C M Schempp

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint Effect of oral administration ofHypericum perforatum extract (St. John's Wort) on skin erythema and pigmentation induced by UVB, UVA, visible light and solar simulated radiation
    Christoph M Schempp
    Department of Dermatology, University of Freiburg, Hauptstr 7, 79104 Freiburg, Germany
    Phytother Res 17:141-6. 2003
  2. ncbi request reprint [St. John's wort (Hypericum perforatum L.). A plant with relevance for dermatology]
    C M Schempp
    Universitäts Hautklinik, Haupstrasse, 7, 79104 Freiburg
    Hautarzt 53:316-21. 2002
  3. ncbi request reprint [Plant-induced toxic and allergic dermatitis (phytodermatitis)]
    C M Schempp
    Universitatshautklinik, Haupstrasse 7, 79104 Freiburg
    Hautarzt 53:93-7. 2002
  4. ncbi request reprint Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis
    Christoph M Schempp
    Department of Dermatology, University of Freiburg, Hauptstrasse 7, D 79104 Freiburg, Germany
    Oncogene 21:1242-50. 2002
  5. ncbi request reprint Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8
    C M Schempp
    Department of Dermatology, University of Freiburg, Hauptstrasse 7, D 79104, Freiburg, Germany
    FEBS Lett 493:26-30. 2001
  6. ncbi request reprint Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokines
    C M Schempp
    Department of Dermatology, University of Freiburg, Freiburg, Germany
    J Invest Dermatol 115:680-6. 2000
  7. ncbi request reprint Topical treatment of atopic dermatitis with St. John's wort cream--a randomized, placebo controlled, double blind half-side comparison
    Christoph M Schempp
    Freiburg University Clinic, Department of Dermatology, Freiburg, Germany
    Phytomedicine 10:31-7. 2003
  8. doi request reprint Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test
    J Reuter
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    Skin Pharmacol Physiol 21:106-10. 2008
  9. ncbi request reprint Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells
    C M Schempp
    Department of Dermatology, Photodermatology Unit, University Medical Center, Haupstr 7, D 79104 Freiburg, Germany
    Br J Dermatol 142:979-84. 2000
  10. ncbi request reprint Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort)
    C M Schempp
    Department of Dermatology, University of Freiburg, Germany
    Skin Pharmacol Appl Skin Physiol 12:299-304. 1999

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Effect of oral administration ofHypericum perforatum extract (St. John's Wort) on skin erythema and pigmentation induced by UVB, UVA, visible light and solar simulated radiation
    Christoph M Schempp
    Department of Dermatology, University of Freiburg, Hauptstr 7, 79104 Freiburg, Germany
    Phytother Res 17:141-6. 2003
    ..This is in accordance with previous pharmacokinetic studies that found hypericin serum and skin levels after oral ingestion of Hypericum extract always to be lower than the assumed phototoxic hypericin threshold level of 1000 ng/mL...
  2. ncbi request reprint [St. John's wort (Hypericum perforatum L.). A plant with relevance for dermatology]
    C M Schempp
    Universitäts Hautklinik, Haupstrasse, 7, 79104 Freiburg
    Hautarzt 53:316-21. 2002
    ..Blood levels of these drugs were dramatically decreased by St. John's wort. This should be considered in the treatment of skin conditions with antiviral drugs or cyclosporin...
  3. ncbi request reprint [Plant-induced toxic and allergic dermatitis (phytodermatitis)]
    C M Schempp
    Universitatshautklinik, Haupstrasse 7, 79104 Freiburg
    Hautarzt 53:93-7. 2002
    ..The present paper reviews the various forms of phytodermatitis, including irritant plant dermatitis, phototoxic and photo-allergic dermatitis, allergic dermatitis, and airborne contact dermatitis...
  4. ncbi request reprint Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis
    Christoph M Schempp
    Department of Dermatology, University of Freiburg, Hauptstrasse 7, D 79104 Freiburg, Germany
    Oncogene 21:1242-50. 2002
    ....
  5. ncbi request reprint Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8
    C M Schempp
    Department of Dermatology, University of Freiburg, Hauptstrasse 7, D 79104, Freiburg, Germany
    FEBS Lett 493:26-30. 2001
    ..Anti-TNF-R1 antibody had no effect. These findings suggest that HYP photo-induced apoptosis of Jurkat cells is mediated in part by the TRAIL/TRAIL-receptor system and subsequent activation of upstream caspases...
  6. ncbi request reprint Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokines
    C M Schempp
    Department of Dermatology, University of Freiburg, Freiburg, Germany
    J Invest Dermatol 115:680-6. 2000
    ..These findings demonstrate that magnesium ions specifically inhibit the antigen-presenting capacity of Langerhans cells and may thus contribute to the efficacy of Dead Sea water in the treatment of inflammatory skin diseases...
  7. ncbi request reprint Topical treatment of atopic dermatitis with St. John's wort cream--a randomized, placebo controlled, double blind half-side comparison
    Christoph M Schempp
    Freiburg University Clinic, Department of Dermatology, Freiburg, Germany
    Phytomedicine 10:31-7. 2003
    ..Recent investigations suggest an anti-inflammatory and antibacterial effect of hyperforin, which is a major constituent of Hypericum perforatum L. (Saint John's wort)...
  8. doi request reprint Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test
    J Reuter
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    Skin Pharmacol Physiol 21:106-10. 2008
    ..In the present study we aimed to explore the anti-inflammatory potential of a highly concentrated A. vera gel in the UV erythema test in vivo...
  9. ncbi request reprint Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells
    C M Schempp
    Department of Dermatology, Photodermatology Unit, University Medical Center, Haupstr 7, D 79104 Freiburg, Germany
    Br J Dermatol 142:979-84. 2000
    ....
  10. ncbi request reprint Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort)
    C M Schempp
    Department of Dermatology, University of Freiburg, Germany
    Skin Pharmacol Appl Skin Physiol 12:299-304. 1999
    ..5 ng/ml and the mean skin blister fluid level was 2.8 ng/ml. These skin levels are far below hypericin skin levels that are estimated to be phototoxic (>100 ng/ml)...
  11. doi request reprint Skin tolerance of a new bath oil containing St. John's wort extract
    J Reuter
    Competence Center skintegral, Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    Skin Pharmacol Physiol 21:306-11. 2008
    ..Dry and atopic skin requires skin care with lipid-rich emollients and moisturizing bath or shower oils. However, it has been shown recently that some bath oils may even impair the skin barrier...
  12. ncbi request reprint Anti-inflammatory effect of pimecrolimus in the sodium lauryl sulphate test
    K Engel
    Department of Dermatology, University Medical Center, Freiburg, Germany
    J Eur Acad Dermatol Venereol 22:447-50. 2008
    ..Pimecrolimus is a calcineurin inhibitor used for the topical treatment of inflammatory skin diseases. We have shown previously that pimecrolimus cream is not effective on intact skin in the ultraviolet erythema test...
  13. ncbi request reprint Salt water bathing prior to UVB irradiation leads to a decrease of the minimal erythema dose and an increased erythema index without affecting skin pigmentation
    C M Schempp
    Department of Dermatology, University of Freiburg, Germany
    Photochem Photobiol 69:341-4. 1999
    ..However, there is also an increased sunburn risk when salt water baths are followed by exposure to UV radiation...
  14. ncbi request reprint Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance
    S Weckesser
    Department of Dermatology, University of Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany
    Phytomedicine 14:508-16. 2007
    ..It is concluded that due to their antimicrobial effects some of the plant extracts may be used for the topical treatment of skin disorders like acne vulgaris and seborrhoic eczema...
  15. doi request reprint Dermocosmetics for dry skin: a new role for botanical extracts
    F Casetti
    Competence Center skintegral, Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    Skin Pharmacol Physiol 24:289-93. 2011
    ..However, more investigations on the mode of action and more vehicle-controlled studies are required...
  16. doi request reprint Double trouble from sunburn: UVB-induced erythema is associated with a transient decrease in skin pigmentation
    F Casetti
    Department of Dermatology, Competence Center skintegral, University Medical Center Freiburg, Freiburg, Germany
    Skin Pharmacol Physiol 24:160-5. 2011
    ..The early time course of erythema and pigmentation has so far not been monitored simultaneously by photometric measurements...
  17. ncbi request reprint Usnea barbata extract prevents ultraviolet-B induced prostaglandin E2 synthesis and COX-2 expression in HaCaT keratinocytes
    K Engel
    Department of Dermatology, University Medical Center Freiburg, Hauptstr 7, D 79104 Freiburg, Germany
    J Photochem Photobiol B 89:9-14. 2007
    ..Besides its known antimicrobial properties, UBE displays specific UVB protective effects that might be useful in the topical treatment of UVB-mediated inflammatory skin conditions...
  18. doi request reprint Reseda luteola L. extract displays antiproliferative and pro-apoptotic activities that are related to its major flavonoids
    U Woelfle
    Competence Center skintegral, Department of Dermatology, University Medical Center Freiburg, Hauptstr 7, D 79104 Freiburg, Germany
    Phytother Res 24:1033-6. 2010
    ..We conclude that Reseda extract is an interesting raw material not only for dyeing purposes but also for further pharmacological investigation...
  19. ncbi request reprint Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid
    T Ahrens
    Department of Dermatology, University of Freiburg, Hauptstrasse 7, D-79104, Freiburg, Germany
    Oncogene 20:3399-408. 2001
    ..Autocrine, or drug-induced secretion of solCD44 by human melanoma cells may thus exert potent antitumoral effects in vivo...
  20. ncbi request reprint The UV erythema test as a model to investigate the anti-inflammatory potency of topical preparations--reevaluation and optimization of the method
    A Jocher
    Universitäts Hautklinik, Albert Ludwigs Universitat Freiburg, Germany
    Skin Pharmacol Physiol 18:234-40. 2005
    ..The ultraviolet (UV) erythema test is one of the most frequently used methods to investigate the anti-inflammatory potency of topical dermatological preparations in vivo...
  21. doi request reprint A novel triterpene extract from mistletoe induces rapid apoptosis in murine B16.F10 melanoma cells
    C M Strüh
    Department of Dermatology, University Freiburg Medical Center, Freiburg, Germany
    Phytother Res 26:1507-12. 2012
    ..These findings suggest the use of STE from mistletoe as a solvent-free anticancer drug for preclinical animal experiments and clinical trials...
  22. doi request reprint Antimicrobial activity against bacteria with dermatological relevance and skin tolerance of the essential oil from Coriandrum sativum L. fruits
    F Casetti
    Competence Centre skintegral, Department of Dermatology, University Medical Centre Freiburg, Hauptstrasse 7, D 79104 Freiburg, Germany
    Phytother Res 26:420-4. 2012
    ....
  23. ncbi request reprint [Umbilicated blisters on sun-exposed skin]
    E Stancu
    Universitäts Hautklinik, Klinikum der Albert Ludwigs Universität Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany
    Hautarzt 58:343-6. 2007
  24. ncbi request reprint Hyperforin acts as an angiogenesis inhibitor
    Christoph M Schempp
    Department of Dermatology, University of Freiburg, Germany
    Planta Med 71:999-1004. 2005
    ..These data suggest that, in addition to the induction of tumor cell apoptosis, hyperforin can also suppress angiogenesis by a direct, non-toxic effect on endothelial cells...
  25. ncbi request reprint [Treatment of actinic keratoses with birch bark extract: a pilot study]
    Constance Huyke
    Universitäts Hautklinik, Hauptstr 7, D 79104 Freiburg
    J Dtsch Dermatol Ges 4:132-6. 2006
    ..Therefore, birch bark extract may be effective in the treatment of actinic keratoses. To address this issue, a pilot study using a standardized birch bark ointment was performed...
  26. ncbi request reprint Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis
    Constance Huyke
    Department of Dermatology, University Medical Center, Freiburg, Germany
    Planta Med 73:1116-26. 2007
    ..We conclude that non-polar SChisandra extracts obtained by CO(2) extraction might be useful in the prevention and treatment of hyperproliferative and inflammatory skin diseases...
  27. ncbi request reprint Physical, chemical and pharmacological characterization of a new oleogel-forming triterpene extract from the outer bark of birch (betulae cortex)
    Melanie Laszczyk
    Carl Gustav Carus Institut, Niefern Oschelbronn, Germany
    Planta Med 72:1389-95. 2006
    ..These experimental data support the notion from a previous clinical study that TE from the outer bark of birch might represent a new tool for the topical treatment of skin cancer and skin cancer precursors like actinic keratoses...
  28. ncbi request reprint Sage extract rich in phenolic diterpenes inhibits ultraviolet-induced erythema in vivo
    Juliane Reuter
    Department of Dermatology, University Medical Centre, Freiburg, Germany
    Planta Med 73:1190-1. 2007
    ..Compared to placebo, SE significantly reduced the ultraviolet-induced erythema, to a similar extent as hydrocortisone. These data suggest that SE might be useful in the topical treatment of inflammatory skin diseases...
  29. ncbi request reprint Solar simulator-induced phototoxicity of the furoquinoline alkaloid dictamnine compared to 8-methoxypsoralen and 5-methoxypsoralen
    Christoph M Schempp
    Department of Dermatology, University Medical Center, Freiburg, Germany
    Planta Med 72:941-3. 2006
    ..Nevertheless, it may play a major role in the elicitation of phytophotodermatitis because of its abundance in plants of the Rutaceae family...
  30. ncbi request reprint Plant phenolics inhibit neutrophil elastase
    Andrea Hrenn
    Institute for Pharmaceutical Sciences, Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Freiburg, Germany
    Planta Med 72:1127-31. 2006
    ..The phenolic genistein deserves special interest as an inhibitor of elastase release because its effect was remarkably potent (IC (50) = 0.6 microM)...
  31. ncbi request reprint Phototoxic and apoptosis-inducing capacity of pseudohypericin
    Christoph M Schempp
    Planta Med 68:171-3. 2002
    ..The cytotoxic potential of PH should be taken into account during systemic therapy with Hypericum extracts, since PH is about two times more abundant than H in Hypericum perforatum...