Rainer Rupprecht

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
    Rainer Rupprecht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Nat Rev Drug Discov 9:971-88. 2010
  2. ncbi Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects
    Rainer Rupprecht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany
    Science 325:490-3. 2009
  3. ncbi GABAA receptors as targets for novel anxiolytic drugs
    Rainer Rupprecht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 7:231-7. 2006
  4. ncbi The angiotensin I converting enzyme insertion/deletion polymorphism influences therapeutic outcome in major depressed women, but not in men
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 363:38-42. 2004
  5. ncbi Neuroactive steroids in responders and nonresponders to sleep deprivation
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Ann N Y Acad Sci 1032:216-23. 2004
  6. ncbi Influence of sleep deprivation on neuroactive steroids in major depression
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuropsychopharmacology 28:577-81. 2003
  7. ncbi Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 31:1019-25. 2006
  8. ncbi The dysbindin gene in major depression: an association study
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 129:55-8. 2004
  9. ncbi Influence of a functional polymorphism within the angiotensin I-converting enzyme gene on partial sleep deprivation in patients with major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 339:223-6. 2003
  10. ncbi Impact of loudness dependency of auditory evoked potentials on the panic response to CCK-4
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 43:393-400. 2009

Detail Information

Publications69

  1. ncbi Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
    Rainer Rupprecht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Nat Rev Drug Discov 9:971-88. 2010
    ..This Review focuses on the biology and pathophysiology of TSPO and the potential of currently available TSPO ligands for the diagnosis and treatment of neurological and psychiatric disorders...
  2. ncbi Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects
    Rainer Rupprecht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany
    Science 325:490-3. 2009
    ..Thus, translocator protein (18 kD) ligands are promising candidates for fast-acting anxiolytic drugs with less severe side effects than benzodiazepines...
  3. ncbi GABAA receptors as targets for novel anxiolytic drugs
    Rainer Rupprecht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 7:231-7. 2006
    ..However, their clinical efficacy has still to be shown in clinical trials...
  4. ncbi The angiotensin I converting enzyme insertion/deletion polymorphism influences therapeutic outcome in major depressed women, but not in men
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 363:38-42. 2004
    ..Our investigation gives the first hint that the speed of onset of antidepressant therapies may be dependent on both variants of the ACE genes and the gender of the patients...
  5. ncbi Neuroactive steroids in responders and nonresponders to sleep deprivation
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Ann N Y Acad Sci 1032:216-23. 2004
    ..In contrast to antidepressant drugs which correct the dysequilibrium of neuroactive steroids in major depression within several weeks, PSD does not affect the concentrations of neuroactive steroids in either responders or nonresponders...
  6. ncbi Influence of sleep deprivation on neuroactive steroids in major depression
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neuropsychopharmacology 28:577-81. 2003
    ....
  7. ncbi Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 31:1019-25. 2006
    ....
  8. ncbi The dysbindin gene in major depression: an association study
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 129:55-8. 2004
    ..Further analysis are needed to confirm these results...
  9. ncbi Influence of a functional polymorphism within the angiotensin I-converting enzyme gene on partial sleep deprivation in patients with major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 339:223-6. 2003
    ..This should result in earlier and more intense additional therapeutic interventions in this group of patients...
  10. ncbi Impact of loudness dependency of auditory evoked potentials on the panic response to CCK-4
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 43:393-400. 2009
    ..The analysis of the loudness dependency of the auditory evoked potentials (LDAEP) is a valid non-invasive indicator of central serotonergic activity...
  11. ncbi Genetic variants in the angiotensin I-converting-enzyme (ACE) and angiotensin II receptor (AT1) gene and clinical outcome in depression
    Brigitta Bondy
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1094-9. 2005
    ..Our data might further suggest that patients with a haplotype combining the CC and DD/ID genotypes respond better to treatment than those with either single allele. These results should however be replicated in future research...
  12. ncbi Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine
    Cornelius Schule
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Psychopharmacology (Berl) 166:271-5. 2003
    ..Mirtazapine acts as an antagonist at presynaptic alpha(2)-receptors and at postsynaptic 5-hydroxytryptamine (5-HT)(2), 5-HT(3) and histamine H(1) receptors. It has been shown acutely to inhibit cortisol secretion in healthy subjects...
  13. ncbi Hypothalamic-pituitary-adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 328:299-303. 2002
    ..The HPA axis stimulating properties of higher ACE and consecutively higher AT-II and/or lower substance P concentrations may be crucial factors for the HPA system hyperactivity during major depressive episodes...
  14. ncbi Time course of hypothalamic-pituitary-adrenocortical axis activity during treatment with reboxetine and mirtazapine in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, Munich, 80336, Germany
    Psychopharmacology (Berl) 186:601-11. 2006
    ....
  15. ncbi Effects of combination treatment with mood stabilizers and mirtazapine on plasma concentrations of neuroactive steroids in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 32:669-80. 2007
    ....
  16. ncbi Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 61:177-83. 2004
    ..Several studies have found reciprocal interactions between the serotonergic system and both brain-derived neurotrophic factor and glutamate, which are known to modulate or affect hippocampal morphologic characteristics...
  17. ncbi Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
    ..Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression...
  18. ncbi Effects of mirtazapine on dehydroepiandrosterone-sulfate and cortisol plasma concentrations in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 43:538-45. 2009
    ..In the present study, the impact of mirtazapine on DHEA-S and cortisol (COR) levels was investigated in relation to clinical response in depressed patients...
  19. ncbi Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1003-7. 2008
    ....
  20. ncbi Neuropsychopharmacological properties of neuroactive steroids in depression and anxiety disorders
    Daniela Eser
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr. 7, 80336, Munich, Germany
    Psychopharmacology (Berl) 186:373-87. 2006
    ..They are important endogenous modulators of depression and anxiety and may provide a basis for the development of novel therapeutic agents in the treatment of affective disorders...
  21. ncbi No Influence of a functional polymorphism within the serotonin transporter gene on partial sleep deprivation in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 4:111-4. 2003
    ..Thus, the previously reported influence of the serotonin transporter gene on PSD outcome in bipolar depression could not be confirmed in unipolar depressed patients...
  22. ncbi The influence of 4-week treatment with sertraline on the combined T3/TRH test in depressed patients
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 255:334-40. 2005
    ..07%) and after the 4-week treatment with sertraline (-58.92%). Apparently, the therapeutic efficacy of antidepressants such as sertraline is not related to the regulation of HPT axis activity in depressed patients...
  23. ncbi Effects of repetitive transcranial magnetic stimulation (rTMS) on panic attacks induced by cholecystokinin-tetrapeptide (CCK-4)
    Peter Zwanzger
    Department of Psychiatry, Ludwig Maximilian University of Munich, Munich, Germany
    Int J Neuropsychopharmacol 10:285-9. 2007
    ..In contrast to the effects of pretreatment with alprazolam on CCK-4-induced panic in healthy subjects LF rTMS does not affect CCK-4-induced panic and cortisol or ACTH release...
  24. ncbi The influence of concomitant neuroleptic medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy
    Caroline Nothdurfter
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany
    World J Biol Psychiatry 7:162-70. 2006
    ..The tolerability of ECT treatment was not influenced by concomitant neuroleptic medication...
  25. ncbi Effects of antidepressant pharmacotherapy after repetitive transcranial magnetic stimulation in major depression: an open follow-up study
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    J Psychiatr Res 37:145-53. 2003
    ....
  26. ncbi Panic induction with cholecystokinin-tetrapeptide (CCK-4) Increases plasma concentrations of the neuroactive steroid 3alpha, 5alpha tetrahydrodeoxycorticosterone (3alpha, 5alpha-THDOC) in healthy volunteers
    Daniela Eser
    Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany
    Neuropsychopharmacology 30:192-5. 2005
    ....
  27. ncbi Mirtazapine does not influence tetrahydrodeoxycorticosterone levels in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 11:308-13. 2010
    ..In the present study, the impact of mirtazapine on 3alpha,5alpha-THDOC levels was investigated in relation to clinical response in depressed patients...
  28. ncbi Plasma concentrations of neuroactive steroids before and after electroconvulsive therapy in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany
    Neuropsychopharmacology 30:1181-6. 2005
    ....
  29. ncbi Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 120:85-9. 2003
    ..05). However, after correction for multiple testing (Bonferroni) these results did not remain significant. Nevertheless, these findings suggest that the presence of the C allele might be an indicator for antidepressant treatment response...
  30. ncbi The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 126:82-7. 2004
    ....
  31. ncbi Neuroactive steroids in depression and anxiety disorders: clinical studies
    Daniela Eser
    Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany
    Neuroendocrinology 84:244-54. 2006
    ..The modulation of GABA(A) receptors by neuroactive steroids might contribute to the pathophysiology of depression and anxiety disorders and might offer new targets for the development of novel anxiolytic compounds...
  32. ncbi Saccadic eye velocity after selective GABAergic treatment with tiagabine in healthy volunteers
    Peter Zwanzger
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
    Neuropsychobiology 52:147-50. 2005
    ..Tiagabine is a new antiepileptic drug which acts via selective blockade of GABA reuptake. Therefore, we examined the effects of tiagabine on saccade parameters...
  33. ncbi Mirtazapine monotherapy versus combination therapy with mirtazapine and aripiprazole in depressed patients without psychotic features: a 4-week open-label parallel-group study
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 8:112-22. 2007
    ....
  34. ncbi Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet 114:530-2. 2002
    ....
  35. ncbi Changes in CCK-4 induced panic after treatment with the GABA-reuptake inhibitor tiagabine are associated with an increase in 3alpha,5alpha-tetrahydrodeoxycorticosterone concentrations
    Peter Zwanzger
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Psychoneuroendocrinology 34:1586-9. 2009
    ..Thus, it might be hypothesized that the anxiolytic effects of GABAergic treatment might in part be mediated by their influence on 3alpha,5alpha-THDOC concentrations...
  36. ncbi Effects of tiagabine on cholecystokinin-tetrapeptide (CCK-4)-induced anxiety in healthy volunteers
    Peter Zwanzger
    Department of Psychiatry, University of Munich, Munich, Germany
    Depress Anxiety 18:140-3. 2003
    ..Our results suggest anxiolytic properties of tiagabine in humans, which provide sufficient rationale to assess its putative anxiolytic effects in patients with panic disorder under controlled conditions...
  37. ncbi Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Psychopharmacology (Berl) 192:479-87. 2007
    ..However, assessment of CCK-4-induced panic does not follow consistent rules...
  38. ncbi The influence of anaesthetic medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 11:447-56. 2010
    ..Furthermore, most anaesthetics have anticonvulsant properties and therefore might additionally influence the efficacy of ECT...
  39. ncbi The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    PLoS ONE 4:e4324. 2009
    ..In this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated...
  40. ncbi The influence of concomitant antidepressant medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 7:82-90. 2006
    ..Also, a concomitant pharmacotherapy can be utilized to augment therapeutic effectiveness. Surprisingly, data in this field are widely lacking and only few studies showed advantages of an ECT/tricyclic antidepressant combination...
  41. ncbi Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Hum Brain Mapp 30:511-22. 2009
    ..In conclusion, while overall brain activation patterns are not related to the subjective anxiety response to CCK-4, amygdala activation may be involved in the subjective perception of CCK-4-induced fear...
  42. ncbi Influence of age on effectiveness and tolerability of electroconvulsive therapy
    Julia Damm
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    J ECT 26:282-8. 2010
    ..Nevertheless, age-specific adverse effects such as greater cognitive impairment and higher somatic risks due to medical comorbidities and concomitant medication may be limiting factors in geriatric patients...
  43. ncbi Plasma concentrations of neuroactive steroids before and after repetitive transcranial magnetic stimulation (rTMS) in major depression
    Frank Padberg
    Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstr. 7, D-80336, Munich, Germany
    Neuropsychopharmacology 27:874-8. 2002
    ..Changes in neuroactive steroid levels after antidepressant pharmacotherapy more likely reflect specific pharmacological effects of antidepressant drugs and are not necessary for the amelioration of depressive symptoms...
  44. ncbi Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results
    Andreas Strohle
    Max Planck Institute of Psychiatry, Munich, Germany
    Arch Gen Psychiatry 60:161-8. 2003
    ..Although animal studies suggest anxiolytic properties of these endogenous modulators of central nervous excitability, no clinical data indicate whether they are also involved in the pathophysiology of anxiety disorders and panic attacks...
  45. ncbi Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants
    Caroline Nothdurfter
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    Neuropsychopharmacology 35:1510-9. 2010
    ....
  46. ncbi Neuroactive steroids as endogenous modulators of anxiety
    Daniela Eser
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Curr Pharm Des 14:3525-33. 2008
    ..In conclusion, neuroactive steroids are important endogenous modulators of depression and anxiety and may provide a basis for development of novel therapeutic agents in the treatment of affective disorders...
  47. ncbi Lithium but not carbamazepine augments antidepressant efficacy of mirtazapine in unipolar depression: an open-label study
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 10:390-9. 2009
    ..The purpose of the present open-label study was to investigate the antidepressant efficacy of lithium and carbamazepine as augmentation strategies in unipolar depressed inpatients...
  48. ncbi Glyoxalase-I mRNA expression and CCK-4 induced panic attacks
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 45:60-3. 2011
    ....
  49. ncbi Impact of state and trait anxiety on the panic response to CCK-4
    Daniela Eser
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    J Neural Transm 115:917-20. 2008
    ..In conclusion, psychological factors are not major determinants for the subjective panic response to CCK-4 thus emphasising the importance of neurobiological factors...
  50. ncbi Major depressive disorder is associated with cardiovascular risk factors and low Omega-3 Index
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Clin Psychiatry 72:1242-7. 2011
    ..Therefore, we studied whether polyunsaturated fatty acids and the Omega-3 Index may represent markers for assessment of the cardiovascular risk in somatically healthy patients suffering from MDD...
  51. ncbi Patterns of response to repetitive transcranial magnetic stimulation (rTMS) in major depression: replication study in drug-free patients
    Eva Lotta Brakemeier
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Affect Disord 108:59-70. 2008
    ..Thus, this study aims to replicate previous findings and explore patterns of response in drug-free patients...
  52. ncbi Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Nat Genet 36:1319-25. 2004
    ..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs...
  53. ncbi Recent developments in potential anxiolytic agents targeting GABAA/BzR complex or the translocator protein (18kDa) (TSPO)
    Caroline Nothdurfter
    Department of Psychiatry and Psychotherapy, University Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany
    Curr Top Med Chem 12:360-70. 2012
    ..First clinical studies revealed promising results. In this review, we discuss putative compounds affecting the GABAergic system which may provide the basis for fast acting anxiolytics with a favorable side effect profile...
  54. ncbi Recent progress in pharmacological and non-pharmacological treatment options of major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Curr Pharm Des 12:503-15. 2006
    ....
  55. ncbi Hypothalamic-pituitary-adrenocortical system dysregulation and new treatment strategies in depression
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Expert Rev Neurother 9:1005-19. 2009
    ..Thus, it is unclear at present to what extent new, clinically effective antidepressant therapies can be developed based on the corticoid receptor hypothesis of depression...
  56. ncbi N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant
    Barbara Di Benedetto
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropharmacology 62:209-16. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  57. ncbi DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression
    Peter Zill
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    PLoS ONE 7:e40479. 2012
    ....
  58. ncbi Analysis of polymorphisms in the olfactory G-protein Golf in major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Psychiatr Genet 12:17-22. 2002
    ..The results of this study agree with the reported parent-of-origin effects on chromosome 18, but do not support the hypothesis that the Golf gene is a major susceptibility factor for major depression...
  59. ncbi Selective GABAergic treatment for panic? Investigations in experimental panic induction and panic disorder
    Peter Zwanzger
    Anxiety Research Unit and Anxiety Outpatient Clinic, Department of Psychiatry, Ludwig Maximilians Universitat, Munich, Germany
    J Psychiatry Neurosci 30:167-75. 2005
    ....
  60. ncbi The combined T3/TRH test in depressed patients and healthy controls
    Cornelius Schule
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Psychoneuroendocrinology 30:341-56. 2005
    ....
  61. ncbi Modulation of ligand-gated ion channels by antidepressants and antipsychotics
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, 80804, Germany
    Mol Neurobiol 35:160-74. 2007
    ..In this review, we focus on the direct interaction of antidepressants and antipsychotics with LGICs, which may provide a basis for the development of novel psychopharmacological drugs...
  62. ncbi Acute prefrontal rTMS increases striatal dopamine to a similar degree as D-amphetamine
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Psychiatry Res 156:251-5. 2007
    ..95% (difference not statistically significant). Acute rTMS challenge showed similar striatal dopaminergic effects to those associated with the administration of d-amphetamine, a substance known to increase synaptic dopamine...
  63. ncbi Relation between responses to repetitive transcranial magnetic stimulation and partial sleep deprivation in major depression
    Frank Padberg
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Psychiatr Res 36:131-5. 2002
    ..Apparently, different subgroups of depressed patients respond to both interventions. Further studies are needed to characterize the response to rTMS by means of clinical and biological parameters...
  64. ncbi Occurrence of delusions during repetitive transcranial magnetic stimulation (rTMS) in major depression
    Peter Zwanzger
    Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Biol Psychiatry 51:602-3. 2002
    ..CONCLUSIONS: In light of preclinical findings showing increased dopaminergic activity after rTMS treatment, occurrence of psychotic symptoms should be considered a potential side effect of rTMS treatment...
  65. ncbi Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e6715. 2009
    ..8-13.4 nM). Thus, individual differences in the primary sequence of 5-HT(3) receptors may be crucial for the antipsychotic potency and/or the side effect profile of clozapine...
  66. ncbi Evaluation of a salivary based combined dexamethasone/CRH test in patients with major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychoneuroendocrinology 27:385-99. 2002
    ....
  67. ncbi Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Neuropsychopharmacology 26:489-93. 2002
    ..Our results suggest that the investigated polymorphisms are not major susceptibility factors in the etiology of major depression...
  68. ncbi Severe dependency on zolpidem in a patient with multiple sclerosis suffering from paraspasticity
    Julia Damm
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    World J Biol Psychiatry 11:516-8. 2010
    ..This should be taken into account by doctors when prescribing higher doses. Zolpidem may improve symptoms of spasticity in high doses via affection of GABA alpha2-receptor and alpha3-receptor subunits...
  69. ncbi GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment
    Andreas Strohle
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Psychiatry 159:145-7. 2002
    ..However, no data on the possible role of these gamma-aminobutyric acid(A) (GABA(A)) receptor-modulating neuroactive steroids in patients with anxiety disorders are available...