Andreas Schaffler

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. doi request reprint CTRP family: linking immunity to metabolism
    Andreas Schaffler
    Department of Internal Medicine I, Regensburg University Medical Center, D 93042 Regensburg, Germany
    Trends Endocrinol Metab 23:194-204. 2012
  2. pmc Papillary thyroid cancer associated with syndrome of inappropriate antidiuresis: a case report
    Fabian Beier
    Division of Hematology and Oncology, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    J Med Case Reports 4:110. 2010
  3. pmc Lipopolysaccharide regulated protein expression is only partly impaired in monocytes from patients with type I diabetes
    Gabriele Wehrwein
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Cardiovasc Diabetol 5:5. 2006
  4. ncbi request reprint Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Biochim Biophys Acta 1732:96-102. 2005
  5. ncbi request reprint Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Biochim Biophys Acta 1678:150-6. 2004
  6. ncbi request reprint Mechanisms of disease: adipocytokines and visceral adipose tissue--emerging role in intestinal and mesenteric diseases
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Nat Clin Pract Gastroenterol Hepatol 2:103-11. 2005
  7. ncbi request reprint Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Trends Immunol 28:393-9. 2007
  8. pmc Hormone replacement after thyroid and parathyroid surgery
    Andreas Schaffler
    Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, 93042 Regensburg, Germany
    Dtsch Arztebl Int 107:827-34. 2010
  9. ncbi request reprint Hypothesis paper Brain talks with fat--evidence for a hypothalamic-pituitary-adipose axis?
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Neuropeptides 39:363-7. 2005
  10. ncbi request reprint Concise review: adipose tissue-derived stromal cells--basic and clinical implications for novel cell-based therapies
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Stem Cells 25:818-27. 2007

Detail Information

Publications102 found, 100 shown here

  1. doi request reprint CTRP family: linking immunity to metabolism
    Andreas Schaffler
    Department of Internal Medicine I, Regensburg University Medical Center, D 93042 Regensburg, Germany
    Trends Endocrinol Metab 23:194-204. 2012
    ..This review focuses on the biochemistry and pleiotropic physiological functions of CTRPs as new molecular mediators connecting inflammatory and metabolic diseases...
  2. pmc Papillary thyroid cancer associated with syndrome of inappropriate antidiuresis: a case report
    Fabian Beier
    Division of Hematology and Oncology, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    J Med Case Reports 4:110. 2010
    ..However, its most frequent causes are related to malignancies, especially lung cancer. In this case report, we describe an unknown association of the syndrome of inappropriate antidiuresis with papillary thyroid cancer...
  3. pmc Lipopolysaccharide regulated protein expression is only partly impaired in monocytes from patients with type I diabetes
    Gabriele Wehrwein
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Cardiovasc Diabetol 5:5. 2006
    ..In the present study the influence of LPS on five different proteins with a function in immunity and atherosclerosis was analyzed in monocytes from controls and T1D patients...
  4. ncbi request reprint Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Biochim Biophys Acta 1732:96-102. 2005
    ..Based on this, omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease...
  5. ncbi request reprint Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Biochim Biophys Acta 1678:150-6. 2004
    ..Pit-1 and PPARgamma can bind specifically to the promoter and might play an additive functional role in gene regulation of murine CORS-26...
  6. ncbi request reprint Mechanisms of disease: adipocytokines and visceral adipose tissue--emerging role in intestinal and mesenteric diseases
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Nat Clin Pract Gastroenterol Hepatol 2:103-11. 2005
    ..In this review, the role of the visceral adipose tissue and its secretory products in intestinal and mesenteric diseases is systematically reviewed, with special focus on 'creeping fat' in Crohn's disease and mesenteric panniculitis...
  7. ncbi request reprint Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Trends Immunol 28:393-9. 2007
    ..Collectively, these data clearly establish the role of adipose tissue as a new member of the immune system...
  8. pmc Hormone replacement after thyroid and parathyroid surgery
    Andreas Schaffler
    Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, 93042 Regensburg, Germany
    Dtsch Arztebl Int 107:827-34. 2010
    ..In this article, the authors provide clinically-oriented recommendations to help surgeons, general practitioners, internists, and endocrinologists give their affected patients adequate hormone replacement therapy...
  9. ncbi request reprint Hypothesis paper Brain talks with fat--evidence for a hypothalamic-pituitary-adipose axis?
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Neuropeptides 39:363-7. 2005
    ..Based on this, the potential existence and clinical impact of a hypothalamic-pituitary-adipose axis should further be investigated...
  10. ncbi request reprint Concise review: adipose tissue-derived stromal cells--basic and clinical implications for novel cell-based therapies
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Stem Cells 25:818-27. 2007
    ..Decoding these molecular mechanisms is a prerequisite for developing novel cell therapies...
  11. ncbi request reprint Mechanisms of disease: adipokines and breast cancer - endocrine and paracrine mechanisms that connect adiposity and breast cancer
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Nat Clin Pract Endocrinol Metab 3:345-54. 2007
    ....
  12. ncbi request reprint Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product "cartonectin"
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Obesity (Silver Spring) 15:303-13. 2007
    ..It was the aim of this study to investigate expression, regulation, and function of CORS-26 in adipocytes...
  13. pmc Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases
    Andreas Schaffler
    Department of Internal Medicine I, Regensburg University Medical Center, Germany
    Cardiovasc Diabetol 6:3. 2007
    ..Omentin represents a new adipokine expressed in and secreted by omental adipose tissue. Therefore, it was the aim to investigate the putative role of a newly described sequence missense variation in the human omentin gene...
  14. ncbi request reprint Potential of adipocytokines in predicting peripancreatic necrosis and severity in acute pancreatitis: pilot study
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Gastroenterol Hepatol 22:326-34. 2007
    ....
  15. ncbi request reprint Secretion of RANTES (CCL5) and interleukin-10 from mesenteric adipose tissue and from creeping fat in Crohn's disease: regulation by steroid treatment
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Gastroenterol Hepatol 21:1412-8. 2006
    ..Pro- or anti-inflammatory adipose tissue-derived secretory products (adipocytokines) might play a role in the pathogenesis of CD...
  16. ncbi request reprint Vascular endothelial growth factor secretion from mesenteric adipose tissue and from creeping fat in Crohn's disease
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Gastroenterol Hepatol 21:1419-23. 2006
    ..Because VEGF serum levels and mucosal VEGF expression is elevated in CD patients, the aim of the present paper was to investigate creeping fat-derived VEGF secretion in CD...
  17. ncbi request reprint The role of 'adipotropins' and the clinical importance of a potential hypothalamic-pituitary-adipose axis
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Nat Clin Pract Endocrinol Metab 2:374-83. 2006
    ..The term 'adipotropins' is introduced in order to describe pituitary and hypothalamic hormones or releasing factors that directly target adipocytes by their specific receptors...
  18. ncbi request reprint [Treatment of pituitary gland hyperfunction: from acromegaly to prolactinoma]
    A Schaffler
    Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, Regensburg
    Internist (Berl) 47:1215-6, 1218-20, 1222. 2006
    ..In some cases, dopamine agonists can be added. In therapy-resistant cases, growth hormone receptor antagonists can be used...
  19. ncbi request reprint Innate immunity and adipose tissue biology
    Andreas Schaffler
    Department of Internal Medicine I, University Hospital of Regensburg, D 93042 Regensburg, Germany
    Trends Immunol 31:228-35. 2010
    ..Visceral adipose tissue is infiltrated by macrophages in obesity, and there is local crosstalk between these two types of cells, leading to an inflammatory transformation of adipose tissue...
  20. pmc Creeping fat in Crohn's disease: travelling in a creeper lane of research?
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Gut 54:742-4. 2005
  21. ncbi request reprint Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes
    B Zietz
    Department of Internal Medicine I, University of Regensburg, D 93042, Regensburg, Germany
    FEBS Lett 545:103-4. 2003
    ..0001) and positively (regression analysis: r=0.86) associated with HDL-cholesterol levels in type 2 diabetes...
  22. ncbi request reprint Frequency and significance of Pro12Ala and Pro115Gln polymorphism in gene for peroxisome proliferation-activated receptor-gamma regarding metabolic parameters in a Caucasian cohort
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Endocrine 14:369-73. 2001
    ..Therefore, a major role of these polymorphisms in the pathogenesis of obesity and diabetes can be excluded...
  23. ncbi request reprint Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein)
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Biochim Biophys Acta 1630:123-9. 2003
    ..The present data provide the basis for further investigation of CORS-26 gene regulation in the context of mesenchymal tissue development and in the pathogenesis of bone or skeletal disease...
  24. ncbi request reprint Mutation analysis of the human adipocyte-specific apM-1 gene
    A Schaffler
    Department of Internal Medicine I, Institute of Clinical Chemistry, University of Regensburg, Germany
    Eur J Clin Invest 30:879-87. 2000
    ..The aim of this study was to analyse the human adipocyte-specific apM-1 gene for sequence variations...
  25. pmc Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity
    Andreas Schaeffler
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    Immunology 126:233-45. 2009
    ..Adipose tissue mRNA expression and serum levels of adipokines did not differ in rats fed a high-fat diet. These data provide a new molecular mechanism by which fatty acids can link nutrition with innate immunity...
  26. ncbi request reprint Identification of influencing variables on adiponectin serum levels in diabetes mellitus type 1 and type 2
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Exp Clin Endocrinol Diabetes 112:383-9. 2004
    ..Adiponectin represents an adipocyte-specific secretory protein that has been discussed recently as candidate gene and promising new drug target to restore insulin sensitivity in diabetes mellitus type 2...
  27. ncbi request reprint Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Horm Metab Res 36:702-7. 2004
    ..The physiological range of serum resistin levels, reference values or adjusted percentiles have not yet been determined, making the interpretation of serum resistin concentrations quite difficult...
  28. ncbi request reprint Identification of a new missense mutation (Gly95Glu) in a highly conserved codon within the high-mobility group box of the sex-determining region Y gene: report on a 46,XY female with gonadal dysgenesis and yolk-sac tumor
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    J Clin Endocrinol Metab 85:2287-92. 2000
    ..This mutation was not detected in the patient's father and her male siblings. The present data provide further evidence to support the functional importance of the putative DNA binding activity of the SRY HMG-box domain...
  29. ncbi request reprint Role of adipose tissue as an inflammatory organ in human diseases
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Endocr Rev 27:449-67. 2006
    ..Future clinical and therapeutic implications are discussed...
  30. doi request reprint C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue
    Andrea Kopp
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Endocrinology 151:5267-78. 2010
    ..CTRP-3 inhibits three basic and common proinflammatory pathways involved in obesity and type 2 diabetes mellitus (adipo-inflammation) by acting as an endogenous LPS antagonist of the adipose tissue...
  31. doi request reprint Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes
    Markus Weber
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    FEBS Lett 583:3718-24. 2009
    ..Circulating levels of total adiponectin did not correlate with cellular or soluble galectin-3 indicating that additional factors contribute to higher cellular monocytic galectin-3 in obesity and T2D...
  32. doi request reprint Systemic and hepatic vein galectin-3 are increased in patients with alcoholic liver cirrhosis and negatively correlate with liver function
    Josef Wanninger
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Cytokine 55:435-40. 2011
    ....
  33. pmc Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro
    Fabian Stogbauer
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    Exp Mol Med 41:501-7. 2009
    ..In agreement with these in vitro finding an increase of monocytic annexin A6 in type 2 diabetes monocytes was observed...
  34. doi request reprint Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes
    Johanna Weigert
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    Clin Endocrinol (Oxf) 72:342-8. 2010
    ..As visceral fat contributes to systemic inflammation, chemerin was measured in portal venous (PVS), hepatic venous (HVS) and systemic venous (SVS) blood of patients with liver cirrhosis...
  35. doi request reprint Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways
    Josef Wanninger
    Department of Internal Medicine I, University Hospital of Regensburg, Regensburg, Germany
    Am J Physiol Gastrointest Liver Physiol 297:G611-8. 2009
    ..CXCL8 is a survival factor, and its upregulation by adiponectin may contribute to the hepatoprotective effects of this adipokine...
  36. doi request reprint Circulating levels of chemerin and adiponectin are higher in ulcerative colitis and chemerin is elevated in Crohn's disease
    Johanna Weigert
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    Inflamm Bowel Dis 16:630-7. 2010
    ..Inflammatory bowel disease (IBD) is linked to an impaired immune response and, therefore, we hypothesized that systemic chemerin may be altered in IBD patients...
  37. doi request reprint Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis
    Roland Walter
    Department of Internal Medicine I, University Hospital of Regensburg, Germany
    Exp Mol Pathol 91:740-4. 2011
    ....
  38. doi request reprint Serum galectin-3 is elevated in obesity and negatively correlates with glycosylated hemoglobin in type 2 diabetes
    Johanna Weigert
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    J Clin Endocrinol Metab 95:1404-11. 2010
    ..Conclusions: Systemic galectin-3 is elevated in obesity and negatively correlates with glycated hemoglobin in T2D patients, pointing to a modifying function of galectin-3 in human metabolic diseases...
  39. doi request reprint Low-abundant adiponectin receptors in visceral adipose tissue of humans and rats are further reduced in diabetic animals
    Sabrina Bauer
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Arch Med Res 41:75-82. 2010
    ..Therefore, we aimed to analyze AdipoR1 and AdipoR2 proteins in adipocytes and paired samples of subcutaneous and visceral adipocytes/adipose tissue...
  40. doi request reprint Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines
    Britta Wölfing
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Obesity (Silver Spring) 16:1481-6. 2008
    ..The receptor and function of cartonectin are unknown and the recombinant protein is not commercially available...
  41. ncbi request reprint Profiling adipocytokine secretion from creeping fat in Crohn's disease
    Gisela Paul
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Inflamm Bowel Dis 12:471-7. 2006
    ..Creeping fat represents a characteristic feature of Crohn's disease (CD). Proinflammatory or anti-inflammatory adipose-derived secretory products, now generally called adipocytokines, may play a role in the pathogenesis of CD...
  42. pmc Adiponectin-induced secretion of interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1, CCL2) and interleukin-8 (IL-8, CXCL8) is impaired in monocytes from patients with type I diabetes
    Sabine Abke
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Cardiovasc Diabetol 5:17. 2006
    ..Because monocytes play an important role in atherosclerosis, we analysed the influence of adiponectin on cytokine and chemokine release in monocytes from T1D patients and controls...
  43. doi request reprint Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes
    Josef Wanninger
    Department of Internal Medicine I, University Hospital of Regensburg, Regensburg, Germany
    FEBS Lett 585:1338-44. 2011
    ..In summary, the current data show that hepatoprotective effects of adiponectin include induction of BAMBI which is reduced in human fatty liver and rodent models of metabolic liver injury...
  44. doi request reprint Elevated free fatty acids and impaired adiponectin bioactivity contribute to reduced SOD2 protein in monocytes of type 2 diabetes patients
    Sabrina Bauer
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Exp Mol Pathol 90:101-6. 2011
    ..In summary this study indicates that elevated systemic free fatty acids and impaired adiponectin activity contribute to reduced SOD2 and most likely increased oxidative stress in T2D monocytes...
  45. doi request reprint Effects of the new adiponectin paralogous protein CTRP-3 and of LPS on cytokine release from monocytes of patients with type 2 diabetes mellitus
    Andrea Kopp
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Cytokine 49:51-7. 2010
    ..It was the aim to investigate the hypothesis that the new C1q/TNF-family member CTRP-3 (C1q/TNF-related protein-3) acts anti-inflammatory in human monocytes from healthy controls and patients with type 2 diabetes mellitus (T2D)...
  46. doi request reprint Adiponectin upregulates monocytic activin A but systemic levels are not altered in obesity or type 2 diabetes
    Johanna Weigert
    Department of Internal Medicine I, Regensburg University Hospital, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Cytokine 45:86-91. 2009
    ..These findings indicate that adiponectin upregulates monocytic activin A release via the p38 MAPK pathway, and this may in part explain the immunoregulatory and antiatherosclerotic effects of this adipokine...
  47. doi request reprint Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3
    Andrea Kopp
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Endocrinology 151:1097-108. 2010
    ..TLR-ligand-induced proinflammatory and prodiabetic activation of adipocytes might couple visceral adipose tissue dysfunction with insulin resistance and type 2 diabetes mellitus...
  48. ncbi request reprint The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells
    Johanna Weigert
    Department of Internal Medicine I, University of Regensburg, Germany
    FEBS Lett 579:5565-70. 2005
    ..Therefore CORS-26 may provide a new target for pharmacological drugs in inflammatory diseases like the metabolic syndrome...
  49. ncbi request reprint Different effects of adiponectin isoforms in human monocytic cells
    Markus Neumeier
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    J Leukoc Biol 79:803-8. 2006
    ..Although apoptosis, the activation of AMPK, and the reduction of MSR are mediated by all APM isoforms, only LMW-APM displays anti-inflammatory properties...
  50. pmc Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults
    Sylvia Wurm
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Cardiovasc Diabetol 6:7. 2007
    ..Whereas contradictory results have been published for leptin and adiponectin, resistin has not been extensively investigated and no reports on omentin and CORS-26 do exist...
  51. pmc Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver
    Josef Wanninger
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg D 93042, Germany
    Mol Cell Endocrinol 349:248-54. 2012
    ..Further, CMKLR1 was suppressed in the liver of adiponectin deficient mice. These data indicate that low CMKLR1 in NAFLD may partly result from reduced adiponectin activity...
  52. doi request reprint Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes
    Johanna Weigert
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    FEBS Lett 582:1777-82. 2008
    ..However, AdipoR1 and AdipoR2 proteins were lower in monocytes of T2D compared to normal-weight donors. Induction of IL-6 and IL-8 by adiponectin, an effect involving p38 MAPK, was also reduced in T2D monocytes...
  53. doi request reprint Insulin induces monocytic CXCL8 secretion by the mitogenic signalling pathway
    Sylvia Wurm
    Department of Internal Medicine I, Regensburg University Hospital, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Cytokine 44:185-90. 2008
    ..In summary, these data indicate that oral glucose uptake in insulin-sensitive adults is associated with elevated monocytic and reduced systemic CXCL8...
  54. doi request reprint Impaired hepatic removal of interleukin-6 in patients with liver cirrhosis
    Reiner Wiest
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    Cytokine 53:178-83. 2011
    ..In summary, the current data provide evidence that impaired hepatic removal of IL-6 is explained by hepatic shunting and liver dysfunction in patients with liver cirrhosis partly explaining higher systemic levels...
  55. ncbi request reprint Mechanisms of disease: adipocytokines and visceral adipose tissue--emerging role in nonalcoholic fatty liver disease
    Andreas Schaffler
    Department of Internal Medicine I, University of Regensburg, Germany
    Nat Clin Pract Gastroenterol Hepatol 2:273-80. 2005
    ..The beneficial effects of the therapeutic approaches so far tested in the treatment of fatty liver disease and fibrosis might be due to the modulation of these adipocytokines...
  56. doi request reprint C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts
    Claudia Hofmann
    Department of Internal Medicine I, University Medical Center Regensburg, Germany
    Inflamm Bowel Dis 17:2462-71. 2011
    ..The aim was to investigate the antiinflammatory and antifibrotic role of CTRP-3 in Crohn's disease (CD)...
  57. doi request reprint MMP-9 activity is increased by adiponectin in primary human hepatocytes but even negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis
    Josef Wanninger
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Exp Mol Pathol 91:603-7. 2011
    ....
  58. doi request reprint Admission visfatin levels predict pancreatic and peripancreatic necrosis in acute pancreatitis and correlate with clinical severity
    Andreas Schaffler
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany andreas schaeffl
    Am J Gastroenterol 106:957-67. 2011
    ..It was the aim of this study to investigate whether the adipocytokine visfatin is able to serve as an early marker predicting peripancreatic necrosis and clinical severity...
  59. ncbi request reprint In vivo suppression of visfatin by oral glucose uptake: evidence for a novel incretin-like effect by glucagon-like peptide-1 (GLP-1)
    Margarita Bala
    Department of Internal Medicine I, University Medical Center, D 93042 Regensburg, Germany
    J Clin Endocrinol Metab 96:2493-501. 2011
    ..The aim of the study was to characterize the physiological regulation of visfatin release in vivo in healthy, nondiabetic probands and in adipocytes in vitro...
  60. ncbi request reprint Lipid accumulation impairs adiponectin-mediated induction of activin A by increasing TGFbeta in primary human hepatocytes
    Josef Wanninger
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Biochim Biophys Acta 1811:626-33. 2011
    ..In summary the current data demonstrate that lipid accumulation in hepatocytes induces TGFβ which impairs adiponectin bioactivity, and thereby may contribute to liver injury...
  61. doi request reprint Portal levels of latent transforming growth factor-β are related to liver function in patients with liver cirrhosis
    Josef Wanninger
    Department of Internal Medicine I, Regensburg University Hospital, Germany
    Eur J Gastroenterol Hepatol 23:218-23. 2011
    ....
  62. ncbi request reprint Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro
    Markus Neumeier
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Biochem Biophys Res Commun 350:731-5. 2006
    ..High AOX1 may be associated with higher ROS well described to induce fibrogenesis in liver tissue but may also influence drug metabolism and activity...
  63. doi request reprint Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes
    Andrea Kopp
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    Obesity (Silver Spring) 17:648-56. 2009
    ..The results of this approach will help to explain the metabolic changes such as insulin resistance observed during infection and the immunological phenomena such as macrophage infiltration of adipose tissue seen in obesity...
  64. doi request reprint Systemic resistin is increased in type 2 diabetic patients treated with loop diuretics
    Sabrina Bauer
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    J Diabetes Complications 25:377-81. 2011
    ..In summary, the current data indicate that changes accompanying renal dysfunction but not obesity or type 2 diabetes are associated with increased serum resistin...
  65. doi request reprint Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid arthritis and osteoarthritis
    Kristina Eisinger
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Exp Mol Pathol 92:90-6. 2012
    ..Here, we analyzed whether synovial fibroblasts express chemerin and its receptor CMKLR1. Further, the role of chemerin in synovial fibroblast chemotaxis, proliferation, insulin response and release of inflammatory proteins was studied...
  66. doi request reprint Adiponectin stimulates release of CCL2, -3, -4 and -5 while the surface abundance of CCR2 and -5 is simultaneously reduced in primary human monocytes
    Markus Neumeier
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Cytokine 56:573-80. 2011
    ..Adiponectin also lowers surface abundance of CCR2 and CCR5 and downregulation of CCR2 seems to depend on autocrine/paracrine effects of CCL2...
  67. ncbi request reprint Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis
    Markus Neumeier
    Department of Internal Medicine I, University of Regensburg, Regensburg D 93042, Germany
    World J Gastroenterol 12:5490-4. 2006
    ..To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level...
  68. doi request reprint Splanchnic concentrations and postprandial release of visceral adipokines
    Reiner Wiest
    Department of Internal Medicine I, University Hospital of Regensburg, Regensburg, Germany
    Metabolism 59:664-70. 2010
    ..The results give insight into the dynamics of splanchnic adipokine concentrations and help critically interpret data derived from messenger RNA expression studies...
  69. ncbi request reprint Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release
    Franziska Schober
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Biochem Biophys Res Commun 361:968-73. 2007
    ..Therefore, the current study indicates that HMW-adiponectin exerts pro- and LMW-adiponectin antiinflammatory effects and reduced LMW-adiponectin in obesity may partly contribute to elevated monocytic IL-6 release...
  70. doi request reprint Soluble CD163 is not increased in visceral fat and steatotic liver and is even suppressed by free fatty acids in vitro
    Sabrina Bauer
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Exp Mol Pathol 91:733-9. 2011
    ..These data suggest that in humans neither visceral fat nor fatty liver are major sources of sCD163...
  71. doi request reprint Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes
    Sabrina Bauer
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Endocrinology 152:26-35. 2011
    ..In conclusion, the current data show that adipocyte hypertrophy and chronic inflammation are equally important in inducing chemerin synthesis...
  72. doi request reprint Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal
    Christa Buechler
    Department of Internal Medicine I, University of Regensburg, Regensburg D 93042, Germany
    J Gastroenterol Hepatol 24:558-63. 2009
    ..Adiponectin is a circulating protein with hepatoprotective effects. Aims: To study the relationship of excessive alcohol consumption and serum adiponectin levels (SAL)...
  73. ncbi request reprint Metformin reduces cellular lysophosphatidylcholine and thereby may lower apolipoprotein B secretion in primary human hepatocytes
    Josef Wanninger
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Biochim Biophys Acta 1781:321-5. 2008
    ..Therefore, it is concluded that metformin reduces lysoPC in human hepatocytes and this may secondarily lead to a therapeutically beneficial lower release of ApoB...
  74. doi request reprint Admission resistin levels predict peripancreatic necrosis and clinical severity in acute pancreatitis
    Andreas Schaffler
    Department of Internal Medicine I, University Hospital of Regensburg, Regensburg, Germany andreas schaeffl
    Am J Gastroenterol 105:2474-84. 2010
    ....
  75. doi request reprint Intracellular survival of Staphylococcus aureus in adipocyte-like differentiated 3T3-L1 cells is glucose dependent and alters cytokine, chemokine, and adipokine secretion
    Frank Hanses
    Department of Internal Medicine I, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Endocrinology 152:4148-57. 2011
    ..Because cell viability is not affected during infection, adipose tissue might function as a host for chronic infection by bacteria-causing metabolic, proinflammatory, and prodiabetic disturbances...
  76. ncbi request reprint Caucasian patients with type 2 diabetes mellitus have elevated levels of monocyte chemoattractant protein-1 that are not influenced by the -2518 A-->G promoter polymorphism
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Diabetes Obes Metab 7:570-8. 2005
    ....
  77. ncbi request reprint Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors
    Markus Neumeier
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Biochem Biophys Res Commun 334:924-9. 2005
    ..Elevated AdipoR1 induced by hepatotoxic troglitazone may indicate a role of this receptor in adiponectin-mediated beneficial effects in liver damage...
  78. ncbi request reprint Identification of regulatory elements in the human adipose most abundant gene transcript-1 ( apM-1) promoter: role of SP1/SP3 and TNF-alpha as regulatory pathways
    N Barth
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Diabetologia 45:1425-33. 2002
    ..Our aim was to characterize the tissue-specific regulation of the recently cloned apM-1 promoter and the mechanisms of TNF-alpha-induced downregulation of the apM-1 gene...
  79. ncbi request reprint Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26 (collagenous repeat-containing sequence of 26 kDa protein)
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee11, D 93042, Regensburg, Germany
    Biochim Biophys Acta 1628:64-70. 2003
    ..The present data provide the basis for further investigation of the CORS-26 gene regulation in the context of mesenchymal tissue development, chondrocyte/adipocyte function and bone or skeletal disease...
  80. doi request reprint Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release
    Johanna Weigert
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    FEBS Lett 582:2965-72. 2008
    ..Knock-down of AOX1 in preadipocytes led to impaired lipid storage and adiponectin release in the differentiated cells. These data indicate that AOX1 is essential for adipogenesis and may link energy and drug metabolism...
  81. doi request reprint Highly efficient and low-cost method to isolate human blood monocytes with high purity
    Fabian Stogbauer
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Immunol Methods 337:78-80. 2008
    ..MicroBeads are widely used to isolate different cell populations and with this report more researchers may be encouraged to use this highly efficient, low-cost and thus affordable method to pursue their scientific goals...
  82. ncbi request reprint Plasminogen activator inhibitor-1 promoter activity in adipocytes is not influenced by the 4 G/5 G promoter polymorphism and is regulated by a USF-1/2 binding site immediately preceding the polymorphic region
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    J Mol Endocrinol 32:155-63. 2004
    ..These data possibly explain the observation that PAI-1 secretion from adipose tissue is not influenced by the PAI-1 promoter polymorphism...
  83. ncbi request reprint The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidaemia (FCH)
    A Schaffler
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Biochem Biophys Res Commun 260:416-25. 1999
    ..Exon- and intron-specific primer sequences are presented as a basis for mutation screening of patients affected with FCH...
  84. ncbi request reprint The potential of adiponectin in driving arthritis
    Angela Ehling
    Department of Internal Medicine I, University Hospital Regensburg, Germany
    J Immunol 176:4468-78. 2006
    ..In summary, articular adipose tissue and adipocytokines cannot be regarded as innocent bystanders any more in chronic inflammatory diseases such as arthritis...
  85. ncbi request reprint GG-genotype in the promotor region of uncoupling-protein-1 gene is associated with lower level of dehydroepiandrosterone in type 2 diabetes
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Germany
    Exp Clin Endocrinol Diabetes 109:102-6. 2001
    ..We suggest a role for UCP-1 polymorphism in the pathogenesis of obesity and arteriosclerosis. This hypothesis, however, needs further investigation...
  86. ncbi request reprint Gly15Gly polymorphism within the human adipocyte-specific apM-1gene but not Tyr111His polymorphism is associated with higher levels of cholesterol and LDL-cholesterol in caucasian patients with type 2 diabetes
    B Zietz
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Exp Clin Endocrinol Diabetes 109:320-5. 2001
    ..The recently described mutations within the human adipocyte-specific apM-1 gene might play a role in the pathogenesis of obesity, type 2 diabetes and related metabolic disorders...
  87. ncbi request reprint Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients
    B Zietz
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Exp Clin Endocrinol Diabetes 110:60-6. 2002
    ..Subsequent to genomic PCR amplification, the Hpa-II RFLP analysis was used for genotyping...
  88. ncbi request reprint Elevated levels of leptin and insulin but not of TNF alpha are associated with hypertension in type 2 diabetic males
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Germany
    Exp Clin Endocrinol Diabetes 108:259-64. 2000
    ..These findings are accompanied by a trend to lower levels of free testosterone in hypertensive type 2 diabetic males. TNF alpha levels were comparable in female and male hypertensive and normotensive type 2 diabetic subjects...
  89. ncbi request reprint Lack of correlation between the vitamin D receptor Fokl start codon polymorphism and bone mineral density in patients with Crohn's disease
    N Bregenzer
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Exp Clin Endocrinol Diabetes 114:1-5. 2006
    ..Vitamin D receptor alleles containing the polymorphism have been denoted by f and alleles lacking the site by F...
  90. ncbi request reprint Long-term follow-up of patients with necrotizing pancreatitis treated by percutaneous necrosectomy
    E Endlicher
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Hepatogastroenterology 50:2225-8. 2003
    ..The objective of this follow-up study was to assess the long-term outcome of patients with infected necrotizing pancreatitis treated with percutaneous catheter drainage and necrosectomy...
  91. ncbi request reprint Does global gene expression analysis in type 2 diabetes provide an opportunity to identify highly promising drug targets?
    C Buechler
    Department of Internal Medicine I, University Hospital of Regensburg, D 93042 Regensburg, Germany
    Endocr Metab Immune Disord Drug Targets 7:250-8. 2007
    ..Impaired adipogenesis, intra-adipose accumulation of macrophages and a sustained release of inflammatory and acute phase proteins are characteristic features of adipose tissue in obesity and may aggravate systemic insulin resistance...
  92. ncbi request reprint Use of anticoagulation during wireless capsule endoscopy for the investigation of recurrent obscure gastrointestinal bleeding
    F Rieder
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Endoscopy 38:526-8. 2006
    ..In both cases a gastrointestinal stromal tumor was identified as the bleeding source and was resected. These two cases demonstrate that provocation of bleeding during capsule endoscopy may increase its sensitivity...
  93. ncbi request reprint Allelic frequency of the PAI-1 4G/5G promoter polymorphism in patients with type 2 diabetes mellitus and lack of association with PAI-1 plasma levels
    B Zietz
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Endocr Res 30:443-53. 2004
    ..In patients with type 2 diabetes mellitus, the PAI-1 4G/5G promoter polymorphism does not predict PAI-1 plasma levels and is not associated with common metabolic parameters besides fibrinogen levels...
  94. doi request reprint Fatty acids as metabolic mediators in innate immunity
    A Kopp
    Regensburg University Hospital, Regensburg, Germany
    Eur J Clin Invest 39:924-33. 2009
    ..We tested whether anti-inflammatory fatty acids are able to inhibit the binding of lipopolysaccharide (LPS) to its receptor, toll-like receptor/MD-2 (TLR4/MD-2)...
  95. doi request reprint Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity
    D Sporrer
    Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany
    Eur J Clin Invest 39:671-9. 2009
    ....
  96. ncbi request reprint Interfering effects of insulin, growth hormone and glucose on adipokine secretion
    B Wölfing
    Department of Internal Medicine I, Regensburg University Medical Center, Germany
    Exp Clin Endocrinol Diabetes 116:47-52. 2008
    ..It was the aim of the study to investigate the impact of standard metabolic conditions (normo-/hyperglycemia, normo-/hyperinsulinemia) and of GH on the secretion of adiponectin and resistin...
  97. doi request reprint The role of domestic hygiene in inflammatory bowel diseases: hepatitis A and worm infestations
    Stefan Hafner
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Eur J Gastroenterol Hepatol 20:561-6. 2008
    ....
  98. ncbi request reprint Peritoneal fluid adipokines: ready for prime time?
    R Wiest
    Regensburg University Hospital, Regensburg, Germany
    Eur J Clin Invest 39:219-29. 2009
    ..It was the aim of this study to investigate peritoneal fluid concentrations of novel (cartonectin, omentin) and classical adipokines (leptin, adiponectin, resistin, visfatin) in patients with ascites...
  99. ncbi request reprint Adiponectin effects on human breast cancer cells are dependent on 17-beta estradiol
    Georg H Pfeiler
    Department of Obstetrics and Gynecology, University of Regensburg, D 93042 Regensburg, Germany
    Oncol Rep 19:787-93. 2008
    ....
  100. ncbi request reprint Detection of adiponectin in cerebrospinal fluid in humans
    Markus Neumeier
    Dept of Internal Medicine I, Regensburg Univ Hospital, D 93042 Regensburg, Germany
    Am J Physiol Endocrinol Metab 293:E965-9. 2007
    ..Additional studies are needed to reveal whether these low levels of adiponectin in CSF have a physiological function...
  101. doi request reprint [A 42-year-old farmer with nonspecific leucocytosis and elevated transaminases. Acute septic reaction in Coxiella burnetii infection]
    U Hempel
    Klinik und Poliklinik für Innere Medizin I, Klinikum der Universitat Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Internist (Berl) 49:743-6. 2008
    ..The diagnosis is made through histology ("doughnut" granulomas), PCR, serology (acute: anti-phase II antibodies, chronic: anti-phase I antibodies) and culture. Standard therapy is doxycycline...