Daniel Sauter

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. pmc A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany
    Retrovirology 10:85. 2013
  2. pmc The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function
    Silvia F Kluge
    Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
    Retrovirology 10:32. 2013
  3. pmc Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host
    Nicola Götz
    Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany
    Cell Host Microbe 12:373-80. 2012
  4. pmc Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains
    Daniel Sauter
    Institute of Molecular Virology, Universitatsklinikum, 89081 Ulm, Germany
    Cell Host Microbe 6:409-21. 2009
  5. pmc HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, 89069, Ulm, Germany
    Retrovirology 8:103. 2011
  6. ncbi request reprint Tetherin antagonism by primate lentiviral nef proteins
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
    Curr HIV Res 9:514-23. 2011
  7. doi request reprint Emerging role of the host restriction factor tetherin in viral immune sensing
    Dominik Hotter
    Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany
    J Mol Biol 425:4956-64. 2013
  8. ncbi request reprint HIV-1 accessory proteins: Nef
    Anke Heigele
    Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
    Methods Mol Biol 1087:115-23. 2014
  9. pmc Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
    PLoS Pathog 8:e1003093. 2012
  10. doi request reprint Ancient origin of a deletion in human BST2/Tetherin that confers protection against viral zoonoses
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany
    Hum Mutat 32:1243-5. 2011

Collaborators

Detail Information

Publications15

  1. pmc A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany
    Retrovirology 10:85. 2013
    ..However, non-synonymous polymorphisms in the bst2 open reading frame have not yet been described or functionally characterized...
  2. pmc The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function
    Silvia F Kluge
    Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
    Retrovirology 10:32. 2013
    ..Thus, SIVcpzPtt strains may require fewer adaptive changes in Vpu than SIVcpzPts or SIVgor strains to counteract human tetherin...
  3. pmc Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host
    Nicola Götz
    Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany
    Cell Host Microbe 12:373-80. 2012
    ..Our data demonstrate that primate lentiviruses can reacquire lost accessory gene functions during a single in vivo passage and suggest that other functional constraints keep Nef ready to regain antitetherin activity...
  4. pmc Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains
    Daniel Sauter
    Institute of Molecular Virology, Universitatsklinikum, 89081 Ulm, Germany
    Cell Host Microbe 6:409-21. 2009
    ..This may explain why group M viruses are almost entirely responsible for the global HIV/AIDS pandemic...
  5. pmc HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, 89069, Ulm, Germany
    Retrovirology 8:103. 2011
    ..Here, we examined how long Group P may have been circulating in humans and determined its capability to antagonize human tetherin as an indicator of adaptation to humans...
  6. ncbi request reprint Tetherin antagonism by primate lentiviral nef proteins
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
    Curr HIV Res 9:514-23. 2011
    ..Here, we summarize some of our current knowledge about Nef-mediated tetherin antagonism...
  7. doi request reprint Emerging role of the host restriction factor tetherin in viral immune sensing
    Dominik Hotter
    Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany
    J Mol Biol 425:4956-64. 2013
    ..Here, we summarize some of our current knowledge about the role of tetherin as a viral immune sensor and discuss how the accessory HIV-1 (human immunodeficiency virus type 1) Vpu protein counteracts this effect. ..
  8. ncbi request reprint HIV-1 accessory proteins: Nef
    Anke Heigele
    Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
    Methods Mol Biol 1087:115-23. 2014
    ..We also report how such proviral constructs and indicator cell lines can be used to quantify the effect of Nef on virion infectivity. ..
  9. pmc Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
    PLoS Pathog 8:e1003093. 2012
    ..These results indicate that HIV-1 group N Vpu is under strong host-specific selection pressure and that the acquisition of effective tetherin antagonism may lead to the emergence of viral variants with increased transmission fitness...
  10. doi request reprint Ancient origin of a deletion in human BST2/Tetherin that confers protection against viral zoonoses
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany
    Hum Mutat 32:1243-5. 2011
    ....
  11. pmc Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection
    Mohammad Khalid
    Institute of Molecular Virology, University Clinic of Ulm, Ulm, Germany
    J Virol 86:4906-20. 2012
    ....
  12. pmc HIV-1 Vpu does not degrade interferon regulatory factor 3
    Dominik Hotter
    Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
    J Virol 87:7160-5. 2013
    ..Thus, Vpu suppresses innate immune activation through inhibition of NF-κB rather than degradation of IRF-3...
  13. pmc The presence of a vpu gene and the lack of Nef-mediated downmodulation of T cell receptor-CD3 are not always linked in primate lentiviruses
    Jan Schmökel
    Institute of Molecular Virology, University Clinic of Ulm, 89081 Ulm, Germany
    J Virol 85:742-52. 2011
    ....
  14. doi request reprint Tetherin: holding on and letting go
    Daniel Sauter
    Institute of Molecular Virology, University Clinic Ulm, Meyerhofstrasse 1, 89081 Ulm, Germany
    Cell 141:392-8. 2010
    ..This Essay discusses the host restriction factor tetherin, which blocks the release of enveloped viruses like HIV-1, and the factors evolved by primate lentiviruses, such as Vpu and Nef, that antagonize tetherin's action...
  15. doi request reprint Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses
    Maral Yolamanova
    Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081 Ulm, Germany
    Nat Nanotechnol 8:130-6. 2013
    ..Our results show that EF-C fibrils comprise a highly versatile, convenient and broadly applicable nanomaterial that holds the potential to significantly facilitate retroviral gene transfer in basic research and clinical applications...