Christian Schlensak

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint Protection of acutely ischemic myocardium by controlled reperfusion
    C Schlensak
    Division of Cardiovascular Surgery, Universtiy of Freiburg, Germany
    Ann Thorac Surg 68:1967-70. 1999
  2. ncbi request reprint Controlled limb reperfusion with a simplified perfusion system
    C Schlensak
    Department of Cardiovascular Surgery, University of Freiburg, Germany
    Thorac Cardiovasc Surg 48:274-8. 2000
  3. ncbi request reprint Bronchial artery perfusion during cardiopulmonary bypass does not prevent ischemia of the lung in piglets: assessment of bronchial artery blood flow with fluorescent microspheres
    C Schlensak
    Department of Cardiovascular Surgery, University of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg, Germany
    Eur J Cardiothorac Surg 19:326-31; disciussion 331-2. 2001
  4. ncbi request reprint [Explantation of aortic stent-grafts]
    C Schlensak
    Abteilung für Herz und Gefässchirurgie, Universitatsklinikum Freiburg, Germany
    Zentralbl Chir 126:975-9; discussion 980-1. 2001
  5. ncbi request reprint Cardiopulmonary bypass reduction of bronchial blood flow: a potential mechanism for lung injury in a neonatal pig model
    Christian Schlensak
    Department of Cardiovascular Surgery, Albert Ludwigs University, Freiburg, Germany
    J Thorac Cardiovasc Surg 123:1199-205. 2002
  6. doi request reprint Reduced pulmonary inflammatory response during cardiopulmonary bypass: effects of combined pulmonary perfusion and carbon monoxide inhalation
    Ulrich Goebel
    Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Freiburg, Germany
    Eur J Cardiothorac Surg 34:1165-72. 2008
  7. doi request reprint Prosthesis oversizing in balloon-expandable transcatheter aortic valve implantation is associated with contained rupture of the aortic root
    Philipp Blanke
    Department of Diagnostic Radiology, University Hospital Freiburg, Hugstetter Strasse 55, Freiburg, Germany
    Circ Cardiovasc Interv 5:540-8. 2012
  8. ncbi request reprint Implantation of a catheter-based self-expanding pulmonary valve in congenital heart surgery: results of a pilot study
    Robert von Wattenwyl
    Department of Cardiovascular Surgery, Albert Ludwigs University of Freiburg, Freiburg, Germany
    Eur J Cardiothorac Surg 40:552-6. 2011
  9. doi request reprint Hepatocyte growth factor-transfected skeletal myoblasts to limit the development of postinfarction heart failure
    Annika Poppe
    Department of Cardiovascular Surgery Department of Radiology, University Medical Center Freiburg, Hugstetterstrasse 55, Freiburg, Germany
    Artif Organs 36:238-46. 2012
  10. pmc Thoratec paracorporeal biventricular assist device therapy: the Freiburg experience
    Kerstin Brehm
    Department of Cardiovascular Surgery, University Heart Center Freiburg Bad Krozingen, Freiburg, Germany
    Eur J Cardiothorac Surg 41:207-12; discussion 212. 2012

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Protection of acutely ischemic myocardium by controlled reperfusion
    C Schlensak
    Division of Cardiovascular Surgery, Universtiy of Freiburg, Germany
    Ann Thorac Surg 68:1967-70. 1999
    ..In this article, we review recent advances in surgically controlled reperfusion and speculate on future prospects for myocardial protective techniques in patients with acute coronary artery occlusion...
  2. ncbi request reprint Controlled limb reperfusion with a simplified perfusion system
    C Schlensak
    Department of Cardiovascular Surgery, University of Freiburg, Germany
    Thorac Cardiovasc Surg 48:274-8. 2000
    ..Controlled reperfusion consisted of a 30 min infusion of a normothermic reperfusate solution, which was mixed with the patient's blood (6:1, blood/reperfusate ratio) distally to the proximal obstruction...
  3. ncbi request reprint Bronchial artery perfusion during cardiopulmonary bypass does not prevent ischemia of the lung in piglets: assessment of bronchial artery blood flow with fluorescent microspheres
    C Schlensak
    Department of Cardiovascular Surgery, University of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg, Germany
    Eur J Cardiothorac Surg 19:326-31; disciussion 331-2. 2001
    ..This study was undertaken to assess the bronchial artery blood flow during CPB with fluorescent microspheres in a piglet model...
  4. ncbi request reprint [Explantation of aortic stent-grafts]
    C Schlensak
    Abteilung für Herz und Gefässchirurgie, Universitatsklinikum Freiburg, Germany
    Zentralbl Chir 126:975-9; discussion 980-1. 2001
    ..In this study the long-term morbidity of the procedure was evaluated...
  5. ncbi request reprint Cardiopulmonary bypass reduction of bronchial blood flow: a potential mechanism for lung injury in a neonatal pig model
    Christian Schlensak
    Department of Cardiovascular Surgery, Albert Ludwigs University, Freiburg, Germany
    J Thorac Cardiovasc Surg 123:1199-205. 2002
    ..We tested the hypothesis that bronchial blood flow during cardiopulmonary bypass is insufficient to prevent ischemia of the lung and that perfusion of the pulmonary arteries with oxygenated blood during bypass would reduce lung injury...
  6. doi request reprint Reduced pulmonary inflammatory response during cardiopulmonary bypass: effects of combined pulmonary perfusion and carbon monoxide inhalation
    Ulrich Goebel
    Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Freiburg, Germany
    Eur J Cardiothorac Surg 34:1165-72. 2008
    ..We hypothesized that a combination of pulmonary perfusion and carbon monoxide inhalation leads to an even stronger reduction of the lung inflammation...
  7. doi request reprint Prosthesis oversizing in balloon-expandable transcatheter aortic valve implantation is associated with contained rupture of the aortic root
    Philipp Blanke
    Department of Diagnostic Radiology, University Hospital Freiburg, Hugstetter Strasse 55, Freiburg, Germany
    Circ Cardiovasc Interv 5:540-8. 2012
    ..To retrospectively investigate the potential cause of contained rupture of the aortic root in balloon-expandable transcatheter aortic valve implantation (TAVI) by means of pre- and postinterventional multislice computed tomography...
  8. ncbi request reprint Implantation of a catheter-based self-expanding pulmonary valve in congenital heart surgery: results of a pilot study
    Robert von Wattenwyl
    Department of Cardiovascular Surgery, Albert Ludwigs University of Freiburg, Freiburg, Germany
    Eur J Cardiothorac Surg 40:552-6. 2011
    ..Dilatation of RV outflow after surgical patch repair represents a problem for seating a percutaneous valve. We present the data of a new catheter-based, self-expanding tissue valve with a diameter up to 31 mm...
  9. doi request reprint Hepatocyte growth factor-transfected skeletal myoblasts to limit the development of postinfarction heart failure
    Annika Poppe
    Department of Cardiovascular Surgery Department of Radiology, University Medical Center Freiburg, Hugstetterstrasse 55, Freiburg, Germany
    Artif Organs 36:238-46. 2012
    ..Scaffold-based therapy in combination with gene therapy accelerates this capacity. This hemodynamic amelioration is accompanied by neovascularization, but not by smaller infarction sizes...
  10. pmc Thoratec paracorporeal biventricular assist device therapy: the Freiburg experience
    Kerstin Brehm
    Department of Cardiovascular Surgery, University Heart Center Freiburg Bad Krozingen, Freiburg, Germany
    Eur J Cardiothorac Surg 41:207-12; discussion 212. 2012
    ..The treatment of severe biventricular (BV) contractile failure using mechanical circulatory support is challenging. We analyzed our center's results following implantation of a biventricular assist device (BVAD)...
  11. doi request reprint Functional regeneration of ischemic myocardium by transplanted cells overexpressing stromal cell-derived factor-1 (SDF-1): intramyocardial injection versus scaffold-based application
    Britta Blumenthal
    Department of Cardiovascular Surgery, University Medical Center Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Eur J Cardiothorac Surg 40:e135-41. 2011
    ..We hypothesized that transplantation of stem cells overexpressing SDF-1 might improve cardiac function after myocardial infarction (MI). We compared intramyocardial injection with a scaffold-based application of SDF-1-transfected cells...
  12. ncbi request reprint Pulsatile pulmonary perfusion during cardiopulmonary bypass reduces the pulmonary inflammatory response
    Matthias Siepe
    Department of Cardiovascular Surgery, University Medical Center, Freiburg, Germany
    Ann Thorac Surg 86:115-22. 2008
    ..We now hypothesized that avoiding ischemia of the lungs during CPB by active pulmonary perfusion would decrease pulmonary inflammatory response...
  13. doi request reprint Acquired Von Willebrand syndrome is an early-onset problem in ventricular assist device patients
    Claudia Heilmann
    Department of Cardiovascular Surgery, University Heart Center Freiburg Bad Krozingen, Hugstetter Str 55, 79194 Freiburg, Germany
    Eur J Cardiothorac Surg 40:1328-33; discussion 1233. 2011
    ..The onset of AVWS after VAD implantation is not yet determined. We examined VAD patients for presence of an AVWS in the early, intermediate, and late phase after VAD implantation...
  14. doi request reprint Acquired von Willebrand syndrome in patients with extracorporeal life support (ECLS)
    Claudia Heilmann
    Department of Cardiovascular Surgery, University Heart Center Freiburg Bad Krozingen, Hugstetter Str 55, 79106 Freiburg, Germany
    Intensive Care Med 38:62-8. 2012
    ..Since ECLS and VAD share several features, we investigated patients with ECLS for AVWS...
  15. doi request reprint Scaffold-based transplantation of akt1-overexpressing skeletal myoblasts: functional regeneration is associated with angiogenesis and reduced infarction size
    Matthias Siepe
    Department of Cardiovascular Surgery, University Medical Center Freiburg, Freiburg, Germany
    Tissue Eng Part A 17:205-12. 2011
    ..In conclusion, SkM overexpressing Akt1 can maintain myocardial function after infarction, reduce infarction size, and induce neovascularization. Scaffold-based cell transfer does not augment this reverse remodeling capacity...
  16. doi request reprint Controlled reperfusion versus conventional treatment of the acutely ischemic limb: results of a randomized, open-label, multicenter trial
    Claudia Heilmann
    Department of Cardiovascular Surgery, Heart Center Freiburg University, Freiburg, Germany
    Circ Cardiovasc Interv 6:417-27. 2013
    ..Amputation rates and mortality in patients with severe acute limb ischemia remain high. The protective effect of controlled reperfusion (CR) on tissue damage because of local and systemic reperfusion injury is unclear...
  17. doi request reprint Hybrid pulmonary valve implantation: injection of a self-expanding tissue valve through the main pulmonary artery
    Sven Dittrich
    Department of Congenital Heart Disease, Albert Ludwigs University of Freiburg, Freiburg, Germany
    Ann Thorac Surg 85:632-4. 2008
    ..The stented valve was fixed with three single sutures to avoid embolization. The interventional result was well with full competence of the valve. The boy was discharged at day 4 after the procedure...
  18. doi request reprint Haemolysis in patients with ventricular assist devices: major differences between systems
    Claudia Heilmann
    Department of Cardiovascular Surgery, University Medical Center Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    Eur J Cardiothorac Surg 36:580-4. 2009
    ..This complex also undergoes lysosomal degradation in various cells. Only now, the excessive free haemoglobin can be measured in plasma. Here, we investigated haemolysis in patients supported by different VAD types...
  19. doi request reprint Polyurethane scaffolds seeded with genetically engineered skeletal myoblasts: a promising tool to regenerate myocardial function
    Britta Blumenthal
    Department of Cardiovascular Surgery, University Medical Center Freiburg, Freiburg, Germany
    Artif Organs 34:E46-54. 2010
    ..Because this matrix also allows us to circumvent previous cell application drawbacks, it may represent a promising tool for tissue regeneration and the re-establishment of cardiac function after myocardial infarction...
  20. doi request reprint Trans-catheter closure of the native aortic valve with an Amplatzer Occluder to treat progressive aortic regurgitation after implantation of a left-ventricular assist device
    Jochen Grohmann
    Department of Pediatric Cardiology CHD, University Hospital Freiburg, Freiburg, Germany
    Eur J Cardiothorac Surg 39:e181-3. 2011
    ....
  21. ncbi request reprint Biventricular cannulation is superior regarding hemodynamics and organ recovery in patients on biventricular assist device support
    Christian Schlensak
    Department of Cardiovascular Surgery, University Medical Center, Freiburg, Germany
    J Heart Lung Transplant 30:1011-7. 2011
    ..We hypothesized that hemodynamics and organ recovery would improve after biventricular, apical cannulation compared with right atrial cannulation...
  22. ncbi request reprint Twenty-four hours postoperative results after orthotopic cardiac transplantation in swine
    Matthias Siepe
    Division of Cardiovascular Surgery, Albert Ludwigs University Medical Center, Freiburg, Germany
    J Card Surg 22:287-94. 2007
    ..However, there is no functional data available for a longer time period after transplantation. We have established a pig model to investigate myocardial function 24 hours after orthotopic transplantation...
  23. doi request reprint Extra-anatomic bypass for recurrent abdominal aortic and renal in-stent stenoses following radiotherapy for neuroblastoma
    Maximilian Luehr
    Department of Cardiovascular Surgery, University Medical Center Freiburg, Freiburg, Germany
    Interact Cardiovasc Thorac Surg 8:488-90. 2009
    ..Vascular surgery with placement of extra-anatomic bypasses will provide a definite treatment...
  24. pmc Penetration of left and right atrial wall and aortic root by an Amplatzer atrial septal occluder in a nine year old boy with Marfan syndrome: Case report
    Florian Loeffelbein
    Clinic of Pediatric Cardiology, Children s University Hospital, Freiburg, Mathildenstrasse 1, D 79106 Freiburg, Germany
    J Cardiothorac Surg 3:25. 2008
    ..To describe complications associated with Amplatzer septal occluders in a patient with Marfan syndrome..
  25. doi request reprint Preoperative assessment of aortic annulus dimensions: comparison of noninvasive and intraoperative measurement
    Alexey Dashkevich
    Department of Cardiovascular Surgery, University Medical Centre Freiburg, Freiburg, Germany
    Ann Thorac Surg 91:709-14. 2011
    ..The purpose of this study was to compare the measurement of the aortic annulus during surgery in patients undergoing conventional aortic valve replacement with noninvasive methods...
  26. doi request reprint Controlled reperfusion after acute and persistent limb ischemia
    Friedhelm Beyersdorf
    Department of Cardiovascular Surgery, University Medical Center, Albert Ludwigs University Freiburg, Freiburg im Breisgau, Germany
    Semin Vasc Surg 22:52-7. 2009
    ....
  27. doi request reprint Stem cells used for cardiovascular tissue engineering
    Matthias Siepe
    Department of Cardiovascular Surgery, University Clinic Freiburg, Hugstetterstrasse 55, Freiburg, Germany
    Eur J Cardiothorac Surg 34:242-7. 2008
    ..It is important that ongoing basic and clinical research in cardiovascular surgery might explore the potential of different cell types either using tissue engineering constructs or in cell transplantation approaches...
  28. doi request reprint Supportive psychotherapy for patients with heart transplantation or ventricular assist devices
    Claudia Heilmann
    Department of Cardiovascular Surgery, University Heart Center Freiburg Bad Krozingen, Hugstetter Str 55, 79196 Freiburg, Germany
    Eur J Cardiothorac Surg 39:e44-50. 2011
    ..In addition, we evaluated the use for supportive psychotherapy for the families of our patients and present two typical cases...
  29. doi request reprint Reducing the ischemic time of donor hearts will decrease morbidity and costs of cardiac transplantations
    Bartosz Rylski
    Department of Cardiovascular Surgery, University of Freiburg, Freiburg, Germany
    Interact Cardiovasc Thorac Surg 10:945-7. 2010
    ..For longer distance harvesting, the reduction of TIT by the fastest possible transport (learjet, helicopter) would have economic advantages with regards to the high cost of treatment in ICU...
  30. doi request reprint Emergency repair of a broken Jarvik 2000 power connector using a paper-clip
    Christoph Benk
    Department of Cardiovascular Surgery, University Clinic Freiburg, Freiburg, Germany
    ASAIO J 55:1-2. 2009
    ..We report the case of a successful emergency repair of a power connector of a Jarvik 2000 left ventricular assist device by using a paper-clip in a patient who was supported with the device for >7 years at our institution...
  31. ncbi request reprint Successful interventional closure of a patent foramen ovale in a pediatric patient supported with a biventricular assist device
    Florian Loeffelbein
    Department of Pediatric Cardiology, Children s University Hospital, Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    Interact Cardiovasc Thorac Surg 6:778-9. 2007
    ..The diagnosis of a PFO may be missed under ECMO-treatment. Interventional closure of a PFO can successfully be performed even if the patient is supported with a BVAD...
  32. ncbi request reprint Controlled reperfusion using a simplified perfusion system preserves function after acute and persistent limb ischemia: a preliminary study
    Markus Peter Wilhelm
    Department of Cardiovascular Surgery Albert Ludwigs University, Freiburg, Germany
    J Vasc Surg 42:690-4. 2005
    ..We hypothesized that controlled reperfusion using a simple blood bag perfusion system reduces reperfusion injury and facilitates the return of normal function...
  33. doi request reprint Increased systemic perfusion pressure during cardiopulmonary bypass is associated with less early postoperative cognitive dysfunction and delirium
    Matthias Siepe
    Department of Cardiovascular Surgery, University Medical Center Freiburg, Freiburg, Germany
    Eur J Cardiothorac Surg 40:200-7. 2011
    ..We hypothesized that low systemic perfusion pressure during cardiopulmonary bypass (CPB) would correlate with early postoperative cognitive dysfunction in on-pump patients...
  34. pmc Heart valve surgery today: indications, operative technique, and selected aspects of postoperative care in acquired valvular heart disease
    Hans Joachim Geissler
    Abteilung für Herz und Gefässchirurgie, Chirurgische Klinik, Universitatsklinikum Freiburg, Germany
    Dtsch Arztebl Int 106:224-33; quiz 234. 2009
    ..The optimal diagnostic evaluation, surgical treatment, and postoperative care of these patients are only possible through a cooperative effort of the primary care physician, the cardiologist, and the cardiac surgeon...
  35. ncbi request reprint Aortic atresia with aortico-left ventricular tunnel mimicking severe aortic incompetence in utero
    Matthias Siepe
    Department of Cardiovascular Surgery, University Hospital Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    Eur J Cardiothorac Surg 29:845-7. 2006
    ..The combination of congenital aortico-left ventricular tunnel and aortic atresia can be misinterpreted in prenatal echocardiography as aortic regurgitation. This pathology may require urgent operative interventions...
  36. doi request reprint Human neonatal thymus-derived mesenchymal stromal cells: characterization, differentiation, and immunomodulatory properties
    Matthias Siepe
    Department of Cardiovascular Surgery, University Medical Center Freiburg, Freiburg, Germany
    Tissue Eng Part A 15:1787-96. 2009
    ..Our results confirm that the neonatal thymus contains mesenchymal stromal cells (nTMSC) with full mesenchymal differentiation potential and immunomodulatory properties...
  37. doi request reprint Sternum augmentation with bovine bone substitute in the neonate
    Robert von Wattenwyl
    Department of Congenital Heart Disease, Albert Ludwigs University Hospital Freiburg, Freiburg, Germany
    Ann Thorac Surg 91:311-3. 2011
    ..We succeeded in closing the chests in these 2 neonates using this augmentation technique. To the best of our knowledge, these are the first 2 reports of this type of sternum augmentation technique in neonates...
  38. ncbi request reprint Cytoprotection by inhaled carbon monoxide before cardiopulmonary bypass in preclinical models
    Torsten Loop
    Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Germany
    Curr Pharm Biotechnol 13:797-802. 2012
    ..Mechanisms like the heat shock response as well as an expanded view regarding toxicity and side effects are described broadly...
  39. doi request reprint Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease
    Ulrich Geisen
    Department of Clinical Chemistry, University Medical Center Freiburg, Freiburg, Germany
    Eur J Cardiothorac Surg 33:679-84. 2008
    ..We, therefore, analysed patients with two VAD types for laboratory parameters of VWD and compared them with patients after heart transplantation (HTX)...
  40. doi request reprint Aorto-caval fistula from acute rupture of an abdominal aortic aneurysm treated with a hybrid approach
    Matthias Siepe
    Department of Cardiovascular Surgery, University Medical Center, Freiburg, Germany
    J Vasc Surg 49:1574-6. 2009
    ..The ease of this hybrid approach justifies suggesting it as a possible treatment option for this severe disease...
  41. ncbi request reprint Images in cardiovascular medicine. Traumatic aortic valve rupture
    Michael P Siegenthaler
    Department of Cardiovascular Surgery, University of Freiburg, Freiburg, Germany
    Circulation 112:e118-9. 2005
  42. ncbi request reprint Cardioplegia in pediatric cardiac surgery: do we believe in magic?
    Torsten Doenst
    Department of Cardiovascular Surgery, Albert Ludwigs University of Freiburg, Freiburg i Br, Germany
    Ann Thorac Surg 75:1668-77. 2003
    ..We provide evidence that the benefit of cardioplegia over hypothermia alone is minor at low temperatures (below 15 degrees C), but becomes substantial when the temperature increases...
  43. doi request reprint Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs
    Ulrich Goebel
    Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Germany
    Anesthesiology 108:1025-36. 2008
    ..The authors hypothesized that inhaled carbon monoxide before initiation of CPB would reduce inflammatory response in the lungs...
  44. ncbi request reprint Cardiopulmonary bypass: Evidence or experience based?
    Claus Bartels
    Clinic for Cardiac Surgery, Medical University of Luebeck, Germany
    J Thorac Cardiovasc Surg 124:20-7. 2002
    ..The purpose of this study was to evaluate the amount and quality of scientific evidence supporting principles that are currently applied for cardiopulmonary bypass performance...
  45. doi request reprint Images in cardiovascular medicine. In vivo 3-dimensional flow connectivity mapping after extracardiac total cavopulmonary connection
    Alex Frydrychowicz
    University Hospital Freiburg, Department of Diagnostic Radiology and Medical Physics, Hugstetter Str 55, 79106 Freiburg, Germany
    Circulation 118:e16-7. 2008