Georg Schett

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arch Intern Med 166:2495-501. 2006
  2. ncbi Erosive arthritis
    Georg Schett
    Department of Internal Medicine 3, University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Res Ther 9:S2. 2007
  3. ncbi Cells of the synovium in rheumatoid arthritis. Osteoclasts
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 9:203. 2007
  4. ncbi How does joint remodeling work?: new insights in the molecular regulation of the architecture of joints
    Georg Schett
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen D 91054, Germany
    Cell Adh Migr 1:102-3. 2007
  5. ncbi Joint remodelling in inflammatory disease
    Georg Schett
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Ann Rheum Dis 66:iii42-4. 2007
  6. ncbi Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine III, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:219-24. 2009
  7. ncbi The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis
    Gerhard Kronke
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1081-7. 2012
  8. ncbi Proteasome inhibition aggravates tumor necrosis factor-mediated bone resorption in a mouse model of inflammatory arthritis
    Karin Polzer
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:670-80. 2011
  9. ncbi Regulatory T cells protect from local and systemic bone destruction in arthritis
    Mario M Zaiss
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 184:7238-46. 2010
  10. ncbi Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis
    Jerome Avouac
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:800-9. 2011

Detail Information

Publications148 found, 100 shown here

  1. ncbi High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arch Intern Med 166:2495-501. 2006
    ..It is unknown, however, whether low-grade inflammation in healthy individuals, as estimated by the high-sensitivity C-reactive protein (hs-CRP) level, interferes with bone metabolism and affects the risk of nontraumatic fractures...
  2. ncbi Erosive arthritis
    Georg Schett
    Department of Internal Medicine 3, University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Res Ther 9:S2. 2007
    ..Blockade of osteoclast formation is thus a key strategy in preventing structural damage in arthritis. Denosumab, a humanized antibody that neutralizes RANKL, is an attractive candidate agent to inhibit inflammatory bone loss...
  3. ncbi Cells of the synovium in rheumatoid arthritis. Osteoclasts
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 9:203. 2007
    ..Osteoclasts thus represent a link between joint inflammation and structural damage since they resorb mineralized tissue adjacent to the joint and destroy the joint architecture...
  4. ncbi How does joint remodeling work?: new insights in the molecular regulation of the architecture of joints
    Georg Schett
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen D 91054, Germany
    Cell Adh Migr 1:102-3. 2007
    ..This mechanism is largely dependent on an activation of wingless protein signaling and can lead to complete joint fusion. This addendum summarized the current concepts of joint remodeling in the limelight of these new findings...
  5. ncbi Joint remodelling in inflammatory disease
    Georg Schett
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Ann Rheum Dis 66:iii42-4. 2007
    ..Whereas a short and self-limited activation of the immune system has no clinically meaningful effect on bone, prolonged immune activation as found in chronic inflammatory disease inevitably leads to bone wasting...
  6. ncbi Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine III, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:219-24. 2009
    ....
  7. ncbi The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis
    Gerhard Kronke
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1081-7. 2012
    ..Understanding endogenous mechanisms, which counteract fibrosis, may yield new therapeutic approaches. Lipoxins are highly potent lipid mediators, which have recently been found to be decreased in SSc...
  8. ncbi Proteasome inhibition aggravates tumor necrosis factor-mediated bone resorption in a mouse model of inflammatory arthritis
    Karin Polzer
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:670-80. 2011
    ..Recently, bortezomib was shown to directly inhibit osteoclastogenesis. The aim of this study was to analyze the influence and therapeutic effect of bortezomib in a mouse model of inflammatory arthritis...
  9. ncbi Regulatory T cells protect from local and systemic bone destruction in arthritis
    Mario M Zaiss
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 184:7238-46. 2010
    ..Thus, enhancing the activity of Treg cells would be beneficial for the treatment of inflammation-induced bone loss observed in rheumatoid arthritis...
  10. ncbi Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis
    Jerome Avouac
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:800-9. 2011
    ..The aim of this study was to investigate the contribution of STAT-4 in the development of a fibrotic phenotype in 2 different mouse models of experimental dermal fibrosis...
  11. ncbi Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis
    Clara Dees
    Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 70:1304-10. 2011
    ..Dermal fibroblasts from patients with systemic sclerosis (SSc) release excessive amounts of collagen resulting in tissue fibrosis. The molecular mechanisms underlying this pathological activation are incompletely understood...
  12. ncbi Lack of inhibitory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo
    Paulius Venalis
    Department for Internal Medicine 3 and Institute for Clinical Immunology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    J Cell Mol Med 13:4185-91. 2009
    ..Imatinib does not inhibit activation, viability, proliferation, migration or tube forming of endothelial cells in vitro and in vivo. Thus, treatment with imatinib might not augment further endothelial cell damage in SSc...
  13. ncbi Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis
    Angelika Horn
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 64:2724-33. 2012
    ..The aim of the present study was to investigate the role of the hedgehog pathway in fibroblast activation in systemic sclerosis (SSc)...
  14. ncbi The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis
    Nicole Reich
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:280-90. 2010
    ..The aim of the present study was to investigate whether Fra-2 plays a role in the pathogenesis of SSc and to identify the molecular mechanisms by which Fra-2 induces fibrosis...
  15. ncbi R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway
    Gerhard Kronke
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:2303-12. 2010
    ..This study was undertaken to investigate the role of the Wnt pathway modulator R-Spondin 1 (RSpo1) in protecting bone and cartilage in a mouse model of arthritis...
  16. ncbi Vitamin D receptor regulates TNF-mediated arthritis
    Karin Zwerina
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 70:1122-9. 2011
    ..The pathophysiological role of vitamin D in joint inflammation is, however, unclear...
  17. ncbi Combined inhibition of c-Abl and PDGF receptors for prevention and treatment of murine sclerodermatous chronic graft-versus-host disease
    Pawel Zerr
    Department of Internal Medicine III, University of Erlangen Nuremberg, Germany
    Am J Pathol 181:1672-80. 2012
    ....
  18. ncbi JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis
    Clara Dees
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 64:3006-15. 2012
    ..To investigate whether JAK-2 contributes to the pathologic activation of fibroblasts in patients with systemic sclerosis (SSc) and to evaluate the antifibrotic potential of JAK-2 inhibition for the treatment of SSc...
  19. ncbi Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Nat Commun 3:735. 2012
    ..These findings demonstrate that canonical Wnt signalling is necessary for TGF-β-mediated fibrosis and highlight a key role for the interaction of both pathways in the pathogenesis of fibrotic diseases...
  20. ncbi Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
    Nicole Reich
    Department for Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:737-45. 2012
    ..This study analysed the antifibrotic effects of the selective c-Jun N-terminal kinase (JNK) inhibitor, CC-930, which recently entered first clinical trials as a novel antifibrotic approach...
  21. ncbi Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway
    Christina Bergmann
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 70:2191-8. 2011
    ..A study was undertaken to define the role of GSK-3 in fibroblast activation and in experimental models of systemic sclerosis (SSc)...
  22. ncbi The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis
    Katrin Palumbo
    Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 70:1320-6. 2011
    ..Here, the role of JunD, a member of the activator protein 1 (AP-1) family of transcription factors, as a downstream mediator of TGFβ signalling in systemic sclerosis (SSc), was investigated...
  23. ncbi Microparticles stimulate angiogenesis by inducing ELR(+) CXC-chemokines in synovial fibroblasts
    Nicole Reich
    Department for Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    J Cell Mol Med 15:756-62. 2011
    ..Our data suggest that MPs may contribute to the hypervascularization of inflamed joints in patients with rheumatoid arthritis...
  24. ncbi Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
    Pawel Zerr
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen Nuremberg, Germany
    Blood 120:2909-17. 2012
    ....
  25. ncbi Ucma is not necessary for normal development of the mouse skeleton
    Nicole Eitzinger
    Department of Experimental Medicine I, Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Bone 50:670-80. 2012
    ....
  26. ncbi Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis
    Jerome Avouac
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 64:1642-52. 2012
    ..To investigate whether c-Jun and c-Fos contribute to the pathologic activation of fibroblasts in systemic sclerosis (SSc) and to evaluate the antifibrotic potential of selective activator protein 1 (AP-1) inhibition...
  27. ncbi Validation of a radiographic scoring system for haemochromatosis arthropathy
    Tomas Dallos
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 69:2145-51. 2010
    ..Although its radiographic features are well known, there is no assessment tool for their evaluation...
  28. ncbi The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss
    Christina Böhm
    Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 183:5938-47. 2009
    ..Thus, our data show that developing specific inhibitors of the alpha-isoenzyme of p38 would be beneficial for the treatment of inflammation-induced bone destruction as observed in rheumatoid arthritis...
  29. ncbi Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo
    Roland Axmann
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Arthritis Rheum 60:2747-56. 2009
    ..To investigate the efficacy of a murine anti-interleukin-6 receptor (anti-IL-6R) antibody in directly blocking tumor necrosis factor (TNF)- and RANKL-mediated osteoclastogenesis in vitro and in vivo...
  30. ncbi IgG opsonized nuclear remnants from dead cells cause systemic inflammation in SLE
    Luis E Munoz
    Department for Internal Medicine 3, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Bavaria, 91054, Germany
    Autoimmunity 43:232-5. 2010
    ..In conclusion, the proinflammatory phagocytosis by circulating phagocytes of IgG-opsonized cellular remnants fosters systemic inflammation in SLE...
  31. ncbi Platelet-derived serotonin links vascular disease and tissue fibrosis
    Clara Dees
    Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Exp Med 208:961-72. 2011
    ..These findings suggest that 5-HT/5-HT(2B) signaling links vascular damage and platelet activation to tissue remodeling and identify 5-HT(2B) as a novel therapeutic target to treat fibrotic diseases...
  32. ncbi Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts
    Alfiya Akhmetshina
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:2553-64. 2008
    ..Inhibitors of Rock are currently being evaluated for the treatment of pulmonary arterial hypertension. This study was undertaken to analyze the role of Rock in the activation of fibroblasts in systemic sclerosis (SSc)...
  33. ncbi Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation
    Mario M Zaiss
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:2328-38. 2010
    ..The aim of this study was to determine whether immune regulatory mechanisms, such as naturally occurring Treg cells, also extend their protective effects to bone homeostasis in vivo...
  34. ncbi Inhibition of sumoylation prevents experimental fibrosis
    Aisa Khodzhigorova
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1904-8. 2012
    ..First epigenetic modifications have recently been shown to contribute to activation of SSc fibroblasts. Here, we investigated inhibition of sumoylation as a novel antifibrotic approach...
  35. ncbi RSK2 protects mice against TNF-induced bone loss
    Christina Böhm
    Internal Medicine 3, Rheumatology and Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    J Cell Sci 125:2160-71. 2012
    ..Thus, RSK2 exerts a strong negative regulatory loop on TNF-induced bone loss...
  36. ncbi Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss
    Arnd Kleyer
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Bone Miner Res 27:2442-51. 2012
    ..These results reveal an unexpected involvement of LXRs in the regulation of bone turnover and highlight a potential role for LXRs as novel targets in the treatment of osteoporosis and related diseases...
  37. ncbi Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1
    Katrin Palumbo-Zerr
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:2051-4. 2012
    ..Selective targeting of the cannabinoid receptors CB1 and CB2 by synthetic compounds has revealed opposing roles of both receptors in fibrosis...
  38. ncbi Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis
    Christian Beyer
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1019-26. 2012
    ..Stimulators of soluble guanylate cyclase (sGC) are vasoactive drugs that are currently being evaluated in phase III clinical trials for pulmonary arterial hypertension...
  39. ncbi Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis
    Angelika Horn
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:785-9. 2012
    ..Effective antifibrotic treatments are not available. Here, the authors investigated inhibition of hedgehog signalling by targeting Smoothened (Smo) as a novel antifibrotic approach...
  40. ncbi Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis
    Gisela Ruiz-Heiland
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nurnberg, Erlangen, Germany
    Ann Rheum Dis 71:400-7. 2012
    ..Osteophyte formation is a common phenomenon in arthritis. Bone formation by endochondral ossification is considered a key pathophysiological process in the formation of osteophytes...
  41. ncbi Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis
    Sieglinde Marquart
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:3467-76. 2010
    ..The aim of the present study was to evaluate the role of CB1 in systemic sclerosis...
  42. ncbi Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis
    Clara Dees
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:1396-404. 2011
    ..The present study was undertaken to investigate the role of Notch signaling in SSc and to evaluate the therapeutic potential of Notch inhibition for the treatment of fibrosis...
  43. ncbi Hereditary hemochromatosis as a risk factor for joint replacement surgery
    Enijad Sahinbegovic
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Am J Med 123:659-62. 2010
    ..Hemochromatosis is an inherited disease with iron overload and joint involvement resembling osteoarthritis. To determine the rate of joint replacement surgery in patients with hemochromatosis, we performed a cross-sectional cohort study...
  44. ncbi Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis
    Vilma Urbonaviciute
    IZKF, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen Nuremberg, Erlangen, Germany
    Autoimmunity 42:305-7. 2009
    ..Also HMGB1 in plasma of patients with systemic lupus was reversibly oxidized. In conclusion, HMGB1 undergoes reversible oxidative modifications at cysteine residues during cell death, which may modulate its biological properties...
  45. ncbi The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis
    Alfiya Akhmetshina
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:1129-36. 2009
    ..The cannabinoid receptor CB2 is predominantly expressed in non-neuronal tissue and exerts potent immunomodulatory effects. This study was undertaken to evaluate the role of CB2 in the pathogenesis of dermal fibrosis...
  46. ncbi Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis
    Sonja Herman
    Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:3041-50. 2008
    ..This study was undertaken to define the role of costimulation in osteoclast differentiation during inflammatory arthritis...
  47. ncbi Induction of apoptosis in circulating angiogenic cells by microparticles
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:2067-77. 2011
    ..The aim of this study was to analyze whether microparticles might link pathologic activation and apoptosis of ECs with reduced numbers of CACs...
  48. ncbi High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice
    Charlotte Starke
    Department of Internal Medicine 3, Clinical Research Group, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 41:2107-12. 2011
    ..Moreover, the frequencies of IgG-secreting cells specific for the autoantigens dsDNA and nucleolin were higher in the kidneys compared with those in the spleen and bone marrow...
  49. ncbi Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Arthritis Rheum 60:2644-54. 2009
    ....
  50. ncbi Pomalidomide is effective for prevention and treatment of experimental skin fibrosis
    Simon Weingärtner
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1895-9. 2012
    ..Here, we investigated the antifibrotic effects of pomalidomide, an analogue of thalidomide with potent immunomodulatory effects, in preclinical models of skin fibrosis...
  51. ncbi The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death
    Christian Beyer
    Department for Internal Medicine and Institute for Clinical Immunology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Innate Immun 18:727-37. 2012
    ..Together, these results indicate that experimental necrosis leads to diverse patterns of nuclear molecule release which could affect their immunologic activity...
  52. ncbi Inflammation-associated changes in bone homeostasis
    Carina Scholtysek
    Department of Internal Medicine 3, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    Inflamm Allergy Drug Targets 11:188-95. 2012
    ..Moreover, chronic inflammation and its consequences for bone turnover are discussed...
  53. ncbi High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis
    Gisela Ruiz Heiland
    Department of Internal Medicine III, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 71:572-4. 2012
    ..The molecular mechanisms of syndesmophyte formation in ankylosing spondylitis (AS) are yet to be characterised. Molecules involved in bone formation such as Wnt proteins and their antagonists probably drive syndesmophyte formation in AS...
  54. ncbi Molecular mechanisms of inflammatory bone damage: emerging targets for therapy
    Sonja Herman
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Trends Mol Med 14:245-53. 2008
    ....
  55. ncbi The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation
    Gerhard Kronke
    Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054, Erlangen, Germany
    Autoimmunity 42:383-5. 2009
    ..Therefore, 12/15-LO and its human homologue 15-LO may display novel targets for the treatment of diseases such as osteoporosis and rheumatoid arthritis...
  56. ncbi Sodium overload and water influx activate the NALP3 inflammasome
    Christine Schorn
    Department of Internal Medicine 3, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 286:35-41. 2011
    ..As a translational aspect one may consider the use of chloroquine for the anti-inflammatory treatment of refractory gout...
  57. ncbi Decreased lymphatic vessel counts in patients with systemic sclerosis: association with fingertip ulcers
    Alfiya Akhmetshina
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:1513-22. 2010
    ..This study was undertaken to assess whether the lymphatic vascular system is affected in SSc, and whether changes to the lymphatic vessels are associated with dystrophic changes and tissue damage in patients with SSc...
  58. ncbi The uptake by blood-borne phagocytes of monosodium urate is dependent on heat-labile serum factor(s) and divalent cations
    Christine Schorn
    Deparment for Internal Medicine 3, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Autoimmunity 43:236-8. 2010
    ..The uptake induces the release of the pro-inflammatory cytokines IL-1beta/IL-18/TNFalpha and IL-6/IL-8 by monocytes and PMN, respectively...
  59. ncbi Musculoskeletal disease burden of hereditary hemochromatosis
    Enijad Sahinbegovic
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:3792-8. 2010
    ..To determine the prevalence, clinical picture, and disease burden of arthritis in patients with hereditary hemochromatosis...
  60. ncbi 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance
    Stefan Uderhardt
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Immunity 36:834-46. 2012
    ..Our data reveal an unexpected key role for enzymatic lipid oxidation during the maintenance of self-tolerance...
  61. ncbi Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
    Ulrike Harre
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Clin Invest 122:1791-802. 2012
    ..Our data thus suggest that autoantibody formation in response to citrullinated vimentin directly induces bone loss, providing a link between the adaptive immune system and bone...
  62. ncbi β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
    Christian Beyer
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:761-7. 2012
    ..catenin is an integral part of adherens junctions and a central component of canonical Wnt signaling. Here, the authors addressed the role of β-catenin in fibroblasts for the development of SSc dermal fibrosis...
  63. ncbi Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
    Gisela Ruiz Heiland
    Department of Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 69:2152-9. 2010
    ..It was hypothesised that impaired bone formation is a key component in inflammatory bone loss and that Dkk-1, a Wnt antagonist, is a strong inhibitor of osteoblast-mediated bone formation...
  64. ncbi Vascular cell adhesion molecule 1 as a predictor of severe osteoarthritis of the hip and knee joints
    Georg Schett
    Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:2381-9. 2009
    ..Osteoarthritis (OA) is a leading cause of pain and physical disability in middle-aged and older individuals. We undertook this study to determine predictors of the development of severe OA, apart from age and overweight...
  65. ncbi The early marginal zone B cell-initiated T-independent type 2 response resists the proteasome inhibitor bortezomib
    Veronika R Lang
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 185:5637-47. 2010
    ..In contrast, the early T-independent type 2 response protecting the organism against blood-borne pathogens remains largely intact due to a remarkable resistance of MZ B cells against proteasome inhibition...
  66. ncbi Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells
    Silke Meister
    IZKF N2, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Neoplasia 12:550-61. 2010
    ..Thus, the combination of bortezomib with verapamil may improve the efficacy of proteasome inhibitory therapy...
  67. ncbi IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss
    Mario M Zaiss
    Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    J Immunol 186:6097-105. 2011
    ..Thus, we show in this study that IL-33 is an important bone-protecting cytokine and may be of therapeutic benefit in treating bone resorption...
  68. ncbi Synovial immunopathology in haemochromatosis arthropathy
    Gisela Ruiz Heiland
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Ann Rheum Dis 69:1214-9. 2010
    ..Hereditary haemochromatosis (HH) is a common autosomal recessive inherited disorder that frequently causes arthritis. The pathophysiology of musculoskeletal involvement is, however, unclear...
  69. ncbi Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis
    Catherine Skhirtladze
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:1475-84. 2008
    ..Src kinases are nonreceptor tyrosine kinases, which have been implicated in cytoskeletal organization and cell mobility. This study was undertaken to evaluate the potential of Src kinases as novel targets of antifibrotic therapies...
  70. ncbi Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus
    Barbara G Fürnrohr
    Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 69:1983-9. 2010
    ..Heat shock proteins (Hsps) play a role in the delivery and presentation of antigenic peptides and are thought to be involved in the pathogenesis of multifactorial diseases...
  71. ncbi Repair of bone erosions in rheumatoid arthritis treated with tumour necrosis factor inhibitors is based on bone apposition at the base of the erosion
    Stephanie Finzel
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 70:1587-93. 2011
    ..To investigate whether bone erosions in patients with rheumatoid arthritis (RA) show evidence of repair...
  72. ncbi Sodium and potassium urate crystals differ in their inflammatory potential
    Christine Schorn
    Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Autoimmunity 42:314-6. 2009
    ..These results show that the cation of urate crystals determines the response of innate immune cells, indicating that the micromilieu at the site of crystal formation is important for their inflammatory potential...
  73. ncbi CCL17/thymus and activation-related chemokine in Churg-Strauss syndrome
    Tomas Dallos
    University of Erlangen Nuremberg, Erlangen, Germany Comenius University in Bratislava, Bratislava, Slovakia
    Arthritis Rheum 62:3496-503. 2010
    ..CCL17/thymus and activation-regulated chemokine (TARC) is a chemokine responsible for the recruitment of Th2 cells. This study was undertaken to explore a possible role of CCL17/TARC in CSS...
  74. ncbi TNF and bone
    Jean Pierre David
    Rheumatology and Immunology, Department of Internal Medicine 3, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Curr Dir Autoimmun 11:135-44. 2010
    ..The role of TNF-alpha in mediating bone remodeling will be presented and discussed in this chapter...
  75. ncbi Treatment with DNAse I fosters binding to nec PBMC of CRP
    Christina Janko
    Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Autoimmunity 42:286-8. 2009
    ..Consequently, reduced DNase I activity in patients with SLE may contribute to the impaired opsonisation by CRP of dead cells, exacerbating the clearance defect in SLE of apo and nec cells...
  76. ncbi A case report of plasma exchange, steroids, mycophenolate mofetil and cyclophosphamide in acquired factor VIII inhibitors
    Jürgen Rech
    Medical Department 3, Division of Rheumatology, University of Erlangen Nuremberg, Munich, Germany
    Ther Apher Dial 12:406-8. 2008
    ..Hence, we present a case of severe idiopathic FVIII inhibitor-positive hemophilia successfully treated with the combination of plasma exchange, corticosteroids, cyclophosphamide and MMF...
  77. ncbi Eotaxin-3 in Churg-Strauss syndrome: a clinical and immunogenetic study
    Jochen Zwerina
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Rheumatology (Oxford) 50:1823-7. 2011
    ..To determine the potential of eotaxin-3 as a diagnostic marker for active disease and genetic susceptibility factor for Churg-Strauss syndrome (CSS)...
  78. ncbi Pharmacotherapy: concepts of pathogenesis and emerging treatments. Novel targets in bone and cartilage
    Christian Beyer
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Best Pract Res Clin Rheumatol 24:489-96. 2010
    ..Future therapies will likely target the pathologic activity of these molecular pathways to specifically block either catabolic or anabolic joint remodelling in arthritis...
  79. ncbi Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high-resolution computed tomography
    Christian M Stach
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:330-9. 2010
    ..To define the nature of structural bone changes in patients with rheumatoid arthritis (RA) compared with those in healthy individuals by using the novel technique of high-resolution microfocal computed tomography (micro-CT)...
  80. ncbi The lonely death: chondrocyte apoptosis in TNF-induced arthritis
    Karin Polzer
    Department of Internal Medicine 3, Institute of Clinical Immunology, University of Erlangen, Erlangen, Germany
    Autoimmunity 40:333-6. 2007
    ..These data indicate that chondrocyte death may play a primary role in inflammatory arthritis fueling cartilage inflammation and damage due to secondary necrosis...
  81. ncbi The controversial role of tumor necrosis factor alpha in fibrotic diseases
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:2228-35. 2008
  82. ncbi Elevated Fra-1 expression causes severe lipodystrophy
    Julia Luther
    Department of Internal Medicine 3, University of Erlangen Nuremberg, D91054 Erlangen, Germany
    J Cell Sci 124:1465-76. 2011
    ....
  83. ncbi Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis
    Christian Beyer
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 11:220. 2009
    ..Altogether, hypoxia might play a central role in pathogenesis of SSc by augmenting vascular disease and tissue fibrosis...
  84. ncbi Dysbalance of angiogenic and angiostatic mediators in patients with mixed connective tissue disease
    Jörg H W Distler
    Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 70:1197-202. 2011
    ..Vascular disease is common in mixed connective tissue disease (MCTD). The aim of the present study was to investigate, whether dysbalance of angiogenic and angiostatic factors occurs in MCTD...
  85. ncbi Can we stop progression of ankylosing spondylitis?
    Georg Schett
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Best Pract Res Clin Rheumatol 24:363-71. 2010
    ..The article reviews the current knowledge regarding the mechanisms and clinical role of ankylosis and explains strategies on how to prevent it in patients with ankylosing spondylitis...
  86. ncbi Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:2538-42. 2008
    ..These findings suggest that imatinib mesylate might be effective in patients with fibrotic diseases and warrant the initiation of larger clinical studies on the safety and efficacy of imatinib mesylate in connective tissue diseases...
  87. ncbi Binary segmentation masks can improve intrasubject registration accuracy of bone structures in CT images
    Oleg Museyko
    Institute for Medical Physics, University of Erlangen Nuremberg, Henkestrasse 91, Erlangen, Germany
    Ann Biomed Eng 38:2464-72. 2010
    ..The use of binary VOI masks was significantly superior to the use of gray value VOIs...
  88. ncbi Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 56:311-22. 2007
    ..This study was undertaken to test the potential use of imatinib mesylate as an antifibrotic drug for the treatment of dermal fibrosis in systemic sclerosis (SSc)...
  89. ncbi Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Universitätsstr 29, 91054 Erlangen, Germany
    FASEB J 22:2214-22. 2008
    ..Thus, we provide the first evidence that dasatinib and nilotinib might be promising drugs for the treatment of patients with SSc...
  90. ncbi Review: Immune cells and mediators of inflammatory arthritis
    Georg Schett
    Department of Internal Medicine 3, University of Erlangen Nurnberg, Erlangen, Germany
    Autoimmunity 41:224-9. 2008
    ..Inhibition of osteoclast formation has proven as an effective approach to inhibit structural damage in experimental arthritis and preliminary data suggest that such approaches are also effective in human RA...
  91. ncbi Bone formation versus bone resorption in ankylosing spondylitis
    Georg Schett
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Adv Exp Med Biol 649:114-21. 2009
    ..AS may thus be considered as a synthesis of inflammatory disease and bone disease...
  92. ncbi Dickkopf-1 is a master regulator of joint remodeling
    Danielle Diarra
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nurnberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Nat Med 13:156-63. 2007
    ..We identified tumor necrosis factor-alpha (TNF) as a key inducer of DKK-1 in the mouse inflammatory arthritis model and in human rheumatoid arthritis. These results suggest that the Wnt pathway is a key regulator of joint remodeling...
  93. ncbi The role of Wnt proteins in arthritis
    Georg Schett
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Nat Clin Pract Rheumatol 4:473-80. 2008
    ..It also addresses the role of Wnt in determining the differences in clinical presentation of inflammatory arthropathies and discusses implications for future therapy...
  94. ncbi Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis
    Cordula Surmann-Schmitt
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Germany
    J Cell Sci 122:3627-37. 2009
    ..These results identify Wif-1 as a novel extracellular Wnt modulator in cartilage biology...
  95. ncbi From bone biology to clinical outcome: state of the art and future perspectives
    Georg Schett
    Department of Internal Medicine 3, Erlangen, Germany
    Ann Rheum Dis 69:1415-9. 2010
    ..In the last decade the well-known negative influences of glucocorticoids on bone have become more treatable as a result of new drugs that stimulate osteoblasts and restore the negative bone balance...
  96. ncbi Treg cells suppress osteoclast formation: a new link between the immune system and bone
    Mario M Zaiss
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Arthritis Rheum 56:4104-12. 2007
    ..To investigate whether Treg cells can suppress osteoclast differentiation, and to define a new potential link between the immune system and the skeleton...
  97. ncbi Clinical images: rheumatologic irony
    Jochen Zwerina
    University of Erlangen, Erlangen, Germany
    Arthritis Rheum 56:1463. 2007
  98. ncbi Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE
    Vilma Urbonaviciute
    Interdisciplinary Center of Clinical Research IZKF, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen Nuremberg, Erlangen, Germany
    J Exp Med 205:3007-18. 2008
    ..In conclusion, HMGB1-nucleosome complexes activate antigen presenting cells and, thereby, may crucially contribute to the pathogenesis of SLE via breaking the immunological tolerance against nucleosomes/dsDNA...
  99. ncbi Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus
    Luis E Munoz
    University Hospital of Erlangen, Department of Radiation Oncology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:1733-42. 2009
    ..The aim of this study was to investigate whether the remnants of apoptotic cells are involved in the induction of inflammatory cytokines in blood-borne phagocytes...
  100. ncbi Mr Outside and Mr Inside: classic and alternative views on the pathogenesis of rheumatoid arthritis
    Georg Schett
    University of Erlangen, Erlangen D 91054, Germany
    Ann Rheum Dis 69:787-9. 2010
    ..The authors discuss these two fundamentally different viewpoints on the pathogenesis of arthritis, each one of which bears attractive explanations for the mystery of the pathogenesis of arthritis...
  101. ncbi 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis
    Gerhard Kronke
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 183:3383-9. 2009
    ..Taken together, these results support an anti-inflammatory and tissue-protective role of 12/15-LO and its products during chronic inflammatory disorders such as arthritis...