Franz Schaefer

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Cardiac disease in children with mild-to-moderate chronic kidney disease
    Franz Schaefer
    Pediatric Nephrology Division, Center for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    Curr Opin Nephrol Hypertens 17:292-7. 2008
  2. doi request reprint Efficacy and safety of valsartan in hypertensive children 6 months to 5 years of age
    Franz Schaefer
    Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University Hospital of Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    J Hypertens 31:993-1000. 2013
  3. doi request reprint Peripheral gangrene in children with atypical hemolytic uremic syndrome
    Michal Malina
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatrics 131:e331-5. 2013
  4. pmc Impact of global economic disparities on practices and outcomes of chronic peritoneal dialysis in children: insights from the International Pediatric Peritoneal Dialysis Network Registry
    Franz Schaefer
    Pediatric Nephrology Division, Center for Pediatrics and Adolescent Medicine, Im Neuenheimer Feld 430, Heidelberg, Germany
    Perit Dial Int 32:399-409. 2012
  5. doi request reprint Efficacy and safety of valsartan compared to enalapril in hypertensive children: a 12-week, randomized, double-blind, parallel-group study
    Franz Schaefer
    Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University Hospital of Heidelberg, ImNeuenheimer Feld, Germany
    J Hypertens 29:2484-90. 2011
  6. ncbi request reprint Worldwide variation of dialysis-associated peritonitis in children
    F Schaefer
    Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany
    Kidney Int 72:1374-9. 2007
  7. doi request reprint Peritoneal dialysis in children with end-stage renal disease
    Franz Schaefer
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Nat Rev Nephrol 7:659-68. 2011
  8. ncbi request reprint The PET-iatrics of peritoneal solute transport: is short also good for the young ones?
    Franz Schaefer
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    Perit Dial Int 27:413-4. 2007
  9. doi request reprint Efficacy, safety and pharmacokinetics of candesartan cilexetil in hypertensive children from 1 to less than 6 years of age
    Franz Schaefer
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    J Hypertens 28:1083-90. 2010
  10. pmc Effect of the dialysis fluid buffer on peritoneal membrane function in children
    Claus Peter Schmitt
    University Children s Hospital, Heidelberg, Germany
    Clin J Am Soc Nephrol 8:108-15. 2013

Collaborators

Detail Information

Publications90

  1. doi request reprint Cardiac disease in children with mild-to-moderate chronic kidney disease
    Franz Schaefer
    Pediatric Nephrology Division, Center for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    Curr Opin Nephrol Hypertens 17:292-7. 2008
    ..This review reflects on recent echocardiographic studies assessing left-ventricular mass, geometry and function in children with mild-to-moderate chronic kidney disease...
  2. doi request reprint Efficacy and safety of valsartan in hypertensive children 6 months to 5 years of age
    Franz Schaefer
    Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University Hospital of Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    J Hypertens 31:993-1000. 2013
    ..To evaluate a dose-dependent reduction in blood pressure (BP) and overall safety of valsartan in hypertensive children...
  3. doi request reprint Peripheral gangrene in children with atypical hemolytic uremic syndrome
    Michal Malina
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatrics 131:e331-5. 2013
    ..Eculizumab appears effective in preserving tissue viability if administered before gangrene occurs and should be considered as first-line rescue therapy in such cases...
  4. pmc Impact of global economic disparities on practices and outcomes of chronic peritoneal dialysis in children: insights from the International Pediatric Peritoneal Dialysis Network Registry
    Franz Schaefer
    Pediatric Nephrology Division, Center for Pediatrics and Adolescent Medicine, Im Neuenheimer Feld 430, Heidelberg, Germany
    Perit Dial Int 32:399-409. 2012
    ..These variations in practice related to economic difference do not appear to affect PD technique survival; however, economic conditions seem to affect mortality on dialysis and standardized height, a marker of global child morbidity...
  5. doi request reprint Efficacy and safety of valsartan compared to enalapril in hypertensive children: a 12-week, randomized, double-blind, parallel-group study
    Franz Schaefer
    Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University Hospital of Heidelberg, ImNeuenheimer Feld, Germany
    J Hypertens 29:2484-90. 2011
    ..This study compares efficacy and safety of valsartan with enalapril in hypertensive children aged 6-17 years...
  6. ncbi request reprint Worldwide variation of dialysis-associated peritonitis in children
    F Schaefer
    Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany
    Kidney Int 72:1374-9. 2007
    ....
  7. doi request reprint Peritoneal dialysis in children with end-stage renal disease
    Franz Schaefer
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Nat Rev Nephrol 7:659-68. 2011
    ....
  8. ncbi request reprint The PET-iatrics of peritoneal solute transport: is short also good for the young ones?
    Franz Schaefer
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    Perit Dial Int 27:413-4. 2007
  9. doi request reprint Efficacy, safety and pharmacokinetics of candesartan cilexetil in hypertensive children from 1 to less than 6 years of age
    Franz Schaefer
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    J Hypertens 28:1083-90. 2010
    ..Few antihypertensive drugs are available in appropriate formulations for infants...
  10. pmc Effect of the dialysis fluid buffer on peritoneal membrane function in children
    Claus Peter Schmitt
    University Children s Hospital, Heidelberg, Germany
    Clin J Am Soc Nephrol 8:108-15. 2013
    ..Double-chamber peritoneal dialysis fluids exert less toxicity by their neutral pH and reduced glucose degradation product content. The role of the buffer compound (lactate and bicarbonate) has not been defined in humans...
  11. doi request reprint Buffer-dependent regulation of aquaporin-1 expression and function in human peritoneal mesothelial cells
    Yihui Zhai
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    Pediatr Nephrol 27:1165-77. 2012
    ..We hypothesized that the reduced toxicity of the biocompatible solutions might unmask specific effects of the buffer type on mesothelial cell functions...
  12. ncbi request reprint Ultradian but not circadian blood pressure rhythms correlate with renal dysfunction in children with chronic renal failure
    Elke Wühl
    Division of Pediatric Nephrology, University Children s Hospital, University of Heidelberg, Im Neuenheimer Feld 151, 69120 Heidelberg, Germany
    J Am Soc Nephrol 16:746-54. 2005
    ..Ultradian but not circadian rhythms or conventional dipping parameters are quantitatively associated with renal function and proteinuria...
  13. pmc BIOKID: randomized controlled trial comparing bicarbonate and lactate buffer in biocompatible peritoneal dialysis solutions in children [ISRCTN81137991]
    Barbara Nau
    University Children s Hospital Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    BMC Nephrol 5:14. 2004
    ..In vitro, lactate is cytotoxic and vasoactive at the concentrations used in PD fluids. The BIOKID trial is designed to clarify the clinical significance of the buffer choice in biocompatible PD fluids...
  14. doi request reprint Long-term control of parathyroid hormone and calcium-phosphate metabolism after parathyroidectomy in children with chronic kidney disease
    Betti Schaefer
    Center for Pediatric and Adolescent Medicine Heidelberg, University of Heidelberg, INF 430, Heidelberg, Germany
    Nephrol Dial Transplant 25:2590-5. 2010
    ..Parathyroidectomy (PTX) is ultimately performed if HPT becomes refractory to conservative measures; the long-term results and the impact of subsequent kidney transplantation (NTX), however, have not yet been evaluated...
  15. doi request reprint Late recovery of renal function by rituximab in a patient with Wegener's granulomatosis
    Michal Malina
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 28:511-4. 2013
    ..Pediatric experience with rituximab in GPA is limited; the impact on renal function is unknown...
  16. pmc Management of anemia in children receiving chronic peritoneal dialysis
    Dagmara Borzych-Duzalka
    Pediatric Nephrology Division, Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany
    J Am Soc Nephrol 24:665-76. 2013
    ..Anemia and high ESA dose requirements independently predict mortality...
  17. doi request reprint Altered cardiovascular rhythmicity in children born small for gestational age
    Ann Wolfenstetter
    Center for Pediatric and Adolescent Medicine, Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany
    Hypertension 60:865-70. 2012
    ..Circadian and ultradian rhythms may be sensitive indicators for detecting subtle early abnormalities of cardiovascular regulation...
  18. ncbi request reprint Normative values for circadian and ultradian cardiovascular rhythms in childhood
    Charlotte Hadtstein
    University Children s Hospital, Im Neuenheimer Feld 151, 69120 Heidelberg, Germany
    Hypertension 43:547-54. 2004
    ..0001 for coupling of BP and HR rhythms of the same period length) and timing, with a median time lag of BP after HR acrophase of only 21, 16, 13, and 5 minutes for the four rhythms, respectively...
  19. ncbi request reprint Improved acidosis correction and recovery of mesothelial cell mass with neutral-pH bicarbonate dialysis solution among children undergoing automated peritoneal dialysis
    Susanne Haas
    Children s Hospital, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 14:2632-8. 2003
    ..Among children undergoing APD, neutral-pH, bicarbonate-buffered PD fluid provides more effective correction of metabolic acidosis and better preservation of peritoneal cell mass than do conventional, acidic, lactate-based fluids...
  20. doi request reprint Bleeding complications in pediatric ABO-incompatible kidney transplantation
    Betti Schaefer
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 28:327-32. 2013
    ..ABO-incompatible renal transplantation (ABOi-RTx) following preconditioning with immunoadsorption (IA) and rituximab is a promising approach to facilitate living-related RTx. However, clinical experience is limited in pediatric patients...
  21. ncbi request reprint Antihypertensive and antiproteinuric efficacy of ramipril in children with chronic renal failure
    Elke Wühl
    Division of Pediatric Nephrology, University Children s Hospital, University of Heidelberg, Heidelberg, Germany
    Kidney Int 66:768-76. 2004
    ....
  22. ncbi request reprint Clinical course and NPHS2 analysis in patients with late steroid-resistant nephrotic syndrome
    Peter Schwaderer
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Im Neuenheimer Feld 150, 69120, Heidelberg, Germany
    Pediatr Nephrol 23:251-6. 2008
    ..With respect to the clinical course, late resistance appears to resemble SSNS and is characterized by a favorable outcome...
  23. doi request reprint Functional analysis of BMP4 mutations identified in pediatric CAKUT patients
    Mansoureh Tabatabaeifar
    Pediatric Nephrology, University of Heidelberg Children s Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 24:2361-8. 2009
    ..This work further supports the role of mutations in BMP4 for abnormalities of human kidney development...
  24. ncbi request reprint Increased injection pain with darbepoetin-alpha compared to epoetin-beta in paediatric dialysis patients
    Claus Peter Schmitt
    Division of Paediatric Nephrology, University Hospital for Paediatric and Adolescent Medicine, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 21:3520-4. 2006
    ..Darbepoetin-alpha is applicable at longer injection intervals. Our early experience in children on peritoneal dialysis suggested increased injection pain compared to epoetin-beta, possibly due to technical differences or patient anxiety...
  25. ncbi request reprint Dialytic phosphate removal: a modifiable measure of dialysis efficacy in automated peritoneal dialysis
    Claus P Schmitt
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University of Heidelberg, Germany
    Perit Dial Int 29:465-71. 2009
    ..Methods and..
  26. pmc Timing and outcome of renal replacement therapy in patients with congenital malformations of the kidney and urinary tract
    Elke Wühl
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany
    Clin J Am Soc Nephrol 8:67-74. 2013
    ..This study assessed the age at onset of renal replacement therapy (RRT) and patient and renal graft survival in patients with CAKUT across the entire age range...
  27. doi request reprint Determinants of blood pressure in preschool children: the role of parental smoking
    Giacomo D Simonetti
    Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    Circulation 123:292-8. 2011
    ....
  28. ncbi request reprint Home, clinic, and ambulatory blood pressure monitoring in children with chronic renal failure
    Elke Wühl
    University Children s Hospital, Im Neuenheimer Feld 151, 69120 Heidelberg, Germany
    Pediatr Res 55:492-7. 2004
    ..The greater specificity of HBP compared with CBP makes it a more suitable tool for diagnosis, rather than screening, of hypertension in children...
  29. doi request reprint Molecular Adsorbents Recirculating System dialysis in children with cholestatic pruritus
    Betti Schaefer
    Center for Pediatric and Adolescent Medicine Heidelberg, University of Heidelberg, INF 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 27:829-34. 2012
    ..Cholestatic pruritus may severely compromise quality of life. The Molecular Adsorbents Recirculating System (MARS) allows removal of pruritogenic substances without exposure to foreign proteins. Pediatric data, however, are scant...
  30. doi request reprint Expression and function of matrix Gla protein in human peritoneal mesothelial cells
    Yihui Zhai
    1Division of Pediatric Nephrology, Center for Children and Adolescent Medicine, University Hospital for Pediatric and Adolescent Medicine, Heidelberg, Germany
    Nephrol Dial Transplant 25:3213-21. 2010
    ..We investigated whether peritoneal calcification is controlled by matrix Gla protein (MGP) secreted by peritoneal mesothelial cells...
  31. ncbi request reprint Reduced systemic advanced glycation end products in children receiving peritoneal dialysis with low glucose degradation product content
    Claus Peter Schmitt
    Division of Pediatric Nephrology, University Hospital for Pediatric and Adolescent Medicine, University of Heidelberg, Germany
    Nephrol Dial Transplant 22:2038-44. 2007
    ..Double chamber PD solutions have a markedly reduced GDP content...
  32. ncbi request reprint The international pediatric peritonitis registry: a global Internet-based initiative in pediatric dialysis
    Reinhard Feneberg
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Heidelberg, Germany
    Perit Dial Int 25:S130-4. 2005
    ..The International Pediatric Peritonitis Registry (IPPR) was established in October 2001 as a global consortium of 47 pediatric dialysis centers in order to assess the validity of these guidelines...
  33. doi request reprint Superior consistency of ambulatory blood pressure monitoring in children: implications for clinical trials
    Charlotte Gimpel
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg 69120, Germany
    J Hypertens 27:1568-74. 2009
    ..We hypothesized that ambulatory BP monitoring (ABPM) may identify treatment effects more sensitively than CBP and thereby reduce sample sizes required in pediatric antihypertensive trials...
  34. ncbi request reprint Beta1-adrenergic blockade augments pulsatile PTH secretion in humans
    Claus P Schmitt
    Departments of Pediatrics and Internal Medicine, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 14:3245-50. 2003
    ..Selective beta-1 adrenergic blockade acutely increases plasma PTH by augmenting the mass of hormone secreted per burst, but it does not alter the rhythmicity of pulsatile PTH release...
  35. ncbi request reprint PTH pulsatility but not calcium sensitivity is restored after total parathyroidectomy with heterotopic autotransplantation
    Claus P Schmitt
    Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 14:407-14. 2003
    ..In conclusion, pulsatile PTH secretion is partially restored within 2 yr of PTX. However, the capacity of the autotransplanted tissue to adapt to changes in ionized calcium remains profoundly disturbed...
  36. doi request reprint Can we slow the progression of chronic kidney disease?
    Elke Wühl
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    Curr Opin Pediatr 22:170-5. 2010
    ..This process is largely independent of the underlying renal disease. Recent clinical trials have provided evidence that the progressive course of chronic kidney disease can be slowed substantially by pharmacological intervention...
  37. pmc Therapeutic strategies to slow chronic kidney disease progression
    Elke Wühl
    Division of Pediatric Nephrology, University Hospital Heidelberg for Pediatric and Adolescent Medicine, Im Neuenheimer Feld 151, Heidelberg, Germany
    Pediatr Nephrol 23:705-16. 2008
    ..Measures to preserve renal function should therefore also comprise the maintenance of hemoglobin, serum lipid, and calcium-phosphorus ion product levels in the normal range...
  38. ncbi request reprint Hypothalamic release of nitric oxide and interaction with amino acid neurotransmitters in chronically uraemic rats
    Johannes Woitzik
    Division of Pediatric Nephrology, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Nephrol Dial Transplant 20:1566-72. 2005
    ..Since GnRH release is influenced by nitric oxide (NO) neurotransmission, we examined the integrity of hypothalamic NO neurotransmission in the chronically uraemic rat model...
  39. doi request reprint Acute cardiovascular effects of the calcimimetic R-568 and its enantiomer S-568 in rats
    Kumiko Nakagawa
    Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany
    Pediatr Nephrol 24:1385-9. 2009
    ..The calcimimetic R-568 exerts acute, CaSR-independent, hypotensive effects via vasodilation and negative chronotropy at concentrations exceeding those required for modulation of PTH secretion...
  40. ncbi request reprint Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats
    Tobias Odenwald
    Department of Pediatrics, University of Heidelberg, Germany
    J Am Soc Nephrol 17:655-62. 2006
    ..1+/-4 versus 32.5+/-1.4 mmol/kg; P=0.01). The calcimimetic R-568 causes an initial BP increase in sham-operated and uremic rats, which in uremic rats is followed by a marked and sustained antihypertensive effect...
  41. doi request reprint The bone and mineral disorder of children undergoing chronic peritoneal dialysis
    Dagmara Borzych
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany
    Kidney Int 78:1295-304. 2010
    ..Our findings support a PTH target range of 100-300 pg/ml in the pediatric age group...
  42. ncbi request reprint Psychosocial rehabilitation and satisfaction with life in adults with childhood-onset of end-stage renal disease
    Joachim Rosenkranz
    Division of Pediatric Nephrology, University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Pediatr Nephrol 20:1288-94. 2005
    ..The patients' self-evaluation of both their general and health-related quality of life proves to be clearly muted, which is a clear indication of the physical and psychological strain of living with a chronic disease...
  43. doi request reprint Managing kidney disease with blood-pressure control
    Elke Wühl
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Nat Rev Nephrol 7:434-44. 2011
    ..In this Review, we describe the role of hypertension in CKD and discuss the therapeutic principle of the prevention of CKD progression with antihypertensive agents...
  44. ncbi request reprint Normative values for intima-media thickness and distensibility of large arteries in healthy adolescents
    Claudia Jourdan
    Department of Pediatric Radiology, Children s Hospital, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    J Hypertens 23:1707-15. 2005
    ..However, normative values and the impact of adolescent growth are largely unknown...
  45. doi request reprint Comparison of Molecular Adsorbents Recirculating System (MARS) dialysis with combined plasma exchange and haemodialysis in children with acute liver failure
    Betti Schaefer
    Department of General Pediatrics, Center for Pediatric and Adolescent Medicine, University of Heidelberg, Germany
    Nephrol Dial Transplant 26:3633-9. 2011
    ..While it is increasingly applied in patients with acute liver failure (ALF), no comparison with standard dialysis methods has yet been performed...
  46. pmc Hypertension in children with chronic kidney disease: pathophysiology and management
    Charlotte Hadtstein
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University Hospital of Heidelberg, Im Neuenheimer Feld 151, 69120, Heidelberg, Germany
    Pediatr Nephrol 23:363-71. 2008
    ..Multiple drug therapy is often needed to maintain blood pressure below the 90th percentile target, but adequate blood pressure control is essential for better renal and cardiovascular long-term outcomes...
  47. doi request reprint Mapping candidate regions and genes for congenital anomalies of the kidneys and urinary tract (CAKUT) by array-based comparative genomic hybridization
    Stefanie Weber
    Division of Pediatric Nephrology, University Children s Hospital, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 26:136-43. 2011
    ..Congenital anomalies of the kidneys and urinary tract (CAKUT) are frequently associated with malformations of other organs...
  48. ncbi request reprint Management of peritonitis in children receiving chronic peritoneal dialysis
    Franz Schaefer
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Heidelberg, Germany
    Paediatr Drugs 5:315-25. 2003
    ....
  49. doi request reprint Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia
    Kumiko Nakagawa
    Division of Pediatric Nephrology, University Hospital for Pediatric and Adolescent Medicine, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 23:2761-7. 2008
    ..Hence, the impact of CIN on the growth plate function requires assessment before routine administration in children...
  50. ncbi request reprint Distribution of 24-h ambulatory blood pressure in children: normalized reference values and role of body dimensions
    Elke Wühl
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    J Hypertens 20:1995-2007. 2002
    ..The statistical use of pediatric ABPM reference values has been compromised by the non-Gaussian distribution of 24-h blood pressure (BP) in children...
  51. ncbi request reprint Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans
    Eva Maria Schönfelder
    Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    Am J Kidney Dis 47:1004-12. 2006
    ..De novo UPIIIA mutations recently were identified in 4 of 17 patients with severe bilateral renal adysplasia...
  52. ncbi request reprint Gene locus ambiguity in posterior urethral valves/prune-belly syndrome
    Stefanie Weber
    Pediatric Nephrology, University Children s Hospital Heidelberg, Germany
    Pediatr Nephrol 20:1036-42. 2005
    ..Analyses of additional informative families will be important to exclude one of the two loci and to restrict the critical interval...
  53. ncbi request reprint Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure
    Jun Oh
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    Circulation 106:100-5. 2002
    ..Young adults with childhood-onset chronic renal failure (CRF) are uniquely suited for risk factor assessment because of their long-term exposure at an age when vascular pathology in the general population is still minimal...
  54. pmc Change in cardiac geometry and function in CKD children during strict BP control: a randomized study
    Maria Chiara Matteucci
    Departments of Pediatric Nephrology and Urology, Bambino Gesu Children s Hospital, IRCCS, Rome, Italy
    Clin J Am Soc Nephrol 8:203-10. 2013
    ....
  55. ncbi request reprint Effects of growth hormone in patients with chronic renal failure: experience in children and adults
    Elke Wühl
    Division of Paediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    Horm Res 58:35-8. 2002
    ..In few pilot studies and two placebo-controlled studies of 6 months duration, GH treatment in adults on dialysis showed clear anabolic effects resulting in a significant increase in lean body mass...
  56. ncbi request reprint Methodological issues in assessing the incidence of peritoneal dialysis-associated peritonitis in children
    Franz Schaefer
    Division of Pediatric Nephrology, Children s Hospital, Ruperto Carolus University, Heidelberg, Germany
    Perit Dial Int 22:234-8. 2002
    ..To evaluate the distribution of peritonitis incidence and assess the usefulness of patient-specific peritonitis rates in children...
  57. ncbi request reprint Laparoscopic Tenckhoff catheter implantation in children
    Markus Daschner
    Department of Pediatric Surgery, University of Heidelberg, Germany
    Perit Dial Int 22:22-6. 2002
    ..To assess the suitability of a laparoscopic Tenckhoff catheter implantation (TCI) technique in children...
  58. ncbi request reprint Mechanisms of mitogen-activated protein kinase inhibition by parathyroid hormone in osteoblast-like cells
    Meike Hömme
    University Children s Hospital, Division of Pediatric Nephrology, University of Heidelberg, Germany
    J Am Soc Nephrol 15:2844-50. 2004
    ..PTH attenuates the stress-induced JNK signaling pathway in osteoblasts via induction of MKP-1 synthesis but inhibits the p42/44 MAPK pathway mainly via transcription-independent mechanisms...
  59. ncbi request reprint Neuroendocrine adaptations in renal disease
    Reinhard Feneberg
    Coordination Centre for Clinical Trials, Im Neuenheimer Feld 221, 69120, Heidelberg, Germany
    Pediatr Nephrol 18:492-7. 2003
    ..The homeostatic consequences of distorted secretory dynamics, tissue resistance, impaired hormone clearance, and altered mean agonist concentrations are evident in certain therapeutic interventions, such as GH supplementation in CRF...
  60. ncbi request reprint Circulating inhibitor of gonadotropin releasing hormone secretion by hypothalamic neurons in uremia
    Markus Daschner
    Division of Pediatric Nephrology, Children s Hospital, University of Heidelberg, Heidelberg, Germany
    Kidney Int 62:1582-90. 2002
    ..Previous studies have suggested a neuroendocrine defect underlying uremic hypogonadism, characterized by a reduced secretion of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH)...
  61. doi request reprint Genetics of hemolytic uremic syndromes
    Michal Malina
    Center for Pediatrics and Adolescent Medicine Heidelberg, Division of Paediatric Nephrology, 69120 Heidelberg, Germany
    Presse Med 41:e105-14. 2012
    ..This review summarizes recent findings regarding the genetic basis of the HUS. The pathophysiology of the disease and the implication of genetic abnormalities in the complement system for the different types of HUS are discussed...
  62. doi request reprint Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis
    Jun Oh
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    Kidney Int 80:483-92. 2011
    ..Hence, calcimimetics limit podocyte damage by antiapoptotic and cytoskeleton-stabilizing effects and may constitute a new approach in the prevention and treatment of glomerular disease...
  63. ncbi request reprint Effects of pH-neutral, bicarbonate-buffered dialysis fluid on peritoneal transport kinetics in children
    Claus P Schmitt
    Department of Pediatrics, Ruperto Carolus University Heidelberg, Heidelberg, Germany
    Kidney Int 61:1527-36. 2002
    ..Such differences may become clinically relevant in patients with frequent short cycles on automated PD (APD)...
  64. doi request reprint Functional polymorphisms in transforming growth factor-beta-1 (TGFbeta-1) and vascular endothelial growth factor (VEGF) genes modify risk of renal parenchymal scarring following childhood urinary tract infection
    Almontaser Hussein
    Division of Paediatric Nephrology, Center for Paediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 25:779-85. 2010
    ..We sought to investigate a possible role of the common polymorphisms in the gene encoding for VEGF and TGFbeta-1, key regulators of tissue repair, in renal scarring...
  65. ncbi request reprint Recurrence of proteinuria 10 years post-transplant in NPHS2-associated focal segmental glomerulosclerosis after conversion from cyclosporin A to sirolimus
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 21:1476-9. 2006
    ..The close temporal relationship of FSGS recurrence with CsA withdrawal and conversion to SRL suggests that caution should be exercised in the use of CsA-free immunosuppression also in patients with NPHS2-associated FSGS...
  66. ncbi request reprint Altered temporal organization of plasma insulin oscillations in chronic renal failure
    Reinhard Feneberg
    Division of Pediatric Nephrology, Ruperto Carolus University, 69115 Heidelberg, Germany
    J Clin Endocrinol Metab 87:1965-73. 2002
    ..In summary, CRF is associated with a complex disruption of the temporal organization of insulin release, which differs from abnormalities observed to date in other states of insulin resistance...
  67. doi request reprint Taking the pulse of a sick kidney: arterial stiffness in glomerulonephritis
    Anke Doyon
    Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany
    Pediatr Nephrol 26:161-3. 2011
    ....
  68. pmc Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like Syndrome
    Stefanie Weber
    Pediatrics II, University Children s Hospital Essen, 45122 Essen, Germany
    Am J Hum Genet 89:668-74. 2011
    ..These observations may imply that M3 has a role beyond its known contribution to detrusor contractions. This Mendelian disease caused by a muscarinic acetylcholine receptor mutation strikingly phenocopies Chrm3 null mutant mice...
  69. pmc Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice
    Bärbel Lange-Sperandio
    Department of Pediatrics, Ruprecht Karls University, Heidelberg, Germany
    Am J Pathol 171:861-71. 2007
    ..Our findings provide evidence that leukocytes induce EMT and renal fibrosis after UUO and suggest that chemokine receptor-1 antagonism may prove beneficial in obstructive nephropathy...
  70. ncbi request reprint Emergency dialysis in neonatal metabolic crises
    Markus Daschner
    Division of Pediatric Nephrology, Children s Hospital, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Adv Ren Replace Ther 9:63-9. 2002
    ..The usefulness of different blood purification techniques for removing accumulated neurotoxins is reviewed in this manuscript...
  71. ncbi request reprint Chronic uremia attenuates growth hormone-induced signal transduction in skeletal muscle
    Di Fei Sun
    Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    J Am Soc Nephrol 15:2630-6. 2004
    ..The other may involve increased signaling protein dephosphorylation because of heightened protein-tyrosine phosphatase activity...
  72. ncbi request reprint Measurement by magnetic resonance imaging of the peritoneal membrane in contact with dialysate in rats
    Michel Fischbach
    Nephrology Dialysis Transplantation Children s Unit, University Hospital, Strasbourg, France
    Adv Perit Dial 21:17-20. 2005
    ....
  73. ncbi request reprint Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study
    Stefanie Weber
    Department of Pediatric Nephrology, Hopital Necker Enfants Malades, Universite Rene Descartes, 147 Rue de Sevres, 75015 Paris, France
    J Am Soc Nephrol 17:2864-70. 2006
    ..In conclusion, 15% of patients with RHD show mutations in TCF2 or PAX2, whereas abnormalities in EYA1, SALL1, and SIX1 are less frequent...
  74. ncbi request reprint Reduced systolic myocardial function in children with chronic renal insufficiency
    Marcello Chinali
    Echocardiography Laboratory, Department of Clinical and Experimental Medicine, Federico II University Hospital School of Medicine, Ed 1, Via Sergio Pansini 5, 80131, Napoli, Italy
    J Am Soc Nephrol 18:593-8. 2007
    ..001). Systolic dysfunction was most common (48%) in patients with concentric hypertrophy and associated with lower hemoglobin levels. CRI in children is associated with impaired intrinsic LV contractility, which parallels increased LVM...
  75. ncbi request reprint Effect of hypertension on the progression of chronic renal failure in children
    Marianne Soergel
    Centre Hospitalier de Luxembourg, Luxembourg
    Am J Hypertens 15:53S-56S. 2002
    ..The optimal target BP for children with CRF is currently being determined in a multinational, randomized, prospective trial...
  76. ncbi request reprint Peritoneal dialysis-related infections recommendations: 2005 update
    Beth Piraino
    University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Perit Dial Int 25:107-31. 2005
  77. ncbi request reprint Altered morphologic properties of large arteries in children with chronic renal failure and after renal transplantation
    Mieczyslaw Litwin
    Department of Nephrology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 08 110 Warsaw, Poland
    J Am Soc Nephrol 16:1494-500. 2005
    ..In children with CKD, thickening of IMT occurs early in the course of disease and is most marked in dialyzed patients. The changes may be partly reversible after Rtx...
  78. ncbi request reprint Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling
    Ralph Rabkin
    Veterans Affairs, Palo Alto Health Care System, Palo Alto, California 94304, USA
    Pediatr Nephrol 20:313-8. 2005
    ....
  79. ncbi request reprint Dialysate leakage into pericardium in an infant on long-term peritoneal dialysis
    Dagmara Borzych
    Department of Pediatric Nephrology, Medical University of Gdansk, Gdansk, Poland
    Pediatr Nephrol 23:335-8. 2008
    ..Dialysis had to be discontinued, since head-down tilt reproducibly induced significant hypotension. In PD patients with pericardial effusion a peritoneo-pericardial leak should be considered...
  80. doi request reprint Gram-negative peritonitis in children undergoing long-term peritoneal dialysis
    Aleksandra Zurowska
    Department of Paediatric and Adolescent Nephrology and Hypertension, Medical University of Gdansk, Poland
    Am J Kidney Dis 51:455-62. 2008
    ..The objective of this study is to evaluate the clinical presentation, early and late response to treatment, and identification of factors influencing the outcome of gram-negative peritonitis (GNP) in children...
  81. ncbi request reprint Urinary excretion of endothelin-1 (ET-1), transforming growth factor- beta1 (TGF- beta1) and vascular endothelial growth factor (VEGF165) in paediatric chronic kidney diseases: results of the ESCAPE trial
    Ryszard Grenda
    Department of Nephrology, Kidney Transplantation and Hypertension, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Nephrol Dial Transplant 22:3487-94. 2007
    ..A positive correlation between urinary TGF-beta1 and VEGF(165) excretion, shown both in patients and healthy controls, indicates an interdependent nature of their generation...
  82. ncbi request reprint Abnormal circadian blood pressure regulation in children born preterm
    Umut Selda Bayrakci
    Division of Pediatric Nephrology, University Hospital for Pediatric and Adolescent Medicine, Hacettepe University, Ankara, Turkey
    J Pediatr 151:399-403. 2007
    ..To assess a possible relationship between prematurity and casual blood pressure (BP) by means of 24-hour ambulatory BP monitoring (ABPM)...
  83. ncbi request reprint Impaired autofeedback regulation of hypothalamic norepinephrine release in experimental uremia
    Katrin Klein
    University Children s Hospital, Im Neuenheimer Feld 150, Heidelberg 69120, Germany
    J Am Soc Nephrol 16:2081-7. 2005
    ..Although impaired hypothalamic NE autoinhibition does not explain reduced GnRH secretion in CRF, it may be involved in the pathogenesis of sympathetic hyperactivity associated with this condition...
  84. ncbi request reprint Effectiveness of growth hormone treatment in short children with chronic renal failure
    Otto Mehls
    J Pediatr 141:147-8; author reply 148-50. 2002
  85. ncbi request reprint Left ventricular geometry in children with mild to moderate chronic renal insufficiency
    Maria Chiara Matteucci
    Division of Pediatric Nephrology, Bambino Gesu, Hospital, Rome, Italy
    J Am Soc Nephrol 17:218-26. 2006
    ..Prevalence of LVH is related to male gender, anemia, and ponderosity but not to BP. Additional effects of volume status and inflammation on cardiac geometry are also evident...
  86. ncbi request reprint Growth hormone-mediated janus associated kinase-signal transducers and activators of transcription signaling in the growth hormone-resistant potassium-deficient rat
    Franz Schaefer
    Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Am Soc Nephrol 15:2299-306. 2004
    ..This suggests the presence of a defect distal to the nuclear binding of STAT or, alternatively, a defect in a STAT-independent GH-activated signaling pathway...
  87. ncbi request reprint Anthropometric prediction of total body water in children who are on pediatric peritoneal dialysis
    Bruce Z Morgenstern
    Division of Pediatric Nephrology, Phoenix Children s Hospital, 1919 East Thomas Road, Phoenix, AZ 85016, USA
    J Am Soc Nephrol 17:285-93. 2006
    ..In summary, a new set of anthropometric TBW prediction equations that are suited specifically for use in pediatric PD patients have been provided...
  88. ncbi request reprint Peritonitis in children who receive long-term peritoneal dialysis: a prospective evaluation of therapeutic guidelines
    Bradley A Warady
    Pediatric Nephrology, Children s Mercy Hospital, Kansas City, MO 64108, USA
    J Am Soc Nephrol 18:2172-9. 2007
    ..These data serve as the basis for new evidence-based guidelines. Modification of empiric therapy to include aminoglycosides should be considered...
  89. ncbi request reprint New concepts: growth hormone, insulin-like growth factor-I and the kidney
    Ralph Rabkin
    Veterans Affairs Palo Alto Health Care System and Department of Medicine, Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Growth Horm IGF Res 14:270-6. 2004
    ....
  90. ncbi request reprint What adult nephrologists should know about childhood blood pressure
    Charlotte Hadtstein
    Nephrol Dial Transplant 22:2119-23. 2007