Osama Sabri

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. pmc No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
    Gerda Thomsen
    Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark
    EJNMMI Res 3:39. 2013
  2. pmc Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson disease
    Ioannis U Isaias
    Dipartimento di Fisiologia Umana, Universita degli Studi di Milano, Milano, Italy
    BMC Neurol 11:88. 2011
  3. doi request reprint Acetylcholine receptors in dementia and mild cognitive impairment
    Osama Sabri
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 35:S30-45. 2008
  4. doi request reprint Dissociating behavioral disorders in early dementia-An FDG-PET study
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    Psychiatry Res 194:235-44. 2011
  5. doi request reprint Neuroimaging of the vesicular acetylcholine transporter by a novel 4-[18F]fluoro-benzoyl derivative of 7-hydroxy-6-(4-phenyl-piperidin-1-yl)-octahydro-benzo[1,4]oxazines
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig 04103, Germany
    Nucl Med Biol 36:17-27. 2009
  6. doi request reprint Effect of progenitor cells on myocardial perfusion and metabolism in patients after recanalization of a chronically occluded coronary artery
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 49:557-63. 2008
  7. ncbi request reprint Measurement of the alpha4beta2* nicotinic acetylcholine receptor ligand 2-[(18)F]Fluoro-A-85380 and its metabolites in human blood during PET investigation: a methodological study
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig, 04103, Germany
    Nucl Med Biol 34:331-42. 2007
  8. doi request reprint Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer's disease assessed with positron emission tomography
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:515-25. 2011
  9. doi request reprint PET quantification of 18F-florbetaben binding to β-amyloid deposits in human brains
    Georg A Becker
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 54:723-31. 2013
  10. doi request reprint The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Int J Neuropsychopharmacol 14:606-17. 2011

Detail Information

Publications72

  1. pmc No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
    Gerda Thomsen
    Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark
    EJNMMI Res 3:39. 2013
    ..We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers...
  2. pmc Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson disease
    Ioannis U Isaias
    Dipartimento di Fisiologia Umana, Universita degli Studi di Milano, Milano, Italy
    BMC Neurol 11:88. 2011
    ..Little is known however, about the functional state of the LC in patients with Parkinson disease (PD)...
  3. doi request reprint Acetylcholine receptors in dementia and mild cognitive impairment
    Osama Sabri
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 35:S30-45. 2008
    ....
  4. doi request reprint Dissociating behavioral disorders in early dementia-An FDG-PET study
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    Psychiatry Res 194:235-44. 2011
    ..Our study contributes to the understanding of behavioral deficits in early dementia and suggests specific diagnostic and therapeutic approaches...
  5. doi request reprint Neuroimaging of the vesicular acetylcholine transporter by a novel 4-[18F]fluoro-benzoyl derivative of 7-hydroxy-6-(4-phenyl-piperidin-1-yl)-octahydro-benzo[1,4]oxazines
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig 04103, Germany
    Nucl Med Biol 36:17-27. 2009
    ..18)F]FBMV exhibits another PET marker within the group of vesamicol derivatives that demonstrates potentials in imaging brain cholinergic deficits, while its usefulness in clinical practice must await further investigation...
  6. doi request reprint Effect of progenitor cells on myocardial perfusion and metabolism in patients after recanalization of a chronically occluded coronary artery
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 49:557-63. 2008
    ....
  7. ncbi request reprint Measurement of the alpha4beta2* nicotinic acetylcholine receptor ligand 2-[(18)F]Fluoro-A-85380 and its metabolites in human blood during PET investigation: a methodological study
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig, 04103, Germany
    Nucl Med Biol 34:331-42. 2007
    ..95). Since SPE is less time-consuming than HPLC and provides comparable results, we conclude that SPE appears to be the most suitable method for measurement of 2-[(18)F]FA parent fraction during PET investigations...
  8. doi request reprint Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer's disease assessed with positron emission tomography
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:515-25. 2011
    ....
  9. doi request reprint PET quantification of 18F-florbetaben binding to β-amyloid deposits in human brains
    Georg A Becker
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 54:723-31. 2013
    ..We evaluated the kinetic model-based approaches to the quantification of β-amyloid binding in the brain from dynamic PET data. The validity of the practically useful tissue ratio was also evaluated against the model-based parameters...
  10. doi request reprint The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Int J Neuropsychopharmacol 14:606-17. 2011
    ..These findings suggest that late but not early onset of OCD is associated with abnormally low SERT availability. In part, functional polymorphisms of the SERT gene might determine the differences...
  11. doi request reprint Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 39:1001-11. 2012
    ..The aim of our study was to firstly use the new highly SERT-selective (18)F-labelled fluoromethyl analogue of (+)-McN5652 ((+)-[(18)F]FMe-McN5652) in humans and to evaluate its potential for SERT quantification...
  12. doi request reprint Monoamine transporter availability in Parkinson's disease patients with or without depression
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:428-35. 2009
    ..Therefore, we studied PD patients with depression (PD+D) and without depression (PD-D) using high-resolution single-photon emission computed tomography (SPECT) and the monoamine transporter marker [(123)I]FP-CIT...
  13. doi request reprint Preserved serotonin transporter binding in de novo Parkinson's disease: negative correlation with the dopamine transporter
    Karl Strecker
    Department of Neurology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    J Neurol 258:19-26. 2011
    ..No alteration of SERT binding in our patients suggests that the serotonergic system is remarkably preserved in early PD. Correlation with DAT might point to a compensatory regulation of the serotonergic system in early stages of PD...
  14. doi request reprint Influence of scan duration on the accuracy of β-amyloid PET with florbetaben in patients with Alzheimer's disease and healthy volunteers
    Solveig Tiepolt
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 40:238-44. 2013
    ..In dementia imaging, shortening of scan duration may simplify future clinical use. The aim of this retrospective study was to investigate the effect of scan duration on diagnostic accuracy...
  15. ncbi request reprint Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder
    Katarina Stengler-Wenzke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neuropsychobiology 53:40-5. 2006
    ..The neurobiological mechanisms of SSRI action and failure to respond to SSRI treatment remain to be elucidated...
  16. doi request reprint Molecular imaging of alpha7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743
    Winnie Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:791-800. 2009
    ..It was our goal to radiolabel the alpha7 nAChR agonist 4-[5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-yl]-1,4-diaza-bicyclo[3.2.2]nonane (NS10743) and to assess the selectivity of [(18)F]NS10743 binding site occupancy in animal experiments...
  17. ncbi request reprint In vivo measurement of nicotinic acetylcholine receptors with [18F]norchloro-fluoro-homoepibatidine
    Peter Brust
    Department of Radiopharmacy, Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, Leipzig, Germany
    Synapse 62:205-18. 2008
    ..Their binding profile in vivo appears to be more selective than that of 2-[(18)F]F-A85380. (-)-[(18)F]NCFHEB offers a faster equilibrium of specific binding than 2-[(18)F]F-A85380...
  18. ncbi request reprint Changes in myocardial perfusion due to physical exercise in patients with stable coronary artery disease
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 9a, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 32:813-9. 2005
    ..The aim of this study was to evaluate changes in myocardial stress perfusion after 1 year of exercise training in comparison with the effects of PTCA in patients with CAD...
  19. doi request reprint Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:1702-14. 2011
    ..The value of various quantitative parameters derived from the PET scans as potential surrogate markers of cognitive decline was also investigated...
  20. doi request reprint Kinetic analyses of [123I]IBZM SPECT for quantification of striatal dopamine D2 receptor binding: a critical evaluation of the single-scan approach
    Philipp T Meyer
    Department of Nuclear Medicine, University Hospital Aachen, Aachen, Germany
    Neuroimage 42:548-58. 2008
    ..The present study addresses these shortcomings...
  21. doi request reprint A new 18F-labeled fluoroacetylmorpholino derivative of vesamicol for neuroimaging of the vesicular acetylcholine transporter
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany
    Nucl Med Biol 35:185-95. 2008
    ....
  22. doi request reprint Executive and behavioral deficits share common neural substrates in frontotemporal lobar degeneration - a pilot FDG-PET study
    Karolina A Raczka
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Psychiatry Res 182:274-80. 2010
    ..This hypothesis might be further explored in studies involving larger patient groups...
  23. ncbi request reprint Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Germany
    AJNR Am J Neuroradiol 24:234-8. 2003
    ..The present study was initiated to intra-individually determine the integrity of these compartments in patients with WD...
  24. doi request reprint Positron-emission tomography imaging in the diagnosis of bisphosphonate-related osteonecrosis of the jaw
    Frank Wilde
    Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University of Leipzig, Leipzig, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:412-9. 2009
    ....
  25. ncbi request reprint Developmental and amyloid plaque-related changes in cerebral cortical capillaries in transgenic Tg2576 Alzheimer mice
    Elena Kouznetsova
    Paul Flechsig Institute for Brain Research, University of Leipzig, Department of Neurochemistry, Jahnallee 59, D 04109 Leipzig, Germany
    Int J Dev Neurosci 24:187-93. 2006
    ....
  26. doi request reprint Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Psychiatry Res 171:120-8. 2009
    ..Further studies will have to deal with the question of whether these findings have the potential to influence treatment decisions in this complex disorder...
  27. doi request reprint Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    Swen Hesse
    Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    J Neurol 255:1059-66. 2008
    ..These data show that clinical improvement and reduction of dopaminergic drugs in patients with advanced PD undergoing bilateral STN-DBS are paralleled by stable DAT and recovery of striatal D2R availability 12 months after surgery...
  28. doi request reprint Reduced alpha4beta2*-nicotinic acetylcholine receptor binding and its relationship to mild cognitive and depressive symptoms in Parkinson disease
    Philipp M Meyer
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Arch Gen Psychiatry 66:866-77. 2009
    ..Cognitive or depressive disorders are frequently noted in patients with Parkinson disease (PD) and may be related to altered signaling through alpha4beta2*-nicotinic acetylcholine receptors (alpha4beta2*-nAChRs)...
  29. ncbi request reprint Effects of left ventricular volume and ejection on myocardial blood flow measured by oxygen-15 water positron emission tomography in coronary heart disease
    Wolfgang M Schaefer
    Department of Nuclear Medicine, University Hospital, Aachen, Germany
    Am J Cardiol 91:469-72. 2003
  30. doi request reprint Fully automated radiosynthesis of both enantiomers of [(18)F]Flubatine under GMP conditions for human application
    Marianne Patt
    Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, D 04103 Leipzig, Germany Electronic address
    Appl Radiat Isot 80:7-11. 2013
    ..Radiochemical yields of 30% within an overall synthesis time of 40min were achieved in more than 70 individual syntheses. Specific activities were approximately 3000GBq/μmol and radiochemical purity was determined to be at least 97%. ..
  31. doi request reprint Pyrrolovesamicols--synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers
    Barbara Wenzel
    Institute of Radiopharmacy, Helmholtz Zentrum Dresden Rossendorf, Research Site Leipzig, Leipzig, Germany
    Bioorg Med Chem Lett 22:2163-6. 2012
    ..Unexpected low binding affinities to VAChT (K(i)=312±73 nM for (±)-6a and K(i)=7320±1840 nM for (±)-6b) were determined by competitive binding analysis using a cell line stably transfected with ratVAChT and (-)-[(3)H]vesamicol...
  32. ncbi request reprint Reduced serotonin transporter-availability in obsessive-compulsive disorder (OCD)
    Katarina Stengler-Wenzke
    Dept of Psychiatry, University of Leipzig, Johannisallee 20, 04317 Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 254:252-5. 2004
    ..76 (OCD patients) and 3.53 +/- 1.01 (controls). This in vivo finding of significant reduced serotonin transporter availability in midbrain/brainstem using [(123)I] beta-CIT SPECT further supports the serotonin deficit hypothesis of OCD...
  33. doi request reprint [18F]Fluorodeoxyglucose positron emission tomography for detection of bone marrow involvement in children and adolescents with Hodgkin's lymphoma
    Sandra Purz
    Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
    J Clin Oncol 29:3523-8. 2011
    ..The value of using FDG-PET to detect BM involvement has not been sufficiently defined. We compared the results of BMBs and FDG-PET for the diagnosis of BM involvement in a large pediatric group with HL...
  34. doi request reprint Residual lymph node metastasis in stage 4 neuroblastoma--advantage of radio-guided surgery?
    Robin Wachowiak
    Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany
    Pediatr Hematol Oncol 27:471-5. 2010
    ..Because study-based knowledge is missing due to the small number of affected patients, individual case reports are helpful to improve future treatment strategies...
  35. ncbi request reprint Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study
    Sandra Erbs
    Department of Cardiology, Heart, University of Leipzig, Germany
    Circ Res 97:756-62. 2005
    ..Hence, intracoronary transplantation of CPCs after recanalization of CTO results in an improvement of macro- and microvascular function and contributes to the recruitment of hibernating myocardium...
  36. doi request reprint Radiosynthesis of racemic and enantiomerically pure (-)-[18F]flubatine--a promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors
    Steffen Fischer
    Department of Neuroradiopharmaceuticals, Institute of Radiopharmacy, Helmholtz Zentrum Dresden Rossendorf, Research Site Leipzig, Permoserstrasse 15, Leipzig, Germany
    Appl Radiat Isot 74:128-36. 2013
    ..The radiosynthesis is easily transferable to an automated synthesis module...
  37. ncbi request reprint Synthesis procedure for routine production of 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]F-A-85380)
    Andreas Schildan
    Department of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany
    Appl Radiat Isot 65:1244-8. 2007
    ..10(5)GBq/mmol and a mean radiochemical purity of more than 99%...
  38. ncbi request reprint Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
    Psychiatry Res 140:63-72. 2005
    ..Our data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD. Further studies with more selective DAT and SERT radiotracers are needed...
  39. ncbi request reprint Correlation between automated writing movements and striatal dopaminergic innervation in patients with Wilson's disease
    Wieland Hermann
    Department of Neurology, University of Leipzig, Liebigstr 22a, 04107 Leipzig, Germany
    J Neurol 249:1082-7. 2002
    ..Furthermore analysis of automated handwriting movements could be useful for therapy monitoring and evaluation of striatal dopaminergic innervation...
  40. ncbi request reprint Different mechanisms for changes in glucose uptake of the right and left ventricular myocardium in pulmonary hypertension
    Regine Kluge
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 46:25-31. 2005
    ..The aim of this study was to measure the metabolic rates of glucose uptake for the RV and LV myocardium in patients in relationship to parameters of RV and LV function...
  41. pmc PET/MR in children. Initial clinical experience in paediatric oncology using an integrated PET/MR scanner
    Franz Wolfgang Hirsch
    Department of Paediatric Radiology, University of Leipzig, Liebigstr 20a, 04103, Leipzig, Germany
    Pediatr Radiol 43:860-75. 2013
    ..In our initial experience, PET/MR has turned out to be an unexpectedly stable and reliable hybrid imaging modality, which generates a complementary diagnostic study of great additional value. ..
  42. doi request reprint Florbetaben to trace amyloid-β in the Alzheimer brain by means of PET
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Alzheimers Dis 26:117-21. 2011
    ....
  43. pmc Combined evaluation of FDG-PET and MRI improves detection and differentiation of dementia
    Juergen Dukart
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    PLoS ONE 6:e18111. 2011
    ....
  44. ncbi request reprint Binding properties of the cerebral alpha4beta2 nicotinic acetylcholine receptor ligand 2-[18F]fluoro-A-85380 to plasma proteins
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Nucl Med Biol 33:899-906. 2006
    ..This study deals with some aspects of PPB of 2-[18F]FA...
  45. ncbi request reprint Investigating dopaminergic neurotransmission with 123I-FP-CIT SPECT: comparability of modern SPECT systems
    Philipp T Meyer
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    J Nucl Med 44:839-45. 2003
    ..g., as part of multicenter therapy trials)...
  46. ncbi request reprint [18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Nucl Med Biol 30:317-26. 2003
    ..This advantage of a faster reduction of unspecific binding, in light of similar or marginally lower tumor uptake, warrants further investigation of (18)FAZA as a marker of regional hypoxia in tumors...
  47. ncbi request reprint Is correction for age necessary in neuroimaging studies of the central serotonin transporter?
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Eur J Nucl Med Mol Imaging 30:427-30. 2003
    ..From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies...
  48. ncbi request reprint Preoperative brain mapping using [15O]water activation PET provides evidence on altered language networks in an adult brain tumour patient
    Philipp T Meyer
    Department of Nuclear Medicine, Aachen University of Technology, Aachen, Germany
    Eur J Nucl Med Mol Imaging 29:1705. 2002
  49. ncbi request reprint New reference intervals for thyrotropin and thyroid hormones based on National Academy of Clinical Biochemistry criteria and regular ultrasonography of the thyroid
    Juergen Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Institute of Transfusion Medicines, Clinics for Nuclear Medicine, University Hospital Leipzig, Germany
    Clin Chem 51:1480-6. 2005
    ..We also assessed the effect of potentially confounding factors to modulate the limits of these intervals...
  50. ncbi request reprint A truly simultaneous combination of functional transcranial Doppler sonography and H(2)(15)O PET adds fundamental new information on differences in cognitive activation between schizophrenics and healthy control subjects
    Osama Sabri
    Department of Nuclear Medicine, Aachen University of Technology, Aachen, Germany
    J Nucl Med 44:671-81. 2003
    ..We therefore investigated the extent to which there are both spatial (PET) and temporal changes (fTCD) in the activation patterns of schizophrenic patients...
  51. doi request reprint Physical and organizational provision for installation, regulatory requirements and implementation of a simultaneous hybrid PET/MR-imaging system in an integrated research and clinical setting
    Bernhard Sattler
    Department of Nuclear Medicine, University Hospital Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
    MAGMA 26:159-71. 2013
    ....
  52. ncbi request reprint Effect of drug-induced cytotoxicity on glucose uptake in Hodgkin's lymphoma cells
    Ursula Banning
    Division of Pediatric Hematology and Oncology, Clinic and Policlinic for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Eur J Haematol 77:102-8. 2006
    ..However, drug-mediated downregulation of glucose uptake in viable Hodgkin's lymphoma cells might limit the use of FDG-PET...
  53. doi request reprint Relative quantification of indium-111 pentetreotide and gallium-68 DOTATOC uptake in the thyroid gland and association with thyroid pathologies
    Thomas Lincke
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Thyroid 19:381-9. 2009
    ..Therefore, we systematically evaluated Indium-111 (In-111) pentetreotide scintigraphies and Gallium-68 (Ga-68) DOTA-Phe(1)-Tyr(3)-Octreotide (DOTATOC) positron emission tomography (PET) scans for thyroid radiotracer uptake...
  54. doi request reprint Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Lancet Neurol 10:424-35. 2011
    ..We aimed to assess the sensitivity and specificity of florbetaben (¹⁸F) PET in discriminating between patients with probable Alzheimer's disease and elderly healthy controls...
  55. ncbi request reprint Preoperative mapping of cortical language areas in adult brain tumour patients using PET and individual non-normalised SPM analyses
    Philipp T Meyer
    Department of Nuclear Medicine, Aachen University of Technology, Aachen, Germany
    Eur J Nucl Med Mol Imaging 30:951-60. 2003
    ..The observed right frontal activations agree with proposed reorganisation processes, but they may also reflect an unspecific recruitment of the right-sided Broca's homologue in the effort to perform the task...
  56. ncbi request reprint Heart abscess revealed by nuclear medicine imaging
    Marcus Förster
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 32:249. 2005
  57. ncbi request reprint Serial 18F-fluoro-2-deoxy-D-glucose positron emission tomography and magnetic resonance imaging of paraneoplastic limbic encephalitis
    Rainer Scheid
    Day Clinic of Cognitive Neurology, University of Leipzig, Leipzig, Germany
    Arch Neurol 61:1785-9. 2004
    ..To review and expand the existing literature of magnetic resonance imaging (MRI) and positron emission tomography (PET) of paraneoplastic limbic encephalitis (PLE)...
  58. ncbi request reprint Simultaneous osteosarcoma and papillary thyroid carcinoma
    Claudia Dannenberg
    Division of Paediatric Haematology Oncology, Children s University Hospital, Leipzig, Germany
    Lancet Oncol 6:126-7. 2005
  59. ncbi request reprint Sentinel lymph node biopsy in squamous cell carcinomas of the lips and the oral cavity - a single center experience
    Bernhard Frerich
    Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University of Leipzig, Leipzig, Germany
    J Surg Oncol 95:97-105. 2007
    ..The aim of this study is to evaluate the feasibility and potential of SLNB as a reliable staging procedure in early stage SCC of the lips and the oral mucosa...
  60. ncbi request reprint Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial
    Rainer Hambrecht
    Universitat Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin Kardiologie, Leipzig, Germany
    Circulation 109:1371-8. 2004
    ....
  61. pmc Diverse functional properties of Wilson disease ATP7B variants
    Dominik Huster
    Department of Medicine, Dermatology and Neurology, Division of Gastroenterology and Rheumatology, University of Leipzig, Leipzig, Germany
    Gastroenterology 142:947-956.e5. 2012
    ..The disease presents with a variable phenotype that complicates the diagnostic process and treatment. Little is known about the mechanisms that contribute to the different phenotypes of the disease...
  62. ncbi request reprint Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders
    Swen Hesse
    Department of Nuclear Medicine, University Hospital, University of Leipzig, Leipzig, Germany
    Neurosci Biobehav Rev 28:547-63. 2004
    ..We furthermore elucidate the potential of SERT imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors...
  63. ncbi request reprint Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology
    Margrit Klingner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Int J Dev Neurosci 21:357-69. 2003
    ....
  64. doi request reprint Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings
    Susanne Graef
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Psychopharmacology (Berl) 215:205-29. 2011
    ..The cholinergic system has long been linked to cognitive processes. Two main classes of acetylcholine (ACh) receptors exist in the human brain, namely muscarinic and nicotinic receptors, of which several subtypes occur...
  65. ncbi request reprint Thyroid volume measurement in patients prior to radioiodine therapy: comparison between three-dimensional magnetic resonance imaging and ultrasonography
    Patrick Reinartz
    Department of Nuclear Medicine, Aachen University of Technology, Aachen, Germany
    Thyroid 12:713-7. 2002
    ..The findings indicate that the use of a correction factor higher than 0.52 in the ellipsoid formula is recommended to improve accuracy. However, further studies are necessary to confirm these findings...
  66. ncbi request reprint Cerebral correlates of selective attention in schizophrenic patients with formal thought disorder: a controlled H2 15O-PET study
    Ralf Erkwoh
    Clinic of Psychiatry and Psychotherapy, Aachen University of Technology, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Psychiatry Res 115:137-53. 2002
    ..We suggest that differing task-solving strategies are applied by both clinical subgroups to achieve comparable results on the selective attention paradigm...
  67. ncbi request reprint Synthesis of novel 4- and 5-substituted benzyl ether derivatives of vesamicol and in vitro evaluation of their binding properties to the vesicular acetylcholine transporter site
    Matthias Scheunemann
    Institut für Interdisziplinäre Isotopenforschung, Permoserstr 15, 04318 Leipzig, Germany
    Bioorg Med Chem 12:1459-65. 2004
    ..5+/-6.9 nM, [(3)H]DTG; K(i)-value(10b)=30.6+/-9.6 nM, [(3)H]haloperidol). The data suggest the potential of vesamicol derivatives to design appropriate radiotracer for PET imaging of central cholinergic deficits...
  68. ncbi request reprint 123I-beta-CIT SPECT for imaging serotonin transporters in Parkinson's disease
    Henryk Barthel
    J Nucl Med 45:923-4. 2004
  69. ncbi request reprint Preoperative mapping of cortical motor function: prospective comparison of functional magnetic resonance imaging and [15O]-H2O-positron emission tomography in the same co-ordinate system
    Marcus H T Reinges
    Department of Neurosurgery, University Hospital Aachen, Germany
    Nucl Med Commun 25:987-97. 2004
    ..As yet, no study has compared these two modalities within the same frame of reference in tumour patients...
  70. ncbi request reprint Autoradiography of 2-[18F]F-A-85380 on nicotinic acetylcholine receptors in the porcine brain in vitro
    Winnie Deuther-Conrad
    Institute of Interdisciplinary Isotope Research, Radiopharmacy, 04318 Leipzig, Germany
    Synapse 59:201-10. 2006
    ..The autoradiographic data confirmed the suitability of swine as a model for the evaluation of radioligands designed for imaging of nAChR subtypes in the living brain...
  71. ncbi request reprint Structural changes of benzylether derivatives of vesamicol and their influence on the binding selectivity to the vesicular acetylcholine transporter
    Barbara Wenzel
    Institut für Interdisziplinäre Isotopenforschung, Permoserstr 15, 04318 Leipzig, Germany
    Eur J Med Chem 40:1197-205. 2005
    ..1+/-1.5 nM and 327.5+/-75.9 nM. Nevertheless, these data provide the basis for future structure-binding-studies and further underline the potential and usefulness of vesamicol analogues for imaging of the VAChT...
  72. ncbi request reprint [46th Congress of the German Society of Nuclear Medicine. Introduction]
    Osama Sabri
    Nuklearmedizin 47:N11. 2008