R Schimpf

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi [Magnetic navigation in invasive electrophysiological diagnostic and therapy]
    R Schimpf
    I Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Herzschrittmacherther Elektrophysiol 18:157-65. 2007
  2. ncbi In vivo effects of mutant HERG K+ channel inhibition by disopyramide in patients with a short QT-1 syndrome: a pilot study
    Rainer Schimpf
    First Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 18:1157-60. 2007
  3. ncbi Electromechanical coupling in patients with the short QT syndrome: further insights into the mechanoelectrical hypothesis of the U wave
    Rainer Schimpf
    1st Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    Heart Rhythm 5:241-5. 2008
  4. ncbi Clinical and molecular genetics of the short QT syndrome
    Rainer Schimpf
    Ist Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    Curr Opin Cardiol 23:192-8. 2008
  5. ncbi Short QT syndrome
    Rainer Schimpf
    1st Department of Medicine Cardiology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Cardiovasc Res 67:357-66. 2005
  6. ncbi Prevalence of supraventricular tachyarrhythmias in a cohort of 115 patients with Brugada syndrome
    Rainer Schimpf
    First Department of Medicine, Division of Cardiology, University Hospital Mannheim, Germany
    Ann Noninvasive Electrocardiol 13:266-9. 2008
  7. ncbi Congenital short QT syndrome and implantable cardioverter defibrillator treatment: inherent risk for inappropriate shock delivery
    Rainer Schimpf
    Ist Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 14:1273-7. 2003
  8. ncbi [Primary electrical heart disease in adulthood--electrophysiological findings and therapy]
    R Schimpf
    I Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim
    Herzschrittmacherther Elektrophysiol 16:250-9. 2005
  9. ncbi Potential device interaction of a dual chamber implantable cardioverter defibrillator in a patient with continuous spinal cord stimulation
    R Schimpf
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Europace 5:397-402. 2003
  10. ncbi [Syncope of uncertain cause and sudden cardiac death in young patients]
    R Schimpf
    I. Medizinische Klinik,
    Dtsch Med Wochenschr 131:1040-6. 2006

Detail Information

Publications49

  1. ncbi [Magnetic navigation in invasive electrophysiological diagnostic and therapy]
    R Schimpf
    I Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Herzschrittmacherther Elektrophysiol 18:157-65. 2007
    ..Future applications will be complex left atrial procedures, magnetically guided cardiac stem cell therapy, local drug application, and extracardiac vessel therapy...
  2. ncbi In vivo effects of mutant HERG K+ channel inhibition by disopyramide in patients with a short QT-1 syndrome: a pilot study
    Rainer Schimpf
    First Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 18:1157-60. 2007
    ..The aim of the present study was to test the in vivo effects of disopyramide in patients with short QT-1 syndrome caused by a N588K mutation in HERG...
  3. ncbi Electromechanical coupling in patients with the short QT syndrome: further insights into the mechanoelectrical hypothesis of the U wave
    Rainer Schimpf
    1st Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    Heart Rhythm 5:241-5. 2008
    ..It is not known whether abbreviation of cardiac repolarization alters mechanical function in SQTS. Controversies persist regarding whether the U wave is a purely electrical or mechanoelectrical phenomenon...
  4. ncbi Clinical and molecular genetics of the short QT syndrome
    Rainer Schimpf
    Ist Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    Curr Opin Cardiol 23:192-8. 2008
    ..Genetically determined arrhythmias are a potential cause for a primary electrical disease. A recently discovered primary electrical disease is discussed...
  5. ncbi Short QT syndrome
    Rainer Schimpf
    1st Department of Medicine Cardiology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Cardiovasc Res 67:357-66. 2005
    ..It may serve as an adjunct to ICD therapy or as a possible alternative treatment, especially for children and newborns...
  6. ncbi Prevalence of supraventricular tachyarrhythmias in a cohort of 115 patients with Brugada syndrome
    Rainer Schimpf
    First Department of Medicine, Division of Cardiology, University Hospital Mannheim, Germany
    Ann Noninvasive Electrocardiol 13:266-9. 2008
    ..Initial reports in small numbers of patients suggest an association between supraventricular tachycardias and Brugada syndrome with a prevalence varying between 13% and 40%...
  7. ncbi Congenital short QT syndrome and implantable cardioverter defibrillator treatment: inherent risk for inappropriate shock delivery
    Rainer Schimpf
    Ist Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 14:1273-7. 2003
    ..We report on the initial use of implantable cardioverter defibrillator (ICD) therapy in patients with inherited short QT interval and discuss sensing abnormalities and detection issues...
  8. ncbi [Primary electrical heart disease in adulthood--electrophysiological findings and therapy]
    R Schimpf
    I Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim
    Herzschrittmacherther Elektrophysiol 16:250-9. 2005
    ....
  9. ncbi Potential device interaction of a dual chamber implantable cardioverter defibrillator in a patient with continuous spinal cord stimulation
    R Schimpf
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Europace 5:397-402. 2003
    ..We report on a patient with existing spinal cord stimulation who survived sudden cardiac death and received a dual chamber cardioverter defibrillator capable of delivering tiered therapies in both the atrium and ventricle...
  10. ncbi [Syncope of uncertain cause and sudden cardiac death in young patients]
    R Schimpf
    I. Medizinische Klinik,
    Dtsch Med Wochenschr 131:1040-6. 2006
  11. ncbi Short QT syndrome: successful prevention of sudden cardiac death in an adolescent by implantable cardioverter-defibrillator treatment for primary prophylaxis
    Rainer Schimpf
    Department of Medicine-Cardiology, University Hospital Mannheim, 1st Department of Medicine-Cardiology, Mannheim, Germany
    Heart Rhythm 2:416-7. 2005
  12. ncbi Clinical experience with implantable atrial and combined atrioventricular defibrillators
    W Jung
    Departments of Medicine Cardiology, University of Bonn, Germany
    J Interv Card Electrophysiol 4:185-95. 2000
    ..The combined atrioventricular defibrillator may be particularly indicated in patients presenting with both a history of atrial and ventricular tachyarrhythmias...
  13. ncbi Prevalence of left atrial chamber and appendage thrombi in patients with atrial flutter and its clinical significance
    H Schmidt
    Department of Medicine-Cardiology, University of Bonn, Bonn, Germany
    J Am Coll Cardiol 38:778-84. 2001
    ..In addition, the presence of clinical risk factors should alert the physician to an increased likelihood for a thrombogenic milieu...
  14. ncbi Incidence of left atrial thrombi in patients in sinus rhythm and with a recent neurologic deficit
    H Omran
    Department of Medicine Cardiology, University of Bonn, Germany
    Am Heart J 140:658-62. 2000
    ..We sought to determine the incidence of left atrial (LA) thrombi in patients in sinus rhythm (SR) and with a recent neurologic deficit and to analyze the relation between LA thrombi and LA chamber and appendage function in patients in SR...
  15. ncbi Incidence and electrophysiological characteristics of spontaneous ventricular tachyarrhythmias in high risk coronary patients and prophylactic implantation of a defibrillator
    C Wolpert
    1st Department of Medicine Cardiology, University Hospital of Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, Mannheim, Germany
    Heart 90:667-71. 2004
    ..To assess the incidence and electrophysiological characteristics of spontaneous ventricular tachyarrhythmias after implantable cardioverter-defibrillator (ICD) implantation for primary prevention...
  16. ncbi Arrhythmogenic hereditary syndromes: Brugada Syndrome, long QT syndrome, short QT syndrome and CPVT
    R Schimpf
    First Department of Medicine Cardiology, University Hospital Mannheim, Mannheim, Germany
    Minerva Cardioangiol 58:623-36. 2010
    ..More insights into the arrhythmogenesis is critical for future development of effective medical treatment strategies...
  17. ncbi Evaluation and management of syncope
    C Veltmann
    Unit of Cardiology, First Department of Medicine, University Medical Centre Mannheim, Mannheim, Germany
    Minerva Cardioangiol 58:701-15. 2010
    ..This review gives a comprehensive summary of definition, work-up and treatment of syncope based on the current guidelines for the evaluation of syncope...
  18. ncbi Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome
    Christian Wolpert
    1st Department of Medicine Cardiology, University Hospital of Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, Germany
    Heart Rhythm 2:254-60. 2005
    ..The purpose of this study was to compare the effect of intravenous flecainide and ajmaline with respect to their ability to induce or accentuate the typical ECG pattern of Brugada syndrome...
  19. ncbi Magnetic resonance imaging findings in patients with Brugada syndrome
    Theano Papavassiliu
    1st Department of Medicine, University Hospital of Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, Mannheim, Germany
    J Cardiovasc Electrophysiol 15:1133-8. 2004
    ..In the present study, we prospectively evaluated CMR findings in patients with Brugada syndrome compared to matched controls...
  20. ncbi A prospective study on spontaneous fluctuations between diagnostic and non-diagnostic ECGs in Brugada syndrome: implications for correct phenotyping and risk stratification
    Christian Veltmann
    First Department of Medicine, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur Heart J 27:2544-52. 2006
    ..The purpose of this study was to prospectively evaluate the spontaneous ECG changes between diagnostic and non-diagnostic ECG patterns in patients diagnosed with Brugada syndrome...
  21. ncbi Fatal inappropriate ICD shock
    Christian Veltmann
    Department of Medicine, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 18:326-8. 2007
    ....
  22. ncbi [Short QT syndrome]
    Christian Wolpert
    Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68259, Mannheim, Germany
    Herz 32:206-10. 2007
    ..g., sotalol or ibutilide in patients with a mutation in the IKr-coding gene KCNH2 (HERG). Quinidine proved to be efficient in prolonging the QT interval and normalizing the effective refractory periods in some patients...
  23. ncbi Incidence and rate characteristics of atrial tachyarrhythmias in patients with a dual chamber defibrillator
    Christian Wolpert
    Department of Cardiology, University of Bonn, Bonn, Germany
    Pacing Clin Electrophysiol 26:1691-8. 2003
    ..Continuous atrial arrhythmia detection with a dual chamber ICD reveals a high incidence of atrial tachyarrhythmias with a predominantly short duration of paroxysmal recurrences <1 hour in the vast majority of episodes...
  24. ncbi Clinical characteristics and treatment of short QT syndrome
    Christian Wolpert
    1st Department of Medicine Cardiology, University Hospital Mannheim, Faculty of Clinical Medicine of the Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Expert Rev Cardiovasc Ther 3:611-7. 2005
    ....
  25. ncbi Short QT syndrome. Genotype-phenotype correlations
    Martin Borggrefe
    1st Department of Medicine Cardiology, University Hospital Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, 68167 Mannheim, Germany
    J Electrocardiol 38:75-80. 2005
    ..It may serve as an adjunct to ICD therapy or as possible alternative treatment especially for children and newborns...
  26. ncbi Insights into the location of type I ECG in patients with Brugada syndrome: correlation of ECG and cardiovascular magnetic resonance imaging
    C Veltmann
    1st Department of Medicine Cardiology, University Medical Centre Mannheim, Mannheim, Germany
    Heart Rhythm 9:414-21. 2012
    ..Electrocardiogram (ECG) leads placed in the 3rd and 2nd intercostal spaces (ICSs) increased the sensitivity for the detection of a type I ECG pattern. The anatomic explanation for this finding is pending...
  27. ncbi Algorithms for better arrhythmia discrimination in implantable cardioverter defibrillators
    R Schimpf
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Curr Cardiol Rep 3:467-72. 2001
    ..Stable electrode position, and a continuous and correct atrial signal quality, are prerequisites for atrial therapies and algorithms for arrhythmia discrimination...
  28. ncbi Channelopathies: Brugada syndrome, long QT syndrome, short QT syndrome, and CPVT
    Rainer Schimpf
    Ist Department of Medicine Cardiology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Herz 34:281-8. 2009
    ..Competitive sports and vigorous exercise are contraindications in almost all patients. Even recreational exercise may have to be avoided in phenotypically overt patients or silent gene carriers depending on the underlying disease...
  29. ncbi Response to intravenous ajmaline: a retrospective analysis of 677 ajmaline challenges
    Christian Veltmann
    11st Department of Medicine Cardiology, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Europace 11:1345-52. 2009
    ..Challenge with intravenous ajmaline is used to unmask the diagnostic Brugada ECG. The aim of this study was to evaluate the safety of the test and to identify predictors for the response to an intravenous ajmaline challenge...
  30. ncbi Decremental intravenous pulse propagation during extrastimulus pacing: relevance for catheter ablation of focal atrial fibrillation
    T Lewalter
    Department of Medicine Cardiology, University of Bonn, Germany
    Europace 4:411-5. 2002
    ..Thus, this pacing manoeuvre may serve to guide RF delivery in the treatment of focal AF...
  31. ncbi Prevention of inappropriate ICD shocks in patients with Brugada syndrome
    Christian Veltmann
    1st Department of Medicine Cardiology, University Medical Centre Mannheim, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Clin Res Cardiol 99:37-44. 2010
    ..7-14.1%/year). Aim of the present study was to evaluate a single ventricular fibrillation (VF) detection zone with a high cut-off rate with respect to prevention of inappropriate ICD shock due to SVT and safety of this programming...
  32. ncbi Induction of atrial fibrillation in mice by rapid transesophageal atrial pacing
    Jan Wilko Schrickel
    Department of Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Basic Res Cardiol 97:452-60. 2002
    ..We therefore evaluated a transesophageal rapid atrial stimulation protocol for the induction of AF in C57Bl/6 mice...
  33. ncbi Advanced pacemaker diagnostic features in the characterization of atrial fibrillation: impact on preventive pacing algorithms
    Alexander Yang
    Dept of Cardiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Pacing Clin Electrophysiol 26:310-3. 2003
    ..In conclusion, frequent, short-lived AF episodes seem best suited for AF preventive pacing therapies. However, the small number of PACs preceding many AF episodes may limit the efficacy of PAC suppressing algorithms...
  34. ncbi Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG
    Christian Wolpert
    1st Department of Medicine-Cardiology, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 16:54-8. 2005
    ....
  35. ncbi Incidence of venous obstruction following insertion of an implantable cardioverter defibrillator. A study of systematic contrast venography on patients presenting for their first elective ICD generator replacement
    Lars Lickfett
    Department of Medicine Cardiology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Europace 6:25-31. 2004
    ..The aim of our study was therefore to evaluate the incidence of venous obstruction after chronic transvenous ICD system implantation...
  36. ncbi Risk stratification in electrical cardiomyopathies
    Christian Veltmann
    1st Department of Medicine Cardiology, University Medicine Mannheim, Mannheim, Germany
    Herz 34:518-27. 2009
    ..The genotype contributes to risk stratification only in LQTS and CPVT.Patients with electrical cardiomyopathies have to be risk-stratified individually based on the data and the current guidelines available...
  37. ncbi Circumferential pulmonary vein mapping and ablation in focal atrial fibrillation: single catheter technique
    Thorsten Lewalter
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    J Interv Card Electrophysiol 7:165-70. 2002
    ..Atrial fibrillation (AF) can be cured in a subgroup of patients performing catheter ablation and eliminate trigger arrhythmias mainly originating in the pulmonary veins (PV's)...
  38. ncbi Long-term follow-up of fast pathway radiofrequency ablation in atrioventricular nodal reentrant tachycardia
    Lars Lickfett
    Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Am J Cardiol 89:1124-5. 2002
  39. ncbi Long-term prognosis of individuals with right precordial ST-segment-elevation Brugada syndrome
    Lars Eckardt
    Westfälische Wilhelms University Hospital, Department of Cardiology and Angiology, Munster, Germany
    Circulation 111:257-63. 2005
    ..Controversy exists with regard to risk stratification and therapeutic management, particularly in asymptomatic individuals...
  40. ncbi A new method to investigate the response to the morphology discrimination algorithm in patients with ICD
    Anil Martin Sinha
    Department of Cardiology, Klinikum Coburg, Germany
    Int J Cardiol 114:323-31. 2007
    ..We analyzed whether rapid atrial pacing and/or exercise testing can be used for identification of responders and compared the results with ICD detected tachycardia...
  41. ncbi Short QT syndrome: clinical findings and diagnostic-therapeutic implications
    Carla Giustetto
    Department of Cardiology, Cardinal Massaia Hospital, Asti, Italy
    Eur Heart J 27:2440-7. 2006
    ..Clinical presentation, occurrence of sudden infant death, and results of the available therapies in the largest group of patients with short QT syndrome (SQTS), studied so far, are reported...
  42. ncbi Electrophysiological characteristics of septal hypertrophy in patients with hypertrophic obstructive cardiomyopathy and moderate to severe symptoms
    Burghard Schumacher
    Department of Cardiology, Center of Cardiovascular Medicine, D 97688 Bad Neustadt Saale, Germany
    Circulation 112:2096-101. 2005
    ..The electrophysiological consequences of this substrate have not yet been investigated. Thus, the aim of this study was to assess the local electrophysiological characteristics of regional left ventricular (LV) septal hypertrophy...
  43. ncbi Short QT syndrome: pharmacological treatment
    Fiorenzo Gaita
    Division of Cardiology, Ospedale Civile di Asti, Asti, Italy
    J Am Coll Cardiol 43:1494-9. 2004
    ..The purpose of this study was to evaluate the efficacy of various antiarrhythmic drugs at prolonging the QT interval into the normal range and preventing ventricular arrhythmias in patients with short QT syndrome...
  44. ncbi Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study
    Martin Hinterseer
    Department of Medicine I, Klinikum Grosshadern, Ludwig Maximilians University Munich, Marchioninistrasse 15, D 81366 Munich, Germany
    Eur Heart J 29:185-90. 2008
    ..Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes...
  45. ncbi Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 115:442-9. 2007
    ..We describe a new clinical entity that consists of an ST-segment elevation in the right precordial ECG leads, a shorter-than-normal QT interval, and a history of sudden cardiac death...
  46. ncbi Short QT Syndrome: a familial cause of sudden death
    Fiorenzo Gaita
    Division of Cardiology, Ospedale Mauriziano Umberto I, Torino, Italy
    Circulation 108:965-70. 2003
    ..Autopsy did not reveal any structural heart disease. All patients had a constantly and uniformly short QT interval at ECG...
  47. ncbi Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome
    Peter Milberg
    Department of Cardiology and Angiology, Hospital of the Westfälische Wilhelms University, Munster, Germany
    J Cardiovasc Electrophysiol 18:658-64. 2007
    ..As therapeutic options in SQTS are still controversial, we examined antiarrhythmic mechanisms in an experimental model of SQTS...
  48. ncbi Sudden death associated with short-QT syndrome linked to mutations in HERG
    Ramon Brugada
    Molecular Genetics Program, Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 109:30-5. 2004
    ..The present study describes the genetic basis for a new clinical entity characterized by sudden death and short-QT intervals in the ECG...
  49. ncbi An unusual case of pacemaker failure: complete disconnection of connector block and battery of a subpectorally implanted dual chamber pacemaker
    Fritz Mellert
    Department of Cardiac Surgery, Heart Center at the University of Bonn, Germany
    Pacing Clin Electrophysiol 25:509-10. 2002
    ....