Ugur Sahin

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development
    Ugur Sahin
    Ganymed Pharmaceuticals, Johannes Gutenberg University, Mainz, Germany
    Clin Cancer Res 14:7624-34. 2008
  2. ncbi request reprint Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals
    Sebastian Kreiter
    Department of Internal Medicine III, Johannes Gutenberg University, Mainz, Germany
    J Immunol 180:309-18. 2008
  3. pmc Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2
    Michael Koslowski
    Department of Internal Medicine III, Experimental and Translational Oncology, Johannes Gutenberg University, Obere Zahlbacherstr, 63, 55131 Mainz, Germany
    Mol Cancer 8:77. 2009
  4. doi request reprint NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells
    Meike Wagner
    Department of Internal Medicine III, Division of Translational and Experimental Oncology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
    BMC Cancer 13:570. 2013
  5. pmc Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2
    Michael Koslowski
    Department of Internal Medicine III, Experimental and Translational Oncology, Johannes Gutenberg University, 55131 Mainz, Germany
    J Biol Chem 284:28607-15. 2009
  6. doi request reprint Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity
    Sebastian Kreiter
    Center for Translational Oncology and Immunology TRON, Mainz, Germany
    Cancer Res 70:9031-40. 2010
  7. doi request reprint FLT3 ligand enhances the cancer therapeutic potency of naked RNA vaccines
    Sebastian Kreiter
    Institute for Translational Oncology and Immunology, Mainz, Germany
    Cancer Res 71:6132-42. 2011
  8. doi request reprint MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes
    Michael Koslowski
    Department of Internal Medicine III, Division of Experimental and Translational Oncology, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:3458-66. 2008
  9. ncbi request reprint Determinants of intracellular RNA pharmacokinetics: Implications for RNA-based immunotherapeutics
    Andreas N Kuhn
    Center for Translational Oncology and Immunology TRON, Mainz, Germany
    RNA Biol 8:35-43. 2011
  10. ncbi request reprint Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA
    Sebastian Kreiter
    Division of Experimental and Translational Oncology, Department of Internal Medicine III, Johannes Gutenberg University, Obere Zahlbacherstr 63, 55131, Mainz, Germany
    Cancer Immunol Immunother 56:1577-87. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development
    Ugur Sahin
    Ganymed Pharmaceuticals, Johannes Gutenberg University, Mainz, Germany
    Clin Cancer Res 14:7624-34. 2008
    ..Antibody-based cancer therapies have emerged as the most promising therapeutics in oncology. The purpose of this study was to discover novel targets for therapeutic antibodies in solid cancer...
  2. ncbi request reprint Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals
    Sebastian Kreiter
    Department of Internal Medicine III, Johannes Gutenberg University, Mainz, Germany
    J Immunol 180:309-18. 2008
    ....
  3. pmc Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2
    Michael Koslowski
    Department of Internal Medicine III, Experimental and Translational Oncology, Johannes Gutenberg University, Obere Zahlbacherstr, 63, 55131 Mainz, Germany
    Mol Cancer 8:77. 2009
    ....
  4. doi request reprint NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells
    Meike Wagner
    Department of Internal Medicine III, Division of Translational and Experimental Oncology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
    BMC Cancer 13:570. 2013
    ....
  5. pmc Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2
    Michael Koslowski
    Department of Internal Medicine III, Experimental and Translational Oncology, Johannes Gutenberg University, 55131 Mainz, Germany
    J Biol Chem 284:28607-15. 2009
    ..Our findings provide first insight into a novel and hitherto unknown regulatory mechanism governing selective activation of trophoblast-specific gene expression in breast cancer...
  6. doi request reprint Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity
    Sebastian Kreiter
    Center for Translational Oncology and Immunology TRON, Mainz, Germany
    Cancer Res 70:9031-40. 2010
    ..This is the first report of strong systemic antigen-specific Th1-type immunity and cancer cure achieved with naked antigen-encoding RNA in preclinical animal models...
  7. doi request reprint FLT3 ligand enhances the cancer therapeutic potency of naked RNA vaccines
    Sebastian Kreiter
    Institute for Translational Oncology and Immunology, Mainz, Germany
    Cancer Res 71:6132-42. 2011
    ..Our findings show how to improve the simple and safe strategy offered by RNA vaccines for cancer immunotherapy...
  8. doi request reprint MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes
    Michael Koslowski
    Department of Internal Medicine III, Division of Experimental and Translational Oncology, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:3458-66. 2008
    ..In summary, these findings have implications for both the physiology of colonic epithelium as well as for the biology and treatment of colon cancer...
  9. ncbi request reprint Determinants of intracellular RNA pharmacokinetics: Implications for RNA-based immunotherapeutics
    Andreas N Kuhn
    Center for Translational Oncology and Immunology TRON, Mainz, Germany
    RNA Biol 8:35-43. 2011
    ..This article summarizes recent developments in identifying optimized RNA for expression of foreign proteins in dendritic cells, as well as their implications for immunotherapy based on antigen-encoding RNA...
  10. ncbi request reprint Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA
    Sebastian Kreiter
    Division of Experimental and Translational Oncology, Department of Internal Medicine III, Johannes Gutenberg University, Obere Zahlbacherstr 63, 55131, Mainz, Germany
    Cancer Immunol Immunother 56:1577-87. 2007
    ..This approach avoids the time consuming generation of dendritic cells as immune stimulators and, in particular when used in the context of the CFC, is robust, broadly applicable and fast...
  11. doi request reprint Antitumor vaccination with synthetic mRNA: strategies for in vitro and in vivo preclinical studies
    Mustafa Diken
    Translational Oncology and Immunology TRON at the Johannes Gutenberg University Mainz, Mainz, Germany
    Methods Mol Biol 969:235-46. 2013
    ..This chapter summarizes the state-of-art in this field and describes methods elementary for preclinical studies of mRNA-based antitumor vaccine protocols...
  12. ncbi request reprint Humoral immune responses of lung cancer patients against tumor antigen NY-ESO-1
    Ozlem Tureci
    Department of Internal Medicine, Johannes Gutenberg University, Obere Zahlbacherstr 63, D 55131 Mainz, Germany
    Cancer Lett 236:64-71. 2006
    ..Our observations indicate that induction of NY-ESO-I autoantibodies depends on the histological subtype within a given tumor entity...
  13. ncbi request reprint mTOR inhibition improves antitumor effects of vaccination with antigen-encoding RNA
    Mustafa Diken
    Authors Affiliations Ganymed Pharmaceuticals, Mainz, Germany
    Cancer Immunol Res 1:386-92. 2013
    ..Our findings indicate that rapamycin enhances therapeutic efficacy of antigen-specific CD8(+) T cells induced by RNA vaccination, and we propose further clinical exploration of rapamycin as a component of immunotherapeutic regimens...
  14. doi request reprint In silico strategy for detection of target candidates for antibody therapy of solid tumors
    Gerd Helftenbein
    Ganymed Pharmaceuticals AG, Mainz, Germany
    Gene 414:76-84. 2008
    ..The impact of such stringent input control on accuracy of prediction is underlined by RT-PCR confirmation of predicted tissue distribution patterns for a number of selected candidates...
  15. ncbi request reprint mRNA as a versatile tool for exogenous protein expression
    Andreas N Kuhn
    TRON Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Curr Gene Ther 12:347-61. 2012
    ..In addition, we summarize current pre-clinical and clinical studies using RNA-based vectors for immunotherapy, T cell, stem cell as well as gene therapy...
  16. ncbi request reprint Frequent nonrandom activation of germ-line genes in human cancer
    Michael Koslowski
    Department of Internal Medicine III, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 64:5988-93. 2004
    ..The identification of highly congruent expression patterns in cancer and in DNA methyltransferase-deficient cells suggests an underlying common epigenetic mechanism for activation of germ-line genes in cancer...
  17. ncbi request reprint Identification of tumor-associated autoantigens with SEREX
    Ozlem Tureci
    Department of Internal Medicine, Johannes Gutenberg University, Mainz, Germany
    Methods Mol Med 109:137-54. 2005
    ..This chapter describes the SEREX technology in detail...
  18. ncbi request reprint Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer
    Carolin Grunwald
    Department of Internal Medicine III, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany, and University Hospital Ghent, Belgium
    Int J Cancer 118:2522-8. 2006
    ..In particular, combining CG genes not localized on the X-chromosome may provide effective treatment for an extended number of patients...
  19. ncbi request reprint The human X chromosome is enriched for germline genes expressed in premeiotic germ cells of both sexes
    Michael Koslowski
    Department of Internal Medicine III, Johannes Gutenberg University, Obere Zahlbacher Street 63, 55131 Mainz, Germany
    Hum Mol Genet 15:2392-9. 2006
    ....
  20. ncbi request reprint A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes
    Michael Koslowski
    Department of Internal Medicine III, Division of Experimental and Translational Oncology, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 67:9528-34. 2007
    ..These features, in summary, make PLAC1 an attractive candidate for targeted immunotherapeutic approaches...
  21. ncbi request reprint Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells
    Silke Holtkamp
    Division of Experimental and Translational Oncology, Department of Internal Medicine III, Johannes Gutenberg University, Obere Zahlbacherstr 63, 55131 Mainz, Germany
    Blood 108:4009-17. 2006
    ..In summary, our data provide a strategy for optimizing RNA-transfected DC vaccines and a basis for defining release criteria for such vaccine preparations...
  22. doi request reprint Antigen identification using SEREX
    Ugur Sahin
    Translational Oncology TRON, Mainz, Germany
    Methods Mol Biol 1061:59-77. 2013
    ..This chapter provides the key protocols for SEREX immunoscreening and for downstream validation of autoantigens. ..
  23. pmc Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model
    Nina Cabezas-Wallscheid
    Medical Center of the Johannes Gutenberg University Mainz, Department of Internal Medicine III, Division of Translational and Experimental Oncology, Mainz, Germany German Cancer Research Center, Department of Stem Cells and Cancer, Heidelberg, Germany Medical Center of the Johannes Gutenberg University Mainz, Institute for Toxicology, Mainz, Germany
    EMBO Mol Med 5:1804-20. 2013
    ....
  24. doi request reprint Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms
    Stefan Wöll
    Ganymed Pharmaceuticals AG, Mainz, Germany
    Int J Cancer 134:731-9. 2014
    ..Thus, a considerable number of patients with pancreatic neoplasms would be in principle eligible for a CLDN18.2-targeting approach...
  25. pmc Confidence-based somatic mutation evaluation and prioritization
    Martin Löwer
    TRON Translational Oncology at Johannes Gutenberg University of Mainz Medicine, Mainz, Germany
    PLoS Comput Biol 8:e1002714. 2012
    ..Using the HiSeq 2000, single end 50 nt reads from replicates generate the highest confidence somatic mutation call set...
  26. doi request reprint Exploiting the mutanome for tumor vaccination
    John C Castle
    TRON Translational Oncology at the University Medical Center Mainz, Germany
    Cancer Res 72:1081-91. 2012
    ..Lastly, they argue that the use of deep sequencing to systematically analyze immunogenicity mutations may pave the way for individualized immunotherapy of cancer patients...
  27. pmc Serum-free freezing media support high cell quality and excellent ELISPOT assay performance across a wide variety of different assay protocols
    Helene Filbert
    III Medical Department, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Cancer Immunol Immunother 62:615-27. 2013
    ..We conclude that defined and accessible serum-free freezing media should be recommended for freezing cells stored for subsequent ELISPOT analysis...
  28. doi request reprint A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin κ C as a compatible prognostic marker in human solid tumors
    Marcus Schmidt
    Departments of Obstetrics and Gynecology, University Hospital, Mainz, Germany
    Clin Cancer Res 18:2695-703. 2012
    ..Although the central role of the immune system for tumor prognosis is generally accepted, a single robust marker is not yet available...
  29. doi request reprint RNA-Seq Atlas--a reference database for gene expression profiling in normal tissue by next-generation sequencing
    Markus Krupp
    Department of Medicine I, Johannes Gutenberg University, 55131 Mainz, Germany
    Bioinformatics 28:1184-5. 2012
    ..Although the perspective is clear and the long-term success of this new technology obvious, bioinformatics resources making these data easily available especially to the biomedical research community are still evolving...
  30. ncbi request reprint Rapid molecular dissection of viral and bacterial immunomes
    Ugur Sahin
    III Department of Internal Medicine, Johannes Gutenberg University Mainz, Mainz, Germany
    Eur J Immunol 36:1049-57. 2006
    ..The established approach is rapid, making it an attractive procedure for the comprehensive dissection of immunomes of known human pathogens and newly emerging infectious agents...
  31. ncbi request reprint CrELISA: a fast and robust enzyme-linked immunosorbent assay bypassing the need for purification of recombinant protein
    Ozlem Tureci
    III Department of Internal Medicine, Johannes Gutenberg University, Mainz, Germany
    J Immunol Methods 289:191-9. 2004
    ..CrELISA is robust and provides a versatile high throughput procedure for the rapid evaluation of multiple antigens in large-scale serology...