Vasiliki Sarli

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi Inhibitors of mitotic kinesins: next-generation antimitotics
    Vasiliki Sarli
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103, Leipzig, Germany
    ChemMedChem 1:293-8. 2006
  2. ncbi Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5
    Nils Sunder-Plassmann
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103 Leipzig, Germany
    Bioorg Med Chem 13:6094-111. 2005
  3. ncbi Synthesis and biological evaluation of novel EG5 inhibitors
    Vasiliki Sarli
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103, Leipzig, Germany
    Chembiochem 6:2005-13. 2005
  4. ncbi Selective inhibition of CBP/p300 HAT
    Vasiliki Sarli
    Institut fur Organische Chemie, Universitat Leipzig, Johannisallee 29, 04103 Leipzig, Germany
    Chem Biol 14:605-6. 2007
  5. ncbi Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells
    Min Liu
    Department of Genetics and Cell Biology and Key Laboratory of Bioactive Materials (Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
    J Biol Chem 281:18090-7. 2006
  6. ncbi Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells
    Christine Muller
    Institute of Pharmacy, University of Regensburg, Universitatsstrasse 31, 93040, Regensburg, Germany
    Cancer Chemother Pharmacol 59:157-64. 2007

Collaborators

  • Athanassios Giannis
  • Christine Muller
  • Min Liu
  • Michael Gartner
  • Nils Sunder-Plassmann
  • Armin Buschauer
  • Dietmar Gross
  • Günther Bernhardt
  • Jinmin Gao
  • Lei Sun
  • Hongxia Wang
  • Ritu Aneja
  • Jin-Tang Dong
  • Harish C Joshi
  • Chunyong Liu
  • Jun Zhou
  • Stefan Huemmer
  • Jeanette Seiler
  • Thomas Surrey
  • Thomas U Mayer
  • Mathias Utz

Detail Information

Publications6

  1. ncbi Inhibitors of mitotic kinesins: next-generation antimitotics
    Vasiliki Sarli
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103, Leipzig, Germany
    ChemMedChem 1:293-8. 2006
  2. ncbi Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5
    Nils Sunder-Plassmann
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103 Leipzig, Germany
    Bioorg Med Chem 13:6094-111. 2005
    ..One of these derivatives (compound trans-24) proved to be a potent and specific Eg5 inhibitor...
  3. ncbi Synthesis and biological evaluation of novel EG5 inhibitors
    Vasiliki Sarli
    University of Leipzig, Institute for Organic Chemistry, Johannisallee 29, 04103, Leipzig, Germany
    Chembiochem 6:2005-13. 2005
    ..Here, we present the synthesis and biological investigation of 3,4-dihydrophenylquinazoline-2(1H)-thiones as selective and potent Eg5 inhibitors...
  4. ncbi Selective inhibition of CBP/p300 HAT
    Vasiliki Sarli
    Institut fur Organische Chemie, Universitat Leipzig, Johannisallee 29, 04103 Leipzig, Germany
    Chem Biol 14:605-6. 2007
    ..Interestingly, it blocks histone acetylation of HIV-infected cells resulting in inhibition of the multiplication of HIV in these cells...
  5. ncbi Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells
    Min Liu
    Department of Genetics and Cell Biology and Key Laboratory of Bioactive Materials (Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
    J Biol Chem 281:18090-7. 2006
    ..In addition, these findings suggest that a combination of Eg5 inhibitors with agents abrogating Hsp70 induction would be useful for myeloma therapy in the clinic...
  6. ncbi Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells
    Christine Muller
    Institute of Pharmacy, University of Regensburg, Universitatsstrasse 31, 93040, Regensburg, Germany
    Cancer Chemother Pharmacol 59:157-64. 2007
    ....