Vasiliki Sarli

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Inhibitors of mitotic kinesins: next-generation antimitotics
    Vasiliki Sarli
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103, Leipzig, Germany
    ChemMedChem 1:293-8. 2006
  2. ncbi request reprint Synthesis and biological evaluation of novel EG5 inhibitors
    Vasiliki Sarli
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103, Leipzig, Germany
    Chembiochem 6:2005-13. 2005
  3. ncbi request reprint Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5
    Nils Sunder-Plassmann
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103 Leipzig, Germany
    Bioorg Med Chem 13:6094-111. 2005
  4. ncbi request reprint Selective inhibition of CBP/p300 HAT
    Vasiliki Sarli
    Institut fur Organische Chemie, Universitat Leipzig, Johannisallee 29, 04103 Leipzig, Germany
    Chem Biol 14:605-6. 2007
  5. ncbi request reprint Targeting the kinesin spindle protein: basic principles and clinical implications
    Vasiliki Sarli
    Institute for Organic Chemistry, University of Leipzig, Leipzig, Germany
    Clin Cancer Res 14:7583-7. 2008
  6. doi request reprint Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
    Anita Büttner
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, D 04103 Leipzig, Germany
    Bioorg Med Chem 17:4943-54. 2009
  7. ncbi request reprint Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells
    Min Liu
    Department of Genetics and Cell Biology and Key Laboratory of Bioactive Materials Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
    J Biol Chem 281:18090-7. 2006
  8. ncbi request reprint Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells
    Christine Muller
    Institute of Pharmacy, University of Regensburg, Universitatsstrasse 31, 93040, Regensburg, Germany
    Cancer Chemother Pharmacol 59:157-64. 2007

Collaborators

  • Thomas U Mayer
  • Thomas Surrey
  • Stefan Scholz
  • Anita Büttner
  • Athanassios Giannis
  • Christine Muller
  • Michael Gartner
  • Min Liu
  • Nils Sunder-Plassmann
  • Dietmar Gross
  • Armin Buschauer
  • Günther Bernhardt
  • Harish C Joshi
  • Jin Tang Dong
  • Jinmin Gao
  • Hongxia Wang
  • Lei Sun
  • Chunyong Liu
  • Ritu Aneja
  • Jun Zhou
  • Stefan Huemmer
  • Jeanette Seiler
  • Mathias Utz

Detail Information

Publications8

  1. ncbi request reprint Inhibitors of mitotic kinesins: next-generation antimitotics
    Vasiliki Sarli
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103, Leipzig, Germany
    ChemMedChem 1:293-8. 2006
  2. ncbi request reprint Synthesis and biological evaluation of novel EG5 inhibitors
    Vasiliki Sarli
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103, Leipzig, Germany
    Chembiochem 6:2005-13. 2005
    ..Here, we present the synthesis and biological investigation of 3,4-dihydrophenylquinazoline-2(1H)-thiones as selective and potent Eg5 inhibitors...
  3. ncbi request reprint Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5
    Nils Sunder-Plassmann
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103 Leipzig, Germany
    Bioorg Med Chem 13:6094-111. 2005
    ..One of these derivatives (compound trans-24) proved to be a potent and specific Eg5 inhibitor...
  4. ncbi request reprint Selective inhibition of CBP/p300 HAT
    Vasiliki Sarli
    Institut fur Organische Chemie, Universitat Leipzig, Johannisallee 29, 04103 Leipzig, Germany
    Chem Biol 14:605-6. 2007
    ..Interestingly, it blocks histone acetylation of HIV-infected cells resulting in inhibition of the multiplication of HIV in these cells...
  5. ncbi request reprint Targeting the kinesin spindle protein: basic principles and clinical implications
    Vasiliki Sarli
    Institute for Organic Chemistry, University of Leipzig, Leipzig, Germany
    Clin Cancer Res 14:7583-7. 2008
    ..Several KSP inhibitors are currently being studied in clinical trials and provide new opportunities for the development of novel anticancer therapeutics alternative from the available microtubule targeting drugs...
  6. doi request reprint Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
    Anita Büttner
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, D 04103 Leipzig, Germany
    Bioorg Med Chem 17:4943-54. 2009
    ..Albeit Gli expression has indicated a 16-fold higher Hh-inhibiting activity than observed for the plant alkaloid cyclopamine, none of the tested compounds were able to induce the cyclopamine-specific phenotype in the medaka assay...
  7. ncbi request reprint Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells
    Min Liu
    Department of Genetics and Cell Biology and Key Laboratory of Bioactive Materials Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
    J Biol Chem 281:18090-7. 2006
    ..In addition, these findings suggest that a combination of Eg5 inhibitors with agents abrogating Hsp70 induction would be useful for myeloma therapy in the clinic...
  8. ncbi request reprint Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells
    Christine Muller
    Institute of Pharmacy, University of Regensburg, Universitatsstrasse 31, 93040, Regensburg, Germany
    Cancer Chemother Pharmacol 59:157-64. 2007
    ....