Affiliation: University of Leipzig
Salameh A, Krautblatter S, Baessler S, Karl S, Rojas Gomez D, Dhein S, et al
. Signal transduction and transcriptional control of cardiac connexin43 up-regulation after alpha 1-adrenoceptor stimulation. J Pharmacol Exp Ther. 2008;326:315-22 pubmed publisher
..Therefore, we conclude that alpha(1)-adrenoceptor stimulation up-regulates cardiac Cx43 expression via a PKC p38- and p42/44 MAPK-regulated pathway, possibly involving AP1. ..
Salameh A, Dhein S. Adrenergic control of cardiac gap junction function and expression. Naunyn Schmiedebergs Arch Pharmacol. 2011;383:331-46 pubmed publisher
..They probably are involved in the formation of an arrhythmogenic substrate in certain heart diseases. ..
Salameh A, KÃ¼hne L, Grassl M, Gerdom M, von Salisch S, Vollroth M, et al
. Protective effects of pulsatile flow during cardiopulmonary bypass. Ann Thorac Surg. 2015;99:192-9 pubmed publisher
..In our study during pulsatile CPB, organ damage was significantly attenuated as compared with non-pulsatile CPB. Therefore, in pediatric patients pulsatile CPB may improve clinical outcomes. ..
Salameh A, Krautblatter S, Karl S, Blanke K, Gomez D, Dhein S, et al
. The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors. Br J Pharmacol. 2009;158:198-208 pubmed publisher
..Beta-adrenoceptor stimulation up-regulated cardiac Cx43 expression via a protein kinase A and MAPK-regulated pathway, possibly involving AP1 and CREB. Cardiomyopathy altered Cx43 expression and distribution. ..
Salameh A, Blanke K, Dhein S, Janousek J. Cardiac gap junction channels are upregulated by metoprolol: an unexpected effect of beta-blockers. Pharmacology. 2010;85:203-10 pubmed publisher
Salameh A, Wustmann A, Karl S, Blanke K, Apel D, Rojas Gomez D, et al
. Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43. Circ Res. 2010;106:1592-602 pubmed publisher
..The Cx43-changes seem to depend on the ERK1/2 signaling cascade. ..
Salameh A, Dhein S, Fleischmann B, Grohe C, Hescheler J, Linz K, et al
. The aging heart: changes in the pharmacodynamic electrophysiological response to verapamil in aged rabbit hearts. J Physiol Pharmacol. 2010;61:141-51 pubmed
..L) (reduced maximum conductance, a shift of the steady state inactivation) in the aged heart which may influence the response to verapamil...