Research Topics
| S RuhrmannSummaryAffiliation: University of Cologne Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Dimensions of working memory dysfunction in schizophreniaRalf Pukrop
Department of Psychiatry and Psychotherapy, University of Cologne, Joseph Stelzmann Str 9, 50928 Cologne, Germany
Schizophr Res 62:259-68. 2003..Schizophr. Bull. 27 (2001) 157]...
Chances and risks of predicting psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 262:S85-90. 2012..Thus, whether a risk model justifies preventive measures can only be decided by weighing the costs of unnecessary intervention and the benefits of avoiding a potentially devastating outcome...- Pharmacological prevention and treatment in clinical at-risk states for psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Curr Pharm Des 18:550-7. 2012..Future prevention studies, however, need to solve the challenge of changing immediate transition rates, demanding for new risk enrichment strategies as a prerequisite for feasible trial designs... - Reduced subjective quality of life in persons at risk for psychosisS Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Acta Psychiatr Scand 117:357-68. 2008..Subjective quality of life (sQoL) and potentially contributing factors were investigated in individuals putatively in an early (EIPS) or late initial prodromal state (LIPS) and healthy controls (HC)... - Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptomsStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, Cologne, Germany
Prog Neuropsychopharmacol Biol Psychiatry 31:1012-22. 2007..Further studies should confirm the latter using neuropsychological performance tests and should investigate whether tolerability improves with a markedly lower dose range... - Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosisS Ruhrmann
Department of Psychiatry and Psychotherapy, University Hospital of the University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
Br J Psychiatry Suppl 51:s88-95. 2007..People in a putatively late prodromal state not only have an enhanced risk for psychosis but already suffer from mental and functional disturbances... - Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis studyStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
Arch Gen Psychiatry 67:241-51. 2010..Existing criteria need improvement in terms of specificity and individual risk assessment to allow for better targeted and earlier interventions... - Probably at-risk, but certainly ill--advocating the introduction of a psychosis spectrum disorder in DSM-VStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Schizophr Res 120:23-37. 2010..Following from this shift in the perception of current at-risk criteria, access to standard medical care would have to be granted, and diagnosis- or symptom- rather than conversion-related interventions would have to be developed... - Intervention in at-risk states for developing psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 260:S90-4. 2010..An overview on the current findings and ongoing research in this area is provided... - Intervention in the at-risk state to prevent transition to psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Curr Opin Psychiatry 22:177-83. 2009..The number of intervention studies aiming to prevent psychosis is still small. Follow-up data of the first studies were published during the last year and neuroprotection has become an important issue... - Preventing progression to first-episode psychosis in early initial prodromal statesA Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Br J Psychiatry 200:22-9. 2012.... - Auditory P300 in individuals clinically at risk for psychosisIngo Frommann
Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany
Int J Psychophysiol 70:192-205. 2008..The aim of this study was to assess the amplitude, latency, and topography of the P300 in individuals at clinical high risk for psychosis... - Early detection and intervention in the initial prodromal phase of schizophreniaS Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Pharmacopsychiatry 36:S162-7. 2003..Initial study results targeting an earlier or later prodromal phase are promising, but longer follow-ups and larger samples are needed... - The initial prodrome of schizophrenia: different duration, different underlying deficits?Frauke Schultze-Lutter
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Compr Psychiatry 48:479-88. 2007.... - Orienting of attention in unmedicated patients with schizophrenia, prodromal subjects and healthy relativesEuphrosyne Gouzoulis-Mayfrank
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, D 50924 Cologne, Germany
Schizophr Res 97:35-42. 2007..In conclusion, blunted IOR in schizophrenia is not secondary to medications. According to this and previous studies blunted IOR may be most probably viewed as a trait cognitive feature of the schizophrenic disorder... - Perceived parental rearing in subjects with obsessive-compulsive disorder and their siblingsL Lennertz
Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
Acta Psychiatr Scand 121:280-8. 2010..In addition, we included data from unaffected siblings to corroborate information on parental rearing... - Impaired mismatch negativity generation in prodromal subjects and patients with schizophreniaAnke Brockhaus-Dumke
Department of Psychiatry and Psychotherapy, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
Schizophr Res 73:297-310. 2005..To elicit MMN, a three-tone auditory oddball paradigm with 10% 'duration deviants' and 10% 'frequency deviants' was used... - Rationale and first results of developing at-risk (prodromal) criteria for bipolar disorderA Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Curr Pharm Des 18:358-75. 2012.... - Impulsiveness in obsessive-compulsive disorder: results from a family studyS Ettelt
Department of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany
Acta Psychiatr Scand 115:41-7. 2007..The purpose of this study was to assess impulsiveness in OCD families and compare it to control families... 
DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosisRainald Mossner
Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...- Antisaccade performance is related to genetic loading for schizophreniaNadine Petrovsky
Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
J Psychiatr Res 43:291-7. 2009..018). No group differences were found for prosaccade parameters. These results support the hypothesis that antisaccade impairment is associated with genetic loading for schizophrenia... - Kraepelin and psychotic prodromal conditionsJoachim Klosterkotter
Dept of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 258:74-84. 2008..This review will outline the current state of the art of a phase specific early detection and intervention based on these syndromes... - Sensory gating in schizophrenia: P50 and N100 gating in antipsychotic-free subjects at risk, first-episode, and chronic patientsAnke Brockhaus-Dumke
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Biol Psychiatry 64:376-84. 2008..Abnormal sensory gating in schizophrenia has frequently been reported; however, only limited data on unmedicated patients and patients at risk to develop a psychosis have, as yet, been available... - [The Cologne Early Recognition and Intervention Center for mental crises (FETZ). Evaluation of service use]Frauke Schultze-Lutter
Klinik fur Psychiatrie und Psychotherapie, Universitätsklinik Köln, Früh Erkennungs and Therapie Zentrum für psychische Krisen FETZ, Koln
Med Klin (Munich) 103:81-9. 2008..Following the German psychopathologic tradition, basic symptoms, especially cognitive-perceptive disturbances, are employed as a means to this aim in addition to the internationally established "ultra-high risk" (UHR) criteria... - Early onset of obsessive-compulsive disorder and associated comorbidityDeborah Janowitz
Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
Depress Anxiety 26:1012-7. 2009..This study was undertaken to discriminate the subtypes of OCD in different AOO levels and to test the hypothesis that different AOO bands are associated with a differential pattern of comorbidity... - Early detection of psychosis - establishing a service for persons at riskFrauke Schultze-Lutter
University of Cologne, Department of Psychiatry and Psychotherapy, 50924 Cologne, Germany
Eur Psychiatry 24:1-10. 2009..The establishment phase of an early detection centre for prodromal psychosis is introduced and characterised, along with its detaining and promoting factors within a universal multi-payer health care system... - Increased neural response related to neutral faces in individuals at risk for psychosisNina Y Seiferth
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
Neuroimage 40:289-97. 2008.... - Basic symptoms and ultrahigh risk criteria: symptom development in the initial prodromal stateFrauke Schultze-Lutter
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Schizophr Bull 36:182-91. 2010..However, as regards the criteria, the results support the notion of BS as at least a complementary approach to the ultrahigh risk criteria, which may also allow for an earlier detection of psychosis... - Subjective quality of life in subjects at risk for a first episode of psychosis: a comparison with first episode schizophrenia patients and healthy controlsAndreas Bechdolf
Cologne Early Recognition and Intervention Centre for mental crises FETZ, Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Schizophr Res 79:137-43. 2005..These findings support the notion that subjects at risk for a first episode of psychosis constitute a clinical population for which further service and intervention research is indicated... - Interventions in the initial prodromal states of psychosis in Germany: concept and recruitmentAndreas Bechdolf
Early Recognition and Intervention Centre for Mental Crisis FETZ, Department of Psychiatry and Psychotherapy, University of Cologne, Kerpenerstrasse 62, 50924 Cologne, Germany
Br J Psychiatry Suppl 48:s45-8. 2005..Two intervention strategies are being studied by two large-scale multicentre projects... - Neurocognitive functioning in subjects at risk for a first episode of psychosis compared with first- and multiple-episode schizophreniaRalf Pukrop
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
J Clin Exp Neuropsychol 28:1388-407. 2006..Results support a neurodevelopmental model of psychosis with further progressive mechanisms and are consistent with a primary involvement of left frontotemporal networks in the prodromal phase... - Neurocognitive indicators for a conversion to psychosis: comparison of patients in a potentially initial prodromal state who did or did not convert to a psychosisRalf Pukrop
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, D 50937 Cologne, Germany
Schizophr Res 92:116-25. 2007.... - Basic symptoms in early psychotic and depressive disordersFrauke Schultze-Lutter
University of Cologne, Department of Psychiatry and Psychotherapy, Early Recognition and Intervention Centre for Mental Crises FETZ, 50924 Cologne, Germany
Br J Psychiatry Suppl 51:s31-7. 2007..Depression is a frequent condition in early psychosis. Therefore, early detection instruments should distinguish depression from beginning psychosis... - Relationship between subjective and objective cognitive function in the early and late prodromeFrauke Schultze-Lutter
University of Cologne, Department of Psychiatry and Psychotherapy, Early Recognition and Intervention Centre for Mental Crises FETZ, 50924 Cologne, Germany
Br J Psychiatry Suppl 51:s43-51. 2007..Yet, the relation between subjective and objective deficits and to different prodromal states is unclear... - Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophreniaDagmar Koethe
Dept of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 259:195-202. 2009..70. Thus, the BDII may be useful as an additional neuropsychological test for assessment of patients at high risk for developing schizophrenia... - The German Research Network on Schizophrenia--impact on the management of schizophreniaWolfgang Wolwer
Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Postbox 12 05 10, D 40605 Düsseldorf, Germany
Dialogues Clin Neurosci 8:115-21. 2006.... - Pharmacological intervention in the initial prodromal phase of psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Eur Psychiatry 20:1-6. 2005..The full benefits of early detection and intervention should be revealed once larger and longer studies are conducted... - The interaction of working memory and emotion in persons clinically at risk for psychosis: an fMRI pilot studyKatharina Pauly
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
Schizophr Res 120:167-76. 2010..Our study underlines that cerebral dysfunctions related to cognitive and emotional processes, as well as their interaction, can emerge in persons with CHR, even in absence of behavioral differences... - Neural correlates of visuo-spatial attention during an antisaccade task in schizophrenia: an ERP studyIndira Tendolkar
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Int J Neurosci 115:681-98. 2005..Left temporo-occipitally, this activity was only evident in schizophrenia patients, possibly reflecting additional neuronal recruitment in order to perform the antisaccade task successfully... - Neural correlates of working memory dysfunction in first-episode schizophrenia patients: an fMRI multi-center studyFrank Schneider
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
Schizophr Res 89:198-210. 2007.... - A roadmap to disentangle the molecular etiology of schizophreniaPeter Falkai
Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, 37075 Goettingen, Germany
Eur Psychiatry 23:224-32. 2008..The coming calls of the frame work program will be used to strengthen this network in order to achieve substantial progress in understanding and treating this devastating illness... - Remembering or knowing: electrophysiological evidence for an episodic memory deficit in schizophreniaI Tendolkar
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Psychol Med 32:1261-71. 2002..The more widespread frontal Know old/new effect in the patients suggests that the prefrontly mediated processes associated with retrieval of semantic memory may be enhanced compensatorily... - Evidence for a dysfunctional retrosplenial cortex in patients with schizophrenia: a functional magnetic resonance imaging study with a semantic-perceptual contrastIndira Tendolkar
Department of Psychiatry, University of Cologne, Joseph Stelzmannstr 9, 50924 Cologne, Germany
Neurosci Lett 369:4-8. 2004..The impaired RS-PCC functionality in a semantic task may relate to verbal memory deficits frequently observed in schizophrenia patients, because this region is pivotal for gating information into the medial temporal lobe memory system... - Harm avoidance in subjects with obsessive-compulsive disorder and their familiesSusan Ettelt
Department of Psychiatry and Psychotherapy, University of Greifswald, Germany
J Affect Disord 107:265-9. 2008..HA is considered to be a genetically influenced personality trait with an increasingly understood neuroanatomical basis... - Neural correlates of temporal context discriminationIndira Tendolkar
Department of Psychiatry, University of Cologne, Joseph Stelzmannstr 9, 50924 Cologne, Germany
Biol Psychol 66:235-55. 2004..The significance of these old/new effects are discussed in relation to the broader pattern of old/new effects seen in standard tests of declarative memory retrieval... - Obsessive-compulsive disorder and posttraumatic stress disorderHans Joergen Grabe
Department of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany
Psychopathology 41:129-34. 2008..This study investigates the hypothesis that traumatic events and posttraumatic stress disorders (PTSD) precede the onset of OCD... - Early detection and secondary prevention of psychosis: facts and visionsHeinz Hafner
Central Institute of Mental Health, J5, 68159 Mannheim, Germany
Eur Arch Psychiatry Clin Neurosci 254:117-28. 2004.... - Alexithymia in obsessive-compulsive disorder - results from a family studyHans Joergen Grabe
Department of Psychiatry, University of Greifswald, Greifswald, Germany
Psychother Psychosom 75:312-8. 2006..This study investigates the hypotheses of an elevated level of alexithymia in subjects with OCD and their first-degree relatives compared to controls and their first-degree relatives...