Ralph Theo Schermuly

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi request reprint Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature
    Manish Mittal
    University of Giessen Lung Center, Medical Clinic II V, Giessen, Germany
    Circ Res 101:258-67. 2007
  2. ncbi request reprint Comparison of pharmacokinetics and vasodilatory effect of nebulized and infused iloprost in experimental pulmonary hypertension: rapid tolerance development
    Ralph Theo Schermuly
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Aerosol Med 19:353-63. 2006
  3. doi request reprint Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension
    Robert Voswinckel
    Department of Internal Medicine, University of Giessen Lung Center, University Hospital Giessen and Marburg GmbH, Giessen, Germany
    Pulm Pharmacol Ther 21:824-32. 2008
  4. ncbi request reprint Hypoxia-induced pulmonary hypertension: different impact of iloprost, sildenafil, and nitric oxide
    Norbert Weissmann
    University of Giessen Lung Center UGLC, Medical Clinic II V, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Respir Med 101:2125-32. 2007
  5. pmc The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats
    Michaela Lang
    University of Giessen and Marburg Lung Center, Giessen, Germany
    PLoS ONE 7:e43433. 2012
  6. ncbi request reprint Basic features of hypoxic pulmonary vasoconstriction in mice
    Norbert Weissmann
    Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Respir Physiol Neurobiol 139:191-202. 2004
  7. ncbi request reprint Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies
    Robert Voswinckel
    Department of Internal Medicine, University Hospital Giessen, Giessen, Germany
    J Am Coll Cardiol 48:1672-81. 2006
  8. doi request reprint Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension
    Robert Voswinckel
    University of Giessen Lung Center, Department of Internal Medicine, University Hospital Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Pulm Pharmacol Ther 22:50-6. 2009
  9. ncbi request reprint A combination hybrid-based vaccination/adoptive cellular therapy to prevent tumor growth by involvement of T cells
    Rajkumar Savai
    Department of Hematology, Universitätsklinikum Giessen und Marburg GmbH, Giessen, Germany
    Cancer Res 67:5443-53. 2007
  10. doi request reprint Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension
    Ying Ju Lai
    University of Giessen Lung Centre, Giessen, Germany
    Am J Respir Crit Care Med 178:188-96. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature
    Manish Mittal
    University of Giessen Lung Center, Medical Clinic II V, Giessen, Germany
    Circ Res 101:258-67. 2007
    ..5-fold upregulated. These results support an important role for NOX4 in the vascular remodeling associated with development of pulmonary hypertension...
  2. ncbi request reprint Comparison of pharmacokinetics and vasodilatory effect of nebulized and infused iloprost in experimental pulmonary hypertension: rapid tolerance development
    Ralph Theo Schermuly
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Aerosol Med 19:353-63. 2006
    ..Surprisingly, rapid tolerance development to the vasodilatory effect of iloprost is noted, occurring even with fully maintained perfusate levels of this agent...
  3. doi request reprint Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension
    Robert Voswinckel
    Department of Internal Medicine, University of Giessen Lung Center, University Hospital Giessen and Marburg GmbH, Giessen, Germany
    Pulm Pharmacol Ther 21:824-32. 2008
    ..We investigated the safety and acute haemodynamic effects of the combination oral sildenafil and inhaled treprostinil in an open label study in patients with precapillary pulmonary hypertension...
  4. ncbi request reprint Hypoxia-induced pulmonary hypertension: different impact of iloprost, sildenafil, and nitric oxide
    Norbert Weissmann
    University of Giessen Lung Center UGLC, Medical Clinic II V, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Respir Med 101:2125-32. 2007
    ..Against this background, we compared the effects of inhaled NO, infused iloprost, a stable prostacyclin analogue, and oral sildenafil, a phosphodiesterase 5 inhibitor, on hypoxia-induced pulmonary hypertension...
  5. pmc The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats
    Michaela Lang
    University of Giessen and Marburg Lung Center, Giessen, Germany
    PLoS ONE 7:e43433. 2012
    ....
  6. ncbi request reprint Basic features of hypoxic pulmonary vasoconstriction in mice
    Norbert Weissmann
    Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Respir Physiol Neurobiol 139:191-202. 2004
    ..In summary, we have characterised HPV and established an experimental set-up optimized for investigation of the basic mechanisms of HPV in mice...
  7. ncbi request reprint Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies
    Robert Voswinckel
    Department of Internal Medicine, University Hospital Giessen, Giessen, Germany
    J Am Coll Cardiol 48:1672-81. 2006
    ..This study sought to investigate the effects of inhaled treprostinil on pulmonary hemodynamics and gas exchange in severe pulmonary hypertension...
  8. doi request reprint Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension
    Robert Voswinckel
    University of Giessen Lung Center, Department of Internal Medicine, University Hospital Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Pulm Pharmacol Ther 22:50-6. 2009
    ..Unique drug characteristics may render this prostanoid feasible for inhalation therapy with a metered dose inhaler...
  9. ncbi request reprint A combination hybrid-based vaccination/adoptive cellular therapy to prevent tumor growth by involvement of T cells
    Rajkumar Savai
    Department of Hematology, Universitätsklinikum Giessen und Marburg GmbH, Giessen, Germany
    Cancer Res 67:5443-53. 2007
    ..Our findings indicate that the combination therapy of dendritic cell-tumor cell HC-Vacc/ACT is a very effective and a promising immunotherapeutic regimen against poorly immunogenic carcinomas...
  10. doi request reprint Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension
    Ying Ju Lai
    University of Giessen Lung Centre, Giessen, Germany
    Am J Respir Crit Care Med 178:188-96. 2008
    ..However, there is evidence that patients with severe pulmonary hypertension have decreased expression of the IP receptor in the remodeled pulmonary arterial smooth muscle...
  11. pmc Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors
    Ralph Theo Schermuly
    Medical Clinic II V, Justus Liebig University Giessen, 35392 Giessen, Germany
    Respir Res 6:76. 2005
    ..The prominent effect of sildenafil may be operative via both PDE1 and PDE5, and is further enhanced by co-application of a PDE3 inhibitor...
  12. ncbi request reprint Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension
    Ralph Theo Schermuly
    Department of Internal Medicine, Justus Liebig University Giessen, Germany
    Circ Res 94:1101-8. 2004
    ..This regimen may therefore offer a possible antiremodeling therapy in severe pulmonary hypertension...
  13. ncbi request reprint Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension
    Ralph Theo Schermuly
    Department of Internal Medicine, Justus Liebig Universitat Giessen, Germany
    Am J Respir Crit Care Med 172:358-63. 2005
    ..Inhaled iloprost is an effective therapy for pulmonary arterial hypertension (PAH). However, no study to date has addressed the effects of inhaled iloprost on changes to pulmonary vascular structure that occur in PAH...
  14. pmc Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration
    Soni Pullamsetti
    University of Giessen Lung Center, Medical Clinic II V, Giessen, Germany
    Respir Res 6:128. 2005
    ..The aim of the study was to assess the chronic effects of combined phosphodiesterase 3/4 inhibitor tolafentrine, administered by inhalation, during monocrotaline-induced pulmonary arterial hypertension (PAH) in rats...
  15. pmc Evaluation of angiogenesis using micro-computed tomography in a xenograft mouse model of lung cancer
    Rajkumar Savai
    Department of Hematology and Oncology, Justus Liebig University, Giessen, Germany
    Neoplasia 11:48-56. 2009
    ..Therefore, micro-CT is a novel method for investigating lung tumor angiogenesis, and this might be considered as an additional complementary tool for precise quantification of angiogenesis...
  16. ncbi request reprint Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling
    Rio Dumitrascu
    Medical Clinic II V, University Hospital, Giessen, Germany
    Circulation 113:286-95. 2006
    ....
  17. doi request reprint Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension
    Christine Veith
    Universities of Giessen and Marburg Lung Center, Giessen, Germany
    Proteomics 13:75-88. 2013
    ..These very early changes allowed us to identify potential triggers of PH. Thus, respective 2DE analysis can lead to the identification of new target proteins for the possible treatment of PH...
  18. pmc Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4
    Ewa Kolosionek
    University of Giessen Lung Centre, Giessen, Germany
    Mol Biol Cell 20:4751-65. 2009
    ..Thus, targeting PDE4 isoforms may be a novel approach to attenuate EMT-associated lung diseases such as pulmonary fibrosis and lung cancer...
  19. doi request reprint Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction
    Beate Fuchs
    Excellence Cluster Cardio Pulmonary System, University of Giessen Lung Center, Department of Internal Medicine II, Justus Liebig University Giessen, Aulweg 130, 35392 Giessen, Germany
    Respir Physiol Neurobiol 174:282-91. 2010
    ..However, there is controversy whether ROS levels decrease or increase during hypoxia. With this background we summarize the current knowledge on the role of ROS and redox state in HPV...
  20. ncbi request reprint Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs
    Ralph Theo Schermuly
    Department of Internal Medicine, Justus Liebig University, Klinikstrasse 36, D 35392 Giessen, Germany
    J Pharmacol Exp Ther 303:741-5. 2002
    ..The lung is capable of metabolizing iloprost via beta-oxidation, and more rapid appearance of dinor- and tetranoriloprost is noted for the inhalative as compared with the intravascular route of iloprost administration...
  21. pmc Reversal of experimental pulmonary hypertension by PDGF inhibition
    Ralph Theo Schermuly
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Clin Invest 115:2811-21. 2005
    ..This regimen offers a unique novel approach for antire-modeling therapy in progressed pulmonary hypertension...
  22. doi request reprint PAR-2 inhibition reverses experimental pulmonary hypertension
    Grazyna Kwapiszewska
    Department of Internal Medicine, University of Giessen Lung Centre, Germany
    Circ Res 110:1179-91. 2012
    ..Accumulating evidence suggests that mast cell mediators play a role in the pathogenesis of PH...
  23. ncbi request reprint Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension
    Soni Pullamsetti
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    FASEB J 19:1175-7. 2005
    ..Suppression of endothelial DDAH2 expression and function represents an important underlying mechanism...
  24. ncbi request reprint Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock
    Soni Savai Pullamsetti
    Departmennt of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Thromb Haemost 95:720-7. 2006
    ....
  25. doi request reprint The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis
    Wiebke Janssen
    Department of Internal Medicine, Member of the German Center for Lung Research, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center UGMLC, Germany
    J Pathol 229:242-9. 2013
    ....
  26. pmc Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling
    Xia Tian
    Medical Clinic II V, University Hospital, Giessen, Germany
    PLoS ONE 6:e18136. 2011
    ..The present study is the first to demonstrate a central role of PDE10A in progressive pulmonary vascular remodeling, and the results suggest a novel therapeutic approach for the treatment of PH...
  27. doi request reprint PDGF receptor and its antagonists: role in treatment of PAH
    Friedrich Grimminger
    University Hospital, Medical Clinic II V, Giessen, Germany
    Adv Exp Med Biol 661:435-46. 2010
    ..This book chapter describes the role of the platelet derived growth factor (PDGF) receptor and its antagonists for treatment of pulmonary hypertension...
  28. pmc Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension
    Piotr Sklepkiewicz
    Medical Clinic II V, University Hospital, Giessen, Germany
    PLoS ONE 6:e18883. 2011
    ..Glycogen synthase kinase 3beta (GSK3ß) is a serine/threonine kinase and can act as a downstream regulatory switch for numerous signaling pathways. Hence, we hypothesized that GSK3ß plays a crucial role in pulmonary vascular remodeling...
  29. ncbi request reprint Mast cell Chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
    Djuro Kosanovic
    Universities of Giessen and Marburg Lung Center UGMLC, Member of the German Center for Lung Research, Giessen, Germany
    Histol Histopathol 28:691-9. 2013
    ..Moreover, the findings from animal model studies will be discussed to highlight the chymase inhibitors as a promising strategy for the treatment of pulmonary fibrosis...
  30. ncbi request reprint Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension
    Hossein Ardeschir Ghofrani
    Department of Internal Medicine, University Hospital, Justus Liebig University, Klinikstrasse 36, 35392 Giessen, Germany
    Ann Intern Med 136:515-22. 2002
    ..Inhalation of the stable prostacyclin analogue iloprost is being studied for treatment of pulmonary hypertension. The selective phosphodiesterase-5 inhibitor sildenafil has been reported to cause pulmonary vasodilatation...
  31. doi request reprint Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not
    Andrea Mietens
    Institute of Anatomy and Cell Biology, Justus Liebig University Giessen, 35385 Giessen, Germany
    Mol Cell Endocrinol 349:145-53. 2012
    ....
  32. ncbi request reprint Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide
    Norbert Weissmann
    Department of Internal Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany
    Am J Physiol Heart Circ Physiol 284:H931-8. 2003
    ..Long-term NO inhalation partially maintains the strength of the hypoxic vasoconstrictor response...
  33. pmc Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation
    Katja Hattar
    Department of Internal Medicine IV V, University of Giessen and Marburg Lung Center UGMLC, Klinikstrasse 33, Giessen, Germany
    Cancer Immunol Immunother 62:309-20. 2013
    ..In summary, LPS induces proliferation of NSCLC cells in vitro, ex vivo in human NSCLC specimen and in vivo in a mouse model of NSCLC. Pulmonary infection may thus directly induce tumor progression in NSCLC...
  34. doi request reprint Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling
    Baktybek Kojonazarov
    Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center UGMLC, Member of the German Center for Lung Research, Germany
    Int J Cardiol 167:2630-7. 2013
    ..We sought to investigate the effects of the multikinase inhibitors sunitinib (PDGFR-, VEGFR- and KIT-inhibitor) and sorafenib (raf1/b-, VEGFR-, PDGFR-inhibitor) on pressure overload induced right ventricular (RV) remodeling...
  35. pmc Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange
    Norbert Weissmann
    University of Giessen Lung Center UGLC, Department of Internal Medicine II V, Klinikstrasse 36, 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 103:19093-8. 2006
    ..We conclude that TRPC6 plays a unique and indispensable role in acute hypoxic pulmonary vasoconstriction. Manipulation of TRPC6 function may thus offer a therapeutic strategy for the control of pulmonary hemodynamics and gas exchange...
  36. ncbi request reprint Hybrid-primed lymphocytes and hybrid vaccination prevent tumor growth of lewis lung carcinoma in mice
    Rajkumar Savai
    Department of Hematology and Oncology, Medical Center University of Giessen, Giessen, Germany
    J Immunother 29:175-87. 2006
    ..Taken together, we demonstrate that HCs offer effective immunotherapy of poorly immunogenic carcinomas. This is independent of whether the HCs are taken for adoptive transfer or as a vaccine...
  37. doi request reprint The role of cGMP in the physiological and molecular responses of the right ventricle to pressure overload
    Wiebke Janssen
    Pulmonary Pharmacotherapy, Universities of Giessen and Marburg Lung Center UGMLC, Excellence Cluster Cardio Pulmonary System ECCPS, Member of German Center for Lung Research, Giessen, Germany
    Exp Physiol 98:1274-8. 2013
    ..In this report, we discuss myocardial regulatory effects of cGMP-PDE5 signalling in preclinical models of RV pressure overload for understanding the physiological/pathophysiological mechanisms involved in maladaptive RVH. ..
  38. ncbi request reprint Small-dose nitric oxide improves oxygenation during one-lung ventilation: an experimental study
    Jochen Sticher
    Department of Anaesthesiology and Intensive Care Medicine, Justus Liebig University, Giessen, Germany
    Anesth Analg 95:1557-62, table of contents. 2002
    ..The authors conclude that NO improves arterial oxygenation more effectively at smaller doses than at larger doses. This dose-dependent effect remains to be confirmed in acute hypoxemia during OLV...
  39. ncbi request reprint In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase
    Martin D Lehner
    Department of Pharmacology, ALTANA Pharma AG, Konstanz, Germany
    J Pharmacol Exp Ther 317:181-7. 2006
    ..Taken together, BYK191023 is a member of a novel class of highly isoform-selective iNOS inhibitors with promising in vivo activity suitable for mechanistic studies on the role of selective iNOS inhibition as well as clinical development...
  40. ncbi request reprint Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy
    Ralph Theo Schermuly
    University of Giessen Lung Centre, Justus Liebig Universitat Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Circulation 115:2331-9. 2007
    ..The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation...
  41. ncbi request reprint Oxygen sensors in hypoxic pulmonary vasoconstriction
    Norbert Weissmann
    University of Giessen Lung Center UGLC, Medical Clinic II, Justus Liebig University, Germany
    Cardiovasc Res 71:620-9. 2006
    ..Within this context, this review focuses on current concepts in the oxygen sensing mechanisms that underlie HPV...