Klemens Rottner

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi request reprint Actin dynamics and turnover in cell motility
    Klemens Rottner
    Helmholtz Centre for Infection Research, Inhoffen Strasse 7, 38124 Braunschweig, Germany
    Curr Opin Cell Biol 23:569-78. 2011
  2. doi request reprint WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond
    Klemens Rottner
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, Inhoffen Strasse 7, Braunschweig, Germany
    Trends Cell Biol 20:650-61. 2010
  3. pmc Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases
    Frank P L Lai
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, D 38124 Braunschweig, Germany
    Mol Biol Cell 20:3209-23. 2009
  4. doi request reprint Activation of a RhoA/myosin II-dependent but Arp2/3 complex-independent pathway facilitates Salmonella invasion
    Jan Hänisch
    Signaling and Motility Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Cell Host Microbe 9:273-85. 2011
  5. pmc Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways
    Tanja Bosse
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research HZI, Inhoffenstrasse 7, D 38124, Braunschweig, Germany
    Mol Cell Biol 27:6615-28. 2007
  6. doi request reprint Molecular dissection of Salmonella-induced membrane ruffling versus invasion
    Jan Hänisch
    Helmholtz Centre for Infection Research, Braunschweig, Germany
    Cell Microbiol 12:84-98. 2010
  7. doi request reprint A novel contractility pathway operating in Salmonella invasion
    Jan Hänisch
    Helmholtz Centre for Infection Research, Braunschweig, Germany
    Virulence 3:81-6. 2012
  8. pmc Arp2/3 complex interactions and actin network turnover in lamellipodia
    Frank P L Lai
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
    EMBO J 27:982-92. 2008
  9. pmc Microtubules as platforms for assaying actin polymerization in vivo
    J Margit Oelkers
    Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 6:e19931. 2011
  10. doi request reprint IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation
    Stefanie M Weiss
    Signalling and Motility Group, Helmholtz Centre for Infection Research, D 38124 Braunschweig, Germany
    Cell Host Microbe 5:244-58. 2009

Collaborators

Detail Information

Publications16

  1. doi request reprint Actin dynamics and turnover in cell motility
    Klemens Rottner
    Helmholtz Centre for Infection Research, Inhoffen Strasse 7, 38124 Braunschweig, Germany
    Curr Opin Cell Biol 23:569-78. 2011
    ..Here we will draft the future steps essential for achieving true progress towards the goal to increase our understanding of actin cytoskeleton dynamics driving cell migration...
  2. doi request reprint WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond
    Klemens Rottner
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, Inhoffen Strasse 7, Braunschweig, Germany
    Trends Cell Biol 20:650-61. 2010
    ..Uncovering the physiological relevance of these unique activities will require concerted efforts from multiple disciplines, and is sure to impact our understanding of how the cytoskeleton controls so many dynamic subcellular events...
  3. pmc Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases
    Frank P L Lai
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, D 38124 Braunschweig, Germany
    Mol Biol Cell 20:3209-23. 2009
    ..Furthermore, we propose that cortactin promotes cell migration indirectly, through contributing to activation of selected Rho-GTPases...
  4. doi request reprint Activation of a RhoA/myosin II-dependent but Arp2/3 complex-independent pathway facilitates Salmonella invasion
    Jan Hänisch
    Signaling and Motility Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Cell Host Microbe 9:273-85. 2011
    ..Thus, Salmonella enters nonphagocytic cells by manipulating the two core machineries of actin-based motility in the host: Arp2/3 complex-driven actin polymerization and actomyosin-mediated contractility...
  5. pmc Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways
    Tanja Bosse
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research HZI, Inhoffenstrasse 7, D 38124, Braunschweig, Germany
    Mol Cell Biol 27:6615-28. 2007
    ..Together, our data establish an intricate signaling network comprising as key molecules Cdc42 and PI3-kinase, which converge on Rac-mediated actin reorganization essential for Listeria invasion and membrane ruffling downstream of c-Met...
  6. doi request reprint Molecular dissection of Salmonella-induced membrane ruffling versus invasion
    Jan Hänisch
    Helmholtz Centre for Infection Research, Braunschweig, Germany
    Cell Microbiol 12:84-98. 2010
    ....
  7. doi request reprint A novel contractility pathway operating in Salmonella invasion
    Jan Hänisch
    Helmholtz Centre for Infection Research, Braunschweig, Germany
    Virulence 3:81-6. 2012
    ..zipper classification of entry mechanisms employed by distinct bacterial pathogens...
  8. pmc Arp2/3 complex interactions and actin network turnover in lamellipodia
    Frank P L Lai
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
    EMBO J 27:982-92. 2008
    ..Network turnover is additionally regulated by the spatially segregated activities of capping protein at the tip and cofilin throughout the mesh...
  9. pmc Microtubules as platforms for assaying actin polymerization in vivo
    J Margit Oelkers
    Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 6:e19931. 2011
    ..This novel approach allows systematic dissection of actin nucleation in the cytosol of live cells, its genetic re-engineering as well as screening for new modifiers of the process...
  10. doi request reprint IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation
    Stefanie M Weiss
    Signalling and Motility Group, Helmholtz Centre for Infection Research, D 38124 Braunschweig, Germany
    Cell Host Microbe 5:244-58. 2009
    ..Genetic and functional loss of IRSp53 abrogates actin assembly mediated by EHEC. Collectively, these data indentify IRSp53 family proteins as the missing host cell factors linking bacterial Tir and EspF(U) in EHEC pedestal formation...
  11. ncbi request reprint Bacteria-host-cell interactions at the plasma membrane: stories on actin cytoskeleton subversion
    Klemens Rottner
    Cytoskeleton Dynamics Group, German Research Center for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Dev Cell 9:3-17. 2005
    ..To accomplish this, these pathogens have evolved common as well as unique strategies to modulate actin dynamics at the plasma membrane, which will be discussed here, exemplified by a number of well-studied bacterial pathogens...
  12. ncbi request reprint Pathogen-induced actin filament rearrangement in infectious diseases
    Klemens Rottner
    Cytoskeleton Dynamics Group, German Research Centre for Biotechnology GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Pathol 204:396-406. 2004
    ..Many pathogens are accomplishing these challenges by exploiting the actin cytoskeleton in a highly sophisticated manner as a result of having evolved common as well as unique strategies...
  13. doi request reprint Poxviruses taking a ride on actin: new users of known hardware
    Klemens Rottner
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, Inhoffen Strasse 7, 38124 Braunschweig, Germany
    Cell Host Microbe 6:497-9. 2009
    ..Now, Dodding and Way identify functional orthologs of A36 in other vertebrate poxviruses that harbor varying numbers of Nck-binding sites and can substitute for A36 despite no sequence homology...
  14. pmc Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation
    Anika Steffen
    German Research Centre for Biotechnology, Department of Cell Biology, Braunschweig, Germany
    EMBO J 23:749-59. 2004
    ..Thus, Sra-1 and Nap1 are constitutive and essential components of a WAVE2- and Abi-1-containing complex linking Rac to site-directed actin assembly...
  15. doi request reprint On the Rho'd: the regulation of membrane protrusions by Rho-GTPases
    Markus Ladwein
    Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research HZI, Inhoffen Strasse 7, D 38124 Braunschweig, Germany
    FEBS Lett 582:2066-74. 2008
    ..We also comment on topical, unresolved controversies in the field, with special emphasis on the interrelation of different protrusion types, and on the composition of the nanomachineries driving them...
  16. ncbi request reprint N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits
    Stefanie Benesch
    Cytoskeleton Dynamics Group, German Research Centre for Biotechnology GBF, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Cell Sci 118:3103-15. 2005
    ....