Affiliation: University of Ulm
Heusinger E, Deppe K, Sette P, Krapp C, Kmiec D, Kluge S, et al
. Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2. J Virol. 2018;92: pubmed publisher
..This finding helps to explain why SIVsmm has been able to cross the species barrier to humans on at least nine independent occasions. ..
Heusinger E, Kluge S, Kirchhoff F, Sauter D. Early Vertebrate Evolution of the Host Restriction Factor Tetherin. J Virol. 2015;89:12154-65 pubmed publisher
..Our findings identify tetherin as an evolutionarily ancient restriction factor and provide new important insights into the continuous arms race between viruses and their hosts. ..
Sauter D, Kirchhoff F. Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins. Cytokine Growth Factor Rev. 2018;40:3-12 pubmed publisher
Sauter D, Hotter D, Engelhart S, Giehler F, Kieser A, Kubisch C, et al
. A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release. Retrovirology. 2013;10:85 pubmed publisher
..Restriction of HIV-1 virion release and immune sensing are two separable functions of human tetherin and the latter activity is severely impaired by a single amino acid variant (R19H) in the cytoplasmic part of tetherin. ..
Sauter D, Hotter D, Van Driessche B, StÃ¼rzel C, Kluge S, Wildum S, et al
. Differential regulation of NF-ÎºB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins. Cell Rep. 2015;10:586-99 pubmed publisher
..Thus, HIV-1 and its simian precursors employ Nef to boost NF-ÎºB activation early during the viral life cycle to initiate proviral transcription, while Vpu is used to downmodulate NF-ÎºB-dependent expression of ISGs at later stages. ..
McLaren P, Gawanbacht A, Pyndiah N, Krapp C, Hotter D, Kluge S, et al
. Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. Retrovirology. 2015;12:41 pubmed publisher
..A limited number of human genes share multiple characteristics of genes encoding for known restriction factors. Most of them display anti-retroviral activity in transient transfection assays and are expressed in primary CD4+ T cells. ..