B Schaub

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative marker
    Jing Liu
    Department of Pulmonary and Allergy, University Children s Hospital Munich, Ludwig Maximilians Universitat Munich, Munich, Germany
    PLoS ONE 5:e13267. 2010
  2. pmc Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression data
    Nikolaus Ballenberger
    University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Munich, Germany
    PLoS ONE 7:e46423. 2012
  3. pmc TBX21 and HLX1 polymorphisms influence cytokine secretion at birth
    Vera Isabel Casaca
    Department of Pulmonary and Allergy, University Childrens Hospital Munich, Munich, Germany
    PLoS ONE 7:e31069. 2012
  4. pmc Exposure to moderate air pollution during late pregnancy and cord blood cytokine secretion in healthy neonates
    Philipp Latzin
    Division of Respiratory Medicine, Department of Paediatrics, Inselspital, University of Bern, Bern, Switzerland
    PLoS ONE 6:e23130. 2011
  5. pmc Long-term follow-up and treatment of congenital alveolar proteinosis
    Matthias Griese
    Dr von Haunersches Kinderspital, University of Munich, Munich, Germany
    BMC Pediatr 11:72. 2011
  6. ncbi request reprint The many faces of the hygiene hypothesis
    Bianca Schaub
    University Children s Hospital Munich, Dr von Haunersches Kinderspital, Pediatric Pulmonary Division, LMU Munich, Germany
    J Allergy Clin Immunol 117:969-77; quiz 978. 2006
  7. doi request reprint Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
    Bianca Schaub
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Munich, Germany
    J Allergy Clin Immunol 123:774-82.e5. 2009
  8. pmc Fetal cord blood: aspects of heightened immune responses
    B Schaub
    University Children s Hospital, Dr von Haunersches Kinderspital, Munich, Germany
    J Clin Immunol 25:329-37. 2005
  9. doi request reprint Impairment of T-regulatory cells in cord blood of atopic mothers
    Bianca Schaub
    Department of Pulmonary and Allergy, University Children s Hospital Munich, Munich, Germany
    J Allergy Clin Immunol 121:1491-9, 1499.e1-13. 2008
  10. ncbi request reprint The marketing of asthma and allergies
    Bianca Schaub
    University Children s Hospital, 80337 Munich, Germany
    Lancet 364:1389-90. 2004

Collaborators

Detail Information

Publications24

  1. pmc T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative marker
    Jing Liu
    Department of Pulmonary and Allergy, University Children s Hospital Munich, Ludwig Maximilians Universitat Munich, Munich, Germany
    PLoS ONE 5:e13267. 2010
    ..We assessed FOXP3 demethylation in cord blood in relation to previously used Treg markers such as CD4+CD25(hi), FOXP3 mRNA, protein expression, and suppressive Treg function...
  2. pmc Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression data
    Nikolaus Ballenberger
    University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Munich, Germany
    PLoS ONE 7:e46423. 2012
    ..Additionally, complex and multiple immunological relationships need to be adjusted for potential confounding and interaction effects...
  3. pmc TBX21 and HLX1 polymorphisms influence cytokine secretion at birth
    Vera Isabel Casaca
    Department of Pulmonary and Allergy, University Childrens Hospital Munich, Munich, Germany
    PLoS ONE 7:e31069. 2012
    ..This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth...
  4. pmc Exposure to moderate air pollution during late pregnancy and cord blood cytokine secretion in healthy neonates
    Philipp Latzin
    Division of Respiratory Medicine, Department of Paediatrics, Inselspital, University of Bern, Bern, Switzerland
    PLoS ONE 6:e23130. 2011
    ..However, effects of prenatal exposure to moderate levels of air pollutants on cytokine regulation in cord blood of healthy infants are unknown...
  5. pmc Long-term follow-up and treatment of congenital alveolar proteinosis
    Matthias Griese
    Dr von Haunersches Kinderspital, University of Munich, Munich, Germany
    BMC Pediatr 11:72. 2011
    ..Clinical presentation, diagnosis, management and outcome of molecularly defined congenital pulmonary alveolar proteinosis (PAP) due to mutations in the GM-CSF receptor are not well known...
  6. ncbi request reprint The many faces of the hygiene hypothesis
    Bianca Schaub
    University Children s Hospital Munich, Dr von Haunersches Kinderspital, Pediatric Pulmonary Division, LMU Munich, Germany
    J Allergy Clin Immunol 117:969-77; quiz 978. 2006
    ..Even if today practical implications cannot directly be deduced from these findings, there is great potential for the development of novel preventive and therapeutic strategies in the future...
  7. doi request reprint Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
    Bianca Schaub
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Munich, Germany
    J Allergy Clin Immunol 123:774-82.e5. 2009
    ..Cross-sectional studies suggest that maternal exposure to farming decreases the risk of allergic diseases in offspring. The potential underlying immunologic mechanisms are not understood...
  8. pmc Fetal cord blood: aspects of heightened immune responses
    B Schaub
    University Children s Hospital, Dr von Haunersches Kinderspital, Munich, Germany
    J Clin Immunol 25:329-37. 2005
    ..37, p < 0.001). For some individuals, a predisposition to a heightened immune response is already evident at birth. Whether this phenotype results in atopy in childhood warrants further investigation...
  9. doi request reprint Impairment of T-regulatory cells in cord blood of atopic mothers
    Bianca Schaub
    Department of Pulmonary and Allergy, University Children s Hospital Munich, Munich, Germany
    J Allergy Clin Immunol 121:1491-9, 1499.e1-13. 2008
    ..The underlying mechanisms are ill defined, yet regulatory T (Treg) and T(H)17 cells may play a key role potentially shaping the early immune system toward a proallergic or antiallergic immune regulation...
  10. ncbi request reprint The marketing of asthma and allergies
    Bianca Schaub
    University Children s Hospital, 80337 Munich, Germany
    Lancet 364:1389-90. 2004
  11. pmc Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression
    Bianca Schaub
    University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
    Respir Res 7:40. 2006
    ..However, little is known about the immunological effects of microbial stimulation on early immune responses and in association with maternal atopy...
  12. ncbi request reprint STAT6 polymorphisms are associated with neonatal regulatory T cells and cytokines and atopic diseases at 3 years
    V I Casaca
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Munich, Germany
    Allergy 68:1249-58. 2013
    ..Associations of STAT6 polymorphisms with IgE levels were described; however, their impact on neonatal immune responses and early disease development is unknown...
  13. doi request reprint TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy
    J Liu
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Germany
    Allergy 66:1020-9. 2011
    ..The aim of this study was to assess whether genetic TLR variants influence Tregs in neonates...
  14. ncbi request reprint Obesity and asthma, what are the links?
    Bianca Schaub
    University Children s Hospital Munich, Munich, Germany
    Curr Opin Allergy Clin Immunol 5:185-93. 2005
    ..The parallel time trend with an increasing prevalence of asthma has induced a lively debate about a potential link between both conditions...
  15. doi request reprint Impairment of T helper and T regulatory cell responses at birth
    B Schaub
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Germany
    Allergy 63:1438-47. 2008
    ..The aim of this study was to investigate T-cell responses to innate (Lipid A/LpA, peptidoglycan/Ppg) and adaptive (phytohemagglutinin) stimuli at birth and to compare these findings with adult immune responses...
  16. ncbi request reprint IRF-1 gene variations influence IgE regulation and atopy
    Michaela Schedel
    University Children s Hospital, Ludwig Maximilian s University Munich, Lindwurmstrasse 4, D 80337 München, Germany
    Am J Respir Crit Care Med 177:613-21. 2008
    ..The development of atopic diseases is characterized by skewed immune responses to common allergens. Only recently, interferons have been identified to play a crucial role in these mechanisms...
  17. pmc Cord blood cytokines and acute lower respiratory illnesses in the first year of life
    Ngoc P Ly
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 119:e171-8. 2007
    ..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children...
  18. pmc Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Allergy Clin Immunol 117:931-8. 2006
    ..However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development...
  19. pmc Prenatal, perinatal, and heritable influences on cord blood immune responses
    Ben M Willwerth
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Allergy Asthma Immunol 96:445-53. 2006
    ..Maternal and perinatal environmental exposures, as well as inherited factors, may influence neonatal immune responses...
  20. ncbi request reprint The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion
    Fiona K Gibbons
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    J Clin Immunol 25:437-44. 2005
    ..018) and allergen-specific lymphocyte proliferation (p = 0.02), while IL-13 secretion was unchanged (p = 0.109). This study indicates a role for Th1 cytokines as well as Th2 cytokines in the allergic response...
  21. ncbi request reprint Toll-like receptor 4 or 2 agonists decrease allergic inflammation
    German Velasco
    Respiratory and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 32:218-24. 2005
    ..Our findings also demonstrate that both TLR4 and TLR2 agonists decrease allergic responses, supporting the concept that exposure to bacterial components under defined conditions may protect against allergic disease...
  22. pmc TLR2 and TLR4 stimulation differentially induce cytokine secretion in human neonatal, adult, and murine mononuclear cells
    Bianca Schaub
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Interferon Cytokine Res 24:543-52. 2004
    ..Therefore, TLR2 and TLR4 stimuli differentially influence IL-13 and IFN-gamma secretion in neonates, adults, and mice, supporting a critical role for innate stimuli in the modulation of cytokine responses...
  23. pmc Nuclear factor kappa B activation in human cord blood mononuclear cells
    Christian H Schroeter
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, U S A
    Pediatr Res 56:212-8. 2004
    ..Whether differential NF-kappaB activity in cord blood is related to the subsequent development of immune diseases requires further investigation...
  24. ncbi request reprint Toll receptors modulate allergic responses: interaction with dendritic cells, T cells and mast cells
    Abdelouahab Bellou
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Allergy Clin Immunol 3:487-94. 2003
    ..The discovery of Toll-like receptors has generated much interest in understanding the impact of innate immunity on adaptive immune responses, including allergic diseases...