Ali Sak

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi request reprint Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines
    Ali Sak
    Department of Radiotherapy, University Essen, 45122 Essen, Germany
    Cancer Res 62:6621-4. 2002
  2. ncbi request reprint Increased radiation-induced apoptosis and altered cell cycle progression of human lung cancer cell lines by antisense oligodeoxynucleotides targeting p53 and p21(WAF1/CIP1)
    Ali Sak
    Department of Radiotherapy, University Essen, 45122 Essen, Germany
    Cancer Gene Ther 10:926-34. 2003
  3. pmc Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines
    A Sak
    Department of Radiotherapy, University Hospital Essen, 45122 Essen, Germany
    Br J Cancer 92:1089-97. 2005
  4. doi request reprint Inhibiting the aurora B kinase potently suppresses repopulation during fractionated irradiation of human lung cancer cell lines
    Ali Sak
    Department of Radiotherapy, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Int J Radiat Oncol Biol Phys 84:492-9. 2012
  5. doi request reprint Long-term in vivo effects of cisplatin on gamma-H2AX foci signaling in peripheral lymphocytes of tumor patients after irradiation
    Ali Sak
    Department of Radiotherapy, University Hospital Essen, Essen, Germany
    Clin Cancer Res 15:2927-34. 2009
  6. doi request reprint Use of γH2AX and other biomarkers of double-strand breaks during radiotherapy
    Ali Sak
    Department of Radiotherapy, University Hospital Essen, Essen, Germany
    Semin Radiat Oncol 20:223-31. 2010
  7. doi request reprint Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines
    A Sak
    Department of Radiotherapy, University Hospital Essen, Essen, Germany
    Cell Prolif 41:660-70. 2008
  8. ncbi request reprint Radiation-induced apoptosis in human non-small-cell lung cancer cell lines is secondary to cell-cycle progression beyond the G2-phase checkpoint
    M Stuschke
    Department of Radiotherapy, Humboldt University, Charite, Berlin, Germany
    Int J Radiat Biol 78:807-19. 2002
  9. ncbi request reprint gamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: dependence on the dose-distribution, irradiated site and time from start of treatment
    Ali Sak
    Department of Radiotherapy, University Hospital Essen, Essen, Germany
    Int J Radiat Biol 83:639-52. 2007
  10. doi request reprint Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Mol Cancer Ther 7:1772-81. 2008

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines
    Ali Sak
    Department of Radiotherapy, University Essen, 45122 Essen, Germany
    Cancer Res 62:6621-4. 2002
    ..These data show that kinase activity of DNA-PKcs can be specifically inhibited with As-ODN as effective as Wortmannin and results in marked inhibition of DNA-Dsb rejoining and radiosensitization of NSCLC cell lines...
  2. ncbi request reprint Increased radiation-induced apoptosis and altered cell cycle progression of human lung cancer cell lines by antisense oligodeoxynucleotides targeting p53 and p21(WAF1/CIP1)
    Ali Sak
    Department of Radiotherapy, University Essen, 45122 Essen, Germany
    Cancer Gene Ther 10:926-34. 2003
    ....
  3. pmc Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines
    A Sak
    Department of Radiotherapy, University Hospital Essen, 45122 Essen, Germany
    Br J Cancer 92:1089-97. 2005
    ..Although most of the Rad51 foci are co-localised with gamma-H2AX foci, no correlation of the relative fraction of persisting gamma-H2AX foci and SF2 is evident...
  4. doi request reprint Inhibiting the aurora B kinase potently suppresses repopulation during fractionated irradiation of human lung cancer cell lines
    Ali Sak
    Department of Radiotherapy, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Int J Radiat Oncol Biol Phys 84:492-9. 2012
    ..We assessed the combined effectiveness of inhibiting Aurora B kinase and irradiation on human NSCLC cell lines in vitro...
  5. doi request reprint Long-term in vivo effects of cisplatin on gamma-H2AX foci signaling in peripheral lymphocytes of tumor patients after irradiation
    Ali Sak
    Department of Radiotherapy, University Hospital Essen, Essen, Germany
    Clin Cancer Res 15:2927-34. 2009
    ..This study determined the effects of cis-diamminedichloroplatinum(II) on radiation-induced foci formation of gamma-H2AX and Rad51 in lymphocytes...
  6. doi request reprint Use of γH2AX and other biomarkers of double-strand breaks during radiotherapy
    Ali Sak
    Department of Radiotherapy, University Hospital Essen, Essen, Germany
    Semin Radiat Oncol 20:223-31. 2010
    ..Validation by prospective studies is needed...
  7. doi request reprint Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines
    A Sak
    Department of Radiotherapy, University Hospital Essen, Essen, Germany
    Cell Prolif 41:660-70. 2008
    ..This study is to evaluate the effect of separase depletion on cell cycle progression of irradiated and non-irradiated cells through the G(2)/M phases and consecutive cell survival...
  8. ncbi request reprint Radiation-induced apoptosis in human non-small-cell lung cancer cell lines is secondary to cell-cycle progression beyond the G2-phase checkpoint
    M Stuschke
    Department of Radiotherapy, Humboldt University, Charite, Berlin, Germany
    Int J Radiat Biol 78:807-19. 2002
    ..To characterize the relationship between cell-cycle progression and radiation-induced apoptosis in NSCLC cell lines with different p53 status...
  9. ncbi request reprint gamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: dependence on the dose-distribution, irradiated site and time from start of treatment
    Ali Sak
    Department of Radiotherapy, University Hospital Essen, Essen, Germany
    Int J Radiat Biol 83:639-52. 2007
    ..To evaluate the relationship between an estimated integral total body radiation dose delivered and phosphorylated histone H2AX protein (gamma-H2AX) foci formation in peripheral blood lymphocytes of cancer patients...
  10. doi request reprint Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Mol Cancer Ther 7:1772-81. 2008
    ..Thus, targeting of AKT enhances radiation sensitivity of lung cancer cell lines A549 and H460 most likely through specific inhibition of DNA-PKcs-dependent DNA-dsb repair but not through enhancement of radiation-induced apoptosis...