Research Topics
| Matthias SchaierSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Detail Information
Publications
Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized ratsMatthias Schaier
Dept of Nephrology, Univ of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
Am J Physiol Renal Physiol 297:F769-80. 2009..FTY720 significantly reduced key mediators of renal inflammation and fibrosis. FTY720 also decreased immunoregulation of M2 macrophages, which are beneficial for tissue remodeling and repair...- The extent of HLA-DR expression on HLA-DR(+) Tregs allows the identification of patients with clinically relevant borderline rejectionMatthias Schaier
Department of Nephrology, University of Heidelberg, D 69120 Heidelberg, Germany
Transpl Int 26:290-9. 2013.... 
DR(high+)CD45RA(-)-Tregs potentially affect the suppressive activity of the total Treg pool in renal transplant patientsMatthias Schaier
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
PLoS ONE 7:e34208. 2012..Therefore, both the monitoring of its percentage within the total Treg pool and the monitoring of the HLA-DR MFI of the DR(+)CD45RA(-)-Treg subset may be useful tools for the prediction of graft rejection...
Henoch-Schönlein purpura in adults is not uncommon in elderly patients with an adverse prognosisM Schaier
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
Clin Nephrol 76:49-56. 2011..Henoch-Schönlein purpura (HSP) is a fairly common disease in children and adolescents. There are only limited data available for adults...- Proton pump inhibitors interfere with the immunosuppressive potency of mycophenolate mofetilMatthias Schaier
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
Rheumatology (Oxford) 49:2061-7. 2010..Since PPIs are widely used, it is useful to clarify whether the total drug amount of MMF is available in patients undergoing PPI treatment... - Uremia aggravates left ventricular remodeling after myocardial infarctionRalf Dikow
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
Am J Nephrol 32:13-22. 2010..Renal failure is a well-established cardiovascular risk factor. We hypothesized that uremia negatively affects post-myocardial infarction (MI) remodeling and left ventricular (LV) function and examined the pathohistological correlations... - Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the ratMatthias Schaier
Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, 69115, Heidelberg, Germany
J Mol Med (Berl) 82:116-25. 2004..Receptor-specific retinoids may provide a novel therapeutic approach for the treatment of chronic glomerulonephritis... - Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized ratsChristian Morath
Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
J Mol Med (Berl) 87:53-64. 2009..We conclude that LD isotretinoin attenuates progressive renal damage, whereas HD isotretinoin cumulates and aggravates renal damage independent of blood pressure reduction... - Pharmacokinetic and pharmacodynamic analysis of enteric-coated mycophenolate sodium: limited sampling strategies and clinical outcome in renal transplant patientsClaudia Sommerer
Department of Nephrology, University Hospital, Heidelberg, Germany
Br J Clin Pharmacol 69:346-57. 2010..Pharmacokinetic (PK) and pharmacodynamic (PD) monitoring strategies and clinical outcome were evaluated in enteric-coated mycophenolate sodium (EC-MPS)-treated renal allograft recipients... - Cellular infiltrates and NFκB subunit c-Rel signaling in kidney allografts of patients with clinical operational toleranceLuis E Becker
Division of Nephrology, Department of Medicine, University of Heidelberg, Heidelberg, Germany
Transplantation 94:729-37. 2012.... - A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantationAnna Kisielewicz
Department of Obstetrics and Gynecology, University of Heidelberg, Voss Strasse 9, 69115 Heidelberg, Germany
Clin Immunol 137:209-20. 2010.... - Methylprednisolone treatment increases the proportion of the highly suppressive HLA-DR(+)-Treg-cells in transplanted patientsNicole Seissler
Department of Nephrology, University of Heidelberg, Germany
Transpl Immunol 27:157-61. 2012.... - In renal transplants with delayed graft function chemokines and chemokine receptor expression predict long-term allograft functionRalf Dikow
Department of Nephrology, University of Heidelberg, INF Heidelberg, Germany
Transplantation 90:771-6. 2010..We studied the role of chemokines in kidney allografts with delayed graft function and the subsequent long-term outcome of renal function and fibrosis... - Effect of insulin and glucose infusion on myocardial infarction size in uraemic ratsRalf Dikow
Department of Nephrology, University Hospital of Heidelberg, Heidelberg, Germany
Basic Res Cardiol 104:571-9. 2009..Further analysis did not reveal a down regulation in GLUT 4 and IRS-1/IRS-2... - Retinoid agonist isotretinoin ameliorates obstructive renal injuryMatthias Schaier
Department of Nephrology, University Hospital Heidelberg, Germany
J Urol 170:1398-402. 2003..Therefore, we studied the dose dependent effects of the retinoid receptor agonist isotretinoin 13-cis retinoic acid in the unilateral ureteral obstruction model (UUO)... - Retinoid receptor-specific agonists alleviate experimental glomerulonephritisIngo Lehrke
Department of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany
Am J Physiol Renal Physiol 282:F741-51. 2002..Further studies are indicated to define the potential use of retinoid agonists in inflammatory renal disease...