Georg Schett

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arch Intern Med 166:2495-501. 2006
  2. pmc Erosive arthritis
    Georg Schett
    Department of Internal Medicine 3, University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Res Ther 9:S2. 2007
  3. pmc Joint remodelling in inflammatory disease
    Georg Schett
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Ann Rheum Dis 66:iii42-4. 2007
  4. pmc How does joint remodeling work?: new insights in the molecular regulation of the architecture of joints
    Georg Schett
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen D 91054, Germany
    Cell Adh Migr 1:102-3. 2007
  5. pmc Cells of the synovium in rheumatoid arthritis. Osteoclasts
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 9:203. 2007
  6. doi request reprint Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine III, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:219-24. 2009
  7. doi request reprint The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis
    Gerhard Kronke
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1081-7. 2012
  8. doi request reprint Proteasome inhibition aggravates tumor necrosis factor-mediated bone resorption in a mouse model of inflammatory arthritis
    Karin Polzer
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:670-80. 2011
  9. doi request reprint Regulatory T cells protect from local and systemic bone destruction in arthritis
    Mario M Zaiss
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 184:7238-46. 2010
  10. doi request reprint Lack of inhibitory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo
    Paulius Venalis
    Department for Internal Medicine 3 and Institute for Clinical Immunology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    J Cell Mol Med 13:4185-91. 2009

Detail Information

Publications160 found, 100 shown here

  1. ncbi request reprint High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arch Intern Med 166:2495-501. 2006
    ..It is unknown, however, whether low-grade inflammation in healthy individuals, as estimated by the high-sensitivity C-reactive protein (hs-CRP) level, interferes with bone metabolism and affects the risk of nontraumatic fractures...
  2. pmc Erosive arthritis
    Georg Schett
    Department of Internal Medicine 3, University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Res Ther 9:S2. 2007
    ..Blockade of osteoclast formation is thus a key strategy in preventing structural damage in arthritis. Denosumab, a humanized antibody that neutralizes RANKL, is an attractive candidate agent to inhibit inflammatory bone loss...
  3. pmc Joint remodelling in inflammatory disease
    Georg Schett
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Ann Rheum Dis 66:iii42-4. 2007
    ..Whereas a short and self-limited activation of the immune system has no clinically meaningful effect on bone, prolonged immune activation as found in chronic inflammatory disease inevitably leads to bone wasting...
  4. pmc How does joint remodeling work?: new insights in the molecular regulation of the architecture of joints
    Georg Schett
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen D 91054, Germany
    Cell Adh Migr 1:102-3. 2007
    ..This mechanism is largely dependent on an activation of wingless protein signaling and can lead to complete joint fusion. This addendum summarized the current concepts of joint remodeling in the limelight of these new findings...
  5. pmc Cells of the synovium in rheumatoid arthritis. Osteoclasts
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 9:203. 2007
    ..Osteoclasts thus represent a link between joint inflammation and structural damage since they resorb mineralized tissue adjacent to the joint and destroy the joint architecture...
  6. doi request reprint Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine III, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:219-24. 2009
    ....
  7. doi request reprint The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis
    Gerhard Kronke
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1081-7. 2012
    ..Understanding endogenous mechanisms, which counteract fibrosis, may yield new therapeutic approaches. Lipoxins are highly potent lipid mediators, which have recently been found to be decreased in SSc...
  8. doi request reprint Proteasome inhibition aggravates tumor necrosis factor-mediated bone resorption in a mouse model of inflammatory arthritis
    Karin Polzer
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:670-80. 2011
    ..Recently, bortezomib was shown to directly inhibit osteoclastogenesis. The aim of this study was to analyze the influence and therapeutic effect of bortezomib in a mouse model of inflammatory arthritis...
  9. doi request reprint Regulatory T cells protect from local and systemic bone destruction in arthritis
    Mario M Zaiss
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 184:7238-46. 2010
    ..Thus, enhancing the activity of Treg cells would be beneficial for the treatment of inflammation-induced bone loss observed in rheumatoid arthritis...
  10. doi request reprint Lack of inhibitory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo
    Paulius Venalis
    Department for Internal Medicine 3 and Institute for Clinical Immunology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    J Cell Mol Med 13:4185-91. 2009
    ..Imatinib does not inhibit activation, viability, proliferation, migration or tube forming of endothelial cells in vitro and in vivo. Thus, treatment with imatinib might not augment further endothelial cell damage in SSc...
  11. doi request reprint Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis
    Jerome Avouac
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:800-9. 2011
    ..The aim of this study was to investigate the contribution of STAT-4 in the development of a fibrotic phenotype in 2 different mouse models of experimental dermal fibrosis...
  12. doi request reprint Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis
    Clara Dees
    Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 70:1304-10. 2011
    ..Dermal fibroblasts from patients with systemic sclerosis (SSc) release excessive amounts of collagen resulting in tissue fibrosis. The molecular mechanisms underlying this pathological activation are incompletely understood...
  13. doi request reprint Combined inhibition of c-Abl and PDGF receptors for prevention and treatment of murine sclerodermatous chronic graft-versus-host disease
    Pawel Zerr
    Department of Internal Medicine III, University of Erlangen Nuremberg, Germany
    Am J Pathol 181:1672-80. 2012
    ....
  14. doi request reprint Idiopathic hand osteoarthritis vs haemochromatosis arthropathy--a clinical, functional and radiographic study
    Tomas Dallos
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Rheumatology (Oxford) 52:910-5. 2013
    ..The aim of this study was to perform a direct clinical, functional and radiographic comparison with idiopathic hand OA (HOA) to unravel important differences between these clinical entities...
  15. doi request reprint Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis
    Angelika Horn
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 64:2724-33. 2012
    ..The aim of the present study was to investigate the role of the hedgehog pathway in fibroblast activation in systemic sclerosis (SSc)...
  16. doi request reprint The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis
    Nicole Reich
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:280-90. 2010
    ..The aim of the present study was to investigate whether Fra-2 plays a role in the pathogenesis of SSc and to identify the molecular mechanisms by which Fra-2 induces fibrosis...
  17. doi request reprint Vitamin D receptor regulates TNF-mediated arthritis
    Karin Zwerina
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 70:1122-9. 2011
    ..The pathophysiological role of vitamin D in joint inflammation is, however, unclear...
  18. doi request reprint R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway
    Gerhard Kronke
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:2303-12. 2010
    ..This study was undertaken to investigate the role of the Wnt pathway modulator R-Spondin 1 (RSpo1) in protecting bone and cartilage in a mouse model of arthritis...
  19. doi request reprint JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis
    Clara Dees
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 64:3006-15. 2012
    ..To investigate whether JAK-2 contributes to the pathologic activation of fibroblasts in patients with systemic sclerosis (SSc) and to evaluate the antifibrotic potential of JAK-2 inhibition for the treatment of SSc...
  20. pmc Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Nat Commun 3:735. 2012
    ..These findings demonstrate that canonical Wnt signalling is necessary for TGF-β-mediated fibrosis and highlight a key role for the interaction of both pathways in the pathogenesis of fibrotic diseases...
  21. doi request reprint Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
    Nicole Reich
    Department for Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:737-45. 2012
    ..This study analysed the antifibrotic effects of the selective c-Jun N-terminal kinase (JNK) inhibitor, CC-930, which recently entered first clinical trials as a novel antifibrotic approach...
  22. doi request reprint The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis
    Katrin Palumbo
    Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 70:1320-6. 2011
    ..Here, the role of JunD, a member of the activator protein 1 (AP-1) family of transcription factors, as a downstream mediator of TGFβ signalling in systemic sclerosis (SSc), was investigated...
  23. doi request reprint Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway
    Christina Bergmann
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 70:2191-8. 2011
    ..A study was undertaken to define the role of GSK-3 in fibroblast activation and in experimental models of systemic sclerosis (SSc)...
  24. doi request reprint Microparticles stimulate angiogenesis by inducing ELR(+) CXC-chemokines in synovial fibroblasts
    Nicole Reich
    Department for Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    J Cell Mol Med 15:756-62. 2011
    ..Our data suggest that MPs may contribute to the hypervascularization of inflamed joints in patients with rheumatoid arthritis...
  25. doi request reprint Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor α-mediated experimental arthritis
    Michael Stock
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 65:2310-22. 2013
    ..Nevertheless, WIF-1(-/-) mice develop normally. In light of these findings, we undertook this study to analyze the role of WIF-1 in arthritis...
  26. doi request reprint Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
    Pawel Zerr
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen Nuremberg, Germany
    Blood 120:2909-17. 2012
    ....
  27. doi request reprint Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis
    Jerome Avouac
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 64:1642-52. 2012
    ..To investigate whether c-Jun and c-Fos contribute to the pathologic activation of fibroblasts in systemic sclerosis (SSc) and to evaluate the antifibrotic potential of selective activator protein 1 (AP-1) inhibition...
  28. doi request reprint Ucma is not necessary for normal development of the mouse skeleton
    Nicole Eitzinger
    Department of Experimental Medicine I, Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Bone 50:670-80. 2012
    ....
  29. doi request reprint Validation of a radiographic scoring system for haemochromatosis arthropathy
    Tomas Dallos
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 69:2145-51. 2010
    ..Although its radiographic features are well known, there is no assessment tool for their evaluation...
  30. pmc Platelet-derived serotonin links vascular disease and tissue fibrosis
    Clara Dees
    Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Exp Med 208:961-72. 2011
    ..These findings suggest that 5-HT/5-HT(2B) signaling links vascular damage and platelet activation to tissue remodeling and identify 5-HT(2B) as a novel therapeutic target to treat fibrotic diseases...
  31. doi request reprint Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation
    Mario M Zaiss
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:2328-38. 2010
    ..The aim of this study was to determine whether immune regulatory mechanisms, such as naturally occurring Treg cells, also extend their protective effects to bone homeostasis in vivo...
  32. doi request reprint IgG opsonized nuclear remnants from dead cells cause systemic inflammation in SLE
    Luis E Munoz
    Department for Internal Medicine 3, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Bavaria, 91054, Germany
    Autoimmunity 43:232-5. 2010
    ..In conclusion, the proinflammatory phagocytosis by circulating phagocytes of IgG-opsonized cellular remnants fosters systemic inflammation in SLE...
  33. doi request reprint Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo
    Roland Axmann
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Arthritis Rheum 60:2747-56. 2009
    ..To investigate the efficacy of a murine anti-interleukin-6 receptor (anti-IL-6R) antibody in directly blocking tumor necrosis factor (TNF)- and RANKL-mediated osteoclastogenesis in vitro and in vivo...
  34. doi request reprint Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts
    Alfiya Akhmetshina
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:2553-64. 2008
    ..Inhibitors of Rock are currently being evaluated for the treatment of pulmonary arterial hypertension. This study was undertaken to analyze the role of Rock in the activation of fibroblasts in systemic sclerosis (SSc)...
  35. doi request reprint The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss
    Christina Böhm
    Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 183:5938-47. 2009
    ..Thus, our data show that developing specific inhibitors of the alpha-isoenzyme of p38 would be beneficial for the treatment of inflammation-induced bone destruction as observed in rheumatoid arthritis...
  36. doi request reprint Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling
    Alfiya Distler
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 72:1575-80. 2013
    ..Here, we investigated tankyrases as novel molecular targets for inhibition of canonical Wnt signalling in fibrotic diseases...
  37. doi request reprint Bone anabolic changes progress in psoriatic arthritis patients despite treatment with methotrexate or tumour necrosis factor inhibitors
    Stephanie Finzel
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 72:1176-81. 2013
    ..To investigate whether methotrexate or tumour necrosis factor inhibitors (TNFi) affect osteophyte formation in patients with psoriatic arthritis (PsA)...
  38. doi request reprint Activation of pregnane X receptor inhibits experimental dermal fibrosis
    Christian Beyer
    Department of Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Ulmenweg 18, Erlangen D 91054, Germany
    Ann Rheum Dis 72:621-5. 2013
    ..To assess the antifibrotic effects of pregnane X receptors (PXRs) in experimental dermal fibrosis...
  39. doi request reprint Inhibition of sumoylation prevents experimental fibrosis
    Aisa Khodzhigorova
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1904-8. 2012
    ..First epigenetic modifications have recently been shown to contribute to activation of SSc fibroblasts. Here, we investigated inhibition of sumoylation as a novel antifibrotic approach...
  40. doi request reprint RSK2 protects mice against TNF-induced bone loss
    Christina Böhm
    Internal Medicine 3, Rheumatology and Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    J Cell Sci 125:2160-71. 2012
    ..Thus, RSK2 exerts a strong negative regulatory loop on TNF-induced bone loss...
  41. doi request reprint PPARβ/δ governs Wnt signaling and bone turnover
    Carina Scholtysek
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nurnberg, Erlangen, Germany
    Nat Med 19:608-13. 2013
    ..Our findings identify PPARβ/δ as a promising target for an alternative approach in the treatment of osteoporosis and related diseases...
  42. doi request reprint Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis
    Marlene Kramer
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Ulmenweg 18, Erlangen D 91054, Germany
    Ann Rheum Dis 72:614-20. 2013
    ..However, histone methylation has not been investigated so far. We therefore aimed to evaluate the role of the trimethylation of histone H3 on lysine 27 (H3K27me3) on fibroblast activation and fibrosis...
  43. doi request reprint Autoantibodies against galectins are associated with antiphospholipid syndrome in patients with systemic lupus erythematosus
    Kerstin Sarter
    Department of Internal Medicine 3, Friedrich Alexander University Erlangen Nuremberg, Germany
    Glycobiology 23:12-22. 2013
    ..Equally of note, the presence of IgG autoantibodies against galectins capable to act as an opsonin may contribute to a sustained immune dysregulation in patients with chronic inflammatory rheumatic diseases...
  44. doi request reprint Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss
    Arnd Kleyer
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Bone Miner Res 27:2442-51. 2012
    ..These results reveal an unexpected involvement of LXRs in the regulation of bone turnover and highlight a potential role for LXRs as novel targets in the treatment of osteoporosis and related diseases...
  45. doi request reprint Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1
    Katrin Palumbo-Zerr
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:2051-4. 2012
    ..Selective targeting of the cannabinoid receptors CB1 and CB2 by synthetic compounds has revealed opposing roles of both receptors in fibrosis...
  46. doi request reprint Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis
    Christian Beyer
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1019-26. 2012
    ..Stimulators of soluble guanylate cyclase (sGC) are vasoactive drugs that are currently being evaluated in phase III clinical trials for pulmonary arterial hypertension...
  47. doi request reprint Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis
    Angelika Horn
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:785-9. 2012
    ..Effective antifibrotic treatments are not available. Here, the authors investigated inhibition of hedgehog signalling by targeting Smoothened (Smo) as a novel antifibrotic approach...
  48. doi request reprint Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis
    Gisela Ruiz-Heiland
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nurnberg, Erlangen, Germany
    Ann Rheum Dis 71:400-7. 2012
    ..Osteophyte formation is a common phenomenon in arthritis. Bone formation by endochondral ossification is considered a key pathophysiological process in the formation of osteophytes...
  49. doi request reprint Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis
    Sieglinde Marquart
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:3467-76. 2010
    ..The aim of the present study was to evaluate the role of CB1 in systemic sclerosis...
  50. doi request reprint Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis
    Clara Dees
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:1396-404. 2011
    ..The present study was undertaken to investigate the role of Notch signaling in SSc and to evaluate the therapeutic potential of Notch inhibition for the treatment of fibrosis...
  51. doi request reprint Hereditary hemochromatosis as a risk factor for joint replacement surgery
    Enijad Sahinbegovic
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Am J Med 123:659-62. 2010
    ..Hemochromatosis is an inherited disease with iron overload and joint involvement resembling osteoarthritis. To determine the rate of joint replacement surgery in patients with hemochromatosis, we performed a cross-sectional cohort study...
  52. doi request reprint Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis
    Christian Beyer
    Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 72:1255-8. 2013
    ..There is growing evidence for a central role of Wnt signalling in fibrotic diseases such as systemic sclerosis, and we therefore evaluated the translational potential of pharmacological Wnt inhibition in experimental dermal fibrosis...
  53. doi request reprint Autophagy regulates TNFα-mediated joint destruction in experimental arthritis
    Neng Yu Lin
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 72:761-8. 2013
    ..Dysregulation of autophagic pathways has recently been implicated in the pathogenesis of various diseases. Here, we investigated the role of autophagy during joint destruction in arthritis...
  54. doi request reprint Moonlighting osteoclasts as undertakers of apoptotic cells
    Ulrike Harre
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Germany
    Autoimmunity 45:612-9. 2012
    ....
  55. doi request reprint Association of brain functional magnetic resonance activity with response to tumor necrosis factor inhibition in rheumatoid arthritis
    Juergen Rech
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 65:325-33. 2013
    ....
  56. doi request reprint Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis
    Sonja Herman
    Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:3041-50. 2008
    ..This study was undertaken to define the role of costimulation in osteoclast differentiation during inflammatory arthritis...
  57. doi request reprint The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis
    Alfiya Akhmetshina
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:1129-36. 2009
    ..The cannabinoid receptor CB2 is predominantly expressed in non-neuronal tissue and exerts potent immunomodulatory effects. This study was undertaken to evaluate the role of CB2 in the pathogenesis of dermal fibrosis...
  58. doi request reprint Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis
    Georg Schett
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Arthritis Rheum 60:2644-54. 2009
    ....
  59. doi request reprint Induction of apoptosis in circulating angiogenic cells by microparticles
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 63:2067-77. 2011
    ..The aim of this study was to analyze whether microparticles might link pathologic activation and apoptosis of ECs with reduced numbers of CACs...
  60. doi request reprint High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice
    Charlotte Starke
    Department of Internal Medicine 3, Clinical Research Group, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 41:2107-12. 2011
    ..Moreover, the frequencies of IgG-secreting cells specific for the autoantigens dsDNA and nucleolin were higher in the kidneys compared with those in the spleen and bone marrow...
  61. ncbi request reprint Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis
    Vilma Urbonaviciute
    IZKF, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen Nuremberg, Erlangen, Germany
    Autoimmunity 42:305-7. 2009
    ..Also HMGB1 in plasma of patients with systemic lupus was reversibly oxidized. In conclusion, HMGB1 undergoes reversible oxidative modifications at cysteine residues during cell death, which may modulate its biological properties...
  62. pmc The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death
    Christian Beyer
    Department for Internal Medicine and Institute for Clinical Immunology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Innate Immun 18:727-37. 2012
    ..Together, these results indicate that experimental necrosis leads to diverse patterns of nuclear molecule release which could affect their immunologic activity...
  63. doi request reprint Pomalidomide is effective for prevention and treatment of experimental skin fibrosis
    Simon Weingärtner
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:1895-9. 2012
    ..Here, we investigated the antifibrotic effects of pomalidomide, an analogue of thalidomide with potent immunomodulatory effects, in preclinical models of skin fibrosis...
  64. ncbi request reprint Inflammation-associated changes in bone homeostasis
    Carina Scholtysek
    Department of Internal Medicine 3, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    Inflamm Allergy Drug Targets 11:188-95. 2012
    ..Moreover, chronic inflammation and its consequences for bone turnover are discussed...
  65. doi request reprint High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis
    Gisela Ruiz Heiland
    Department of Internal Medicine III, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 71:572-4. 2012
    ..The molecular mechanisms of syndesmophyte formation in ankylosing spondylitis (AS) are yet to be characterised. Molecules involved in bone formation such as Wnt proteins and their antagonists probably drive syndesmophyte formation in AS...
  66. doi request reprint Decreased lymphatic vessel counts in patients with systemic sclerosis: association with fingertip ulcers
    Alfiya Akhmetshina
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:1513-22. 2010
    ..This study was undertaken to assess whether the lymphatic vascular system is affected in SSc, and whether changes to the lymphatic vessels are associated with dystrophic changes and tissue damage in patients with SSc...
  67. ncbi request reprint The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation
    Gerhard Kronke
    Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054, Erlangen, Germany
    Autoimmunity 42:383-5. 2009
    ..Therefore, 12/15-LO and its human homologue 15-LO may display novel targets for the treatment of diseases such as osteoporosis and rheumatoid arthritis...
  68. doi request reprint Musculoskeletal disease burden of hereditary hemochromatosis
    Enijad Sahinbegovic
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:3792-8. 2010
    ..To determine the prevalence, clinical picture, and disease burden of arthritis in patients with hereditary hemochromatosis...
  69. pmc Sodium overload and water influx activate the NALP3 inflammasome
    Christine Schorn
    Department of Internal Medicine 3, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 286:35-41. 2011
    ..As a translational aspect one may consider the use of chloroquine for the anti-inflammatory treatment of refractory gout...
  70. doi request reprint The uptake by blood-borne phagocytes of monosodium urate is dependent on heat-labile serum factor(s) and divalent cations
    Christine Schorn
    Deparment for Internal Medicine 3, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Autoimmunity 43:236-8. 2010
    ..The uptake induces the release of the pro-inflammatory cytokines IL-1beta/IL-18/TNFalpha and IL-6/IL-8 by monocytes and PMN, respectively...
  71. doi request reprint Molecular mechanisms of inflammatory bone damage: emerging targets for therapy
    Sonja Herman
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Trends Mol Med 14:245-53. 2008
    ....
  72. doi request reprint 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance
    Stefan Uderhardt
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Immunity 36:834-46. 2012
    ..Our data reveal an unexpected key role for enzymatic lipid oxidation during the maintenance of self-tolerance...
  73. pmc Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
    Ulrike Harre
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Clin Invest 122:1791-802. 2012
    ..Our data thus suggest that autoantibody formation in response to citrullinated vimentin directly induces bone loss, providing a link between the adaptive immune system and bone...
  74. doi request reprint β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
    Christian Beyer
    Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 71:761-7. 2012
    ..catenin is an integral part of adherens junctions and a central component of canonical Wnt signaling. Here, the authors addressed the role of β-catenin in fibroblasts for the development of SSc dermal fibrosis...
  75. doi request reprint Vascular cell adhesion molecule 1 as a predictor of severe osteoarthritis of the hip and knee joints
    Georg Schett
    Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:2381-9. 2009
    ..Osteoarthritis (OA) is a leading cause of pain and physical disability in middle-aged and older individuals. We undertook this study to determine predictors of the development of severe OA, apart from age and overweight...
  76. doi request reprint Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
    Gisela Ruiz Heiland
    Department of Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 69:2152-9. 2010
    ..It was hypothesised that impaired bone formation is a key component in inflammatory bone loss and that Dkk-1, a Wnt antagonist, is a strong inhibitor of osteoblast-mediated bone formation...
  77. doi request reprint IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss
    Mario M Zaiss
    Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    J Immunol 186:6097-105. 2011
    ..Thus, we show in this study that IL-33 is an important bone-protecting cytokine and may be of therapeutic benefit in treating bone resorption...
  78. pmc Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells
    Silke Meister
    IZKF N2, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Neoplasia 12:550-61. 2010
    ..Thus, the combination of bortezomib with verapamil may improve the efficacy of proteasome inhibitory therapy...
  79. doi request reprint The early marginal zone B cell-initiated T-independent type 2 response resists the proteasome inhibitor bortezomib
    Veronika R Lang
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 185:5637-47. 2010
    ..In contrast, the early T-independent type 2 response protecting the organism against blood-borne pathogens remains largely intact due to a remarkable resistance of MZ B cells against proteasome inhibition...
  80. pmc Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus
    Barbara G Fürnrohr
    Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 69:1983-9. 2010
    ..Heat shock proteins (Hsps) play a role in the delivery and presentation of antigenic peptides and are thought to be involved in the pathogenesis of multifactorial diseases...
  81. doi request reprint Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis
    Catherine Skhirtladze
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:1475-84. 2008
    ..Src kinases are nonreceptor tyrosine kinases, which have been implicated in cytoskeletal organization and cell mobility. This study was undertaken to evaluate the potential of Src kinases as novel targets of antifibrotic therapies...
  82. doi request reprint Synovial immunopathology in haemochromatosis arthropathy
    Gisela Ruiz Heiland
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Ann Rheum Dis 69:1214-9. 2010
    ..Hereditary haemochromatosis (HH) is a common autosomal recessive inherited disorder that frequently causes arthritis. The pathophysiology of musculoskeletal involvement is, however, unclear...
  83. doi request reprint Repair of bone erosions in rheumatoid arthritis treated with tumour necrosis factor inhibitors is based on bone apposition at the base of the erosion
    Stephanie Finzel
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 70:1587-93. 2011
    ..To investigate whether bone erosions in patients with rheumatoid arthritis (RA) show evidence of repair...
  84. doi request reprint TNF and bone
    Jean Pierre David
    Rheumatology and Immunology, Department of Internal Medicine 3, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Curr Dir Autoimmun 11:135-44. 2010
    ..The role of TNF-alpha in mediating bone remodeling will be presented and discussed in this chapter...
  85. doi request reprint A case report of plasma exchange, steroids, mycophenolate mofetil and cyclophosphamide in acquired factor VIII inhibitors
    Jürgen Rech
    Medical Department 3, Division of Rheumatology, University of Erlangen Nuremberg, Munich, Germany
    Ther Apher Dial 12:406-8. 2008
    ..Hence, we present a case of severe idiopathic FVIII inhibitor-positive hemophilia successfully treated with the combination of plasma exchange, corticosteroids, cyclophosphamide and MMF...
  86. ncbi request reprint Sodium and potassium urate crystals differ in their inflammatory potential
    Christine Schorn
    Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Autoimmunity 42:314-6. 2009
    ..These results show that the cation of urate crystals determines the response of innate immune cells, indicating that the micromilieu at the site of crystal formation is important for their inflammatory potential...
  87. ncbi request reprint Treatment with DNAse I fosters binding to nec PBMC of CRP
    Christina Janko
    Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Autoimmunity 42:286-8. 2009
    ..Consequently, reduced DNase I activity in patients with SLE may contribute to the impaired opsonisation by CRP of dead cells, exacerbating the clearance defect in SLE of apo and nec cells...
  88. doi request reprint CCL17/thymus and activation-related chemokine in Churg-Strauss syndrome
    Tomas Dallos
    University of Erlangen Nuremberg, Erlangen, Germany Comenius University in Bratislava, Bratislava, Slovakia
    Arthritis Rheum 62:3496-503. 2010
    ..CCL17/thymus and activation-regulated chemokine (TARC) is a chemokine responsible for the recruitment of Th2 cells. This study was undertaken to explore a possible role of CCL17/TARC in CSS...
  89. doi request reprint Eotaxin-3 in Churg-Strauss syndrome: a clinical and immunogenetic study
    Jochen Zwerina
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Rheumatology (Oxford) 50:1823-7. 2011
    ..To determine the potential of eotaxin-3 as a diagnostic marker for active disease and genetic susceptibility factor for Churg-Strauss syndrome (CSS)...
  90. doi request reprint Can we stop progression of ankylosing spondylitis?
    Georg Schett
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Best Pract Res Clin Rheumatol 24:363-71. 2010
    ..The article reviews the current knowledge regarding the mechanisms and clinical role of ankylosis and explains strategies on how to prevent it in patients with ankylosing spondylitis...
  91. pmc Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis
    Christian Beyer
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 11:220. 2009
    ..Altogether, hypoxia might play a central role in pathogenesis of SSc by augmenting vascular disease and tissue fibrosis...
  92. doi request reprint Elevated Fra-1 expression causes severe lipodystrophy
    Julia Luther
    Department of Internal Medicine 3, University of Erlangen Nuremberg, D91054 Erlangen, Germany
    J Cell Sci 124:1465-76. 2011
    ....
  93. doi request reprint Dysbalance of angiogenic and angiostatic mediators in patients with mixed connective tissue disease
    Jörg H W Distler
    Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen Nuremberg, Germany
    Ann Rheum Dis 70:1197-202. 2011
    ..Vascular disease is common in mixed connective tissue disease (MCTD). The aim of the present study was to investigate, whether dysbalance of angiogenic and angiostatic factors occurs in MCTD...
  94. doi request reprint Pharmacotherapy: concepts of pathogenesis and emerging treatments. Novel targets in bone and cartilage
    Christian Beyer
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Best Pract Res Clin Rheumatol 24:489-96. 2010
    ..Future therapies will likely target the pathologic activity of these molecular pathways to specifically block either catabolic or anabolic joint remodelling in arthritis...
  95. ncbi request reprint The lonely death: chondrocyte apoptosis in TNF-induced arthritis
    Karin Polzer
    Department of Internal Medicine 3, Institute of Clinical Immunology, University of Erlangen, Erlangen, Germany
    Autoimmunity 40:333-6. 2007
    ..These data indicate that chondrocyte death may play a primary role in inflammatory arthritis fueling cartilage inflammation and damage due to secondary necrosis...
  96. doi request reprint Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high-resolution computed tomography
    Christian M Stach
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:330-9. 2010
    ..To define the nature of structural bone changes in patients with rheumatoid arthritis (RA) compared with those in healthy individuals by using the novel technique of high-resolution microfocal computed tomography (micro-CT)...
  97. doi request reprint The controversial role of tumor necrosis factor alpha in fibrotic diseases
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:2228-35. 2008
  98. doi request reprint Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Universitätsstr 29, 91054 Erlangen, Germany
    FASEB J 22:2214-22. 2008
    ..Thus, we provide the first evidence that dasatinib and nilotinib might be promising drugs for the treatment of patients with SSc...
  99. doi request reprint Binary segmentation masks can improve intrasubject registration accuracy of bone structures in CT images
    Oleg Museyko
    Institute for Medical Physics, University of Erlangen Nuremberg, Henkestrasse 91, Erlangen, Germany
    Ann Biomed Eng 38:2464-72. 2010
    ..The use of binary VOI masks was significantly superior to the use of gray value VOIs...
  100. ncbi request reprint Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 56:311-22. 2007
    ..This study was undertaken to test the potential use of imatinib mesylate as an antifibrotic drug for the treatment of dermal fibrosis in systemic sclerosis (SSc)...
  101. doi request reprint Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease
    Jörg H W Distler
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 58:2538-42. 2008
    ..These findings suggest that imatinib mesylate might be effective in patients with fibrotic diseases and warrant the initiation of larger clinical studies on the safety and efficacy of imatinib mesylate in connective tissue diseases...