G Scheiner-Bobis

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi request reprint Palytoxin-induced channel formation within the Na+/K+-ATPase does not require a catalytically active enzyme
    G Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Eur J Biochem 248:717-23. 1997
  2. ncbi request reprint Glutamic acid 472 and lysine 480 of the sodium pump alpha 1 subunit are essential for activity. Their conservation in pyrophosphatases suggests their involvement in recognition of ATP phosphates
    G Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Biochemistry 38:9198-208. 1999
  3. ncbi request reprint Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps
    G Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 363:203-8. 2001
  4. ncbi request reprint Action of palytoxin on apical H+/K+-ATPase in rat colon
    Georgios Scheiner-Bobis
    Institute for Biochemistry and Endocrinology, Institute for Veterinary Physiology, Justus Liebig University Giessen, Germany
    Eur J Biochem 269:3905-11. 2002
  5. ncbi request reprint Signalling pathways involving sodium pump stimulate endothelin-1 secretion and nitric oxide production in endothelial cells
    G Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Justus Liebig Universitat Giessen, Fachbereich Veterinarmedizin, Giessen, Germany
    Cell Mol Biol (Noisy-le-grand) 52:58-63. 2006
  6. ncbi request reprint The sodium pump. Its molecular properties and mechanics of ion transport
    Georgios Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Eur J Biochem 269:2424-33. 2002
  7. ncbi request reprint Endogenous and exogenous cardiac glycosides and their mechanisms of action
    Wilhelm Schoner
    Institute of Biochemistry and Endocrinology, Justus Liebig University Giessen, Giessen, Germany
    Am J Cardiovasc Drugs 7:173-89. 2007
  8. ncbi request reprint Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth
    Wilhelm Schoner
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Frankfurter Str 100, Giessen, Germany
    Am J Physiol Cell Physiol 293:C509-36. 2007
  9. ncbi request reprint Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer
    Wilhelm Schoner
    Institut für Biochemie und Endokrinologie, Justus Liebig Universitat Giessen, Giessen, Germany
    Semin Nephrol 25:343-51. 2005
  10. doi request reprint Histological, hormonal and biomolecular analysis of the pathogenesis of ovine Prolapsus vaginae ante partum
    S Ennen
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Faculty of Veterinary Medicine, Justus Liebig University, Frankfurter Str 106, 35392 Giessen, Germany
    Theriogenology 75:212-9. 2011

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Palytoxin-induced channel formation within the Na+/K+-ATPase does not require a catalytically active enzyme
    G Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Eur J Biochem 248:717-23. 1997
    ..Since ion fluxes through the sodium pump protein do not depend on ATP hydrolysis, the results suggest that the ionophores of pumps and ion channels might share common structural features...
  2. ncbi request reprint Glutamic acid 472 and lysine 480 of the sodium pump alpha 1 subunit are essential for activity. Their conservation in pyrophosphatases suggests their involvement in recognition of ATP phosphates
    G Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Biochemistry 38:9198-208. 1999
    ....
  3. ncbi request reprint Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps
    G Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 363:203-8. 2001
    ..5+/-4.3 microM, all indicate that sanguinarine specifically targets the sodium pump, and that the observed K+ outflow is tightly associated with the presence of the enzyme...
  4. ncbi request reprint Action of palytoxin on apical H+/K+-ATPase in rat colon
    Georgios Scheiner-Bobis
    Institute for Biochemistry and Endocrinology, Institute for Veterinary Physiology, Justus Liebig University Giessen, Germany
    Eur J Biochem 269:3905-11. 2002
    ..Consequently, the pore-forming action of palytoxin is not restricted to Na+/K+-ATPase but is also observed with the colonic H+/K+-ATPase...
  5. ncbi request reprint Signalling pathways involving sodium pump stimulate endothelin-1 secretion and nitric oxide production in endothelial cells
    G Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Justus Liebig Universitat Giessen, Fachbereich Veterinarmedizin, Giessen, Germany
    Cell Mol Biol (Noisy-le-grand) 52:58-63. 2006
    ..This reaction cascade reaches its maximum approximately 30 min after exposure to the steroid. The results indicate that ouabain or similar compounds might actively participate in the regulation of vascular tone...
  6. ncbi request reprint The sodium pump. Its molecular properties and mechanics of ion transport
    Georgios Scheiner-Bobis
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Eur J Biochem 269:2424-33. 2002
    ....
  7. ncbi request reprint Endogenous and exogenous cardiac glycosides and their mechanisms of action
    Wilhelm Schoner
    Institute of Biochemistry and Endocrinology, Justus Liebig University Giessen, Giessen, Germany
    Am J Cardiovasc Drugs 7:173-89. 2007
    ..It lowers BP in ouabain- and adducin-dependent hypertension in rats and is a promising new class of antihypertensive medication in humans...
  8. ncbi request reprint Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth
    Wilhelm Schoner
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Frankfurter Str 100, Giessen, Germany
    Am J Physiol Cell Physiol 293:C509-36. 2007
    ..Bufalin and oleandrin or the cardenolide analog UNBS-1450 block tumor cell proliferation and induce apoptosis at low concentrations in tumors with constitutive activation of NF-kappaB...
  9. ncbi request reprint Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer
    Wilhelm Schoner
    Institut für Biochemie und Endokrinologie, Justus Liebig Universitat Giessen, Giessen, Germany
    Semin Nephrol 25:343-51. 2005
    ..Apparently, Na+/K+-ATPase is used by these steroids as a signal transducer to activate tissue proliferation, heart contractility, arterial hypertension, and natriuresis via various intracellular signaling pathways...
  10. doi request reprint Histological, hormonal and biomolecular analysis of the pathogenesis of ovine Prolapsus vaginae ante partum
    S Ennen
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Faculty of Veterinary Medicine, Justus Liebig University, Frankfurter Str 106, 35392 Giessen, Germany
    Theriogenology 75:212-9. 2011
    ..The biomolecular analysis led to the new result, that ewes suffering from vaginal prolapse show alterations in the antepartal metabolism of vaginal connective tissue...
  11. ncbi request reprint Ouabain activates signaling pathways associated with cell death in human neuroblastoma
    Andrey Kulikov
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universität Frankfurter Str 100, D 35392 Giessen, Germany
    Biochim Biophys Acta 1768:1691-702. 2007
    ....
  12. ncbi request reprint Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump
    Robert Saunders
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Eur J Biochem 271:1054-62. 2004
    ..The data also confirm that it is not a global inhibition of the sodium pump that is involved in the mechanism of action of this cardiac glycoside...
  13. ncbi request reprint Signaling pathways involving the sodium pump stimulate NO production in endothelial cells
    Alexander Eva
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Germany
    Biochim Biophys Acta 1758:1809-14. 2006
    ..Together with results from previous publications, the current investigation implies that the sodium pump is involved in vascular tone regulation...
  14. ncbi request reprint Lys691 and Asp714 of the Na+/K+-ATPase alpha subunit are essential for phosphorylation, dephosphorylation, and enzyme turnover
    Ping Su
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, Frankfurter Strasse 100, D 35392 Giessen, Germany
    Biochemistry 43:4731-40. 2004
    ..The results are consistent with Lys691 and Asp714 being essential for the phosphorylation/dephosphorylation process that allows the sodium pump to accomplish the catalytic cycle...
  15. ncbi request reprint The highly conserved extracellular peptide, DSYG(893-896), is a critical structure for sodium pump function
    Susanne Becker
    Institut für Biochemie und Endokrinologie, Fachbereich Veterinarmedizin, Justus Liebig Universitat Giessen, D 35392 Giessen, Germany
    Eur J Biochem 271:3821-31. 2004
    ..The results obtained here demonstrate the importance of the highly conserved peptide DSYG(893-896) for the function of alpha/beta heterodimeric P-type ATPases...