stage at presentation and of cancer control in European men treated with radical prostatectomy for clinically localized prostate cancer
    Andrea Gallina
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    BJU Int 99:1404-8. 2007
    ....
  93. ncbi request reprint The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit and the Department of Urology, University of Montreal Health Center, Montreal, Canada
    Eur Urol 49:273-8; discussion 278-9. 2006
    ..We examined the prognostic value of AJCC pT2 substages in prediction of biochemical recurrence (BCR) after radical prostatectomy (RP), in European patients...
  94. doi request reprint Currently used criteria for active surveillance in men with low-risk prostate cancer: an analysis of pathologic features
    Nazareno Suardi
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    Cancer 113:2068-72. 2008
    ..In this report, the authors addressed the rates of misclassification associated with the use of 5 different clinical criteria for AS. Misclassification was defined as the presence of either nonorgan-confined disease or high-grade PCa...
  95. doi request reprint Biopsies performed at tertiary care centers are superior to referral biopsies in predicting pathologic Gleason sum
    Pierre I Karakiewicz
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    J Endourol 22:533-8. 2008
    ..Biopsy grading at tertiary care centers may or may not be superior to biopsies performed at referral institutions...
  96. ncbi request reprint Body mass index does not improve the ability to predict biochemical recurrence after radical prostatectomy
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre CHUM, 1058, rue St Denis, Montreal, Quebec H2X 3J4, Canada
    Eur J Cancer 43:375-82. 2007
    ..To test whether body mass index (BMI) improves pre- or post-operative biochemical recurrence (BCR) predictions after radical prostatectomy...
  97. ncbi request reprint Tumour volume and high grade tumour volume are the best predictors of pathologic stage and biochemical recurrence after radical prostatectomy
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center CHUM, 1058, rue St Denis, Montreal, Que, Canada H2X 3J4
    Eur J Cancer 43:536-43. 2007
    ..Our goal was to examine to what extent tumour volume (TV) and percentage of high grade tumour volume (%HGTV) affect the rate of positive surgical margins and the rate of biochemical recurrence after radical prostatectomy...
  98. ncbi request reprint Surgical volume is related to the rate of positive surgical margins at radical prostatectomy in European patients
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    BJU Int 98:1204-9. 2006
    ..To assess the association between surgical volume (SV) and the rate of positive surgical margins (PSM) after radical prostatectomy (RP) in a large single-institution European cohort of patients...
  99. ncbi request reprint Development and external validation of an extended 10-core biopsy nomogram
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    Eur Urol 52:436-44. 2007
    ..To test the accuracy of a previously externally validated sextant biopsy nomogram in referred men exposed to > or =10 or more biopsy cores. Moreover, we explored the hypothesis that a more accurate predictive tool could be developed...
  100. ncbi request reprint Development and external validation of an extended repeat biopsy nomogram
    Felix K H Chun
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Quebec, Canada
    J Urol 177:510-5. 2007
    ..We hypothesized that the outcome of repeat biopsy could be accurately predicted. We tested this hypothesis in a contemporary cohort from 3 centers...