A Saalbach

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Inhibition of the iNOS pathway in inflammatory macrophages by low-dose X-irradiation in vitro. Is there a time dependence?
    Guido Hildebrandt
    Department of Radiotherapy and Radiooncology, University of Leipzig, Germany
    Strahlenther Onkol 179:158-66. 2003
  2. ncbi request reprint Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium
    Anja Saalbach
    Saxon Academy of Science, D 04107 Leipzig, Germany
    Oncogene 24:4710-20. 2005
  3. ncbi request reprint A ligand of human thy-1 is localized on polymorphonuclear leukocytes and monocytes and mediates the binding to activated thy-1-positive microvascular endothelial cells and fibroblasts
    A Saalbach
    Department of Dermatology, University of Leipzig, Leipzig, Germany
    J Invest Dermatol 115:882-8. 2000
  4. ncbi request reprint The Thy-1/Thy-1 ligand interaction is involved in binding of melanoma cells to activated Thy-1- positive microvascular endothelial cells
    A Saalbach
    Department of Dermatology, University of Leipzig, 04103 Leipzig, Germany
    Microvasc Res 64:86-93. 2002
  5. ncbi request reprint Fibroblasts surrounding melanoma express elevated levels of matrix metalloproteinase-1 (MMP-1) and intercellular adhesion molecule-1 (ICAM-1) in vitro
    E Wandel
    Department of Dermatology, University of Leipzig, Germany
    Exp Dermatol 9:34-41. 2000
  6. doi request reprint Human fibroblasts support the expansion of IL-17-producing T cells via up-regulation of IL-23 production by dendritic cells
    Christine Schirmer
    Department of Dermatology, Venerology and Allergology, Medical Faculty of the Leipzig University, Leipzig, Germany
    Blood 116:1715-25. 2010
  7. ncbi request reprint Increased neutrophil adherence in psoriasis: role of the human endothelial cell receptor Thy-1 (CD90)
    Anne Wetzel
    Department of Dermatology, Venerology and Allergy, University of Leipzig, Leipzig, Germany
    J Invest Dermatol 126:441-52. 2006
  8. ncbi request reprint Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    Anne Wetzel
    Department of Dermatology, University of Leipzig, Leipzig, Germany
    J Immunol 172:3850-9. 2004
  9. ncbi request reprint Chemokine release from activated human dermal microvascular endothelial cells--implications for the pathophysiology of scleroderma?
    U Anderegg
    Department of Dermatology, Leipzig University, Germany
    Arch Dermatol Res 292:341-7. 2000
  10. ncbi request reprint Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4
    Verena Voelcker
    Department of Dermatology, Venerology and Allergology, Leipzig University, Leipzig, Germany
    Exp Dermatol 17:100-7. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Inhibition of the iNOS pathway in inflammatory macrophages by low-dose X-irradiation in vitro. Is there a time dependence?
    Guido Hildebrandt
    Department of Radiotherapy and Radiooncology, University of Leipzig, Germany
    Strahlenther Onkol 179:158-66. 2003
    ..We therefore investigated the time dependence and the underlying molecular mechanism of this effect, since it may be involved in the clinically observed anti-inflammatory and analgesic efficacy of low-dose radiotherapy...
  2. ncbi request reprint Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium
    Anja Saalbach
    Saxon Academy of Science, D 04107 Leipzig, Germany
    Oncogene 24:4710-20. 2005
    ..These data explain at least in part the high tumorigenicity of alphavbeta3-expressing melanoma cells and the association of alphavbeta3-positive melanoma cells with a high risk of metastasis and poor prognosis...
  3. ncbi request reprint A ligand of human thy-1 is localized on polymorphonuclear leukocytes and monocytes and mediates the binding to activated thy-1-positive microvascular endothelial cells and fibroblasts
    A Saalbach
    Department of Dermatology, University of Leipzig, Leipzig, Germany
    J Invest Dermatol 115:882-8. 2000
    ..Cell adhesion assays and blocking experiments revealed a direct involvement of the Thy-1/Thy-1 ligand interaction in the binding of monocytes and polymorphonuclear leukocytes to Thy-1-positive activated endothelial cells and fibroblasts...
  4. ncbi request reprint The Thy-1/Thy-1 ligand interaction is involved in binding of melanoma cells to activated Thy-1- positive microvascular endothelial cells
    A Saalbach
    Department of Dermatology, University of Leipzig, 04103 Leipzig, Germany
    Microvasc Res 64:86-93. 2002
    ....
  5. ncbi request reprint Fibroblasts surrounding melanoma express elevated levels of matrix metalloproteinase-1 (MMP-1) and intercellular adhesion molecule-1 (ICAM-1) in vitro
    E Wandel
    Department of Dermatology, University of Leipzig, Germany
    Exp Dermatol 9:34-41. 2000
    ..These results support the idea that fibroblasts surrounding melanoma are activated and are possibly involved in the degradation of matrix proteins surrounding the tumour...
  6. doi request reprint Human fibroblasts support the expansion of IL-17-producing T cells via up-regulation of IL-23 production by dendritic cells
    Christine Schirmer
    Department of Dermatology, Venerology and Allergology, Medical Faculty of the Leipzig University, Leipzig, Germany
    Blood 116:1715-25. 2010
    ..In conclusion, skin fibroblasts are involved in regulation of IL-23 production in DCs and, as a result, of Th17 expansion...
  7. ncbi request reprint Increased neutrophil adherence in psoriasis: role of the human endothelial cell receptor Thy-1 (CD90)
    Anne Wetzel
    Department of Dermatology, Venerology and Allergy, University of Leipzig, Leipzig, Germany
    J Invest Dermatol 126:441-52. 2006
    ..In conclusion, our data indicate that the adhesion of neutrophils to activated ECs mediated by Thy-1/Mac-1 interaction is an important attachment mechanism facilitating their subsequent migration into lesional psoriatic skin...
  8. ncbi request reprint Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    Anne Wetzel
    Department of Dermatology, University of Leipzig, Leipzig, Germany
    J Immunol 172:3850-9. 2004
    ..This additional pathway in leukocyte-endothelium interaction may play an important role in the regulation of leukocyte recruitment to sites of inflammation...
  9. ncbi request reprint Chemokine release from activated human dermal microvascular endothelial cells--implications for the pathophysiology of scleroderma?
    U Anderegg
    Department of Dermatology, Leipzig University, Germany
    Arch Dermatol Res 292:341-7. 2000
    ..From our data we conclude that RANTES and MCP-1 induction by silica may be an initiating event in inflammatory infiltration, whereas TNFalpha-mediated inflammation may propagate the disease more efficiently...
  10. ncbi request reprint Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4
    Verena Voelcker
    Department of Dermatology, Venerology and Allergology, Leipzig University, Leipzig, Germany
    Exp Dermatol 17:100-7. 2008
    ....
  11. doi request reprint Dermal fibroblasts promote the migration of dendritic cells
    Anja Saalbach
    Department of Dermatology, Venerology and Allergology, Medical Faculty of the Leipzig University, Leipzig, Germany
    J Invest Dermatol 130:444-54. 2010
    ..In summary, fibroblasts in the local dermal microenvironment are capable of potentiating the migratory capacity of DCs, and thus have the potential to actively participate in the regulation of a cutaneous immune response...
  12. doi request reprint ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells
    Ulf Anderegg
    Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany
    J Invest Dermatol 129:1471-82. 2009
    ....
  13. doi request reprint Human Thy-1 induces secretion of matrix metalloproteinase-9 and CXCL8 from human neutrophils
    Anja Saalbach
    Department of Dermatology, Venerology and Allergology, Medical Faculty of the Leipzig University, Leipzig, Germany
    Eur J Immunol 38:1391-403. 2008
    ..Our results support the general concept that the function of 'adhesion molecules' in particular of human Thy-1, may not only be to provide mechanical support but also regulate neutrophil functions...
  14. ncbi request reprint Ultraviolet-B irradiation enhances melanoma cell motility via induction of autocrine interleukin 8 secretion
    Carl Gebhardt
    Department of Dermatology, Venerology and Allergology, University of Leipzig, Leipzig, Germany
    Exp Dermatol 16:636-43. 2007
    ..Our findings are consistent with the hypothesis that UVB is not only involved in the initiation of melanoma, but may also be important for some aspects of tumor progression...
  15. ncbi request reprint Dermal fibroblasts induce maturation of dendritic cells
    Anja Saalbach
    Department of Dermatology, Venerology, and Allergology, Medical Faculty of Leipzig University, Leipzig, Germany
    J Immunol 178:4966-74. 2007
    ....
  16. ncbi request reprint MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF-beta and pro-inflammatory cytokines
    Ulf Anderegg
    Saxon Academy of Science in Leipzig, University of Leipzig, Leipzig, Germany
    Exp Dermatol 14:709-18. 2005
    ..The expression MEL4B3 therefore reflects closely cell activation occurring during tumor growth, metastasis and inflammation...
  17. ncbi request reprint Norepinephrine-induced changes in cardiac transforming growth factor-beta isoform expression pattern of female and male rats
    Wilfried Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
    Hypertension 44:410-8. 2004
    ..The increase in TGF-beta isoforms correlated with that of the mRNA expression of collagens, MMP-2 and TIMP-2...
  18. ncbi request reprint Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors
    Margrit Hollborn
    Department of Ophthalmology, Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany
    Invest Ophthalmol Vis Sci 45:2033-8. 2004
    ..The purpose of this study was to investigate the expression of this receptor and its regulation, at the protein and mRNA levels, in human (h)RPE cells...
  19. ncbi request reprint Minocycline does not alter collagen type I metabolism of dermal fibroblasts in culture
    Ulf Anderegg
    Department of Dermatology, Leipzig University and Saxon Academy of Science, Leipzig, Germany
    Arch Dermatol Res 294:103-8. 2002
    ..Therefore, other mechanisms are probably responsible for the clinical effect observed in the treatment of systemic sclerosis...
  20. ncbi request reprint Fibroblasts enhance the invasive capacity of melanoma cells in vitro
    E Wandel
    Department of Dermatology, University of Leipzig, Liebigstr 21, 04103 Leipzig, Germany
    Arch Dermatol Res 293:601-8. 2002
    ..g. bfgf)...
  21. pmc Involvement of the chemokine-like receptor GPR33 in innate immunity
    Jens Bohnekamp
    Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 396:272-7. 2010
    ..Our data indicate an important role of GPR33 function in innate immunity which became dispensable during human evolution most likely due to past or balancing selection...