Research Topics
Genomes and GenesSpecies | Bianca SchaubSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
Obesity and asthma, what are the links?Bianca Schaub
University Children s Hospital Munich, Munich, Germany
Curr Opin Allergy Clin Immunol 5:185-93. 2005..The parallel time trend with an increasing prevalence of asthma has induced a lively debate about a potential link between both conditions...- T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative markerJing Liu
Department of Pulmonary and Allergy, University Children s Hospital Munich, Ludwig Maximilians Universitat Munich, Munich, Germany
PLoS ONE 5:e13267. 2010..We assessed FOXP3 demethylation in cord blood in relation to previously used Treg markers such as CD4+CD25(hi), FOXP3 mRNA, protein expression, and suppressive Treg function... - TBX21 and HLX1 Polymorphisms Influence Cytokine Secretion at BirthVera Isabel Casaca
Department of Pulmonary and Allergy, University Childrens Hospital Munich, Munich, Germany
PLoS ONE 7:e31069. 2012..This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth... - Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretionAnna Lluis
University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Germany
J Allergy Clin Immunol 127:1587-94.e6. 2011..Regulation of the 17q21 locus and its immunologic relevance early in life have not been well characterized... - Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cellsBianca Schaub
Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Munich, Germany
J Allergy Clin Immunol 123:774-82.e5. 2009..Cross-sectional studies suggest that maternal exposure to farming decreases the risk of allergic diseases in offspring. The potential underlying immunologic mechanisms are not understood... - Lesson from the farm environmentAnna Lluis
Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU, Munich, Germany
Curr Opin Allergy Clin Immunol 12:158-63. 2012..From these studies, novel insights into potential allergy-protective mechanisms were retrieved. This review focuses on consistent and novel findings of immune mechanisms involved in the 'farm effect'... - Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression dataNikolaus Ballenberger
University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Munich, Germany
PLoS ONE 7:e46423. 2012..Additionally, complex and multiple immunological relationships need to be adjusted for potential confounding and interaction effects... - Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expressionBianca Schaub
University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
Respir Res 7:40. 2006..However, little is known about the immunological effects of microbial stimulation on early immune responses and in association with maternal atopy... - The marketing of asthma and allergiesBianca Schaub
University Children's Hospital, 80337 Munich, Germany
Lancet 364:1389-90. 2004 - Impairment of T-regulatory cells in cord blood of atopic mothersBianca Schaub
Department of Pulmonary and Allergy, University Children s Hospital Munich, Munich, Germany
J Allergy Clin Immunol 121:1491-9, 1499.e1-13. 2008..The underlying mechanisms are ill defined, yet regulatory T (Treg) and T(H)17 cells may play a key role potentially shaping the early immune system toward a proallergic or antiallergic immune regulation... - The many faces of the hygiene hypothesisBianca Schaub
University Children s Hospital Munich, Dr von Haunersches Kinderspital, Pediatric Pulmonary Division, LMU Munich, Germany
J Allergy Clin Immunol 117:969-77; quiz 978. 2006..Even if today practical implications cannot directly be deduced from these findings, there is great potential for the development of novel preventive and therapeutic strategies in the future... - Cord blood cytokines and acute lower respiratory illnesses in the first year of lifeNgoc P Ly
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Pediatrics 119:e171-8. 2007..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children... - Nuclear factor kappa B activation in human cord blood mononuclear cellsChristian H Schroeter
Pulmonary and Critical Care Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, U.S.A
Pediatr Res 56:212-8. 2004..Whether differential NF-kappaB activity in cord blood is related to the subsequent development of immune diseases requires further investigation... - IRF-1 gene variations influence IgE regulation and atopyMichaela Schedel
University Children s Hospital, Ludwig Maximilian s University Munich, Lindwurmstrasse 4, D 80337 München, Germany
Am J Respir Crit Care Med 177:613-21. 2008..The development of atopic diseases is characterized by skewed immune responses to common allergens. Only recently, interferons have been identified to play a crucial role in these mechanisms... - Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gammaDiane R Gold
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Allergy Clin Immunol 117:931-8. 2006..However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development... - Prenatal, perinatal, and heritable influences on cord blood immune responsesBen M Willwerth
Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Ann Allergy Asthma Immunol 96:445-53. 2006..The implications of these findings for future development of allergy or asthma are, as yet, unknown... - The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretionFiona K Gibbons
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
J Clin Immunol 25:437-44. 2005..018) and allergen-specific lymphocyte proliferation (p = 0.02), while IL-13 secretion was unchanged (p = 0.109). This study indicates a role for Th1 cytokines as well as Th2 cytokines in the allergic response... - Toll-like receptor 4 or 2 agonists decrease allergic inflammationGerman Velasco
Respiratory and Critical Care Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 32:218-24. 2005..Our findings also demonstrate that both TLR4 and TLR2 agonists decrease allergic responses, supporting the concept that exposure to bacterial components under defined conditions may protect against allergic disease... - TLR2 and TLR4 stimulation differentially induce cytokine secretion in human neonatal, adult, and murine mononuclear cellsBianca Schaub
Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Interferon Cytokine Res 24:543-52. 2004..Therefore, TLR2 and TLR4 stimuli differentially influence IL-13 and IFN-gamma secretion in neonates, adults, and mice, supporting a critical role for innate stimuli in the modulation of cytokine responses... - Toll receptors modulate allergic responses: interaction with dendritic cells, T cells and mast cellsAbdelouahab Bellou
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Curr Opin Allergy Clin Immunol 3:487-94. 2003....