Christian Schlensak

..In this article, we review recent advances in surgically controlled reperfusion and speculate on future prospects for myocardial protective techniques in patients with acute coronary artery occlusion...

..The results support the notion that controlled limb reperfusion should be applied in any patient with acute ischemia of an extremity...

..This study was undertaken to assess the bronchial artery blood flow during CPB with fluorescent microspheres in a piglet model...

..In this study the long-term morbidity of the procedure was evaluated...

..We tested the hypothesis that bronchial blood flow during cardiopulmonary bypass is insufficient to prevent ischemia of the lung and that perfusion of the pulmonary arteries with oxygenated blood during bypass would reduce lung injury...

..We hypothesized that a combination of pulmonary perfusion and carbon monoxide inhalation leads to an even stronger reduction of the lung inflammation...

..To retrospectively investigate the potential cause of contained rupture of the aortic root in balloon-expandable transcatheter aortic valve implantation (TAVI) by means of pre- and postinterventional multislice computed tomography...

..Dilatation of RV outflow after surgical patch repair represents a problem for seating a percutaneous valve. We present the data of a new catheter-based, self-expanding tissue valve with a diameter up to 31 mm...

..Scaffold-based therapy in combination with gene therapy accelerates this capacity. This hemodynamic amelioration is accompanied by neovascularization, but not by smaller infarction sizes...

..The treatment of severe biventricular (BV) contractile failure using mechanical circulatory support is challenging. We analyzed our center's results following implantation of a biventricular assist device (BVAD)...

..We hypothesized that transplantation of stem cells overexpressing SDF-1 might improve cardiac function after myocardial infarction (MI). We compared intramyocardial injection with a scaffold-based application of SDF-1-transfected cells...

..We now hypothesized that avoiding ischemia of the lungs during CPB by active pulmonary perfusion would decrease pulmonary inflammatory response...

..The onset of AVWS after VAD implantation is not yet determined. We examined VAD patients for presence of an AVWS in the early, intermediate, and late phase after VAD implantation...

..Since ECLS and VAD share several features, we investigated patients with ECLS for AVWS...

..In conclusion, SkM overexpressing Akt1 can maintain myocardial function after infarction, reduce infarction size, and induce neovascularization. Scaffold-based cell transfer does not augment this reverse remodeling capacity...

..The stented valve was fixed with three single sutures to avoid embolization. The interventional result was well with full competence of the valve. The boy was discharged at day 4 after the procedure...

..Because this matrix also allows us to circumvent previous cell application drawbacks, it may represent a promising tool for tissue regeneration and the re-establishment of cardiac function after myocardial infarction...

..This complex also undergoes lysosomal degradation in various cells. Only now, the excessive free haemoglobin can be measured in plasma. Here, we investigated haemolysis in patients supported by different VAD types...

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..We hypothesized that hemodynamics and organ recovery would improve after biventricular, apical cannulation compared with right atrial cannulation...

..However, there is no functional data available for a longer time period after transplantation. We have established a pig model to investigate myocardial function 24 hours after orthotopic transplantation...

..To describe complications associated with Amplatzer septal occluders in a patient with Marfan syndrome..

..Vascular surgery with placement of extra-anatomic bypasses will provide a definite treatment...

..The purpose of this study was to compare the measurement of the aortic annulus during surgery in patients undergoing conventional aortic valve replacement with noninvasive methods...

..It is important that ongoing basic and clinical research in cardiovascular surgery might explore the potential of different cell types either using tissue engineering constructs or in cell transplantation approaches...

..For longer distance harvesting, the reduction of TIT by the fastest possible transport (learjet, helicopter) would have economic advantages with regards to the high cost of treatment in ICU...

..We report the case of a successful emergency repair of a power connector of a Jarvik 2000 left ventricular assist device by using a paper-clip in a patient who was supported with the device for >7 years at our institution...

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..In addition, we evaluated the use for supportive psychotherapy for the families of our patients and present two typical cases...

..The diagnosis of a PFO may be missed under ECMO-treatment. Interventional closure of a PFO can successfully be performed even if the patient is supported with a BVAD...

..We hypothesized that low systemic perfusion pressure during cardiopulmonary bypass (CPB) would correlate with early postoperative cognitive dysfunction in on-pump patients...

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..The combination of congenital aortico-left ventricular tunnel and aortic atresia can be misinterpreted in prenatal echocardiography as aortic regurgitation. This pathology may require urgent operative interventions...

..Our results confirm that the neonatal thymus contains mesenchymal stromal cells (nTMSC) with full mesenchymal differentiation potential and immunomodulatory properties...

..We succeeded in closing the chests in these 2 neonates using this augmentation technique. To the best of our knowledge, these are the first 2 reports of this type of sternum augmentation technique in neonates...

..The optimal diagnostic evaluation, surgical treatment, and postoperative care of these patients are only possible through a cooperative effort of the primary care physician, the cardiologist, and the cardiac surgeon...

..Mechanisms like the heat shock response as well as an expanded view regarding toxicity and side effects are described broadly...

..We, therefore, analysed patients with two VAD types for laboratory parameters of VWD and compared them with patients after heart transplantation (HTX)...

..The ease of this hybrid approach justifies suggesting it as a possible treatment option for this severe disease...

..We provide evidence that the benefit of cardioplegia over hypothermia alone is minor at low temperatures (below 15 degrees C), but becomes substantial when the temperature increases...

..The authors hypothesized that inhaled carbon monoxide before initiation of CPB would reduce inflammatory response in the lungs...

..The purpose of this study was to evaluate the amount and quality of scientific evidence supporting principles that are currently applied for cardiopulmonary bypass performance...