Research Topics

Genomes and Genes


A Salameh


Affiliation: University of Leipzig
Country: Germany


  1. Salameh A, Krautblatter S, Baessler S, Karl S, Rojas Gomez D, Dhein S, et al. Signal transduction and transcriptional control of cardiac connexin43 up-regulation after alpha 1-adrenoceptor stimulation. J Pharmacol Exp Ther. 2008;326:315-22 pubmed publisher
    ..Therefore, we conclude that alpha(1)-adrenoceptor stimulation up-regulates cardiac Cx43 expression via a PKC p38- and p42/44 MAPK-regulated pathway, possibly involving AP1. ..
  2. Salameh A, Dhein S. Adrenergic control of cardiac gap junction function and expression. Naunyn Schmiedebergs Arch Pharmacol. 2011;383:331-46 pubmed publisher
    ..They probably are involved in the formation of an arrhythmogenic substrate in certain heart diseases. ..
  3. Salameh A, Kühne L, Grassl M, Gerdom M, von Salisch S, Vollroth M, et al. Protective effects of pulsatile flow during cardiopulmonary bypass. Ann Thorac Surg. 2015;99:192-9 pubmed publisher
    ..In our study during pulsatile CPB, organ damage was significantly attenuated as compared with non-pulsatile CPB. Therefore, in pediatric patients pulsatile CPB may improve clinical outcomes. ..
  4. Salameh A, Krautblatter S, Karl S, Blanke K, Gomez D, Dhein S, et al. The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors. Br J Pharmacol. 2009;158:198-208 pubmed publisher
    ..Beta-adrenoceptor stimulation up-regulated cardiac Cx43 expression via a protein kinase A and MAPK-regulated pathway, possibly involving AP1 and CREB. Cardiomyopathy altered Cx43 expression and distribution. ..
  5. Salameh A, Blanke K, Dhein S, Janousek J. Cardiac gap junction channels are upregulated by metoprolol: an unexpected effect of beta-blockers. Pharmacology. 2010;85:203-10 pubmed publisher
  6. Salameh A, Wustmann A, Karl S, Blanke K, Apel D, Rojas Gomez D, et al. Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43. Circ Res. 2010;106:1592-602 pubmed publisher
    ..The Cx43-changes seem to depend on the ERK1/2 signaling cascade. ..
  7. request reprint
    Salameh A, Dhein S, Fleischmann B, Grohe C, Hescheler J, Linz K, et al. The aging heart: changes in the pharmacodynamic electrophysiological response to verapamil in aged rabbit hearts. J Physiol Pharmacol. 2010;61:141-51 pubmed
    ..L) (reduced maximum conductance, a shift of the steady state inactivation) in the aged heart which may influence the response to verapamil...