H Sauer

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Reactive oxygen species as intracellular messengers during cell growth and differentiation
    H Sauer
    Department of Neurophysiology, University of Cologne, Germany
    Cell Physiol Biochem 11:173-86. 2001
  2. ncbi request reprint Calcium-dependence of hydrogen peroxide-induced c-fos expression and growth stimulation of multicellular prostate tumor spheroids
    H Sauer
    Institute for Neurophysiologie, University of Cologne, Germany
    FEBS Lett 419:201-5. 1997
  3. ncbi request reprint Spontaneous calcium oscillations in embryonic stem cell-derived primitive endodermal cells
    H Sauer
    Institute for Neurophysiology, University of Cologne, Germany
    Exp Cell Res 238:13-22. 1998
  4. ncbi request reprint Doxorubicin distribution in multicellular prostate cancer spheroids evaluated by confocal laser scanning microscopy and the "optical probe technique"
    M Wartenberg
    Department of Neurophysiology, University of Cologne, Germany
    Cytometry 31:137-45. 1998
  5. ncbi request reprint Hypotonic Ca2+ signaling and volume regulation in proliferating and quiescent cells from multicellular spheroids
    H Sauer
    Institute for Neurophysiology, University of Cologne, Germany
    J Cell Physiol 175:129-40. 1998
  6. ncbi request reprint Mechanical strain-induced Ca(2+) waves are propagated via ATP release and purinergic receptor activation
    H Sauer
    Department of Neurophysiology, University of Cologne, Germany
    Am J Physiol Cell Physiol 279:C295-307. 2000
  7. ncbi request reprint Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species
    M Wartenberg
    Department of Neurophysiology and the Department III for Internal Medicine, University of Cologne, D-50931 Cologne, Germany
    J Biol Chem 276:17420-8. 2001
  8. ncbi request reprint Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
    H Sauer
    Department of Neurophysiology, University of Cologne, D-50931 Cologne, Germany
    FASEB J 15:2539-41. 2001
  9. ncbi request reprint The embryoid body as a novel in vitro assay system for antiangiogenic agents
    M Wartenberg
    Institute for Neurophysiology, University of Cologne, Germany
    Lab Invest 78:1301-14. 1998
  10. ncbi request reprint Measurement of apoptosis in long-term cultures of human ovarian tissue
    G Rahimi
    Department of Obstetrics and Gynaecology, University of Cologne, Kerpener Str. 34, 50931 Cologne, Germany
    Reproduction 122:657-63. 2001

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Reactive oxygen species as intracellular messengers during cell growth and differentiation
    H Sauer
    Department of Neurophysiology, University of Cologne, Germany
    Cell Physiol Biochem 11:173-86. 2001
    ..The delicate intracellular interplay between oxidizing and reducing equivalents allows ROS to function as second messengers in the control of cell proliferation and differentiation...
  2. ncbi request reprint Calcium-dependence of hydrogen peroxide-induced c-fos expression and growth stimulation of multicellular prostate tumor spheroids
    H Sauer
    Institute for Neurophysiologie, University of Cologne, Germany
    FEBS Lett 419:201-5. 1997
    ....
  3. ncbi request reprint Spontaneous calcium oscillations in embryonic stem cell-derived primitive endodermal cells
    H Sauer
    Institute for Neurophysiology, University of Cologne, Germany
    Exp Cell Res 238:13-22. 1998
    ..In the presence of brefeldin A or thapsigargin or in the absence of extracellular Ca2+, endocytotic vesicles were absent, suggesting that oscillating [Ca2+]i transients are involved in the exo/endocytotic vesicle shuttle...
  4. ncbi request reprint Doxorubicin distribution in multicellular prostate cancer spheroids evaluated by confocal laser scanning microscopy and the "optical probe technique"
    M Wartenberg
    Department of Neurophysiology, University of Cologne, Germany
    Cytometry 31:137-45. 1998
    ..The optical probe technique proved to be well suited to study MDR in a living three dimensional tissue context...
  5. ncbi request reprint Hypotonic Ca2+ signaling and volume regulation in proliferating and quiescent cells from multicellular spheroids
    H Sauer
    Institute for Neurophysiology, University of Cologne, Germany
    J Cell Physiol 175:129-40. 1998
    ..The absence of RVD and [Ca2+]i transient in quiescent cells may be due to differences in the amount and the cytosolic arrangement of F-actin observed in quiescent cells...
  6. ncbi request reprint Mechanical strain-induced Ca(2+) waves are propagated via ATP release and purinergic receptor activation
    H Sauer
    Department of Neurophysiology, University of Cologne, Germany
    Am J Physiol Cell Physiol 279:C295-307. 2000
    ..Hence, ATP is secreted via mechanosensitive anion channels and activates purinergic receptors on the same cell or neighboring cells in an autocrine and paracrine manner, thus leading to Ca(i)(2+) wave propagation...
  7. ncbi request reprint Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species
    M Wartenberg
    Department of Neurophysiology and the Department III for Internal Medicine, University of Cologne, D-50931 Cologne, Germany
    J Biol Chem 276:17420-8. 2001
    ..ROS involved as second messengers in receptor tyrosine kinase signaling pathways may act as negative regulators of Pgp expression...
  8. ncbi request reprint Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
    H Sauer
    Department of Neurophysiology, University of Cologne, D-50931 Cologne, Germany
    FASEB J 15:2539-41. 2001
    ..Our data indicate that p90RSK downstream of ERK1/2 is the molecular target for ROS generated through stimulation of purinergic receptors by ATP...
  9. ncbi request reprint The embryoid body as a novel in vitro assay system for antiangiogenic agents
    M Wartenberg
    Institute for Neurophysiology, University of Cologne, Germany
    Lab Invest 78:1301-14. 1998
    ..Furthermore, EBs provide a unique model to investigate the diffusion of anticancer agents in a tissue in both the avascular and vascularized states...
  10. ncbi request reprint Measurement of apoptosis in long-term cultures of human ovarian tissue
    G Rahimi
    Department of Obstetrics and Gynaecology, University of Cologne, Kerpener Str. 34, 50931 Cologne, Germany
    Reproduction 122:657-63. 2001
    ..These results indicate that under optimal culture conditions it is possible to cultivate human ovarian tissue long term. The influence of long-term culture on hormone synthesis and follicle maturity will be investigated further...
  11. pmc DC electrical field-induced c-fos expression and growth stimulation in multicellular prostate cancer spheroids
    H Sauer
    Department of Neurophysiology, University of Cologne, Germany
    Br J Cancer 75:1481-8. 1997
    ..The growth stimulation may be mediated by the proto-oncogene c-fos as its expression increased by a factor of 2.5 within 2 h post pulse. c-fos expression declined towards control values within 8 h post pulse...
  12. ncbi request reprint Characteristics of calcium sparks in cardiomyocytes derived from embryonic stem cells
    H Sauer
    Department of Neurophysiology, University of Cologne, D-50931 Cologne, Germany
    Am J Physiol Heart Circ Physiol 281:H411-21. 2001
    ..The characteristics of Ca(2+) sparks occurring in cardiomyocytes differentiated from ES cells may be governed by the Ca(2+) load of the SR and/or the density of RyRs...
  13. ncbi request reprint Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells
    M Wartenberg
    Department of Neurophysiology, University of Cologne, D-50931 Cologne, Germany
    FASEB J 15:995-1005. 2001
    ....
  14. pmc Increased doxorubicin uptake and toxicity in multicellular tumour spheroids treated with DC electrical fields
    H Sauer
    Department of Neurophysiology, University of Cologne, Germany
    Br J Cancer 80:1204-13. 1999
    ..Treatment of tumours with low intensity electrical fields may be useful to improve the cytotoxic capacity of anthracyclines...
  15. ncbi request reprint Calcium sparks in human ventricular cardiomyocytes from patients with terminal heart failure
    M Lindner
    Department of Medicine III, University of Cologne, Cologne, Germany
    Cell Calcium 31:175-82. 2002
    ..A reduced Ca(2+) load of the SR alone is unlikely to account for the observed differences between HF and NF and additional alterations in intracellular Ca(2+) release mechanisms must be postulated...
  16. ncbi request reprint Embryonic stem cells as a model for the physiological analysis of the cardiovascular system
    J Hescheler
    Institute of Neurophysiology, University of Cologne, Koln, Germany
    Methods Mol Biol 185:169-87. 2002
  17. ncbi request reprint Comparison of necrosis in human ovarian tissue after conventional slow freezing or vitrification and transplantation in ovariectomized SCID mice
    G Rahimi
    Department of Obstetrics and Gynaecology, University of Cologne, Kerpener Strasse 34, 50931 Cologne, Germany
    Reprod Biomed Online 9:187-93. 2004
    ..The proportion of necrotic areas in the tumour spheroids was significantly higher than in the ovarian tissue. Vitrification could, after these results, be presented as an alternative to conventional slow cryoconservation...
  18. ncbi request reprint Implication of therapeutic cloning for organ transplantation
    J Hescheler
    Institut fur Neurophysiologie, University of Cologne, Robert Koch Str 39, 50931 Koln, Germany
    Eur J Cardiothorac Surg 26:S54-5; discussion S55-6. 2004
    ....
  19. ncbi request reprint Myocardial beta-blockade as an alternative to cardioplegic arrest during coronary artery surgery
    U Mehlhorn
    Department of Cardiovascular Surgery, University of Cologne, Germany
    Cardiovasc Surg 7:549-57. 1999
    ..It is concluded that the concept of beta-blocker-induced cardiac surgical conditions may be a useful alternative for myocardial protection during coronary artery surgery...
  20. ncbi request reprint [Ca2+] oscillations in a model of energy-dependent Ca2+ uptake by the endoplasmic reticulum
    B K Dellen
    Institut fur Theoretische Physik, Universitat zu Koln, D 50937 Koln, Germany
    J Theor Biol 237:279-90. 2005
    ..The simulation results are further compared to spontaneous [Ca2+] oscillations in primitive endodermal cells...
  21. ncbi request reprint Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes
    E Kolossov
    Axiogenesis AG, Cologne, Germany
    FASEB J 19:577-9. 2005
    ..Thus, quantitation of the alpha-myosin heavy chain driven reporter gene expression allows identification and functional characterization of early cardiac subtypes...
  22. ncbi request reprint Renal and neuronal abnormalities in mice lacking GDNF
    M W Moore
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 382:76-9. 1996
    ..Thus GDNF is important for the development and/or survival of enteric, sympathetic and sensory neurons and the renal system, but is not essential for catecholaminergic neurons in the central nervous system (CNS)...
  23. ncbi request reprint Combined treatment of metastatic breast cancer (MBC) by high-dose chemotherapy (HDCT) and bispecific antibodies: a pilot study
    H J Stemmler
    Department of Hematology Oncology, University of Munich, Germany
    Anticancer Res 25:3047-54. 2005
    ....