Bianca Schaub

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Obesity and asthma, what are the links?
    Bianca Schaub
    University Children s Hospital Munich, Munich, Germany
    Curr Opin Allergy Clin Immunol 5:185-93. 2005
  2. pmc Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression
    Bianca Schaub
    University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
    Respir Res 7:40. 2006
  3. doi request reprint Regulation of TH17 markers early in life through maternal farm exposure
    Anna Lluis
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Munich, Germany
    J Allergy Clin Immunol 133:864-71. 2014
  4. pmc T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative marker
    Jing Liu
    Department of Pulmonary and Allergy, University Children s Hospital Munich, Ludwig Maximilians Universitat Munich, Munich, Germany
    PLoS ONE 5:e13267. 2010
  5. ncbi request reprint Clinical and epidemiologic phenotypes of childhood asthma
    Martin Depner
    1 Dr von Hauner Children s Hospital, Ludwig Maximilians University Munich, Member of the German Center for Lung Research DZL, Munich, Germany
    Am J Respir Crit Care Med 189:129-38. 2014
  6. ncbi request reprint Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood
    Anna Lluis
    LMU Munich, University Children s Hospital, Munich, Germany
    J Allergy Clin Immunol 133:551-9. 2014
  7. pmc TBX21 and HLX1 polymorphisms influence cytokine secretion at birth
    Vera Isabel Casaca
    Department of Pulmonary and Allergy, University Childrens Hospital Munich, Munich, Germany
    PLoS ONE 7:e31069. 2012
  8. doi request reprint Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion
    Anna Lluis
    University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Germany
    J Allergy Clin Immunol 127:1587-94.e6. 2011
  9. doi request reprint IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years
    Diana Raedler
    University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Munich, Germany
    J Allergy Clin Immunol 131:789-96. 2013
  10. pmc Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression data
    Nikolaus Ballenberger
    University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Munich, Germany
    PLoS ONE 7:e46423. 2012

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Obesity and asthma, what are the links?
    Bianca Schaub
    University Children s Hospital Munich, Munich, Germany
    Curr Opin Allergy Clin Immunol 5:185-93. 2005
    ..The parallel time trend with an increasing prevalence of asthma has induced a lively debate about a potential link between both conditions...
  2. pmc Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression
    Bianca Schaub
    University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
    Respir Res 7:40. 2006
    ..However, little is known about the immunological effects of microbial stimulation on early immune responses and in association with maternal atopy...
  3. doi request reprint Regulation of TH17 markers early in life through maternal farm exposure
    Anna Lluis
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Munich, Germany
    J Allergy Clin Immunol 133:864-71. 2014
    ..However, the underlying mechanisms might involve immune modulation of additional T-cell populations, such as TH17 cells, influenced by genetic predisposition...
  4. pmc T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative marker
    Jing Liu
    Department of Pulmonary and Allergy, University Children s Hospital Munich, Ludwig Maximilians Universitat Munich, Munich, Germany
    PLoS ONE 5:e13267. 2010
    ..We assessed FOXP3 demethylation in cord blood in relation to previously used Treg markers such as CD4+CD25(hi), FOXP3 mRNA, protein expression, and suppressive Treg function...
  5. ncbi request reprint Clinical and epidemiologic phenotypes of childhood asthma
    Martin Depner
    1 Dr von Hauner Children s Hospital, Ludwig Maximilians University Munich, Member of the German Center for Lung Research DZL, Munich, Germany
    Am J Respir Crit Care Med 189:129-38. 2014
    ..Clinical and epidemiologic approaches have identified two distinct sets of classifications for asthma and wheeze phenotypes...
  6. ncbi request reprint Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood
    Anna Lluis
    LMU Munich, University Children s Hospital, Munich, Germany
    J Allergy Clin Immunol 133:551-9. 2014
    ..Underlying immunologic mechanisms are still not understood but might be modulated by immune-regulatory cells early in life, such as regulatory T (Treg) cells...
  7. pmc TBX21 and HLX1 polymorphisms influence cytokine secretion at birth
    Vera Isabel Casaca
    Department of Pulmonary and Allergy, University Childrens Hospital Munich, Munich, Germany
    PLoS ONE 7:e31069. 2012
    ..This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth...
  8. doi request reprint Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion
    Anna Lluis
    University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Germany
    J Allergy Clin Immunol 127:1587-94.e6. 2011
    ..Regulation of the 17q21 locus and its immunologic relevance early in life have not been well characterized...
  9. doi request reprint IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years
    Diana Raedler
    University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Munich, Germany
    J Allergy Clin Immunol 131:789-96. 2013
    ..Several IL10 single nucleotide polymorphisms (SNPs) were associated with inflammatory diseases, such as atopic diseases, which might have their onset during early immune maturation...
  10. pmc Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression data
    Nikolaus Ballenberger
    University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Munich, Germany
    PLoS ONE 7:e46423. 2012
    ..Additionally, complex and multiple immunological relationships need to be adjusted for potential confounding and interaction effects...
  11. doi request reprint Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
    Bianca Schaub
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Munich, Germany
    J Allergy Clin Immunol 123:774-82.e5. 2009
    ..Cross-sectional studies suggest that maternal exposure to farming decreases the risk of allergic diseases in offspring. The potential underlying immunologic mechanisms are not understood...
  12. doi request reprint Lesson from the farm environment
    Anna Lluis
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU, Munich, Germany
    Curr Opin Allergy Clin Immunol 12:158-63. 2012
    ..From these studies, novel insights into potential allergy-protective mechanisms were retrieved. This review focuses on consistent and novel findings of immune mechanisms involved in the 'farm effect'...
  13. ncbi request reprint The marketing of asthma and allergies
    Bianca Schaub
    University Children s Hospital, 80337 Munich, Germany
    Lancet 364:1389-90. 2004
  14. doi request reprint Impairment of T-regulatory cells in cord blood of atopic mothers
    Bianca Schaub
    Department of Pulmonary and Allergy, University Children s Hospital Munich, Munich, Germany
    J Allergy Clin Immunol 121:1491-9, 1499.e1-13. 2008
    ..The underlying mechanisms are ill defined, yet regulatory T (Treg) and T(H)17 cells may play a key role potentially shaping the early immune system toward a proallergic or antiallergic immune regulation...
  15. ncbi request reprint The many faces of the hygiene hypothesis
    Bianca Schaub
    University Children s Hospital Munich, Dr von Haunersches Kinderspital, Pediatric Pulmonary Division, LMU Munich, Germany
    J Allergy Clin Immunol 117:969-77; quiz 978. 2006
    ..Even if today practical implications cannot directly be deduced from these findings, there is great potential for the development of novel preventive and therapeutic strategies in the future...
  16. pmc Cord blood cytokines and acute lower respiratory illnesses in the first year of life
    Ngoc P Ly
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 119:e171-8. 2007
    ..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children...
  17. pmc Nuclear factor kappa B activation in human cord blood mononuclear cells
    Christian H Schroeter
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, U S A
    Pediatr Res 56:212-8. 2004
    ..Whether differential NF-kappaB activity in cord blood is related to the subsequent development of immune diseases requires further investigation...
  18. ncbi request reprint IRF-1 gene variations influence IgE regulation and atopy
    Michaela Schedel
    University Children s Hospital, Ludwig Maximilian s University Munich, Lindwurmstrasse 4, D 80337 M√ľnchen, Germany
    Am J Respir Crit Care Med 177:613-21. 2008
    ..The development of atopic diseases is characterized by skewed immune responses to common allergens. Only recently, interferons have been identified to play a crucial role in these mechanisms...
  19. pmc Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Allergy Clin Immunol 117:931-8. 2006
    ..However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development...
  20. pmc Prenatal, perinatal, and heritable influences on cord blood immune responses
    Ben M Willwerth
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Allergy Asthma Immunol 96:445-53. 2006
    ..Maternal and perinatal environmental exposures, as well as inherited factors, may influence neonatal immune responses...
  21. ncbi request reprint The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion
    Fiona K Gibbons
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    J Clin Immunol 25:437-44. 2005
    ..018) and allergen-specific lymphocyte proliferation (p = 0.02), while IL-13 secretion was unchanged (p = 0.109). This study indicates a role for Th1 cytokines as well as Th2 cytokines in the allergic response...
  22. ncbi request reprint Toll-like receptor 4 or 2 agonists decrease allergic inflammation
    German Velasco
    Respiratory and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 32:218-24. 2005
    ..Our findings also demonstrate that both TLR4 and TLR2 agonists decrease allergic responses, supporting the concept that exposure to bacterial components under defined conditions may protect against allergic disease...
  23. pmc TLR2 and TLR4 stimulation differentially induce cytokine secretion in human neonatal, adult, and murine mononuclear cells
    Bianca Schaub
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Interferon Cytokine Res 24:543-52. 2004
    ..Therefore, TLR2 and TLR4 stimuli differentially influence IL-13 and IFN-gamma secretion in neonates, adults, and mice, supporting a critical role for innate stimuli in the modulation of cytokine responses...
  24. ncbi request reprint Toll receptors modulate allergic responses: interaction with dendritic cells, T cells and mast cells
    Abdelouahab Bellou
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Allergy Clin Immunol 3:487-94. 2003
    ..The discovery of Toll-like receptors has generated much interest in understanding the impact of innate immunity on adaptive immune responses, including allergic diseases...